Gene/Proteome Database (LMPD)
LMPD ID
LMP001413
Gene ID
Species
Homo sapiens (Human)
Gene Name
squalene epoxidase
Gene Symbol
Synonyms
-
Alternate Names
squalene monooxygenase; SE
Chromosome
8
Map Location
8q24.1
EC Number
1.14.13.132
Summary
Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| squalene monooxygenase | |
|---|---|
| Refseq ID | NP_003120 |
| Protein GI | 62865635 |
| UniProt ID | Q14534 |
| mRNA ID | NM_003129 |
| Length | 574 |
| RefSeq Status | REVIEWED |
| MWTFLGIATFTYFYKKFGDFITLANREVLLCVLVFLSLGLVLSYRCRHRNGGLLGRQQSGSQFALFSDILSGLPFIGFFWAKSPPESENKEQLEARRRRKGTNISETSLIGTAACTSTSSQNDPEVIIVGAGVLGSALAAVLSRDGRKVTVIERDLKEPDRIVGEFLQPGGYHVLKDLGLGDTVEGLDAQVVNGYMIHDQESKSEVQIPYPLSENNQVQSGRAFHHGRFIMSLRKAAMAEPNAKFIEGVVLQLLEEDDVVMGVQYKDKETGDIKELHAPLTVVADGLFSKFRKSLVSNKVSVSSHFVGFLMKNAPQFKANHAELILANPSPVLIYQISSSETRVLVDIRGEMPRNLREYMVEKIYPQIPDHLKEPFLEATDNSHLRSMPASFLPPSSVKKRGVLLLGDAYNMRHPLTGGGMTVAFKDIKLWRKLLKGIPDLYDDAAIFEAKKSFYWARKTSHSFVVNILAQALYELFSATDDSLHQLRKACFLYFKLGGECVAGPVGLLSVLSPNPLVLIGHFFAVAIYAVYFCFKSEPWITKPRALLSSGAVLYKACSVIFPLIYSEMKYMVH | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005789 | TAS:Reactome | C | endoplasmic reticulum membrane |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0050660 | IEA:InterPro | F | flavin adenine dinucleotide binding |
| GO:0004506 | NAS:UniProtKB | F | squalene monooxygenase activity |
| GO:0006725 | IEA:Ensembl | P | cellular aromatic compound metabolic process |
| GO:0006695 | TAS:Reactome | P | cholesterol biosynthetic process |
| GO:0010033 | IEA:Ensembl | P | response to organic substance |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
| GO:0016126 | NAS:UniProtKB | P | sterol biosynthetic process |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_147904 | Activation of gene expression by SREBF (SREBP) |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Squalene + NADPH + O(2) = (3S)-2,3-epoxy-2,3- dihydrosqualene + NADP(+) + H(2)O. |
| Cofactor | Name=FAD; Xref=ChEBI |
| Function | Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway. |
| Pathway | Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 2/3. |
| Similarity | Belongs to the squalene monooxygenase family. |
| Subcellular Location | Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. |
| Subunit | May form a complex with squalene synthase. |
Identical and Related Proteins
Unique RefSeq proteins for LMP001413 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 62865635 | RefSeq | NP_003120 | 574 | squalene monooxygenase |
Identical Sequences to LMP001413 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:62865635 | DBBJ | BAG36182.1 | 574 | unnamed protein product [Homo sapiens] |
| GI:62865635 | GenBank | AAH17033.1 | 574 | Squalene epoxidase [Homo sapiens] |
| GI:62865635 | GenBank | EAW92079.1 | 574 | squalene epoxidase [Homo sapiens] |
| GI:62865635 | GenBank | ABM85583.1 | 574 | squalene epoxidase, partial [synthetic construct] |
| GI:62865635 | GenBank | AIC49781.1 | 574 | SQLE, partial [synthetic construct] |
| GI:62865635 | SwissProt | Q14534.3 | 574 | RecName: Full=Squalene monooxygenase; AltName: Full=Squalene epoxidase; Short=SE [Homo sapiens] |
Related Sequences to LMP001413 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:62865635 | EMBL | CAI46076.1 | 574 | hypothetical protein [Homo sapiens] |
| GI:62865635 | GenBank | ACM85656.1 | 629 | Sequence 11154 from patent US 6812339 |
| GI:62865635 | GenBank | JAA15146.1 | 574 | squalene epoxidase [Pan troglodytes] |
| GI:62865635 | GenBank | JAA26522.1 | 574 | squalene epoxidase [Pan troglodytes] |
| GI:62865635 | RefSeq | XP_004047566.1 | 574 | PREDICTED: squalene monooxygenase [Gorilla gorilla gorilla] |
| GI:62865635 | RefSeq | XP_009454171.1 | 574 | PREDICTED: squalene monooxygenase isoform X1 [Pan troglodytes] |