Gene/Proteome Database (LMPD)

LMPD ID
LMP001370
Gene ID
10678
Species
Homo sapiens (Human)
Gene Name
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
Gene Symbol
B3GNT2
Synonyms
B3GN-T2; B3GNT; B3GNT-2; B3GNT1; BETA3GNT; BGNT2; BGnT-2
Alternate Names
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2; beta3Gn-T1; beta3Gn-T2; beta-1,3-Gn-T1; beta-1,3-Gn-T2; beta-1,3-N-acetylglucosaminyltransferase bGnT-1; beta-1,3-N-acetylglucosaminyltransferase bGnT-2; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
Chromosome
2
Map Location
2p15
EC Number
2.4.1.-
Summary
This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It prefers the substrate of lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for B3GNT2

Proteins

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
Refseq ID NP_006568
Protein GI 9845238
UniProt ID Q9NY97
mRNA ID NM_006577
Length 397
RefSeq Status REVIEWED
MSVGRRRIKLLGILMMANVFIYFIMEVSKSSSQEKNGKGEVIIPKEKFWKISTPPEAYWNREQEKLNRQYNPILSMLTNQTGEAGRLSNISHLNYCEPDLRVTSVVTGFNNLPDRFKDFLLYLRCRNYSLLIDQPDKCAKKPFLLLAIKSLTPHFARRQAIRESWGQESNAGNQTVVRVFLLGQTPPEDNHPDLSDMLKFESEKHQDILMWNYRDTFFNLSLKEVLFLRWVSTSCPDTEFVFKGDDDVFVNTHHILNYLNSLSKTKAKDLFIGDVIHNAGPHRDKKLKYYIPEVVYSGLYPPYAGGGGFLYSGHLALRLYHITDQVHLYPIDDVYTGMCLQKLGLVPEKHKGFRTFDIEEKNKNNICSYVDLMLVHSRKPQEMIDIWSQLQSAHLKC

Gene Information

Entrez Gene ID
10678
Gene Name
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
Gene Symbol
B3GNT2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0000139 TAS:Reactome C Golgi membrane
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0008378 IEA:InterPro F galactosyltransferase activity
GO:0016266 TAS:Reactome P O-glycan processing
GO:0007411 IEA:Ensembl P axon guidance
GO:0005975 TAS:Reactome P carbohydrate metabolic process
GO:0044267 TAS:Reactome P cellular protein metabolic process
GO:0030203 TAS:Reactome P glycosaminoglycan metabolic process
GO:0018146 TAS:Reactome P keratan sulfate biosynthetic process
GO:0042339 TAS:Reactome P keratan sulfate metabolic process
GO:0043687 TAS:Reactome P post-translational protein modification
GO:0007608 IEA:Ensembl P sensory perception of smell
GO:0044281 TAS:Reactome P small molecule metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00533 Glycosaminoglycan biosynthesis - keratan sulfate

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_121120 Keratan sulfate biosynthesis
REACT_121288 Keratan sulfate/keratin metabolism
REACT_200727 O-linked glycosylation

Domain Information

InterPro Annotations

Accession Description
IPR002659 Glycosyl transferase, family 31

UniProt Annotations

Entry Information

Gene Name
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
Protein Entry
B3GN2_HUMAN
UniProt ID
Q9NY97
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NY97-1; Sequence=Displayed; Name=2; IsoId=Q9NY97-2; Sequence=VSP_001791; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.;
Caution Was indicated as B3Gal-T6 in submitted DNA entries.
Cofactor Name=Mn(2+); Xref=ChEBI
Function Catalyzes the initiation and elongation of poly-N- acetyllactosamine chains.
Pathway Protein modification; protein glycosylation.
Sequence Caution Sequence=BAA92031.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the glycosyltransferase 31 family.
Subcellular Location Golgi apparatus membrane ; Single-pass type II membrane protein .
Subunit Interacts with B3GNT8; this interaction greatly increases B3GNT2 catalytic activity, independently of B3GNT8 enzymatic activity.
Tissue Specificity Ubiquitous.
Web Resource Name=Functional Glycomics Gateway - GTase; Note=UDP- GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_434";
Web Resource Name=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=B3GNT1";

Identical and Related Proteins

Unique RefSeq proteins for LMP001370 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
9845238 RefSeq NP_006568 397 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2

Identical Sequences to LMP001370 proteins

Reference Database Accession Length Protein Name
GI:9845238 GenBank JAA13191.1 397 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 [Pan troglodytes]
GI:9845238 GenBank JAA24984.1 397 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 [Pan troglodytes]
GI:9845238 GenBank JAA43865.1 397 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 [Pan troglodytes]
GI:9845238 GenBank AIC50695.1 397 B3GNT2, partial [synthetic construct]
GI:9845238 RefSeq XP_004029346.1 397 PREDICTED: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 isoform 1 [Gorilla gorilla gorilla]
GI:9845238 RefSeq XP_004029347.1 397 PREDICTED: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 isoform 2 [Gorilla gorilla gorilla]

Related Sequences to LMP001370 proteins

Reference Database Accession Length Protein Name
GI:9845238 EMBL CAB91546.1 398 beta-1,3-galactosyltransferase [Homo sapiens]
GI:9845238 GenBank EAW99980.1 411 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1, isoform CRA_b [Homo sapiens]
GI:9845238 GenBank EHH22154.1 397 hypothetical protein EGK_05370 [Macaca mulatta]
GI:9845238 GenBank EHH55602.1 397 hypothetical protein EGM_04843 [Macaca fascicularis]
GI:9845238 RefSeq XP_005575827.1 397 PREDICTED: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 isoform X1 [Macaca fascicularis]
GI:9845238 RefSeq XP_009235535.1 397 PREDICTED: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 [Pongo abelii]