Gene/Proteome Database (LMPD)

LMPD ID
LMP001417
Gene ID
866
Species
Homo sapiens (Human)
Gene Name
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
Gene Symbol
SERPINA6
Synonyms
CBG
Alternate Names
corticosteroid-binding globulin; serpin A6; transcortin; corticosteroid binding globulin; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
Chromosome
14
Map Location
14q32.1
Summary
This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for SERPINA6

Proteins

corticosteroid-binding globulin precursor
Refseq ID NP_001747
Protein GI 73858564
UniProt ID P08185
mRNA ID NM_001756
Length 405
RefSeq Status REVIEWED
MPLLLYTCLLWLPTSGLWTVQAMDPNAAYVNMSNHHRGLASANVDFAFSLYKHLVALSPKKNIFISPVSISMALAMLSLGTCGHTRAQLLQGLGFNLTERSETEIHQGFQHLHQLFAKSDTSLEMTMGNALFLDGSLELLESFSADIKHYYESEVLAMNFQDWATASRQINSYVKNKTQGKIVDLFSGLDSPAILVLVNYIFFKGTWTQPFDLASTREENFYVDETTVVKVPMMLQSSTISYLHDAELPCQLVQMNYVGNGTVFFILPDKGKMNTVIAALSRDTINRWSAGLTSSQVDLYIPKVTISGVYDLGDVLEEMGIADLFTNQANFSRITQDAQLKSSKVVHKAVLQLNEEGVDTAGSTGVTLNLTSKPIILRFNQPFIIMIFDHFTWSSLFLARVMNPV
sig_peptide: 1..22 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2520 peptide sequence: MPLLLYTCLLWLPTSGLWTVQA mat_peptide: 23..405 product: corticosteroid-binding globulin calculated_mol_wt: 42623 peptide sequence: MDPNAAYVNMSNHHRGLASANVDFAFSLYKHLVALSPKKNIFISPVSISMALAMLSLGTCGHTRAQLLQGLGFNLTERSETEIHQGFQHLHQLFAKSDTSLEMTMGNALFLDGSLELLESFSADIKHYYESEVLAMNFQDWATASRQINSYVKNKTQGKIVDLFSGLDSPAILVLVNYIFFKGTWTQPFDLASTREENFYVDETTVVKVPMMLQSSTISYLHDAELPCQLVQMNYVGNGTVFFILPDKGKMNTVIAALSRDTINRWSAGLTSSQVDLYIPKVTISGVYDLGDVLEEMGIADLFTNQANFSRITQDAQLKSSKVVHKAVLQLNEEGVDTAGSTGVTLNLTSKPIILRFNQPFIIMIFDHFTWSSLFLARVMNPV

Gene Information

Entrez Gene ID
866
Gene Name
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
Gene Symbol
SERPINA6
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005615 IDA:UniProt C extracellular space
GO:0070062 IDA:UniProtKB C extracellular vesicular exosome
GO:0004867 IBA:RefGenome F serine-type endopeptidase inhibitor activity
GO:0005496 IDA:UniProtKB F steroid binding
GO:0008211 IEA:Ensembl P glucocorticoid metabolic process
GO:0010951 IBA:RefGenome P negative regulation of endopeptidase activity
GO:0030162 IBA:RefGenome P regulation of proteolysis
GO:0006810 IEA:UniProtKB-KW P transport

Domain Information

InterPro Annotations

Accession Description
IPR023796 Serpin domain
IPR000215 Serpin family
IPR023795 Serpin, conserved site

UniProt Annotations

Entry Information

Gene Name
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
Protein Entry
CBG_HUMAN
UniProt ID
P08185
Species
Human

Comments

Comment Type Description
Disease Corticosteroid-binding globulin deficiency (CBG deficiency) [MIM
Domain Proteolytic cleavage leads to an important conformation change. This reduces the affinity for steroids.
Function Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
Ptm Glycosylation in position Asn-260 is needed for steroid binding.
Ptm N-glycosylated; binds 5 oligosaccharide chains.
Similarity Belongs to the serpin family.
Subcellular Location Secreted.
Tissue Specificity Plasma; synthesized in liver. Has also been identified in a number of glycocorticoid responsive cells.
Web Resource Name=Wikipedia; Note=Transcortin entry; URL="http://en.wikipedia.org/wiki/Transcortin";

Identical and Related Proteins

Unique RefSeq proteins for LMP001417 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
73858564 RefSeq NP_001747 405 corticosteroid-binding globulin precursor

Identical Sequences to LMP001417 proteins

Reference Database Accession Length Protein Name
GI:73858564 DBBJ BAG72766.1 405 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6, partial [synthetic construct]
GI:73858564 EMBL CAL37483.1 405 hypothetical protein [synthetic construct]
GI:73858564 EMBL CAL37486.1 405 hypothetical protein, partial [synthetic construct]
GI:73858564 GenBank AFO05910.1 405 Sequence 548 from patent US 8216786
GI:73858564 GenBank AHE01366.1 405 Sequence 56282 from patent US 8586006
GI:73858564 GenBank AIC48429.1 405 SERPINA6, partial [synthetic construct]

Related Sequences to LMP001417 proteins

Reference Database Accession Length Protein Name
GI:73858564 DBBJ BAF83510.1 405 unnamed protein product [Homo sapiens]
GI:73858564 GenBank AAB59523.1 405 corticosteroid binding globulin precursor [Homo sapiens]
GI:73858564 GenBank AAA71502.1 405 Sequence 2 from patent US 5432080
GI:73858564 GenBank EAW81568.1 405 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6, isoform CRA_b [Homo sapiens]
GI:73858564 GenBank ADA53288.1 405 Sequence 1118 from patent US 7625699
GI:73858564 SwissProt P08185.1 405 RecName: Full=Corticosteroid-binding globulin; Short=CBG; AltName: Full=Serpin A6; AltName: Full=Transcortin; Flags: Precursor [Homo sapiens]