Gene/Proteome Database (LMPD)

LMPD ID
LMP001438
Gene ID
27329
Species
Homo sapiens (Human)
Gene Name
angiopoietin-like 3
Gene Symbol
ANGPTL3
Synonyms
ANG-5; ANGPT5; ANL3; FHBL2
Alternate Names
angiopoietin-related protein 3; angiopoietin 5
Chromosome
1
Map Location
1p31.3
Summary
This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metablism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2. [provided by RefSeq, Feb 2013]
Orthologs
View orthologs and multiple alignments for ANGPTL3

Proteins

angiopoietin-related protein 3 preproprotein
Refseq ID NP_055310
Protein GI 7656888
UniProt ID Q9Y5C1
mRNA ID NM_014495
Length 460
RefSeq Status REVIEWED
MFTIKLLLFIVPLVISSRIDQDNSSFDSLSPEPKSRFAMLDDVKILANGLLQLGHGLKDFVHKTKGQINDIFQKLNIFDQSFYDLSLQTSEIKEEEKELRRTTYKLQVKNEEVKNMSLELNSKLESLLEEKILLQQKVKYLEEQLTNLIQNQPETPEHPEVTSLKTFVEKQDNSIKDLLQTVEDQYKQLNQQHSQIKEIENQLRRTSIQEPTEISLSSKPRAPRTTPFLQLNEIRNVKHDGIPAECTTIYNRGEHTSGMYAIRPSNSQVFHVYCDVISGSPWTLIQHRIDGSQNFNETWENYKYGFGRLDGEFWLGLEKIYSIVKQSNYVLRIELEDWKDNKHYIEYSFYLGNHETNYTLHLVAITGNVPNAIPENKDLVFSTWDHKAKGHFNCPEGYSGGWWWHDECGENNLNGKYNKPRAKSKPERRRGLSWKSQNGRLYSIKSTKMLIHPTDSESFE
sig_peptide: 1..16 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1847 peptide sequence: MFTIKLLLFIVPLVIS mat_peptide: 17..224 product: N-terminal coiled-coil domain calculated_mol_wt: 24281 peptide sequence: SRIDQDNSSFDSLSPEPKSRFAMLDDVKILANGLLQLGHGLKDFVHKTKGQINDIFQKLNIFDQSFYDLSLQTSEIKEEEKELRRTTYKLQVKNEEVKNMSLELNSKLESLLEEKILLQQKVKYLEEQLTNLIQNQPETPEHPEVTSLKTFVEKQDNSIKDLLQTVEDQYKQLNQQHSQIKEIENQLRRTSIQEPTEISLSSKPRAPR mat_peptide: 225..460 product: C-terminal fibrinogen domain note: The cleavage site was determined in PMID: 12909640. calculated_mol_wt: 27545 peptide sequence: TTPFLQLNEIRNVKHDGIPAECTTIYNRGEHTSGMYAIRPSNSQVFHVYCDVISGSPWTLIQHRIDGSQNFNETWENYKYGFGRLDGEFWLGLEKIYSIVKQSNYVLRIELEDWKDNKHYIEYSFYLGNHETNYTLHLVAITGNVPNAIPENKDLVFSTWDHKAKGHFNCPEGYSGGWWWHDECGENNLNGKYNKPRAKSKPERRRGLSWKSQNGRLYSIKSTKMLIHPTDSESFE

Gene Information

Entrez Gene ID
27329
Gene Name
angiopoietin-like 3
Gene Symbol
ANGPTL3
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009986 IDA:BHF-UCL C cell surface
GO:0005615 IDA:BHF-UCL C extracellular space
GO:0004857 ISS:UniProtKB F enzyme inhibitor activity
GO:0008083 IDA:BHF-UCL F growth factor activity
GO:0005178 IPI:UniProtKB F integrin binding
GO:0004859 IDA:BHF-UCL F phospholipase inhibitor activity
GO:0055090 IDA:BHF-UCL P acylglycerol homeostasis
GO:0048844 ISS:BHF-UCL P artery morphogenesis
GO:0007160 IPI:UniProtKB P cell-matrix adhesion
GO:0042632 IDA:BHF-UCL P cholesterol homeostasis
GO:0008203 IDA:BHF-UCL P cholesterol metabolic process
GO:0006631 IDA:BHF-UCL P fatty acid metabolic process
GO:0006071 IDA:BHF-UCL P glycerol metabolic process
GO:0007229 NAS:UniProtKB P integrin-mediated signaling pathway
GO:0055088 IDA:BHF-UCL P lipid homeostasis
GO:0019915 IDA:BHF-UCL P lipid storage
GO:0051005 IDA:BHF-UCL P negative regulation of lipoprotein lipase activity
GO:0010519 IDA:BHF-UCL P negative regulation of phospholipase activity
GO:0009395 IDA:BHF-UCL P phospholipid catabolic process
GO:0055091 IDA:BHF-UCL P phospholipid homeostasis
GO:0006644 IDA:BHF-UCL P phospholipid metabolic process
GO:0045766 IDA:UniProtKB P positive regulation of angiogenesis
GO:0030335 IDA:UniProtKB P positive regulation of cell migration
GO:0050996 IDA:BHF-UCL P positive regulation of lipid catabolic process
GO:0009725 IEA:Ensembl P response to hormone
GO:0007165 IDA:BHF-UCL P signal transduction
GO:0070328 ISS:BHF-UCL P triglyceride homeostasis

Domain Information

InterPro Annotations

Accession Description
IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2

UniProt Annotations

Entry Information

Gene Name
angiopoietin-like 3
Protein Entry
ANGL3_HUMAN
UniProt ID
Q9Y5C1
Species
Human

Comments

Comment Type Description
Disease Hypobetalipoproteinemia, familial, 2 (FHBL2) [MIM
Sequence Caution Sequence=AAH07059.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence= ;
Similarity Contains 1 fibrinogen C-terminal domain.
Subcellular Location Secreted .
Subunit Interacts with C19orf80/ANGPTL8.
Tissue Specificity Expressed principally in liver. Weakly expressed in kidney.

Identical and Related Proteins

Unique RefSeq proteins for LMP001438 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
7656888 RefSeq NP_055310 460 angiopoietin-related protein 3 preproprotein

Identical Sequences to LMP001438 proteins

Reference Database Accession Length Protein Name
GI:7656888 GenBank AEF63137.1 460 Sequence 3 from patent US 7935796
GI:7656888 GenBank AGD89216.1 460 Sequence 485 from patent US 8354103
GI:7656888 GenBank AGU30808.1 460 Sequence 4 from patent US 8506955
GI:7656888 GenBank AGX47922.1 460 Sequence 2 from patent US 8541376
GI:7656888 GenBank AHD74865.1 460 Sequence 15569 from patent US 8586006
GI:7656888 GenBank AIC51220.1 460 ANGPTL3, partial [synthetic construct]

Related Sequences to LMP001438 proteins

Reference Database Accession Length Protein Name
GI:7656888 DBBJ BAF82115.1 460 unnamed protein product [Homo sapiens]
GI:7656888 DBBJ BAG37708.1 460 unnamed protein product [Homo sapiens]
GI:7656888 EMBL CAC32431.1 460 unnamed protein product [Homo sapiens]
GI:7656888 GenBank ACM82442.1 475 Sequence 7940 from patent US 6812339
GI:7656888 GenBank AEF63138.1 467 Sequence 4 from patent US 7935796
GI:7656888 RefSeq XP_003809202.1 460 PREDICTED: angiopoietin-related protein 3 [Pan paniscus]