Gene/Proteome Database (LMPD)

LMPD ID
LMP001364
Gene ID
2819
Species
Homo sapiens (Human)
Gene Name
glycerol-3-phosphate dehydrogenase 1 (soluble)
Gene Symbol
GPD1
Synonyms
GPD-C; GPDH-C; HTGTI
Alternate Names
glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic; glycerophosphate dehydrogenase; glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic
Chromosome
12
Map Location
12q13.12
EC Number
1.1.1.8
Summary
This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria. Mutations in this gene are a cause of transient infantile hypertriglyceridemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
Orthologs
View orthologs and multiple alignments for GPD1

Proteins

glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic isoform 1
Refseq ID NP_005267
Protein GI 33695088
UniProt ID P21695
mRNA ID NM_005276
Length 349
RefSeq Status REVIEWED
MASKKVCIVGSGNWGSAIAKIVGGNAAQLAQFDPRVTMWVFEEDIGGKKLTEIINTQHENVKYLPGHKLPPNVVAVPDVVQAAEDADILIFVVPHQFIGKICDQLKGHLKANATGISLIKGVDEGPNGLKLISEVIGERLGIPMSVLMGANIASEVADEKFCETTIGCKDPAQGQLLKELMQTPNFRITVVQEVDTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAKLFCSGPVSSATFLESCGVADLITTCYGGRNRKVAEAFARTGKSIEQLEKELLNGQKLQGPETARELYSILQHKGLVDKFPLFMAVYKVCYEGQPVGEFIHCLQNHPEHM
glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic isoform 2
Refseq ID NP_001244128
Protein GI 380714668
UniProt ID P21695
mRNA ID NM_001257199
Length 326
RefSeq Status REVIEWED
MASKKVCIVGSGNWGSAIAKIVGGNAAQLAQFDPRVTMWVFEEDIGGKKLTEIINTQHENVKYLPGHKLPPNVFIGKICDQLKGHLKANATGISLIKGVDEGPNGLKLISEVIGERLGIPMSVLMGANIASEVADEKFCETTIGCKDPAQGQLLKELMQTPNFRITVVQEVDTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAKLFCSGPVSSATFLESCGVADLITTCYGGRNRKVAEAFARTGKSIEQLEKELLNGQKLQGPETARELYSILQHKGLVDKFPLFMAVYKVCYEGQPVGEFIHCLQNHPEHM

Gene Information

Entrez Gene ID
2819
Gene Name
glycerol-3-phosphate dehydrogenase 1 (soluble)
Gene Symbol
GPD1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 TAS:Reactome C cytosol
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0009331 IEA:InterPro C glycerol-3-phosphate dehydrogenase complex
GO:0005739 IEA:Ensembl C mitochondrion
GO:0051287 IEA:Ensembl F NAD binding
GO:0004367 TAS:ProtInc F glycerol-3-phosphate dehydrogenase [NAD+] activity
GO:0004368 IEA:Ensembl F glycerol-3-phosphate dehydrogenase activity
GO:0006116 IEA:Ensembl P NADH oxidation
GO:0044255 TAS:Reactome P cellular lipid metabolic process
GO:0071320 IEA:Ensembl P cellular response to cAMP
GO:0071356 IEA:Ensembl P cellular response to tumor necrosis factor
GO:0006094 IEA:Ensembl P gluconeogenesis
GO:0046168 IEA:InterPro P glycerol-3-phosphate catabolic process
GO:0006127 IEA:Ensembl P glycerophosphate shuttle
GO:0046474 TAS:Reactome P glycerophospholipid biosynthetic process
GO:0006654 TAS:Reactome P phosphatidic acid biosynthetic process
GO:0006644 TAS:Reactome P phospholipid metabolic process
GO:0045821 IEA:Ensembl P positive regulation of glycolytic process
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0019432 TAS:Reactome P triglyceride biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00564 Glycerophospholipid metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6118 glycerol-3-phosphate shuttle

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_121401 Glycerophospholipid biosynthesis
REACT_120906 Synthesis of PA

Domain Information

InterPro Annotations

Accession Description
IPR008927 6-phosphogluconate dehydrogenase, C-terminal-like
IPR013328 Dehydrogenase, multihelical
IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent
IPR006109 Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal
IPR011128 Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal
IPR017751 Glycerol-3-phosphate dehydrogenase, NAD-dependent, eukaryotic
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
glycerol-3-phosphate dehydrogenase 1 (soluble)
Protein Entry
GPDA_HUMAN
UniProt ID
P21695
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P21695-1; Sequence=Displayed; Name=2; IsoId=P21695-2; Sequence=VSP_045999; Note=No experimental confirmation available.;
Catalytic Activity sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH.
Disease Hypertriglyceridemia, transient infantile (HTGTI) [MIM
Enzyme Regulation Inhibited by zinc ions and sulfate.
Similarity Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
Subcellular Location Cytoplasm.
Subunit Homodimer.

Identical and Related Proteins

Unique RefSeq proteins for LMP001364 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
33695088 RefSeq NP_005267 349 glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic isoform 1
380714668 RefSeq NP_001244128 326 glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic isoform 2

Identical Sequences to LMP001364 proteins

Reference Database Accession Length Protein Name
GI:33695088 GenBank EAW58128.1 349 glycerol-3-phosphate dehydrogenase 1 (soluble), isoform CRA_a [Homo sapiens]
GI:33695088 GenBank EAW58129.1 349 glycerol-3-phosphate dehydrogenase 1 (soluble), isoform CRA_a [Homo sapiens]
GI:33695088 GenBank ABM84719.1 349 glycerol-3-phosphate dehydrogenase 1 (soluble), partial [synthetic construct]
GI:33695088 GenBank ABM92243.1 349 glycerol-3-phosphate dehydrogenase 1 (soluble) [synthetic construct]
GI:33695088 GenBank AIC48862.1 349 GPD1, partial [synthetic construct]
GI:33695088 SwissProt P21695.4 349 RecName: Full=Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic; Short=GPD-C; Short=GPDH-C [Homo sapiens]

Related Sequences to LMP001364 proteins

Reference Database Accession Length Protein Name
GI:33695088 DBBJ BAG35417.1 349 unnamed protein product [Homo sapiens]
GI:33695088 GenBank AAA92863.1 349 L-glycerol-3-phosphate:NAD oxidoreductase [Homo sapiens]
GI:33695088 GenBank AAX36153.1 350 glycerol-3-phosphate dehydrogenase 1, partial [synthetic construct]
GI:380714668 GenBank ABM92243.1 349 glycerol-3-phosphate dehydrogenase 1 (soluble) [synthetic construct]
GI:33695088 PDB 1WPQ 349 Chain A, Ternary Complex Of Glycerol 3-Phosphate Dehydrogenase 1 With Nad And Dihydroxyactone
GI:33695088 PDB 1WPQ 349 Chain B, Ternary Complex Of Glycerol 3-Phosphate Dehydrogenase 1 With Nad And Dihydroxyactone
GI:33695088 PDB 1X0X 354 Chain A, Co-Structure Of Homo Sapiens Glycerol-3-Phosphate Dehydrogenase 1 Complex With Nad
GI:380714668 RefSeq NP_005267.2 349 glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic isoform 1 [Homo sapiens]
GI:380714668 RefSeq XP_004053155.1 326 PREDICTED: glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic isoform 2 [Gorilla gorilla gorilla]
GI:380714668 RefSeq XP_004088673.1 326 PREDICTED: glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic isoform 2 [Nomascus leucogenys]
GI:380714668 RefSeq XP_009245926.1 326 PREDICTED: glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic isoform X1 [Pongo abelii]
GI:380714668 SwissProt P21695.4 349 RecName: Full=Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic; Short=GPD-C; Short=GPDH-C [Homo sapiens]