Gene/Proteome Database (LMPD)
LMPD ID
LMP001434
Gene ID
Species
Homo sapiens (Human)
Gene Name
inositol hexakisphosphate kinase 2
Gene Symbol
Synonyms
IHPK2; PIUS
Chromosome
3
Map Location
3p21.31
EC Number
2.7.4.21
Summary
This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| inositol hexakisphosphate kinase 2 isoform a | |
|---|---|
| Refseq ID | NP_001005909 |
| Protein GI | 55769520 |
| UniProt ID | Q9UHH9 |
| mRNA ID | NM_001005909 |
| Length | 426 |
| RefSeq Status | REVIEWED |
| MSPAFRAMDVEPRAKGVLLEPFVHQVGGHSCVLRFNETTLCKPLVPREHQFYETLPAEMRKFTPQYKGVVSVRFEEDEDRNLCLIAYPLKGDHGIVDIVDNSDCEPKSKLLRWTTNKKHHVLETEKTPKDWVRQHRKEEKMKSHKLEEEFEWLKKSEVLYYTVEKKGNISSQLKHYNPWSMKCHQQQLQRMKENAKHRNQYKFILLENLTSRYEVPCVLDLKMGTRQHGDDASEEKAANQIRKCQQSTSAVIGVRVCGMQVYQAGSGQLMFMNKYHGRKLSVQGFKEALFQFFHNGRYLRRELLGPVLKKLTELKAVLERQESYRFYSSSLLVIYDGKERPEVVLDSDAEDLEDLSEESADESAGAYAYKPIGASSVDVRMIDFAHTTCRLYGEDTVVHEGQDAGYIFGLQSLIDIVTEISEESGE | |
| inositol hexakisphosphate kinase 2 isoform a | |
|---|---|
| Refseq ID | NP_057375 |
| Protein GI | 56237025 |
| UniProt ID | Q9UHH9 |
| mRNA ID | NM_016291 |
| Length | 426 |
| RefSeq Status | REVIEWED |
| Protein sequence is identical to GI:55769520 (mRNA isoform) | |
| inositol hexakisphosphate kinase 2 isoform b | |
|---|---|
| Refseq ID | NP_001005910 |
| Protein GI | 55769522 |
| UniProt ID | Q9UHH9 |
| mRNA ID | NM_001005910 |
| Length | 97 |
| RefSeq Status | REVIEWED |
| MSPAFRAMDVEPRAKGVLLEPFVHQVGGHSCVLRFNETTLCKPLVPREHQFYETLPAEMRKFTPQYKGQSQRPLVSWPSLPHFFPWSFPLWPQGSVA | |
| inositol hexakisphosphate kinase 2 isoform b | |
|---|---|
| Refseq ID | NP_001005911 |
| Protein GI | 55769524 |
| UniProt ID | Q9UHH9 |
| mRNA ID | NM_001005911 |
| Length | 97 |
| RefSeq Status | REVIEWED |
| Protein sequence is identical to GI:55769522 (mRNA isoform) | |
| inositol hexakisphosphate kinase 2 isoform c | |
|---|---|
| Refseq ID | NP_001139650 |
| Protein GI | 226051954 |
| UniProt ID | Q9UHH9 |
| mRNA ID | NM_001146178 |
| Length | 87 |
| RefSeq Status | REVIEWED |
| MSPAFRAMDVEPRAKGVLLEPFVHQVGGHSCVLRFNETTLCKPLVPREHQFYETLPAEMRKFTPQYKGDISSHQHGGVFVGEWGSLL | |
| inositol hexakisphosphate kinase 2 isoform c | |
|---|---|
| Refseq ID | NP_001139651 |
| Protein GI | 226051970 |
| UniProt ID | Q9UHH9 |
| mRNA ID | NM_001146179 |
| Length | 87 |
| RefSeq Status | REVIEWED |
| Protein sequence is identical to GI:226051954 (mRNA isoform) | |
| inositol hexakisphosphate kinase 2 isoform d | |
|---|---|
| Refseq ID | NP_001177245 |
| Protein GI | 298286521 |
| UniProt ID | Q9UHH9 |
| mRNA ID | NM_001190316 |
| Length | 185 |
| RefSeq Status | REVIEWED |
| MSLNLPEASLLSRASWPEQAKEPRREGHTDKQQTEDVLAAGLRCLPHLPAICARRMSPAFRAMDVEPRAKGVLLEPFVHQVGGHSCVLRFNETTLCKPLVPREHQFYETLPAEMRKFTPQYKGKSQLLEGLPHWRGDVRDRGHGRPWQPSLEPSLPPTLCFPSLSSFSSSWPSAQHLTPSVFNPW | |
| inositol hexakisphosphate kinase 2 isoform e | |
|---|---|
| Refseq ID | NP_001177246 |
| Protein GI | 298286523 |
| UniProt ID | Q9UHH9 |
| mRNA ID | NM_001190317 |
| Length | 188 |
| RefSeq Status | REVIEWED |
| MNLCQSPFQEGCQSLLASWPEQAKEPRREGHTDKQQTEDVLAAGLRCLPHLPAICARRMSPAFRAMDVEPRAKGVLLEPFVHQVGGHSCVLRFNETTLCKPLVPREHQFYETLPAEMRKFTPQYKGKSQLLEGLPHWRGDVRDRGHGRPWQPSLEPSLPPTLCFPSLSSFSSSWPSAQHLTPSVFNPW | |
Gene Information
Entrez Gene ID
Gene Name
inositol hexakisphosphate kinase 2
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0045111 | IDA:HPA | C | intermediate filament cytoskeleton |
| GO:0005654 | TAS:Reactome | C | nucleoplasm |
| GO:0005634 | IDA:UniProtKB | C | nucleus |
| GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
| GO:0052723 | IEA:UniProtKB-EC | F | inositol hexakisphosphate 1-kinase activity |
| GO:0052724 | IEA:UniProtKB-EC | F | inositol hexakisphosphate 3-kinase activity |
| GO:0000832 | IEA:UniProtKB-EC | F | inositol hexakisphosphate 5-kinase activity |
| GO:0008440 | IEA:InterPro | F | inositol-1,4,5-trisphosphate 3-kinase activity |
| GO:0019221 | TAS:Reactome | P | cytokine-mediated signaling pathway |
| GO:0043647 | TAS:Reactome | P | inositol phosphate metabolic process |
| GO:0030308 | IMP:UniProtKB | P | negative regulation of cell growth |
| GO:0006817 | IEA:Ensembl | P | phosphate ion transport |
| GO:0046854 | IDA:UniProtKB | P | phosphatidylinositol phosphorylation |
| GO:0043065 | IMP:UniProtKB | P | positive regulation of apoptotic process |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
| GO:0060337 | TAS:Reactome | P | type I interferon signaling pathway |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY-6369 | inositol pyrophosphates biosynthesis |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_75790 | Cytokine Signaling in Immune system |
| REACT_150154 | Inositol phosphate metabolism |
| REACT_150275 | Synthesis of IPs in the nucleus |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR005522 | Inositol polyphosphate kinase |
UniProt Annotations
Entry Information
Gene Name
inositol hexakisphosphate kinase 2
Protein Entry
IP6K2_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q9UHH9-1; Sequence=Displayed; Name=2; IsoId=Q9UHH9-2; Sequence=VSP_010925, VSP_010928; Name=3; IsoId=Q9UHH9-3; Sequence=VSP_010926, VSP_010927; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=4; IsoId=Q9UHH9-4; Sequence=VSP_042698, VSP_042699, VSP_042700; Name=5; IsoId=Q9UHH9-5; Sequence=VSP_042845, VSP_042699, VSP_042700; Name=6; IsoId=Q9UHH9-6; Sequence=VSP_045416, VSP_045417; Note=No experimental confirmation available.; |
| Catalytic Activity | ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6- pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate. |
| Catalytic Activity | ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate. |
| Function | Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. |
| Similarity | Belongs to the inositol phosphokinase (IPK) family. |
| Subcellular Location | Nucleus . |
Identical and Related Proteins
Unique RefSeq proteins for LMP001434 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 55769520 | RefSeq | NP_001005909 | 426 | inositol hexakisphosphate kinase 2 isoform a |
| 55769522 | RefSeq | NP_001005910 | 97 | inositol hexakisphosphate kinase 2 isoform b |
| 226051954 | RefSeq | NP_001139650 | 87 | inositol hexakisphosphate kinase 2 isoform c |
| 298286521 | RefSeq | NP_001177245 | 185 | inositol hexakisphosphate kinase 2 isoform d |
| 298286523 | RefSeq | NP_001177246 | 188 | inositol hexakisphosphate kinase 2 isoform e |
Identical Sequences to LMP001434 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:298286521 | DBBJ | BAF83215.1 | 185 | unnamed protein product [Homo sapiens] |
| GI:298286523 | DBBJ | BAG65478.1 | 188 | unnamed protein product [Homo sapiens] |
| GI:55769522 | GenBank | AHD72902.1 | 97 | Sequence 9970 from patent US 8586006 |
| GI:55769522 | GenBank | AIC63421.1 | 97 | IP6K2, partial [synthetic construct] |
| GI:226051954 | RefSeq | NP_001139651.1 | 87 | inositol hexakisphosphate kinase 2 isoform c [Homo sapiens] |
| GI:226051954 | RefSeq | XP_004034147.1 | 87 | PREDICTED: inositol hexakisphosphate kinase 2 [Gorilla gorilla gorilla] |
| GI:55769522 | RefSeq | XP_008969950.1 | 97 | PREDICTED: inositol hexakisphosphate kinase 2 isoform X9 [Pan paniscus] |
| GI:55769522 | RefSeq | XP_008969951.1 | 97 | PREDICTED: inositol hexakisphosphate kinase 2 isoform X9 [Pan paniscus] |
| GI:55769520 | RefSeq | XP_009199094.1 | 426 | PREDICTED: inositol hexakisphosphate kinase 2 isoform X1 [Papio anubis] |
| GI:55769520 | RefSeq | XP_009199095.1 | 426 | PREDICTED: inositol hexakisphosphate kinase 2 isoform X1 [Papio anubis] |
| GI:55769520 | RefSeq | XP_009237313.1 | 426 | PREDICTED: inositol hexakisphosphate kinase 2 isoform X2 [Pongo abelii] |
| GI:55769520 | RefSeq | XP_009237314.1 | 426 | PREDICTED: inositol hexakisphosphate kinase 2 isoform X2 [Pongo abelii] |
| GI:55769522 | RefSeq | XP_009443692.1 | 97 | PREDICTED: inositol hexakisphosphate kinase 2 isoform X10 [Pan troglodytes] |
| GI:55769522 | RefSeq | XP_009443693.1 | 97 | PREDICTED: inositol hexakisphosphate kinase 2 isoform X10 [Pan troglodytes] |
| GI:55769520 | RefSeq | XP_010368530.1 | 426 | PREDICTED: inositol hexakisphosphate kinase 2 isoform X1 [Rhinopithecus roxellana] |
| GI:55769520 | RefSeq | XP_010368539.1 | 426 | PREDICTED: inositol hexakisphosphate kinase 2 isoform X1 [Rhinopithecus roxellana] |
Related Sequences to LMP001434 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:298286521 | DBBJ | BAF84190.1 | 184 | unnamed protein product [Homo sapiens] |
| GI:55769520 | EMBL | CAI93564.1 | 481 | unnamed protein product [Homo sapiens] |
| GI:55769520 | GenBank | ABH92444.1 | 481 | Sequence 415 from patent US 7060479 |
| GI:55769520 | GenBank | EAW64920.1 | 481 | inositol hexaphosphate kinase 2, isoform CRA_a [Homo sapiens] |
| GI:298286521 | GenBank | JAA05664.1 | 189 | inositol hexakisphosphate kinase 2 [Pan troglodytes] |
| GI:298286523 | GenBank | JAA05664.1 | 189 | inositol hexakisphosphate kinase 2 [Pan troglodytes] |
| GI:298286523 | GenBank | JAA20772.1 | 189 | inositol hexakisphosphate kinase 2 [Pan troglodytes] |
| GI:298286521 | GenBank | JAA20772.1 | 189 | inositol hexakisphosphate kinase 2 [Pan troglodytes] |
| GI:298286521 | GenBank | JAA28409.1 | 185 | inositol hexakisphosphate kinase 2 [Pan troglodytes] |
| GI:55769520 | GenBank | JAA28410.1 | 481 | inositol hexakisphosphate kinase 2 [Pan troglodytes] |
| GI:298286521 | GenBank | JAA28411.1 | 189 | inositol hexakisphosphate kinase 2 [Pan troglodytes] |
| GI:298286523 | GenBank | JAA28411.1 | 189 | inositol hexakisphosphate kinase 2 [Pan troglodytes] |
| GI:298286521 | GenBank | JAA33803.1 | 185 | inositol hexakisphosphate kinase 2 [Pan troglodytes] |
| GI:55769520 | GenBank | JAA33804.1 | 481 | inositol hexakisphosphate kinase 2 [Pan troglodytes] |
| GI:298286523 | GenBank | JAA33805.1 | 188 | inositol hexakisphosphate kinase 2 [Pan troglodytes] |
| GI:226051954 | RefSeq | XP_004625126.1 | 87 | PREDICTED: inositol hexakisphosphate kinase 2 isoform X3 [Octodon degus] |
| GI:226051954 | RefSeq | XP_004881650.1 | 93 | PREDICTED: inositol hexakisphosphate kinase 2 isoform X4 [Heterocephalus glaber] |
| GI:226051954 | RefSeq | XP_004834033.1 | 93 | PREDICTED: inositol hexakisphosphate kinase 2 isoform X4 [Heterocephalus glaber] |
| GI:226051954 | RefSeq | XP_005006684.1 | 88 | PREDICTED: inositol hexakisphosphate kinase 2 isoform X5 [Cavia porcellus] |
| GI:226051954 | RefSeq | XP_005669585.1 | 94 | PREDICTED: inositol hexakisphosphate kinase 2 isoform X2 [Sus scrofa] |
| GI:55769520 | RefSeq | XP_006713264.1 | 481 | PREDICTED: inositol hexakisphosphate kinase 2 isoform X3 [Homo sapiens] |
| GI:226051954 | RefSeq | XP_007982344.1 | 87 | PREDICTED: inositol hexakisphosphate kinase 2 isoform X4 [Chlorocebus sabaeus] |
| GI:55769522 | RefSeq | XP_008969947.1 | 156 | PREDICTED: inositol hexakisphosphate kinase 2 isoform X6 [Pan paniscus] |
| GI:55769522 | RefSeq | XP_008969948.1 | 155 | PREDICTED: inositol hexakisphosphate kinase 2 isoform X7 [Pan paniscus] |
| GI:55769522 | RefSeq | XP_008969949.1 | 151 | PREDICTED: inositol hexakisphosphate kinase 2 isoform X8 [Pan paniscus] |
| GI:298286523 | RefSeq | XP_009443682.1 | 196 | PREDICTED: inositol hexakisphosphate kinase 3 isoform X2 [Pan troglodytes] |
| GI:298286523 | RefSeq | XP_009443683.1 | 195 | PREDICTED: inositol hexakisphosphate kinase 3 isoform X3 [Pan troglodytes] |
| GI:55769522 | RefSeq | XP_009443684.1 | 156 | PREDICTED: uncharacterized protein LOC460352 isoform X4 [Pan troglodytes] |
| GI:55769522 | RefSeq | XP_009443685.1 | 155 | PREDICTED: uncharacterized protein LOC460352 isoform X5 [Pan troglodytes] |
| GI:55769522 | RefSeq | XP_009443686.1 | 151 | PREDICTED: uncharacterized protein LOC460352 isoform X6 [Pan troglodytes] |