Gene/Proteome Database (LMPD)

LMPD ID
LMP001420
Gene ID
11808
Species
Mus musculus (Mouse)
Gene Name
apolipoprotein A-IV
Gene Symbol
Apoa4
Synonyms
Apoa-4
Alternate Names
apolipoprotein A-IV; apo-AIV; apoA-IV; apolipoprotein A4
Chromosome
9
Map Location
9 A5.2|9 25.36 cM

Proteins

apolipoprotein A-IV precursor
Refseq ID NP_031494
Protein GI 110347473
UniProt ID P06728
mRNA ID NM_007468
Length 395
RefSeq Status VALIDATED
MFLKAAVLTLALVAITGTRAEVTSDQVANVVWDYFTQLSNNAKEAVEQFQKTDVTQQLSTLFQDKLGDASTYADGVHNKLVPFVVQLSGHLAQETERVKEEIKKELEDLRDRMMPHANKVTQTFGENMQKLQEHLKPYAVDLQDQINTQTQEMKLQLTPYIQRMQTTIKENVDNLHTSMMPLATNLKDKFNRNMEELKGHLTPRANELKATIDQNLEDLRRSLAPLTVGVQEKLNHQMEGLAFQMKKNAEELQTKVSAKIDQLQKNLAPLVEDVQSKVKGNTEGLQKSLEDLNRQLEQQVEEFRRTVEPMGEMFNKALVQQLEQFRQQLGPNSGEVESHLSFLEKSLREKVNSFMSTLEKKGSPDQPQALPLPEQAQEQAQEQAQEQVQPKPLES
sig_peptide: 1..20 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2061 peptide sequence: MFLKAAVLTLALVAITGTRA mat_peptide: 21..395 product: Apolipoprotein A-IV experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P06728.3) calculated_mol_wt: 42987 peptide sequence: EVTSDQVANVVWDYFTQLSNNAKEAVEQFQKTDVTQQLSTLFQDKLGDASTYADGVHNKLVPFVVQLSGHLAQETERVKEEIKKELEDLRDRMMPHANKVTQTFGENMQKLQEHLKPYAVDLQDQINTQTQEMKLQLTPYIQRMQTTIKENVDNLHTSMMPLATNLKDKFNRNMEELKGHLTPRANELKATIDQNLEDLRRSLAPLTVGVQEKLNHQMEGLAFQMKKNAEELQTKVSAKIDQLQKNLAPLVEDVQSKVKGNTEGLQKSLEDLNRQLEQQVEEFRRTVEPMGEMFNKALVQQLEQFRQQLGPNSGEVESHLSFLEKSLREKVNSFMSTLEKKGSPDQPQALPLPEQAQEQAQEQAQEQVQPKPLES

Gene Information

Entrez Gene ID
11808
Gene Name
apolipoprotein A-IV
Gene Symbol
Apoa4
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0072562 IEA:Ensembl C blood microparticle
GO:0009986 IEA:Ensembl C cell surface
GO:0042627 IEA:UniProtKB-KW C chylomicron
GO:0005829 TAS:Reactome C cytosol
GO:0005576 TAS:Reactome C extracellular region
GO:0005615 IDA:MGI C extracellular space
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0034364 IEA:UniProtKB-KW C high-density lipoprotein particle
GO:0034361 IEA:Ensembl C very-low-density lipoprotein particle
GO:0016209 IEA:Ensembl F antioxidant activity
GO:0017127 IEA:Ensembl F cholesterol transporter activity
GO:0005507 IEA:Ensembl F copper ion binding
GO:0031210 IEA:Ensembl F phosphatidylcholine binding
GO:0060228 IEA:Ensembl F phosphatidylcholine-sterol O-acyltransferase activator activity
GO:0033344 IEA:Ensembl P cholesterol efflux
GO:0042632 IEA:Ensembl P cholesterol homeostasis
GO:0008203 IEA:Ensembl P cholesterol metabolic process
GO:0042744 IEA:Ensembl P hydrogen peroxide catabolic process
GO:0002227 IMP:BHF-UCL P innate immune response in mucosa
GO:0007159 IEA:Ensembl P leukocyte cell-cell adhesion
GO:0042157 IEA:InterPro P lipoprotein metabolic process
GO:0044240 IEA:Ensembl P multicellular organismal lipid catabolic process
GO:0034445 IEA:Ensembl P negative regulation of plasma lipoprotein particle oxidation
GO:0046470 IEA:Ensembl P phosphatidylcholine metabolic process
GO:0033700 IEA:Ensembl P phospholipid efflux
GO:0010873 IEA:Ensembl P positive regulation of cholesterol esterification
GO:0045723 IEA:Ensembl P positive regulation of fatty acid biosynthetic process
GO:0051006 IEA:Ensembl P positive regulation of lipoprotein lipase activity
GO:0010898 IEA:Ensembl P positive regulation of triglyceride catabolic process
GO:0065005 IEA:Ensembl P protein-lipid complex assembly
GO:0030300 IMP:MGI P regulation of intestinal cholesterol absorption
GO:0019430 IEA:Ensembl P removal of superoxide radicals
GO:0006982 IEA:Ensembl P response to lipid hydroperoxide
GO:0035634 IEP:UniProtKB P response to stilbenoid
GO:0043691 IEA:Ensembl P reverse cholesterol transport
GO:0034372 IEA:Ensembl P very-low-density lipoprotein particle remodeling

KEGG Pathway Links

KEGG Pathway ID Description
mmu04975 Fat digestion and absorption
mmu04977 Vitamin digestion and absorption

REACTOME Pathway Links

REACTOME Pathway ID Description
5893389 Chylomicron-mediated lipid transport

Domain Information

InterPro Annotations

Accession Description
IPR000074 Apolipoprotein A/E

UniProt Annotations

Entry Information

Gene Name
apolipoprotein A-IV
Protein Entry
APOA4_MOUSE
UniProt ID
P06728
Species
Mouse

Comments

Comment Type Description
Domain Nine of the thirteen 22-amino acid tandem repeats (each 22-mer is actually a tandem array of two, A and B, related 11- mers) occurring in this sequence are predicted to be highly alpha- helical, and many of these helices are amphipathic. They may therefore serve as lipid-binding domains with lecithin:cholesterol acyltransferase (LCAT) activating abilities.
Function May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.
Polymorphism There is a polymorphism within a series of imperfect repeats encoding the sequence E-Q-[AV]-Q. Insertions or deletions of 12 nucleotides have given rise to three forms characterized by three (129), four (C57BL/6), or five (M.castaneus) copies of the repeat unit.
Similarity Belongs to the apolipoprotein A1/A4/E family. {ECO:0000305}.
Subcellular Location Secreted.
Subunit Homodimer. {ECO:0000250|UniProtKB:P06727}.
Tissue Specificity Secreted in plasma.

Identical and Related Proteins

Unique RefSeq proteins for LMP001420 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
110347473 RefSeq NP_031494 395 apolipoprotein A-IV precursor

Identical Sequences to LMP001420 proteins

Reference Database Accession Length Protein Name
GI:110347473 DBBJ BAE36447.1 395 unnamed protein product [Mus musculus]
GI:110347473 DBBJ BAE40533.1 395 unnamed protein product [Mus musculus]
GI:110347473 GenBank AAH10769.1 395 Apolipoprotein A-IV [Mus musculus]
GI:110347473 GenBank EDL25684.1 395 apolipoprotein A-IV [Mus musculus]
GI:110347473 SwissProt P06728.3 395 RecName: Full=Apolipoprotein A-IV; Short=Apo-AIV; Short=ApoA-IV; AltName: Full=Apolipoprotein A4; Flags: Precursor [Mus musculus]

Related Sequences to LMP001420 proteins

Reference Database Accession Length Protein Name
GI:110347473 DBBJ BAB23620.1 395 unnamed protein product [Mus musculus]
GI:110347473 GenBank AAA37214.1 391 apolipoprotein A-IV [Mus musculus domesticus]
GI:110347473 GenBank AAA37215.1 395 apolipoprotein A-IV [Mus musculus domesticus]
GI:110347473 GenBank AAA37216.1 435 apolipoprotein A-IV [Mus musculus castaneus]
GI:110347473 GenBank AAR40699.1 391 Sequence 208 from patent US 6605592
GI:110347473 GenBank AAY74297.1 395 Sequence 35 from patent US 6897039