Gene/Proteome Database (LMPD)

LMPD ID
LMP001404
Gene ID
27349
Species
Homo sapiens (Human)
Gene Name
malonyl CoA:ACP acyltransferase (mitochondrial)
Gene Symbol
MCAT
Synonyms
FASN2C; MCT; MT; NET62; fabD
Alternate Names
malonyl-CoA-acyl carrier protein transacylase, mitochondrial; mitochondrial malonyltransferase; [Acyl-carrier-protein] malonyltransferase; mitochondrial malonyl CoA:ACP acyltransferase; malonyl-CoA:acyl carrier protein transacylase, mitochondrial
Chromosome
22
Map Location
22q13.31
EC Number
2.3.1.39
Summary
The protein encoded by this gene is found exclusively in the mitochondrion, where it catalyzes the transfer of a malonyl group from malonyl-CoA to the mitochondrial acyl carrier protein. The encoded protein may be part of a fatty acid synthase complex that is more like the type II prokaryotic and plastid complexes rather than the type I human cytosolic complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2012]
Orthologs
View orthologs and multiple alignments for MCAT

Proteins

malonyl-CoA-acyl carrier protein transacylase, mitochondrial isoform a precursor
Refseq ID NP_775738
Protein GI 51243059
UniProt ID Q8IVS2
mRNA ID NM_173467
Length 390
RefSeq Status REVIEWED
MSVRVARVAWVRGLGASYRRGASSFPVPPPGAQGVAELLRDATGAEEEAPWAATERRMPGQCSVLLFPGQGSQVVGMGRGLLNYPRVRELYAAARRVLGYDLLELSLHGPQETLDRTVHCQPAIFVASLAAVEKLHHLQPSVIENCVAAAGFSVGEFAALVFAGAMEFAEGLYAVKIRAEAMQEASEAVPSGMLSVLGQPQSKFNFACLEAREHCKSLGIENPVCEVSNYLFPDCRVISGHQEALRFLQKNSSKFHFRRTRMLPVSGAFHTRLMEPAVEPLTQALKAVDIKKPLVSVYSNVHAHRYRHPGHIHKLLAQQLVSPVKWEQTMHAIYERKKGRGFPQTFEVGPGRQLGAILKSCNMQAWKSYSAVDVLQTLEHVDLDPQEPPR
transit_peptide: 1..21 calculated_mol_wt: 2348 peptide sequence: MSVRVARVAWVRGLGASYRRG mat_peptide: 22..180 product: malonyl-CoA-acyl carrier protein transacylase, mitochondrial isoform b calculated_mol_wt: 16846 peptide sequence: ASSFPVPPPGAQGVAELLRDATGAEEEAPWAATERRMPGQCSVLLFPGQGSQVVGMGRGLLNYPRVRELYAAARRVLGYDLLELSLHGPQETLDRTVHCQPAIFVASLAAVEKLHHLQPSVIENCVAAAGFSVGEFAALVFAGAMEFAEGSTVSPEEFL transit_peptide: 1..21 calculated_mol_wt: 2348 peptide sequence: MSVRVARVAWVRGLGASYRRG mat_peptide: 22..390 product: malonyl-CoA-acyl carrier protein transacylase, mitochondrial isoform a calculated_mol_wt: 40632 peptide sequence: ASSFPVPPPGAQGVAELLRDATGAEEEAPWAATERRMPGQCSVLLFPGQGSQVVGMGRGLLNYPRVRELYAAARRVLGYDLLELSLHGPQETLDRTVHCQPAIFVASLAAVEKLHHLQPSVIENCVAAAGFSVGEFAALVFAGAMEFAEGLYAVKIRAEAMQEASEAVPSGMLSVLGQPQSKFNFACLEAREHCKSLGIENPVCEVSNYLFPDCRVISGHQEALRFLQKNSSKFHFRRTRMLPVSGAFHTRLMEPAVEPLTQALKAVDIKKPLVSVYSNVHAHRYRHPGHIHKLLAQQLVSPVKWEQTMHAIYERKKGRGFPQTFEVGPGRQLGAILKSCNMQAWKSYSAVDVLQTLEHVDLDPQEPPR
malonyl-CoA-acyl carrier protein transacylase, mitochondrial isoform b precursor
Refseq ID NP_055322
Protein GI 27477045
UniProt ID Q8IVS2
mRNA ID NM_014507
Length 180
RefSeq Status REVIEWED
MSVRVARVAWVRGLGASYRRGASSFPVPPPGAQGVAELLRDATGAEEEAPWAATERRMPGQCSVLLFPGQGSQVVGMGRGLLNYPRVRELYAAARRVLGYDLLELSLHGPQETLDRTVHCQPAIFVASLAAVEKLHHLQPSVIENCVAAAGFSVGEFAALVFAGAMEFAEGSTVSPEEFL

Gene Information

Entrez Gene ID
27349
Gene Name
malonyl CoA:ACP acyltransferase (mitochondrial)
Gene Symbol
MCAT
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IDA:UniProtKB C mitochondrion
GO:0004314 IDA:UniProtKB F [acyl-carrier-protein] S-malonyltransferase activity
GO:0044822 IDA:UniProtKB F poly(A) RNA binding
GO:0016740 IDA:UniProtKB F transferase activity
GO:0006633 IDA:UniProtKB P fatty acid biosynthetic process
GO:0008152 IDA:UniProtKB P metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00061 Fatty acid biosynthesis
hsa01212 Fatty acid metabolism
hsa01100 Metabolic pathways

Domain Information

InterPro Annotations

Accession Description
IPR014043 Acyl transferase
IPR001227 Acyl transferase domain
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
IPR016036 Malonyl-CoA ACP transacylase, ACP-binding

UniProt Annotations

Entry Information

Gene Name
malonyl CoA:ACP acyltransferase (mitochondrial)
Protein Entry
FABD_HUMAN
UniProt ID
Q8IVS2
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8IVS2-1; Sequence=Displayed; Name=2; IsoId=Q8IVS2-2; Sequence=VSP_010517, VSP_010518;
Catalytic Activity Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].
Function Catalyzes the transfer of a malonyl moiety from malonyl- CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondrias.
Pathway Lipid metabolism; fatty acid biosynthesis.
Similarity Belongs to the type II malonyltransferase family.
Subcellular Location Mitochondrion .

Identical and Related Proteins

Unique RefSeq proteins for LMP001404 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
51243059 RefSeq NP_775738 390 malonyl-CoA-acyl carrier protein transacylase, mitochondrial isoform a precursor
27477045 RefSeq NP_055322 180 malonyl-CoA-acyl carrier protein transacylase, mitochondrial isoform b precursor

Identical Sequences to LMP001404 proteins

Reference Database Accession Length Protein Name
GI:27477045 DBBJ BAG36765.1 180 unnamed protein product [Homo sapiens]
GI:51243059 EMBL CAA18261.1 390 malonyl CoA:ACP acyltransferase (mitochondrial) [Homo sapiens]
GI:51243059 EMBL CAB94789.1 390 hypothetical protein [Homo sapiens]
GI:27477045 EMBL CAB94790.1 180 hypothetical protein [Homo sapiens]
GI:27477045 EMBL CAQ07851.1 180 malonyl CoA:ACP acyltransferase (mitochondrial) [Homo sapiens]
GI:27477045 GenBank AAH30985.1 180 Malonyl CoA:ACP acyltransferase (mitochondrial) [Homo sapiens]
GI:27477045 GenBank EAW73286.1 180 malonyl-CoA:acyl carrier protein transacylase, mitochondrial, isoform CRA_a [Homo sapiens]
GI:51243059 GenBank EAW73287.1 390 malonyl-CoA:acyl carrier protein transacylase, mitochondrial, isoform CRA_b [Homo sapiens]
GI:51243059 SwissProt Q8IVS2.2 390 RecName: Full=Malonyl-CoA-acyl carrier protein transacylase, mitochondrial; Short=MCT; AltName: Full=Mitochondrial malonyl CoA:ACP acyltransferase; AltName: Full=Mitochondrial malonyltransferase; AltName: Full=[Acyl-carrier-protein] malonyltransferase; Flags: Precursor [Homo sapiens]

Related Sequences to LMP001404 proteins

Reference Database Accession Length Protein Name
GI:51243059 GenBank AAH42195.2 390 Malonyl CoA:ACP acyltransferase (mitochondrial) [Homo sapiens]
GI:27477045 GenBank JAA10801.1 180 malonyl CoA:ACP acyltransferase (mitochondrial) [Pan troglodytes]
GI:51243059 GenBank JAA10802.1 390 malonyl CoA:ACP acyltransferase (mitochondrial) [Pan troglodytes]
GI:27477045 GenBank JAA14758.1 180 malonyl CoA:ACP acyltransferase (mitochondrial) [Pan troglodytes]
GI:51243059 GenBank JAA14759.1 390 malonyl CoA:ACP acyltransferase (mitochondrial) [Pan troglodytes]
GI:27477045 GenBank JAA27319.1 180 malonyl CoA:ACP acyltransferase (mitochondrial) [Pan troglodytes]
GI:51243059 GenBank JAA27320.1 390 malonyl CoA:ACP acyltransferase (mitochondrial) [Pan troglodytes]
GI:27477045 GenBank JAA36530.1 180 malonyl CoA:ACP acyltransferase (mitochondrial) [Pan troglodytes]
GI:51243059 GenBank JAA36531.1 390 malonyl CoA:ACP acyltransferase (mitochondrial) [Pan troglodytes]
GI:51243059 GenBank AIC56250.1 390 MCAT, partial [synthetic construct]
GI:27477045 RefSeq XP_001171690.1 180 PREDICTED: malonyl-CoA-acyl carrier protein transacylase, mitochondrial isoform X2 [Pan troglodytes]
GI:27477045 RefSeq XP_004063646.1 180 PREDICTED: malonyl-CoA-acyl carrier protein transacylase, mitochondrial isoform 2 [Gorilla gorilla gorilla]