Gene/Proteome Database (LMPD)

LMPD ID
LMP001426
Gene ID
11668
Species
Mus musculus (Mouse)
Gene Name
aldehyde dehydrogenase family 1, subfamily A1
Gene Symbol
Aldh1a1
Synonyms
Ahd-2; Ahd2; Aldh1; Aldh1a2; E1; Raldh1
Alternate Names
retinal dehydrogenase 1; ALHDII; ALDH-E1; RALDH 1; aldehyde dehydrogenase, cytosolic; aldehyde dehydrogenase family 1 member A1; alcohol dehydrogenase family 1, subfamily A1; alcohol dehydrogenase family 1, subfamily A2; aldehyde dehydrogenase 1, liver cytosolic (class 1)
Chromosome
19
Map Location
19 B|19 13.91 cM
EC Number
1.2.1.36

Proteins

retinal dehydrogenase 1
Refseq ID NP_038495
Protein GI 85861182
UniProt ID P24549
mRNA ID NM_013467
Length 501
RefSeq Status PROVISIONAL
MSSPAQPAVPAPLADLKIQHTKIFINNEWHNSVSGKKFPVLNPATEEVICHVEEGDKADVDKAVKAARQAFQIGSPWRTMDASERGRLLNKLADLMERDRLLLATMEALNGGKVFANAYLSDLGGCIKALKYCAGWADKIHGQTIPSDGDIFTYTRREPIGVCGQIIPWNFPMLMFIWKIGPALSCGNTVVVKPAEQTPLTALHLASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDVDKVAFTGSTQVGKLIKEAAGKSNLKRVTLELGGKSPCIVFADADLDIAVEFAHHGVFYHQGQCCVAASRIFVEESVYDEFVKRSVERAKKYVLGNPLTPGINQGPQIDKEQHDKILDLIESGKKEGAKLECGGGRWGNKGFFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSVDDVIKRANNTTYGLAAGLFTKDLDKAITVSSALQAGVVWVNCYMMLSAQCPFGGFKMSGNGRELGEHGLYEYTELKTVAMKISQKNS

Gene Information

Entrez Gene ID
11668
Gene Name
aldehyde dehydrogenase family 1, subfamily A1
Gene Symbol
Aldh1a1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005634 IEA:Ensembl C nucleus
GO:0004028 IDA:MGI F 3-chloroallyl aldehyde dehydrogenase activity
GO:0018479 IEA:Ensembl F benzaldehyde dehydrogenase (NAD+) activity
GO:0001758 IEA:UniProtKB-EC F retinal dehydrogenase activity
GO:0042904 IDA:MGI P 9-cis-retinoic acid biosynthetic process
GO:0048048 IGI:MGI P embryonic eye morphogenesis
GO:0060206 IEA:Ensembl P estrous cycle phase
GO:0001822 IEA:Ensembl P kidney development
GO:0001889 IEA:Ensembl P liver development
GO:0007494 IEA:Ensembl P midgut development
GO:0002072 IGI:MGI P optic cup morphogenesis involved in camera-type eye development
GO:0043065 IGI:MGI P positive regulation of apoptotic process
GO:0051289 IEA:Ensembl P protein homotetramerization
GO:0042493 IDA:MGI P response to drug
GO:0032355 IEA:Ensembl P response to estradiol
GO:0045471 IEA:Ensembl P response to ethanol
GO:0006979 IEA:Ensembl P response to oxidative stress
GO:0032526 IEA:Ensembl P response to retinoic acid
GO:0042573 IDA:MGI P retinoic acid metabolic process
GO:0042572 IMP:MGI P retinol metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu00830 Retinol metabolism

Domain Information

InterPro Annotations

Accession Description
IPR016162 Aldehyde dehydrogenase N-terminal domain
IPR015590 Aldehyde dehydrogenase domain
IPR016163 Aldehyde dehydrogenase, C-terminal
IPR016160 Aldehyde dehydrogenase, cysteine active site
IPR029510 Aldehyde dehydrogenase, glutamic acid active site
IPR016161 Aldehyde/histidinol dehydrogenase

UniProt Annotations

Entry Information

Gene Name
aldehyde dehydrogenase family 1, subfamily A1
Protein Entry
AL1A1_MOUSE
UniProt ID
P24549
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Retinal + NAD(+) + H(2)O = retinoate + NADH.
Function In addition to the activity on acetaldehyde and related substrates, is also involved in the oxidation of aldehydes derived from biogenic amines such as epinephrine and norepinephrine, as well as the aldehydes generated via lipid peroxidation. Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity). {ECO:0000250}.
Pathway Cofactor metabolism; retinol metabolism.
Sequence Caution Sequence=AAH44729.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Belongs to the aldehyde dehydrogenase family. {ECO:0000305}.
Subcellular Location Cytoplasm.
Subunit Homodimer.
Tissue Specificity Expressed in the liver, lung, and testis. Apparently not expressed at detectable levels in kidney, stomach, ovary, heart, and brain.

Identical and Related Proteins

Unique RefSeq proteins for LMP001426 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
85861182 RefSeq NP_038495 501 retinal dehydrogenase 1

Identical Sequences to LMP001426 proteins

Reference Database Accession Length Protein Name
GI:85861182 GenBank AAH54386.1 501 Aldehyde dehydrogenase family 1, subfamily A1 [Mus musculus]
GI:85861182 GenBank EDL41577.1 501 mCG119957 [Mus musculus]
GI:85861182 SwissProt P24549.5 501 RecName: Full=Retinal dehydrogenase 1; Short=RALDH 1; Short=RalDH1; AltName: Full=ALDH-E1; AltName: Full=ALHDII; AltName: Full=Aldehyde dehydrogenase family 1 member A1; AltName: Full=Aldehyde dehydrogenase, cytosolic [Mus musculus]

Related Sequences to LMP001426 proteins

Reference Database Accession Length Protein Name
GI:85861182 GenBank AAA37202.1 501 aldehyde dehydrogenase II [Mus musculus]
GI:85861182 GenBank AAC53304.1 501 aldehyde dehydrogenase [Rattus norvegicus]
GI:85861182 GenBank AAB32754.2 501 acetaldehyde dehydrogenase [Mus musculus]
GI:85861182 GenBank AAH44729.1 511 Aldh1a1 protein, partial [Mus musculus]
GI:85861182 GenBank AFL62046.1 501 Sequence 44 from patent US 8187804
GI:85861182 GenBank AHD63008.1 501 Sequence 44 from patent US 8580523