Gene/Proteome Database (LMPD)

LMPD ID
LMP001366
Gene ID
5338
Species
Homo sapiens (Human)
Gene Name
phospholipase D2
Gene Symbol
PLD2
Synonyms
-
Alternate Names
phospholipase D2; PLD1C; hPLD2; choline phosphatase 2; phosphatidylcholine-hydrolyzing phospholipase D2
Chromosome
17
Map Location
17p13.1
EC Number
3.1.4.4
Summary
The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
Orthologs
View orthologs and multiple alignments for PLD2

Proteins

phospholipase D2 isoform PLD2A
Refseq ID NP_002654
Protein GI 156564407
UniProt ID O14939
mRNA ID NM_002663
Length 933
RefSeq Status REVIEWED
MTATPESLFPTGDELDSSQLQMESDEVDTLKEGEDPADRMHPFLAIYELQSLKVHPLVFAPGVPVTAQVVGTERYTSGSKVGTCTLYSVRLTHGDFSWTTKKKYRHFQELHRDLLRHKVLMSLLPLARFAVAYSPARDAGNREMPSLPRAGPEGSTRHAASKQKYLENYLNRLLTMSFYRNYHAMTEFLEVSQLSFIPDLGRKGLEGMIRKRSGGHRVPGLTCCGRDQVCYRWSKRWLVVKDSFLLYMCLETGAISFVQLFDPGFEVQVGKRSTEARHGVRIDTSHRSLILKCSSYRQARWWAQEITELAQGPGRDFLQLHRHDSYAPPRPGTLARWFVNGAGYFAAVADAILRAQEEIFITDWWLSPEVYLKRPAHSDDWRLDIMLKRKAEEGVRVSILLFKEVELALGINSGYSKRALMLLHPNIKVMRHPDQVTLWAHHEKLLVVDQVVAFLGGLDLAYGRWDDLHYRLTDLGDSSESAASQPPTPRPDSPATPDLSHNQFFWLGKDYSNLITKDWVQLDRPFEDFIDRETTPRMPWRDVGVVVHGLPARDLARHFIQRWNFTKTTKAKYKTPTYPYLLPKSTSTANQLPFTLPGGQCTTVQVLRSVDRWSAGTLENSILNAYLHTIRESQHFLYIENQFFISCSDGRTVLNKVGDEIVDRILKAHKQGWCYRVYVLLPLLPGFEGDISTGGGNSIQAILHFTYRTLCRGEYSILHRLKAAMGTAWRDYISICGLRTHGELGGHPVSELIYIHSKVLIADDRTVIIGSANINDRSLLGKRDSELAVLIEDTETEPSLMNGAEYQAGRFALSLRKHCFGVILGANTRPDLDLRDPICDDFFQLWQDMAESNANIYEQIFRCLPSNATRSLRTLREYVAVEPLATVSPPLARSELTQVQGHLVHFPLKFLEDESLLPPLGSKEGMIPLEVWT
phospholipase D2 isoform PLD2B
Refseq ID NP_001230037
Protein GI 340805823
UniProt ID O14939
mRNA ID NM_001243108
Length 922
RefSeq Status REVIEWED
MTATPESLFPTGDELDSSQLQMESDEVDTLKEGEDPADRMHPFLAIYELQSLKVHPLVFAPGVPVTAQVVGTERYTSGSKVGTCTLYSVRLTHGDFSWTTKKKYRHFQELHRDLLRHKVLMSLLPLARFAVAYSPARDAGNREMPSLPRAGPEGSTRHAASKQKYLENYLNRLLTMSFYRNYHAMTEFLEVSQLSFIPDLGRKGLEGMIRKRSGGHRVPGLTCCGRDQVCYRWSKRWLVVKDSFLLYMCLETGAISFVQLFDPGFEVQVGKRSTEARHGVRIDTSHRSLILKCSSYRQARWWAQEITELAQGPGRDFLQLHRHDSYAPPRPGTLARWFVNGAGYFAAVADAILRAQEEIFITDWWLSPEVYLKRPAHSDDWRLDIMLKRKAEEGVRVSILLFKEVELALGINSGYSKRALMLLHPNIKVMRHPDQVTLWAHHEKLLVVDQVVAFLGGLDLAYGRWDDLHYRLTDLGDSSESAASQPPTPRPDSPATPDLSHNQFFWLGKDYSNLITKDWVQLDRPFEDFIDRETTPRMPWRDVGVVVHGLPARDLARHFIQRWNFTKTTKAKYKTPTYPYLLPKSTSTANQLPFTLPGGQCTTVQVLRSVDRWSAGTLENSILNAYLHTIRESQHFLYIENQFFISCSDGRTVLNKVGDEIVDRILKAHKQGWCYRVYVLLPLLPGFEGDISTGGGNSIQAILHFTYRTLCRGEYSILHRLKAAMGTAWRDYISICGLRTHGELGGHPVSELIYIHSKVLIADDRTVIIGSANINDRSLLGKRDSELAVLIEDTETEPSLMNGAEYQAGSVILGANTRPDLDLRDPICDDFFQLWQDMAESNANIYEQIFRCLPSNATRSLRTLREYVAVEPLATVSPPLARSELTQVQGHLVHFPLKFLEDESLLPPLGSKEGMIPLEVWT

Gene Information

Entrez Gene ID
5338
Gene Name
phospholipase D2
Gene Symbol
PLD2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0031526 IEA:Ensembl C brush border membrane
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0005886 TAS:Reactome C plasma membrane
GO:0070290 IEA:UniProtKB-EC F N-acylphosphatidylethanolamine-specific phospholipase D activity
GO:0035091 IEA:InterPro F phosphatidylinositol binding
GO:0004630 TAS:ProtInc F phospholipase D activity
GO:0038096 TAS:Reactome P Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0002031 IEA:Ensembl P G-protein coupled receptor internalization
GO:0007010 TAS:ProtInc P cytoskeleton organization
GO:0046474 TAS:Reactome P glycerophospholipid biosynthetic process
GO:0045087 TAS:Reactome P innate immune response
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0006654 TAS:Reactome P phosphatidic acid biosynthetic process
GO:0006655 TAS:Reactome P phosphatidylglycerol biosynthetic process
GO:0006644 TAS:Reactome P phospholipid metabolic process
GO:0007264 TAS:ProtInc P small GTPase mediated signal transduction
GO:0044281 TAS:Reactome P small molecule metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa04724 Glutamatergic synapse
hsa04014 Ras signaling pathway
hsa04024 cAMP signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR015679 Phospholipase D family
IPR016555 Phospholipase D, eukaryota
IPR025202 Phospholipase D-like domain
IPR001736 Phospholipase D/Transphosphatidylase
IPR001683 Phox homologous domain
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain

UniProt Annotations

Entry Information

Gene Name
phospholipase D2
Protein Entry
PLD2_HUMAN
UniProt ID
O14939
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=PLD2A; IsoId=O14939-1; Sequence=Displayed; Name=PLD2C; IsoId=O14939-3; Sequence=VSP_005027; Name=PLD2B; IsoId=O14939-4; Sequence=VSP_054769;
Catalytic Activity A phosphatidylcholine + H(2)O = choline + a phosphatidate.
Enzyme Regulation Stimulated by phosphatidylinositol 4,5- bisphosphate and activated by the ADP-ribosylation factor-1 (ARF- 1).
Function May have a role in signal-induced cytoskeletal regulation and/or endocytosis.
Interaction P23528:CFL1; NbExp=2; IntAct=EBI-1053996, EBI-352733; P62993:GRB2; NbExp=4; IntAct=EBI-1053996, EBI-401755;
Ptm Phosphorylated by FGR.
Similarity Belongs to the phospholipase D family.
Similarity Contains 1 PH domain.
Similarity Contains 1 PX (phox homology) domain.
Similarity Contains 2 PLD phosphodiesterase domains.
Subcellular Location Membrane ; Peripheral membrane protein .
Subunit Interacts with EGFR (By similarity). Interacts with PIP5K1B.
Tissue Specificity Ubiquitous.
Web Resource Name=Wikipedia; Note=Phospholipase D entry; URL="http://en.wikipedia.org/wiki/Phospholipase_D";

Identical and Related Proteins

Unique RefSeq proteins for LMP001366 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
156564407 RefSeq NP_002654 933 phospholipase D2 isoform PLD2A
340805823 RefSeq NP_001230037 922 phospholipase D2 isoform PLD2B

Identical Sequences to LMP001366 proteins

Reference Database Accession Length Protein Name
GI:156564407 GenBank EAW90404.1 933 phospholipase D2, isoform CRA_a [Homo sapiens]
GI:340805823 GenBank EAW90405.1 922 phospholipase D2, isoform CRA_b [Homo sapiens]
GI:156564407 RefSeq XP_006721610.1 933 PREDICTED: phospholipase D2 isoform X4 [Homo sapiens]
GI:156564407 SwissProt O14939.2 933 RecName: Full=Phospholipase D2; Short=PLD 2; Short=hPLD2; AltName: Full=Choline phosphatase 2; AltName: Full=PLD1C; AltName: Full=Phosphatidylcholine-hydrolyzing phospholipase D2 [Homo sapiens]

Related Sequences to LMP001366 proteins

Reference Database Accession Length Protein Name
GI:156564407 EMBL CAL38027.1 933 hypothetical protein [synthetic construct]
GI:156564407 EMBL CAL38028.1 933 hypothetical protein, partial [synthetic construct]
GI:156564407 GenBank AAD04197.1 933 phospholipase D2 [Homo sapiens]
GI:340805823 GenBank AAB96655.1 933 phospholipase D2 [Homo sapiens]
GI:340805823 GenBank AAE59695.1 922 Sequence 6 from patent US 6187559
GI:156564407 GenBank AAE79381.1 933 Sequence 17 from patent US 6274363
GI:156564407 GenBank AAH56871.1 933 Phospholipase D2 [Homo sapiens]
GI:340805823 GenBank EAW90404.1 933 phospholipase D2, isoform CRA_a [Homo sapiens]
GI:156564407 GenBank ACM84436.1 933 Sequence 9934 from patent US 6812339
GI:340805823 RefSeq NP_002654.3 933 phospholipase D2 isoform PLD2A [Homo sapiens]
GI:340805823 RefSeq XP_006721610.1 933 PREDICTED: phospholipase D2 isoform X4 [Homo sapiens]
GI:340805823 SwissProt O14939.2 933 RecName: Full=Phospholipase D2; Short=PLD 2; Short=hPLD2; AltName: Full=Choline phosphatase 2; AltName: Full=PLD1C; AltName: Full=Phosphatidylcholine-hydrolyzing phospholipase D2 [Homo sapiens]