Gene/Proteome Database (LMPD)

LMPD ID
LMP001427
Gene ID
3991
Species
Homo sapiens (Human)
Gene Name
lipase, hormone-sensitive
Gene Symbol
LIPE
Synonyms
AOMS4; HSL; LHS
Chromosome
19
Map Location
19q13.2
Summary
The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for LIPE

Proteins

hormone-sensitive lipase
Refseq ID NP_005348
Protein GI 21328446
UniProt ID Q05469
mRNA ID NM_005357
Length 1076
RefSeq Status REVIEWED
MEPGSKSVSRSDWQPEPHQRPITPLEPGPEKTPIAQPESKTLQGSNTQQKPASNQRPLTQQETPAQHDAESQKEPRAQQKSASQEEFLAPQKPAPQQSPYIQRVLLTQQEAASQQGPGLGKESITQQEPALRQRHVAQPGPGPGEPPPAQQEAESTPAAQAKPGAKREPSAPTESTSQETPEQSDKQTTPVQGAKSKQGSLTELGFLTKLQELSIQRSALEWKALSEWVTDSESESDVGSSSDTDSPATMGGMVAQGVKLGFKGKSGYKVMSGYSGTSPHEKTSARNHRHYQDTASRLIHNMDLRTMTQSLVTLAEDNIAFFSSQGPGETAQRLSGVFAGVREQALGLEPALGRLLGVAHLFDLDPETPANGYRSLVHTARCCLAHLLHKSRYVASNRRSIFFRTSHNLAELEAYLAALTQLRALVYYAQRLLVTNRPGVLFFEGDEGLTADFLREYVTLHKGCFYGRCLGFQFTPAIRPFLQTISIGLVSFGEHYKRNETGLSVAASSLFTSGRFAIDPELRGAEFERITQNLDVHFWKAFWNITEMEVLSSLANMASATVRVSRLLSLPPEAFEMPLTADPTLTVTISPPLAHTGPGPVLVRLISYDLREGQDSEELSSLIKSNGQRSLELWPRPQQAPRSRSLIVHFHGGGFVAQTSRSHEPYLKSWAQELGAPIISIDYSLAPEAPFPRALEECFFAYCWAIKHCALLGSTGERICLAGDSAGGNLCFTVALRAAAYGVRVPDGIMAAYPATMLQPAASPSRLLSLMDPLLPLSVLSKCVSAYAGAKTEDHSNSDQKALGMMGLVRRDTALLLRDFRLGASSWLNSFLELSGRKSQKMSEPIAEPMRRSVSEAALAQPQGPLGTDSLKNLTLRDLSLRGNSETSSDTPEMSLSAETLSPSTPSDVNFLLPPEDAGEEAEAKNELSPMDRGLGVRAAFPEGFHPRRSSQGATQMPLYSSPIVKNPFMSPLLAPDSMLKSLPPVHIVACALDPMLDDSVMLARRLRNLGQPVTLRVVEDLPHGFLTLAALCRETRQAAELCVERIRLVLTPPAGAGPSGETGAAGVDGGCGGRH

Gene Information

Entrez Gene ID
3991
Gene Name
lipase, hormone-sensitive
Gene Symbol
LIPE
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016298 IEA:InterPro F lipase activity
GO:0008203 IEA:InterPro P cholesterol metabolic process
GO:0016042 IEA:InterPro P lipid catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa04152 AMPK signaling pathway
hsa04024 cAMP signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR013094 Alpha/beta hydrolase fold-3
IPR010468 Hormone-sensitive lipase, N-terminal
IPR002168 Lipase, GDXG, active site

UniProt Annotations

Entry Information

Gene Name
lipase, hormone-sensitive
Protein Entry
LIPS_HUMAN
UniProt ID
Q05469
Species
Human

Identical and Related Proteins

Unique RefSeq proteins for LMP001427 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
21328446 RefSeq NP_005348 1076 hormone-sensitive lipase

Identical Sequences to LMP001427 proteins

Reference Database Accession Length Protein Name
GI:21328446 GenBank ABA03168.1 1076 lipase, hormone-sensitive [Homo sapiens]
GI:21328446 SwissProt Q05469.4 1076 RecName: Full=Hormone-sensitive lipase; Short=HSL [Homo sapiens]

Related Sequences to LMP001427 proteins

Reference Database Accession Length Protein Name
GI:21328446 DBBJ BAF85171.1 1076 unnamed protein product [Homo sapiens]
GI:21328446 EMBL CAC37855.1 1076 unnamed protein product [Homo sapiens]
GI:21328446 GenBank AAC50666.1 1076 hormone-sensitive lipase testicular isoform [Homo sapiens]
GI:21328446 GenBank ABH83701.1 1076 Sequence 2 from patent US 7049092
GI:21328446 GenBank ACM81112.1 1076 Sequence 6610 from patent US 6812339
GI:21328446 GenBank ACM82026.1 1100 Sequence 7524 from patent US 6812339