Gene/Proteome Database (LMPD)

LMPD ID
LMP001415
Gene ID
4536
Species
Homo sapiens (Human)
Gene Name
MTND2
Gene Symbol
ND2
Synonyms
MTND2
Chromosome
MT
Map Location
-
EC Number
1.6.5.3 ;

Proteins

NADH dehydrogenase subunit 2 (mitochondrion)
Refseq ID YP_003024027
Protein GI 251831108
UniProt ID Q7GXY9
Length 347
MNPLAQPVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPVLTKKMNPRSTEAAIKYFLTQATASMILLMAILFNNMLSGQWTMTNTTNQYSSLMIMMAMAMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQISPSLNVSLLLTLSILSIMAGSWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYIILTTTAFLLLNLNSSTTTLLLSRTWNKLTWLTPLIPSTLLSLGGLPPLTGFLPKWAIIEEFTKNNSLIIPTIMATITLLNLYFYLRLIYSTSITLLPMSNNVKMKWQFEHTKPTPFLPTLIALTTLLLPISPFMLMIL

Gene Information

Entrez Gene ID
4536
Gene Name
MTND2
Gene Symbol
ND2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005743 IEA:UniProtKB-SubCell C mitochondrial inner membrane
GO:0070469 IEA:UniProtKB-KW C respiratory chain
GO:0008137 IEA:UniProtKB-EC F NADH dehydrogenase (ubiquinone) activity
GO:0006120 IEA:InterPro P mitochondrial electron transport, NADH to ubiquinone
GO:0072593 IEA:Ensembl P reactive oxygen species metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa05012 Parkinson's disease

Domain Information

InterPro Annotations

Accession Description
IPR010933 NADH dehydrogenase subunit 2, C-terminal
IPR001750 NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit
IPR003917 NADH:ubiquinone oxidoreductase, chain 2

UniProt Annotations

Entry Information

Gene Name
MTND2
Protein Entry
Q7GXY9_HUMAN
UniProt ID
Q7GXY9
Species
Human

Comments

Comment Type Description
Catalytic Activity NADH + ubiquinone + 5 H(+)(In) = NAD(+) + ubiquinol + 4 H(+)(Out). {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS00093735}.
Function Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Similarity Belongs to the complex I subunit 2 family
Subcellular Location Mitochondrion inner membrane ; Multi-pass membrane protein {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS00093751}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001415 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
251831108 RefSeq YP_003024027 347 NADH dehydrogenase subunit 2 (mitochondrion)

Identical Sequences to LMP001415 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP001415 proteins

Reference Database Accession Length Protein Name