Gene/Proteome Database (LMPD)

LMPD ID
LMP001412
Gene ID
2822
Species
Homo sapiens (Human)
Gene Name
glycosylphosphatidylinositol specific phospholipase D1
Gene Symbol
GPLD1
Synonyms
GPIPLD; GPIPLDM; PIGPLD; PIGPLD1; PLD
Alternate Names
phosphatidylinositol-glycan-specific phospholipase D; GPI-PLD; PI-G PLD; GPI-specific phospholipase D; glycoprotein phospholipase D; glycosylphosphatidylinositol specific phospholipase D1, isoform 2
Chromosome
6
Map Location
6p22.1
EC Number
3.1.4.50
Summary
Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for GPLD1

Proteins

phosphatidylinositol-glycan-specific phospholipase D precursor
Refseq ID NP_001494
Protein GI 29171717
UniProt ID P80108
mRNA ID NM_001503
Length 840
RefSeq Status REVIEWED
MSAFRLWPGLLIMLGSLCHRGSPCGLSTHVEIGHRALEFLQLHNGRVNYRELLLEHQDAYQAGIVFPDCFYPSICKGGKFHDVSESTHWTPFLNASVHYIRENYPLPWEKDTEKLVAFLFGITSHMAADVSWHSLGLEQGFLRTMGAIDFHGSYSEAHSAGDFGGDVLSQFEFNFNYLARRWYVPVKDLLGIYEKLYGRKVITENVIVDCSHIQFLEMYGEMLAVSKLYPTYSTKSPFLVEQFQEYFLGGLDDMAFWSTNIYHLTSFMLENGTSDCNLPENPLFIACGGQQNHTQGSKMQKNDFHRNLTTSLTESVDRNINYTERGVFFSVNSWTPDSMSFIYKALERNIRTMFIGGSQLSQKHVSSPLASYFLSFPYARLGWAMTSADLNQDGHGDLVVGAPGYSRPGHIHIGRVYLIYGNDLGLPPVDLDLDKEAHRILEGFQPSGRFGSALAVLDFNVDGVPDLAVGAPSVGSEQLTYKGAVYVYFGSKQGGMSSSPNITISCQDIYCNLGWTLLAADVNGDSEPDLVIGSPFAPGGGKQKGIVAAFYSGPSLSDKEKLNVEAANWTVRGEEDFSWFGYSLHGVTVDNRTLLLVGSPTWKNASRLGHLLHIRDEKKSLGRVYGYFPPNGQSWFTISGDKAMGKLGTSLSSGHVLMNGTLKQVLLVGAPTYDDVSKVAFLTVTLHQGGATRMYALTSDAQPLLLSTFSGDRRFSRFGGVLHLSDLDDDGLDEIIMAAPLRIADVTSGLIGGEDGRVYVYNGKETTLGDMTGKCKSWITPCPEEKAQYVLISPEASSRFGSSLITVRSKAKNQVVIAAGRSSLGARLSGALHVYSLGSD
sig_peptide: 1..23 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2543 peptide sequence: MSAFRLWPGLLIMLGSLCHRGSP mat_peptide: 24..840 product: Phosphatidylinositol-glycan-specific phospholipase D experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P80108.3) calculated_mol_wt: 89812 peptide sequence: CGLSTHVEIGHRALEFLQLHNGRVNYRELLLEHQDAYQAGIVFPDCFYPSICKGGKFHDVSESTHWTPFLNASVHYIRENYPLPWEKDTEKLVAFLFGITSHMAADVSWHSLGLEQGFLRTMGAIDFHGSYSEAHSAGDFGGDVLSQFEFNFNYLARRWYVPVKDLLGIYEKLYGRKVITENVIVDCSHIQFLEMYGEMLAVSKLYPTYSTKSPFLVEQFQEYFLGGLDDMAFWSTNIYHLTSFMLENGTSDCNLPENPLFIACGGQQNHTQGSKMQKNDFHRNLTTSLTESVDRNINYTERGVFFSVNSWTPDSMSFIYKALERNIRTMFIGGSQLSQKHVSSPLASYFLSFPYARLGWAMTSADLNQDGHGDLVVGAPGYSRPGHIHIGRVYLIYGNDLGLPPVDLDLDKEAHRILEGFQPSGRFGSALAVLDFNVDGVPDLAVGAPSVGSEQLTYKGAVYVYFGSKQGGMSSSPNITISCQDIYCNLGWTLLAADVNGDSEPDLVIGSPFAPGGGKQKGIVAAFYSGPSLSDKEKLNVEAANWTVRGEEDFSWFGYSLHGVTVDNRTLLLVGSPTWKNASRLGHLLHIRDEKKSLGRVYGYFPPNGQSWFTISGDKAMGKLGTSLSSGHVLMNGTLKQVLLVGAPTYDDVSKVAFLTVTLHQGGATRMYALTSDAQPLLLSTFSGDRRFSRFGGVLHLSDLDDDGLDEIIMAAPLRIADVTSGLIGGEDGRVYVYNGKETTLGDMTGKCKSWITPCPEEKAQYVLISPEASSRFGSSLITVRSKAKNQVVIAAGRSSLGARLSGALHVYSLGSD

Gene Information

Entrez Gene ID
2822
Gene Name
glycosylphosphatidylinositol specific phospholipase D1
Gene Symbol
GPLD1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:UniProtKB C cytoplasm
GO:0005615 IDA:UniProtKB C extracellular space
GO:0070062 IDA:UniProtKB C extracellular vesicular exosome
GO:0005622 IDA:UniProtKB C intracellular
GO:0043231 IDA:UniProtKB C intracellular membrane-bounded organelle
GO:0005765 IDA:UniProtKB C lysosomal membrane
GO:0005578 ISS:UniProtKB C proteinaceous extracellular matrix
GO:0004621 IDA:UniProtKB F glycosylphosphatidylinositol phospholipase D activity
GO:0004630 IDA:UniProtKB F phospholipase D activity
GO:0017080 ISS:UniProtKB F sodium channel regulator activity
GO:0006507 IDA:UniProtKB P GPI anchor release
GO:0002042 IMP:UniProtKB P cell migration involved in sprouting angiogenesis
GO:0071277 IDA:UniProtKB P cellular response to calcium ion
GO:0071397 IMP:UniProtKB P cellular response to cholesterol
GO:0035690 IDA:UniProtKB P cellular response to drug
GO:0032869 IDA:UniProtKB P cellular response to insulin stimulus
GO:0071467 IDA:UniProtKB P cellular response to pH
GO:0071401 IMP:UniProtKB P cellular response to triglyceride
GO:0002062 ISS:UniProtKB P chondrocyte differentiation
GO:0002430 IDA:UniProtKB P complement receptor mediated signaling pathway
GO:0035701 TAS:UniProtKB P hematopoietic stem cell migration
GO:0097241 TAS:UniProtKB P hematopoietic stem cell migration to bone marrow
GO:0008286 IDA:UniProtKB P insulin receptor signaling pathway
GO:0008285 IDA:UniProtKB P negative regulation of cell proliferation
GO:0010897 ISS:UniProtKB P negative regulation of triglyceride catabolic process
GO:0001503 ISS:UniProtKB P ossification
GO:0046470 ISS:UniProtKB P phosphatidylcholine metabolic process
GO:0010694 ISS:UniProtKB P positive regulation of alkaline phosphatase activity
GO:0043065 IDA:UniProtKB P positive regulation of apoptotic process
GO:0045919 IDA:UniProtKB P positive regulation of cytolysis
GO:0010595 IMP:UniProtKB P positive regulation of endothelial cell migration
GO:0010907 ISS:UniProtKB P positive regulation of glucose metabolic process
GO:0010983 ISS:UniProtKB P positive regulation of high-density lipoprotein particle clearance
GO:0035774 ISS:UniProtKB P positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0051044 IDA:UniProtKB P positive regulation of membrane protein ectodomain proteolysis
GO:0051047 ISS:UniProtKB P positive regulation of secretion
GO:0010867 ISS:UniProtKB P positive regulation of triglyceride biosynthetic process
GO:1900076 IDA:UniProtKB P regulation of cellular response to insulin stimulus
GO:0009749 IDA:UniProtKB P response to glucose
GO:0070633 ISS:UniProtKB P transepithelial transport

KEGG Pathway Links

KEGG Pathway ID Description
hsa00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
ko00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR013517 FG-GAP repeat
IPR001028 Glycoprotein phospholipase D
IPR013519 Integrin alpha beta-propellor
IPR029002 Phospholipase C/D

UniProt Annotations

Entry Information

Gene Name
glycosylphosphatidylinositol specific phospholipase D1
Protein Entry
PHLD_HUMAN
UniProt ID
P80108
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P80108-1; Sequence=Displayed; Name=2; IsoId=P80108-2; Sequence=VSP_023261, VSP_023262;
Catalytic Activity 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D- myo-inositol + H(2)O = 6-(alpha-D-glucosaminyl)-1D-myo-inositol + phosphatidate.
Function This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane.
Sequence Caution Sequence=AAA36444.1; Type=Miscellaneous discrepancy; Note=This sequence has numerous of conflicts with the human genome.; Evidence= ;
Similarity Belongs to the GPLD1 family.
Similarity Contains 7 FG-GAP repeats.
Subcellular Location Secreted.
Subunit Monomer.

Identical and Related Proteins

Unique RefSeq proteins for LMP001412 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
29171717 RefSeq NP_001494 840 phosphatidylinositol-glycan-specific phospholipase D precursor

Identical Sequences to LMP001412 proteins

Reference Database Accession Length Protein Name
GI:29171717 GenBank AAI57057.1 840 Glycosylphosphatidylinositol specific phospholipase D1 [synthetic construct]
GI:29171717 GenBank AAI56272.1 840 Glycosylphosphatidylinositol specific phospholipase D1, partial [synthetic construct]
GI:29171717 GenBank ADC20585.1 840 Sequence 1069 from patent US 7638288
GI:29171717 GenBank AEJ66618.1 840 Sequence 16 from patent US 7968293
GI:29171717 GenBank AGD01546.1 840 Sequence 1069 from patent US 8338124
GI:29171717 SwissProt P80108.3 840 RecName: Full=Phosphatidylinositol-glycan-specific phospholipase D; Short=PI-G PLD; AltName: Full=Glycoprotein phospholipase D; AltName: Full=Glycosyl-phosphatidylinositol-specific phospholipase D; Short=GPI-PLD; Short=GPI-specific phospholipase D; Flags: Precursor [Homo sapiens]

Related Sequences to LMP001412 proteins

Reference Database Accession Length Protein Name
GI:29171717 EMBL CAC87068.1 840 glycosylphosphatidylinositol phospholipase D [Homo sapiens]
GI:29171717 GenBank AAA36445.1 840 phospholipase D [Homo sapiens]
GI:29171717 GenBank AAG16627.2 840 glycosylphosphatidylinositol-specific phospholipase D precursor [Homo sapiens]
GI:29171717 GenBank EAW55448.1 840 glycosylphosphatidylinositol specific phospholipase D1, isoform CRA_a [Homo sapiens]
GI:29171717 GenBank EAW55450.1 850 glycosylphosphatidylinositol specific phospholipase D1, isoform CRA_c [Homo sapiens]
GI:29171717 RefSeq XP_004043388.1 840 PREDICTED: phosphatidylinositol-glycan-specific phospholipase D isoform 1 [Gorilla gorilla gorilla]