Gene/Proteome Database (LMPD)
LMPD ID
LMP001417
Gene ID
Species
Homo sapiens (Human)
Gene Name
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
Gene Symbol
Synonyms
CBG
Alternate Names
corticosteroid-binding globulin; serpin A6; transcortin; corticosteroid binding globulin; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
Chromosome
14
Map Location
14q32.1
Summary
This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| corticosteroid-binding globulin precursor | |
|---|---|
| Refseq ID | NP_001747 |
| Protein GI | 73858564 |
| UniProt ID | P08185 |
| mRNA ID | NM_001756 |
| Length | 405 |
| RefSeq Status | REVIEWED |
| MPLLLYTCLLWLPTSGLWTVQAMDPNAAYVNMSNHHRGLASANVDFAFSLYKHLVALSPKKNIFISPVSISMALAMLSLGTCGHTRAQLLQGLGFNLTERSETEIHQGFQHLHQLFAKSDTSLEMTMGNALFLDGSLELLESFSADIKHYYESEVLAMNFQDWATASRQINSYVKNKTQGKIVDLFSGLDSPAILVLVNYIFFKGTWTQPFDLASTREENFYVDETTVVKVPMMLQSSTISYLHDAELPCQLVQMNYVGNGTVFFILPDKGKMNTVIAALSRDTINRWSAGLTSSQVDLYIPKVTISGVYDLGDVLEEMGIADLFTNQANFSRITQDAQLKSSKVVHKAVLQLNEEGVDTAGSTGVTLNLTSKPIILRFNQPFIIMIFDHFTWSSLFLARVMNPV | |
| sig_peptide: 1..22 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2520 peptide sequence: MPLLLYTCLLWLPTSGLWTVQA mat_peptide: 23..405 product: corticosteroid-binding globulin calculated_mol_wt: 42623 peptide sequence: MDPNAAYVNMSNHHRGLASANVDFAFSLYKHLVALSPKKNIFISPVSISMALAMLSLGTCGHTRAQLLQGLGFNLTERSETEIHQGFQHLHQLFAKSDTSLEMTMGNALFLDGSLELLESFSADIKHYYESEVLAMNFQDWATASRQINSYVKNKTQGKIVDLFSGLDSPAILVLVNYIFFKGTWTQPFDLASTREENFYVDETTVVKVPMMLQSSTISYLHDAELPCQLVQMNYVGNGTVFFILPDKGKMNTVIAALSRDTINRWSAGLTSSQVDLYIPKVTISGVYDLGDVLEEMGIADLFTNQANFSRITQDAQLKSSKVVHKAVLQLNEEGVDTAGSTGVTLNLTSKPIILRFNQPFIIMIFDHFTWSSLFLARVMNPV | |
Gene Information
Entrez Gene ID
Gene Name
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005615 | IDA:UniProt | C | extracellular space |
| GO:0070062 | IDA:UniProtKB | C | extracellular vesicular exosome |
| GO:0004867 | IBA:RefGenome | F | serine-type endopeptidase inhibitor activity |
| GO:0005496 | IDA:UniProtKB | F | steroid binding |
| GO:0008211 | IEA:Ensembl | P | glucocorticoid metabolic process |
| GO:0010951 | IBA:RefGenome | P | negative regulation of endopeptidase activity |
| GO:0030162 | IBA:RefGenome | P | regulation of proteolysis |
| GO:0006810 | IEA:UniProtKB-KW | P | transport |
Domain Information
UniProt Annotations
Entry Information
Gene Name
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
Protein Entry
CBG_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Disease | Corticosteroid-binding globulin deficiency (CBG deficiency) [MIM |
| Domain | Proteolytic cleavage leads to an important conformation change. This reduces the affinity for steroids. |
| Function | Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species. |
| Ptm | Glycosylation in position Asn-260 is needed for steroid binding. |
| Ptm | N-glycosylated; binds 5 oligosaccharide chains. |
| Similarity | Belongs to the serpin family. |
| Subcellular Location | Secreted. |
| Tissue Specificity | Plasma; synthesized in liver. Has also been identified in a number of glycocorticoid responsive cells. |
| Web Resource | Name=Wikipedia; Note=Transcortin entry; URL="http://en.wikipedia.org/wiki/Transcortin"; |
Identical and Related Proteins
Unique RefSeq proteins for LMP001417 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 73858564 | RefSeq | NP_001747 | 405 | corticosteroid-binding globulin precursor |
Identical Sequences to LMP001417 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:73858564 | DBBJ | BAG72766.1 | 405 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6, partial [synthetic construct] |
| GI:73858564 | EMBL | CAL37483.1 | 405 | hypothetical protein [synthetic construct] |
| GI:73858564 | EMBL | CAL37486.1 | 405 | hypothetical protein, partial [synthetic construct] |
| GI:73858564 | GenBank | AFO05910.1 | 405 | Sequence 548 from patent US 8216786 |
| GI:73858564 | GenBank | AHE01366.1 | 405 | Sequence 56282 from patent US 8586006 |
| GI:73858564 | GenBank | AIC48429.1 | 405 | SERPINA6, partial [synthetic construct] |
Related Sequences to LMP001417 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:73858564 | DBBJ | BAF83510.1 | 405 | unnamed protein product [Homo sapiens] |
| GI:73858564 | GenBank | AAB59523.1 | 405 | corticosteroid binding globulin precursor [Homo sapiens] |
| GI:73858564 | GenBank | AAA71502.1 | 405 | Sequence 2 from patent US 5432080 |
| GI:73858564 | GenBank | EAW81568.1 | 405 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6, isoform CRA_b [Homo sapiens] |
| GI:73858564 | GenBank | ADA53288.1 | 405 | Sequence 1118 from patent US 7625699 |
| GI:73858564 | SwissProt | P08185.1 | 405 | RecName: Full=Corticosteroid-binding globulin; Short=CBG; AltName: Full=Serpin A6; AltName: Full=Transcortin; Flags: Precursor [Homo sapiens] |