Gene/Proteome Database (LMPD)

LMPD ID
LMP001449
Gene ID
5734
Species
Homo sapiens (Human)
Gene Name
prostaglandin E receptor 4 (subtype EP4)
Gene Symbol
PTGER4
Synonyms
EP4; EP4R
Chromosome
5
Map Location
5p13.1
Summary
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for PTGER4

Proteins

prostaglandin E2 receptor EP4 subtype
Refseq ID NP_000949
Protein GI 4506259
UniProt ID P35408
mRNA ID NM_000958
Length 488
RefSeq Status REVIEWED
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI

Gene Information

Entrez Gene ID
5734
Gene Name
prostaglandin E receptor 4 (subtype EP4)
Gene Symbol
PTGER4
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0004957 IEA:InterPro F prostaglandin E receptor activity
GO:0070371 IEA:Ensembl P ERK1 and ERK2 cascade
GO:0007254 IEA:Ensembl P JNK cascade
GO:0042093 IEA:Ensembl P T-helper cell differentiation
GO:0060348 IEA:Ensembl P bone development
GO:0071260 IEA:Ensembl P cellular response to mechanical stimulus
GO:0050710 IEA:Ensembl P negative regulation of cytokine secretion
GO:0050728 IEA:Ensembl P negative regulation of inflammatory response
GO:0050715 IEA:Ensembl P positive regulation of cytokine secretion
GO:0050729 IEA:Ensembl P positive regulation of inflammatory response
GO:0030278 IEA:Ensembl P regulation of ossification
GO:0051492 IEA:Ensembl P regulation of stress fiber assembly
GO:0032496 IEA:Ensembl P response to lipopolysaccharide

KEGG Pathway Links

KEGG Pathway ID Description
hsa04750 Inflammatory mediator regulation of TRP channels

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_19327 G alpha (s) signalling events

Domain Information

InterPro Annotations

Accession Description
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
IPR001244 Prostaglandin DP receptor
IPR001758 Prostanoid EP4 receptor
IPR008365 Prostanoid receptor

UniProt Annotations

Entry Information

Gene Name
prostaglandin E receptor 4 (subtype EP4)
Protein Entry
PE2R4_HUMAN
UniProt ID
P35408
Species
Human

Identical and Related Proteins

Unique RefSeq proteins for LMP001449 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
4506259 RefSeq NP_000949 488 prostaglandin E2 receptor EP4 subtype

Identical Sequences to LMP001449 proteins

Reference Database Accession Length Protein Name
GI:4506259 EMBL CCF76996.1 488 unnamed protein product [Homo sapiens]
GI:4506259 GenBank EAW55997.1 488 prostaglandin E receptor 4 (subtype EP4), isoform CRA_b [Homo sapiens]
GI:4506259 GenBank ADR83198.1 488 prostaglandin E receptor 4 (subtype EP4), partial [synthetic construct]
GI:4506259 GenBank ADS18346.1 488 Sequence 176 from patent US 7763425
GI:4506259 GenBank AEJ66643.1 488 Sequence 68 from patent US 7968293
GI:4506259 GenBank AIC49525.1 488 PTGER4, partial [synthetic construct]

Related Sequences to LMP001449 proteins

Reference Database Accession Length Protein Name
GI:4506259 GenBank AAL15039.1 490 prostaglandin E2 subtype EP4 receptor [Pan troglodytes]
GI:4506259 GenBank AAW10848.1 488 Sequence 561 from patent US 6806054
GI:4506259 GenBank ABJ30560.1 488 Sequence 561 from patent US 7097969
GI:4506259 GenBank ACE50292.1 488 Sequence 561 from patent US 7381522
GI:4506259 RefSeq XP_003811016.1 490 PREDICTED: prostaglandin E2 receptor EP4 subtype [Pan paniscus]
GI:4506259 RefSeq XP_009447464.1 490 PREDICTED: prostaglandin E2 receptor EP4 subtype isoform X1 [Pan troglodytes]