Gene/Proteome Database (LMPD)

LMPD ID
LMP001389
Gene ID
8733
Species
Homo sapiens (Human)
Gene Name
glycosylphosphatidylinositol anchor attachment 1
Gene Symbol
GPAA1
Synonyms
GAA1; hGAA1
Alternate Names
glycosylphosphatidylinositol anchor attachment 1 protein; GAA1 protein homolog; GPI transamidase subunit; GPI anchor attachment protein 1; GPAA1P anchor attachment protein 1 homolog; glycophosphatidylinositol anchor attachment 1; anchor attachment protein 1 (Gaa1p, yeast) homolog; glycosylphosphatidylinositol anchor attachment protein 1 homolog
Chromosome
8
Map Location
8q24.3
Summary
Posttranslational glycosylphosphatidylinositol (GPI) anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane. The protein encoded by this gene presumably functions in GPI anchoring at the GPI transfer step. The mRNA transcript is ubiquitously expressed in both fetal and adult tissues. The anchor attachment protein 1 contains an N-terminal signal sequence, 1 cAMP- and cGMP-dependent protein kinase phosphorylation site, 1 leucine zipper pattern, 2 potential N-glycosylation sites, and 8 putative transmembrane domains. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for GPAA1

Proteins

glycosylphosphatidylinositol anchor attachment 1 protein
Refseq ID NP_003792
Protein GI 4504079
UniProt ID O43292
mRNA ID NM_003801
Length 621
RefSeq Status REVIEWED
MGLLSDPVRRRALARLVLRLNAPLCVLSYVAGIAWFLALVFPPLTQRTYMSENAMGSTMVEEQFAGGDRARAFARDFAAHRKKSGALPVAWLERTMRSVGLEVYTQSFSRKLPFPDETHERYMVSGTNVYGILRAPRAASTESLVLTVPCGSDSTNSQAVGLLLALAAHFRGQIYWAKDIVFLVTEHDLLGTEAWLEAYHDVNVTGMQSSPLQGRAGAIQAAVALELSSDVVTSLDVAVEGLNGQLPNLDLLNLFQTFCQKGGLLCTLQGKLQPEDWTSLDGPLQGLQTLLLMVLRQASGRPHGSHGLFLRYRVEALTLRGINSFRQYKYDLVAVGKALEGMFRKLNHLLERLHQSFFLYLLPGLSRFVSIGLYMPAVGFLLLVLGLKALELWMQLHEAGMGLEEPGGAPGPSVPLPPSQGVGLASLVAPLLISQAMGLALYVLPVLGQHVATQHFPVAEAEAVVLTLLAIYAAGLALPHNTHRVVSTQAPDRGWMALKLVALIYLALQLGCIALTNFSLGFLLATTMVPTAALAKPHGPRTLYAALLVLTSPAATLLGSLFLWRELQEAPLSLAEGWQLFLAALAQGVLEHHTYGALLFPLLSLGLYPCWLLFWNVLFWK

Gene Information

Entrez Gene ID
8733
Gene Name
glycosylphosphatidylinositol anchor attachment 1
Gene Symbol
GPAA1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0042765 TAS:UniProtKB C GPI-anchor transamidase complex
GO:0016020 IDA:UniProtKB C membrane
GO:0015631 NAS:UniProtKB F tubulin binding
GO:0016255 NAS:UniProtKB P attachment of GPI anchor to protein
GO:0044267 TAS:Reactome P cellular protein metabolic process
GO:0006501 TAS:Reactome P C-terminal protein lipidation
GO:0043687 TAS:Reactome P post-translational protein modification
GO:0006461 NAS:UniProtKB P protein complex assembly
GO:0006621 NAS:UniProtKB P protein retention in ER lumen

KEGG Pathway Links

KEGG Pathway ID Description
hsa00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
ko00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
hsa01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_1830 Attachment of GPI anchor to uPAR

Domain Information

InterPro Annotations

Accession Description
IPR007246 Gaa1-like, GPI transamidase component
IPR017063 Glycosylphosphatidylinositol:protein transamidase complex, GAA1 component

UniProt Annotations

Entry Information

Gene Name
glycosylphosphatidylinositol anchor attachment 1
Protein Entry
GPAA1_HUMAN
UniProt ID
O43292
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O43292-1; Sequence=Displayed; Name=2; IsoId=O43292-2; Sequence=VSP_009542;
Function Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate.
Pathway Glycolipid biosynthesis; glycosylphosphatidylinositol- anchor biosynthesis.
Sequence Caution Sequence=CAB75660.2; Type=Erroneous gene model prediction; Note=Erroneous prediction from an unspliced cDNA.; Evidence= ;
Subcellular Location Endoplasmic reticulum membrane ; Multi-pass membrane protein .
Subunit Forms a complex with PIGK/GPI8, PIGT, PIGU and PIGS.
Tissue Specificity Ubiquitously expressed in fetal and adult tissues. Expressed at higher levels in fetal tissues than adult tissues.

Identical and Related Proteins

Unique RefSeq proteins for LMP001389 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
4504079 RefSeq NP_003792 621 glycosylphosphatidylinositol anchor attachment 1 protein

Identical Sequences to LMP001389 proteins

Reference Database Accession Length Protein Name
GI:4504079 EMBL CAH05399.1 621 unnamed protein product [Homo sapiens]
GI:4504079 GenBank AAH04129.1 621 Glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast) [Homo sapiens]
GI:4504079 GenBank ABM85965.1 621 glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast), partial [synthetic construct]
GI:4504079 GenBank ABW03763.1 621 glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast) [synthetic construct]
GI:4504079 GenBank AIC50194.1 621 GPAA1, partial [synthetic construct]
GI:4504079 SwissProt O43292.3 621 RecName: Full=Glycosylphosphatidylinositol anchor attachment 1 protein; Short=GPI anchor attachment protein 1; AltName: Full=GAA1 protein homolog; Short=hGAA1 [Homo sapiens]

Related Sequences to LMP001389 proteins

Reference Database Accession Length Protein Name
GI:4504079 DBBJ BAG35625.1 621 unnamed protein product [Homo sapiens]
GI:4504079 GenBank ACE24955.1 621 Sequence 10199 from patent US 7368531
GI:4504079 GenBank ACH32940.1 622 Sequence 7421 from patent US 7411051
GI:4504079 GenBank ACH35706.1 621 Sequence 10199 from patent US 7411051
GI:4504079 GenBank ADT49334.1 620 Sequence 1351 from patent US 7842467
GI:4504079 RefSeq XP_003819478.1 621 PREDICTED: glycosylphosphatidylinositol anchor attachment 1 protein isoform X2 [Pan paniscus]