Gene/Proteome Database (LMPD)

LMPD ID
LMP001367
Gene ID
8605
Species
Homo sapiens (Human)
Gene Name
phospholipase A2, group IVC (cytosolic, calcium-independent)
Gene Symbol
PLA2G4C
Synonyms
CPLA2-gamma
Alternate Names
cytosolic phospholipase A2 gamma; phospholipase A2 group IVC
Chromosome
19
Map Location
19q13.3
EC Number
3.1.1.4
Summary
This gene encodes a protein which is a member of the phospholipase A2 enzyme family which hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids, both of which serve as precursors in the production of signaling molecules. The encoded protein has been shown to be a calcium-independent and membrane bound enzyme. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]
Orthologs
View orthologs and multiple alignments for PLA2G4C

Proteins

cytosolic phospholipase A2 gamma isoform 1 precursor
Refseq ID NP_003697
Protein GI 226693354
UniProt ID Q9UP65
mRNA ID NM_003706
Length 541
RefSeq Status REVIEWED
MGSSEVSIIPGLQKEEKAAVERRRLHVLKALKKLRIEADEAPVVAVLGSGGGLRAHIACLGVLSEMKEQGLLDAVTYLAGVSGSTWAISSLYTNDGDMEALEADLKHRFTRQEWDLAKSLQKTIQAARSENYSLTDFWAYMVISKQTRELPESHLSNMKKPVEEGTLPYPIFAAIDNDLQPSWQEARAPETWFEFTPHHAGFSALGAFVSITHFGSKFKKGRLVRTHPERDLTFLRGLWGSALGNTEVIREYIFDQLRNLTLKGLWRRAVANAKSIGHLIFARLLRLQESSQGEHPPPEDEGGEPEHTWLTEMLENWTRTSLEKQEQPHEDPERKGSLSNLMDFVKKTGICASKWEWGTTHNFLYKHGGIRDKIMSSRKHLHLVDAGLAINTPFPLVLPPTREVHLILSFDFSAGDPFETIRATTDYCRRHKIPFPQVEEAELDLWSKAPASCYILKGETGPVVMHFPLFNIDACGGDIEAWSDTYDTFKLADTYTLDVVVLLLALAKKNVRENKKKILRELMNVAGLYYPKDSARSCCLA
mat_peptide: 1..548 product: cytosolic phospholipase A2 gamma isoform 2 calculated_mol_wt: 62164 peptide sequence: MRTRPRPRLRRTENFLTAVHHGKKEEKAAVERRRLHVLKALKKLRIEADEAPVVAVLGSGGGLRAHIACLGVLSEMKEQGLLDAVTYLAGVSGSTWAISSLYTNDGDMEALEADLKHRFTRQEWDLAKSLQKTIQAARSENYSLTDFWAYMVISKQTRELPESHLSNMKKPVEEGTLPYPIFAAIDNDLQPSWQEARAPETWFEFTPHHAGFSALGAFVSITHFGSKFKKGRLVRTHPERDLTFLRGLWGSALGNTEVIREYIFDQLRNLTLKGLWRRAVANAKSIGHLIFARLLRLQESSQGEHPPPEDEGGEPEHTWLTEMLENWTRTSLEKQEQPHEDPERKGSLSNLMDFVKKTGICASKWEWGTTHNFLYKHGGIRDKIMSSRKHLHLVDAGLAINTPFPLVLPPTREVHLILSFDFSAGDPFETIRATTDYCRRHKIPFPQVEEAELDLWSKAPASCYILKGETGPVVMHFPLFNIDACGGDIEAWSDTYDTFKLADTYTLDVVVLLLALAKKNVRENKKKILRELMNVAGLYYPKDSARSC mat_peptide: 1..538 product: cytosolic phospholipase A2 gamma isoform 1 calculated_mol_wt: 60652 peptide sequence: MGSSEVSIIPGLQKEEKAAVERRRLHVLKALKKLRIEADEAPVVAVLGSGGGLRAHIACLGVLSEMKEQGLLDAVTYLAGVSGSTWAISSLYTNDGDMEALEADLKHRFTRQEWDLAKSLQKTIQAARSENYSLTDFWAYMVISKQTRELPESHLSNMKKPVEEGTLPYPIFAAIDNDLQPSWQEARAPETWFEFTPHHAGFSALGAFVSITHFGSKFKKGRLVRTHPERDLTFLRGLWGSALGNTEVIREYIFDQLRNLTLKGLWRRAVANAKSIGHLIFARLLRLQESSQGEHPPPEDEGGEPEHTWLTEMLENWTRTSLEKQEQPHEDPERKGSLSNLMDFVKKTGICASKWEWGTTHNFLYKHGGIRDKIMSSRKHLHLVDAGLAINTPFPLVLPPTREVHLILSFDFSAGDPFETIRATTDYCRRHKIPFPQVEEAELDLWSKAPASCYILKGETGPVVMHFPLFNIDACGGDIEAWSDTYDTFKLADTYTLDVVVLLLALAKKNVRENKKKILRELMNVAGLYYPKDSARSC
cytosolic phospholipase A2 gamma isoform 2 precursor
Refseq ID NP_001152794
Protein GI 226693357
UniProt ID Q9UP65
mRNA ID NM_001159322
Length 551
RefSeq Status REVIEWED
MRTRPRPRLRRTENFLTAVHHGKKEEKAAVERRRLHVLKALKKLRIEADEAPVVAVLGSGGGLRAHIACLGVLSEMKEQGLLDAVTYLAGVSGSTWAISSLYTNDGDMEALEADLKHRFTRQEWDLAKSLQKTIQAARSENYSLTDFWAYMVISKQTRELPESHLSNMKKPVEEGTLPYPIFAAIDNDLQPSWQEARAPETWFEFTPHHAGFSALGAFVSITHFGSKFKKGRLVRTHPERDLTFLRGLWGSALGNTEVIREYIFDQLRNLTLKGLWRRAVANAKSIGHLIFARLLRLQESSQGEHPPPEDEGGEPEHTWLTEMLENWTRTSLEKQEQPHEDPERKGSLSNLMDFVKKTGICASKWEWGTTHNFLYKHGGIRDKIMSSRKHLHLVDAGLAINTPFPLVLPPTREVHLILSFDFSAGDPFETIRATTDYCRRHKIPFPQVEEAELDLWSKAPASCYILKGETGPVVMHFPLFNIDACGGDIEAWSDTYDTFKLADTYTLDVVVLLLALAKKNVRENKKKILRELMNVAGLYYPKDSARSCCLA
cytosolic phospholipase A2 gamma isoform 3
Refseq ID NP_001152795
Protein GI 226693363
UniProt ID Q9UP65
mRNA ID NM_001159323
Length 527
RefSeq Status REVIEWED
MGSSEVSIIPGLQKEEKAAVERRRLHVLKALKKLRIEADEAPVVAVLGSGGGLRAHIACLGVLSEMKEQGLLDAVTYLAGVSGSTWAISSLYTNDGDMEALEADLKHRFTRQEWDLAKSLQKTIQAARSENYSLTDFWAYMVISKQTRELPESHLSNMKKPVEEGTLPYPIFAAIDNDLQPSWQEARAPETWFEFTPHHAGFSALGAFVSITHFGSKFKKGRLVRTHPERDLTFLRGLWGSALGNTEVIREYIFDQLRNLTLKGLWRRAVANAKSIGHLIFARLLRLQESSQGEHPPPEDEGGEPEHTWLTEMLENWTRTSLEKQEQPHEDPERKGSLSNLMDFVKKTGICASKWEWGTTHNFLYKHGGIRDKIMSSRKHLHLVDAGLAINTPFPLVLPPTREVHLILSFDFSAGDPFETIRATTDYCRRHKIPFPQVEEAELDLWSKAPASCYILKGETGPVVMHFPLFNIDACGGDIEAWSDTYDTFKLADTYTLDVVVLLLALAKKNVRENKKKILRELMNVAG

Gene Information

Entrez Gene ID
8605
Gene Name
phospholipase A2, group IVC (cytosolic, calcium-independent)
Gene Symbol
PLA2G4C
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005938 IEA:Ensembl C cell cortex
GO:0005829 TAS:UniProtKB C cytosol
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0016020 TAS:UniProtKB C membrane
GO:0005635 IEA:Ensembl C nuclear envelope
GO:0005654 IEA:Ensembl C nucleoplasm
GO:0047499 IDA:UniProtKB F calcium-independent phospholipase A2 activity
GO:0005543 NAS:UniProtKB F phospholipid binding
GO:0019369 NAS:UniProtKB P arachidonic acid metabolic process
GO:0046474 TAS:Reactome P glycerophospholipid biosynthetic process
GO:0046475 IDA:UniProtKB P glycerophospholipid catabolic process
GO:0006954 NAS:UniProtKB P inflammatory response
GO:0035556 NAS:UniProtKB P intracellular signal transduction
GO:0007567 NAS:UniProtKB P parturition
GO:0036151 TAS:Reactome P phosphatidylcholine acyl-chain remodeling
GO:0036152 TAS:Reactome P phosphatidylethanolamine acyl-chain remodeling
GO:0036149 TAS:Reactome P phosphatidylinositol acyl-chain remodeling
GO:0006644 TAS:UniProtKB P phospholipid metabolic process
GO:0044281 TAS:Reactome P small molecule metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa04750 Inflammatory mediator regulation of TRP channels
hsa04921 Oxytocin signaling pathway
hsa04611 Platelet activation
hsa04014 Ras signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
IPR002642 Lysophospholipase, catalytic domain

UniProt Annotations

Entry Information

Gene Name
phospholipase A2, group IVC (cytosolic, calcium-independent)
Protein Entry
PA24C_HUMAN
UniProt ID
Q9UP65
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9UP65-1; Sequence=Displayed; Name=2; IsoId=Q9UP65-2; Sequence=VSP_045850; Name=3; IsoId=Q9UP65-3; Sequence=VSP_045849;
Biophysicochemical Properties Kinetic parameters: Vmax=218 pmol/min/mg enzyme ;
Catalytic Activity Phosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate.
Enzyme Regulation Not regulated by calcium.
Function Has a preference for arachidonic acid at the sn-2 position of phosphatidylcholine as compared with palmitic acid.
Similarity Contains 1 PLA2c domain. {ECO
Subcellular Location Membrane ; Lipid-anchor .
Tissue Specificity Highly expressed in heart and skeletal muscle.
Web Resource Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/pla2g4c/";

Identical and Related Proteins

Unique RefSeq proteins for LMP001367 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
226693354 RefSeq NP_003697 541 cytosolic phospholipase A2 gamma isoform 1 precursor
226693357 RefSeq NP_001152794 551 cytosolic phospholipase A2 gamma isoform 2 precursor
226693363 RefSeq NP_001152795 527 cytosolic phospholipase A2 gamma isoform 3

Identical Sequences to LMP001367 proteins

Reference Database Accession Length Protein Name
GI:226693354 DBBJ BAG37118.1 541 unnamed protein product [Homo sapiens]
GI:226693363 EMBL CAE90375.1 527 unnamed protein product [Homo sapiens]
GI:226693363 GenBank EAW52313.1 527 phospholipase A2, group IVC (cytosolic, calcium-independent), isoform CRA_c [Homo sapiens]
GI:226693354 GenBank ACP56708.1 541 Sequence 837 from patent US 7482117
GI:226693354 GenBank ACP56709.1 541 Sequence 838 from patent US 7482117
GI:226693354 GenBank ADS30305.1 541 Sequence 837 from patent US 7781168
GI:226693354 GenBank ADS30306.1 541 Sequence 838 from patent US 7781168
GI:226693354 SwissProt Q9UP65.2 541 RecName: Full=Cytosolic phospholipase A2 gamma; Short=cPLA2-gamma; AltName: Full=Phospholipase A2 group IVC; Flags: Precursor [Homo sapiens]

Related Sequences to LMP001367 proteins

Reference Database Accession Length Protein Name
GI:226693354 GenBank AAC32823.1 541 cytosolic phospholipase A2-gamma [Homo sapiens]
GI:226693354 GenBank AAN27294.1 541 Sequence 2 from patent US 6440683
GI:226693363 GenBank AAH63416.1 541 PLA2G4C protein [Homo sapiens]
GI:226693354 GenBank AAY75453.1 541 Sequence 356 from patent US 6900016
GI:226693354 GenBank ABE15813.1 541 Sequence 2 from patent US 6979565
GI:226693363 GenBank ACP56709.1 541 Sequence 838 from patent US 7482117
GI:226693363 GenBank ADS30305.1 541 Sequence 837 from patent US 7781168
GI:226693363 GenBank ADS30306.1 541 Sequence 838 from patent US 7781168
GI:226693357 GenBank EHH30210.1 526 hypothetical protein EGK_10827, partial [Macaca mulatta]
GI:226693357 GenBank EHH59737.1 526 hypothetical protein EGM_09924, partial [Macaca fascicularis]
GI:226693354 GenBank AEU43316.1 541 Sequence 65 from patent US 8052970
GI:226693354 GenBank AHD74983.1 541 Sequence 15687 from patent US 8586006
GI:226693363 RefSeq NP_003697.2 541 cytosolic phospholipase A2 gamma isoform 1 precursor [Homo sapiens]
GI:226693357 RefSeq XP_004061170.1 520 PREDICTED: cytosolic phospholipase A2 gamma [Gorilla gorilla gorilla]
GI:226693357 RefSeq XP_006723514.1 523 PREDICTED: cytosolic phospholipase A2 gamma isoform X1 [Homo sapiens]
GI:226693357 RefSeq XP_009434232.1 541 PREDICTED: LOW QUALITY PROTEIN: cytosolic phospholipase A2 gamma [Pan troglodytes]
GI:226693357 RefSeq XP_010375849.1 617 PREDICTED: cytosolic phospholipase A2 gamma [Rhinopithecus roxellana]
GI:226693363 SwissProt Q9UP65.2 541 RecName: Full=Cytosolic phospholipase A2 gamma; Short=cPLA2-gamma; AltName: Full=Phospholipase A2 group IVC; Flags: Precursor [Homo sapiens]