Gene/Proteome Database (LMPD)

LMPD ID
LMP001408
Gene ID
18797
Species
Mus musculus (Mouse)
Gene Name
phospholipase C, beta 3
Gene Symbol
Plcb3
Synonyms
mKIAA4098
Alternate Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3; PLC-beta-3; phospholipase C-beta-3; phosphoinositide phospholipase C-beta-3; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3
Chromosome
19
Map Location
19 B|19 5.1 cM
EC Number
3.1.4.11

Proteins

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform a
Refseq ID NP_001277278
Protein GI 594140695
UniProt ID P51432
mRNA ID NM_001290349
Length 1234
RefSeq Status VALIDATED
MAGARPGVHALQLEPPTVVETLRRGSKFIKWDEEASSRNLVTLRVDPNGFFLYWTGPNMEVDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDTRLEEKLMTVVAGPDPVNTTFLNFMAVQDDTVKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFSADKKRVETALESCGLNFNRSESIRPDEFPLEIFERFLNKLCLRPDIDKILLEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLRSSQARLLIEKYETNKQFLERDQMSMEGFSRYLGGEENGILPLEALDLSMDMTQPLSAYFINSSHNTYLTAGQLAGPSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAEAAFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIDPLDKYPLSAGIPLPSPQDLMGRILVKNKKRHRPSTGVPDSSVRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKTSLEPQKSLGEESLSREPNVPMPDRDREDEEEDEEEEETTDPKKPTTDEGTASSEVNATEEMSTLVNYVEPVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVALNFQTLDLPMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVANALRVKVISGQFLSDKKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLIYTEASDYIPDDHQDYAEALINPIKHVSLMDQRAKQLAALIGESEAQASTETYQETPCQQPGSQLPSNPTPNPLDASPRWPPGPTTSSTSSSLSSPGQRDDLIASILSEVTPTPLEELRSHKAMVKLRSRQDRDLRELHKKHQRKAVALTRRLLDGLAQARAEGKCRPSPSALGKATNSEDVKEEEEAKQYREFQNRQVQSLLELREAQADVETKRKLEHLRQAHQRLKEVVLDTHTTQFKRLKELNEREKKELQKILDRKRNNSISEAKTREKHKKEVELTEINRRHITESVNSIRRLEEAQKQRHERLVAGQQQVLQQLEEEEPKLLAQLTQECQEQRERLPQEIRRCLLGETAEGLGDGPLVACASNGHAPGSGGHLSSADSESQEENTQL
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform b
Refseq ID NP_032900
Protein GI 31982122
UniProt ID P51432
mRNA ID NM_008874
Length 1234
RefSeq Status VALIDATED
MAGARPGVHALQLEPPTVVETLRRGSKFIKWDEEASSRNLVTLRVDPNGFFLYWTGPNMEVDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDTRLEEKLMTVVAGPDPVNTTFLNFMAVQDDTVKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFSADKKRVETALESCGLNFNRVESIRPDEFPLEIFERFLNKLCLRPDIDKILLEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLRSSQARLLIEKYETNKQFLERDQMSMEGFSRYLGGEENGILPLEALDLSMDMTQPLSAYFINSSHNTYLTAGQLAGPSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAEAAFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIDPLDKYPLSAGIPLPSPQDLMGRILVKNKKRHRPSTGVPDSSVRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKTSLEPQKSLGEESLSREPNVPMPDRDREDEEEDEEEEETTDPKKPTTDEGTASSEVNATEEMSTLVNYVEPVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVALNFQTLDLPMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVANALRVKVISGQFLSDKKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLIYTEASDYIPDDHQDYAEALINPIKHVSLMDQRAKQLAALIGESEAQASTETYQETPCQQPGSQLPSNPTPNPLDASPRWPPGPTTSSTSSSLSSPGQRDDLIASILSEVTPTPLEELRSHKAMVKLRSRQDRDLRELHKKHQRKAVALTRRLLDGLAQARAEGKCRPSPSALGKATNSEDVKEEEEAKQYREFQNRQVQSLLELREAQADVETKRKLEHLRQAHQRLKEVVLDTHTTQFKRLKELNEREKKELQKILDRKRNNSISEAKTREKHKKEVELTEINRRHITESVNSIRRLEEAQKQRHERLVAGQQQVLQQLEEEEPKLLAQLTQECQEQRERLPQEIRRCLLGETAEGLGDGPLVACASNGHAPGSGGHLSSADSESQEENTQL

Gene Information

Entrez Gene ID
18797
Gene Name
phospholipase C, beta 3
Gene Symbol
Plcb3
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0043234 ISO:MGI C protein complex
GO:0005509 IEA:InterPro F calcium ion binding
GO:0004435 IEA:UniProtKB-EC F phosphatidylinositol phospholipase C activity
GO:0004871 IEA:UniProtKB-KW F signal transducer activity
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0003073 ISO:MGI P regulation of systemic arterial blood pressure
GO:0007268 IEA:InterPro P synaptic transmission

KEGG Pathway Links

KEGG Pathway ID Description
mmu04750 Inflammatory mediator regulation of TRP channels
mmu04921 Oxytocin signaling pathway
mmu04611 Platelet activation
mmu04022 cGMP-PKG signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR028390 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
IPR000008 C2 domain
IPR011992 EF-hand domain pair
IPR014815 PLC-beta, C-terminal
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR016280 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
IPR009535 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta, conserved site
IPR001192 Phosphoinositide phospholipase C family
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like

UniProt Annotations

Entry Information

Gene Name
phospholipase C, beta 3
Protein Entry
PLCB3_MOUSE
UniProt ID
P51432
Species
Mouse

Comments

Comment Type Description
Catalytic Activity 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
Cofactor Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250};
Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Similarity Contains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
Similarity Contains 1 PI-PLC X-box domain. {ECO:0000255|PROSITE- ProRule:PRU00270}.
Similarity Contains 1 PI-PLC Y-box domain. {ECO:0000255|PROSITE- ProRule:PRU00271}.
Subcellular Location Nucleus {ECO:0000269|PubMed:9714794}.
Subunit Interacts with SHANK2 and LPAR2. {ECO:0000250}.
Tissue Specificity Highly expressed in kidney, skeletal muscle, liver, lung, heart and brain.

Identical and Related Proteins

Unique RefSeq proteins for LMP001408 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
594140695 RefSeq NP_001277278 1234 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform a
31982122 RefSeq NP_032900 1234 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform b

Identical Sequences to LMP001408 proteins

Reference Database Accession Length Protein Name
GI:594140695 DBBJ BAE27436.1 1234 unnamed protein product [Mus musculus]
GI:31982122 EMBL CBF74670.1 1234 unnamed protein product [Mus musculus]
GI:31982122 EMBL CBF62936.1 1234 unnamed protein product [Mus musculus]
GI:31982122 EMBL CBU87812.1 1234 unnamed protein product [Mus musculus]
GI:31982122 EMBL CBU96759.1 1234 unnamed protein product [Mus musculus]
GI:594140695 GenBank EDL33267.1 1234 phospholipase C, beta 3, isoform CRA_a [Mus musculus]
GI:31982122 GenBank AGX54747.1 1234 Sequence 9850 from patent US 8541208
GI:31982122 GenBank AGX64187.1 1234 Sequence 28484 from patent US 8541208
GI:594140695 SwissProt P51432.2 1234 RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3; AltName: Full=Phosphoinositide phospholipase C-beta-3; AltName: Full=Phospholipase C-beta-3; Short=PLC-beta-3 [Mus musculus]

Related Sequences to LMP001408 proteins

Reference Database Accession Length Protein Name
GI:31982122 DBBJ BAE27436.1 1234 unnamed protein product [Mus musculus]
GI:31982122 DBBJ BAE35282.1 1234 unnamed protein product [Mus musculus]
GI:594140695 EMBL CBF74670.1 1234 unnamed protein product [Mus musculus]
GI:594140695 EMBL CBF62936.1 1234 unnamed protein product [Mus musculus]
GI:594140695 EMBL CBU87812.1 1234 unnamed protein product [Mus musculus]
GI:594140695 EMBL CBU96759.1 1234 unnamed protein product [Mus musculus]
GI:31982122 GenBank AAA85199.1 1234 phospholipase C beta3 [Mus musculus]
GI:31982122 GenBank EDL33267.1 1234 phospholipase C, beta 3, isoform CRA_a [Mus musculus]
GI:594140695 GenBank AGX54747.1 1234 Sequence 9850 from patent US 8541208
GI:594140695 GenBank AGX64187.1 1234 Sequence 28484 from patent US 8541208
GI:31982122 RefSeq NP_001277278.1 1234 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform a [Mus musculus]
GI:31982122 SwissProt P51432.2 1234 RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3; AltName: Full=Phosphoinositide phospholipase C-beta-3; AltName: Full=Phospholipase C-beta-3; Short=PLC-beta-3 [Mus musculus]