Gene/Proteome Database (LMPD)

LMPD ID
LMP001413
Gene ID
6713
Species
Homo sapiens (Human)
Gene Name
squalene epoxidase
Gene Symbol
SQLE
Synonyms
-
Alternate Names
squalene monooxygenase; SE
Chromosome
8
Map Location
8q24.1
EC Number
1.14.13.132
Summary
Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for SQLE

Proteins

squalene monooxygenase
Refseq ID NP_003120
Protein GI 62865635
UniProt ID Q14534
mRNA ID NM_003129
Length 574
RefSeq Status REVIEWED
MWTFLGIATFTYFYKKFGDFITLANREVLLCVLVFLSLGLVLSYRCRHRNGGLLGRQQSGSQFALFSDILSGLPFIGFFWAKSPPESENKEQLEARRRRKGTNISETSLIGTAACTSTSSQNDPEVIIVGAGVLGSALAAVLSRDGRKVTVIERDLKEPDRIVGEFLQPGGYHVLKDLGLGDTVEGLDAQVVNGYMIHDQESKSEVQIPYPLSENNQVQSGRAFHHGRFIMSLRKAAMAEPNAKFIEGVVLQLLEEDDVVMGVQYKDKETGDIKELHAPLTVVADGLFSKFRKSLVSNKVSVSSHFVGFLMKNAPQFKANHAELILANPSPVLIYQISSSETRVLVDIRGEMPRNLREYMVEKIYPQIPDHLKEPFLEATDNSHLRSMPASFLPPSSVKKRGVLLLGDAYNMRHPLTGGGMTVAFKDIKLWRKLLKGIPDLYDDAAIFEAKKSFYWARKTSHSFVVNILAQALYELFSATDDSLHQLRKACFLYFKLGGECVAGPVGLLSVLSPNPLVLIGHFFAVAIYAVYFCFKSEPWITKPRALLSSGAVLYKACSVIFPLIYSEMKYMVH

Gene Information

Entrez Gene ID
6713
Gene Name
squalene epoxidase
Gene Symbol
SQLE
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0050660 IEA:InterPro F flavin adenine dinucleotide binding
GO:0004506 NAS:UniProtKB F squalene monooxygenase activity
GO:0006725 IEA:Ensembl P cellular aromatic compound metabolic process
GO:0006695 TAS:Reactome P cholesterol biosynthetic process
GO:0010033 IEA:Ensembl P response to organic substance
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0016126 NAS:UniProtKB P sterol biosynthetic process

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_147904 Activation of gene expression by SREBF (SREBP)

Domain Information

InterPro Annotations

Accession Description
IPR003042 Aromatic-ring hydroxylase-like
IPR001327 Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain
IPR013698 Squalene_epoxidase

UniProt Annotations

Entry Information

Gene Name
squalene epoxidase
Protein Entry
ERG1_HUMAN
UniProt ID
Q14534
Species
Human

Comments

Comment Type Description
Catalytic Activity Squalene + NADPH + O(2) = (3S)-2,3-epoxy-2,3- dihydrosqualene + NADP(+) + H(2)O.
Cofactor Name=FAD; Xref=ChEBI
Function Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway.
Pathway Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 2/3.
Similarity Belongs to the squalene monooxygenase family.
Subcellular Location Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Subunit May form a complex with squalene synthase.

Identical and Related Proteins

Unique RefSeq proteins for LMP001413 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
62865635 RefSeq NP_003120 574 squalene monooxygenase

Identical Sequences to LMP001413 proteins

Reference Database Accession Length Protein Name
GI:62865635 DBBJ BAG36182.1 574 unnamed protein product [Homo sapiens]
GI:62865635 GenBank AAH17033.1 574 Squalene epoxidase [Homo sapiens]
GI:62865635 GenBank EAW92079.1 574 squalene epoxidase [Homo sapiens]
GI:62865635 GenBank ABM85583.1 574 squalene epoxidase, partial [synthetic construct]
GI:62865635 GenBank AIC49781.1 574 SQLE, partial [synthetic construct]
GI:62865635 SwissProt Q14534.3 574 RecName: Full=Squalene monooxygenase; AltName: Full=Squalene epoxidase; Short=SE [Homo sapiens]

Related Sequences to LMP001413 proteins

Reference Database Accession Length Protein Name
GI:62865635 EMBL CAI46076.1 574 hypothetical protein [Homo sapiens]
GI:62865635 GenBank ACM85656.1 629 Sequence 11154 from patent US 6812339
GI:62865635 GenBank JAA15146.1 574 squalene epoxidase [Pan troglodytes]
GI:62865635 GenBank JAA26522.1 574 squalene epoxidase [Pan troglodytes]
GI:62865635 RefSeq XP_004047566.1 574 PREDICTED: squalene monooxygenase [Gorilla gorilla gorilla]
GI:62865635 RefSeq XP_009454171.1 574 PREDICTED: squalene monooxygenase isoform X1 [Pan troglodytes]