Gene/Proteome Database (LMPD)
LMPD ID
LMP001390
Gene ID
Species
Homo sapiens (Human)
Gene Name
phosphatidylinositol 4-kinase, catalytic, alpha
Gene Symbol
Synonyms
PI4K-ALPHA; PIK4CA; pi4K230
Chromosome
22
Map Location
22q11.21
Summary
This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. [provided by RefSeq, Sep 2014]
Orthologs
Proteins
| phosphatidylinositol 4-kinase alpha | |
|---|---|
| Refseq ID | NP_477352 |
| Protein GI | 348041302 |
| UniProt ID | Q4LE69 |
| mRNA ID | NM_058004 |
| Length | 2102 |
| RefSeq Status | REVIEWED |
| MAAAPARGGGGGGGGGGGCSGSGSSASRGFYFNTVLSLARSLAVQRPASLEKVQKLLCMCPVDFHGIFQLDERRRDAVIALGIFLIESDLQHKDCVVPYLLRLLKGLPKVYWVEESTARKGRGALPVAESFSFCLVTLLSDVAYRDPSLRDEILEVLLQVLHVLLGMCQALEIQDKEYLCKYAIPCLIGISRAFGRYSNMEESLLSKLFPKIPPHSLRVLEELEGVRRRSFNDFRSILPSNLLTVCQEGTLKRKTSSVSSISQVSPERGMPPPSSPGGSAFHYFEASCLPDGTALEPEYYFSTISSSFSVSPLFNGVTYKEFNIPLEMLRELLNLVKKIVEEAVLKSLDAIVASVMEANPSADLYYTSFSDPLYLTMFKMLRDTLYYMKDLPTSFVKEIHDFVLEQFNTSQGELQKILHDADRIHNELSPLKLRCQANAACVDLMVWAVKDEQGAENLCIKLSEKLQSKTSSKVIIAHLPLLICCLQGLGRLCERFPVVVHSVTPSLRDFLVIPSPVLVKLYKYHSQYHTVAGNDIKISVTNEHSESTLNVMSGKKSQPSMYEQLRDIAIDNICRCLKAGLTVDPVIVEAFLASLSNRLYISQESDKDAHLIPDHTIRALGHIAVALRDTPKVMEPILQILQQKFCQPPSPLDVLIIDQLGCLVITGNQYIYQEVWNLFQQISVKASSVVYSATKDYKDHGYRHCSLAVINALANIAANIQDEHLVDELLMNLLELFVQLGLEGKRASERASEKGPALKASSSAGNLGVLIPVIAVLTRRLPPIKEAKPRLQKLFRDFWLYSVLMGFAVEGSGLWPEEWYEGVCEIATKSPLLTFPSKEPLRSVLQYNSAMKNDTVTPAELSELRSTIINLLDPPPEVSALINKLDFAMSTYLLSVYRLEYMRVLRSTDPDRFQVMFCYFEDKAIQKDKSGMMQCVIAVADKVFDAFLNMMADKAKTKENEEELERHAQFLLVNFNHIHKRIRRVADKYLSGLVDKFPHLLWSGTVLKTMLDILQTLSLSLSADIHKDQPYYDIPDAPYRITVPDTYEARESIVKDFAARCGMILQEAMKWAPTVTKSHLQEYLNKHQNWVSGLSQHTGLAMATESILHFAGYNKQNTTLGATQLSERPACVKKDYSNFMASLNLRNRYAGEVYGMIRFSGTTGQMSDLNKMMVQDLHSALDRSHPQHYTQAMFKLTAMLISSKDCDPQLLHHLCWGPLRMFNEHGMETALACWEWLLAGKDGVEVPFMREMAGAWHMTVEQKFGLFSAEIKEADPLAASEASQPKPCPPEVTPHYIWIDFLVQRFEIAKYCSSDQVEIFSSLLQRSMSLNIGGAKGSMNRHVAAIGPRFKLLTLGLSLLHADVVPNATIRNVLREKIYSTAFDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDKKYLTASQLVPPDNQDTRSNLDITVGSRQQATQGWINTYPLSSGMSTISKKSGMSKKTNRGSQLHKYYMKRRTLLLSLLATEIERLITWYNPLSAPELELDQAGENSVANWRSKYISLSEKQWKDNVNLAWSISPYLAVQLPARFKNTEAIGNEVTRLVRLDPGAVSDVPEAIKFLVTWHTIDADAPELSHVLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKMGYVREYILWAASKSQLLAHQFIWNMKTNIYLDEEGHQKDPDIGDLLDQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDERKKACLSALSEVKVQPGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFRGQTIKLLKHRFSPNMTEREAANFIMKVIQSCFLSNRSRTYDMIQYYQNDIPY | |
Gene Information
Entrez Gene ID
Gene Name
phosphatidylinositol 4-kinase, catalytic, alpha
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0016301 | IEA:UniProtKB-KW | F | kinase activity |
| GO:0016773 | IEA:InterPro | F | phosphotransferase activity, alcohol group as acceptor |
| GO:0046854 | IEA:InterPro | P | phosphatidylinositol phosphorylation |
| GO:0048015 | IEA:InterPro | P | phosphatidylinositol-mediated signaling |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY-6352 | 3-phosphoinositide biosynthesis |
| PWY-6351 | D-myo-inositol (1,4,5)-trisphosphate biosynthesis |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_121168 | Synthesis of PIPs at the ER membrane |
| REACT_120836 | Synthesis of PIPs at the Golgi membrane |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR016024 | Armadillo-type fold |
| IPR000403 | Phosphatidylinositol 3-/4-kinase, catalytic domain |
| IPR018936 | Phosphatidylinositol 3/4-kinase, conserved site |
| IPR015433 | Phosphatidylinositol Kinase |
| IPR001263 | Phosphoinositide 3-kinase, accessory (PIK) domain |
| IPR011009 | Protein kinase-like domain |
UniProt Annotations
Entry Information
Gene Name
phosphatidylinositol 4-kinase, catalytic, alpha
Protein Entry
B4DYG5_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Similarity | Contains PI3K/PI4K domain. |
| Similarity | Contains PIK helical domain. |
Identical and Related Proteins
Unique RefSeq proteins for LMP001390 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 348041302 | RefSeq | NP_477352 | 2102 | phosphatidylinositol 4-kinase alpha |
Identical Sequences to LMP001390 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:348041302 | DBBJ | BAG10559.1 | 2102 | phosphatidylinositol 4-kinase, catalytic, alpha polypeptide, partial [synthetic construct] |
Related Sequences to LMP001390 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:348041302 | RefSeq | XP_003281481.1 | 2101 | PREDICTED: phosphatidylinositol 4-kinase alpha [Nomascus leucogenys] |
| GI:348041302 | RefSeq | XP_005261691.1 | 2099 | PREDICTED: phosphatidylinositol 4-kinase alpha isoform X1 [Homo sapiens] |
| GI:348041302 | RefSeq | XP_005567944.1 | 2130 | PREDICTED: phosphatidylinositol 4-kinase alpha isoform X1 [Macaca fascicularis] |
| GI:348041302 | RefSeq | XP_007973125.1 | 2124 | PREDICTED: phosphatidylinositol 4-kinase alpha [Chlorocebus sabaeus] |
| GI:348041302 | RefSeq | XP_009005436.1 | 2095 | PREDICTED: phosphatidylinositol 4-kinase alpha [Callithrix jacchus] |
| GI:348041302 | RefSeq | XP_010380092.1 | 2088 | PREDICTED: phosphatidylinositol 4-kinase alpha [Rhinopithecus roxellana] |