Gene/Proteome Database (LMPD)

LMPD ID
LMP001450
Gene ID
231086
Species
Mus musculus (Mouse)
Gene Name
hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit
Gene Symbol
Hadhb
Synonyms
4930479F15Rik; Mtpb; TP-beta
Alternate Names
trifunctional enzyme subunit beta, mitochondrial; hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta aubunit
Chromosome
5
Map Location
5 B1|5
EC Number
2.3.1.16

Proteins

trifunctional enzyme subunit beta, mitochondrial precursor
Refseq ID NP_663533
Protein GI 21704100
UniProt ID Q99JY0
mRNA ID NM_145558
Length 475
RefSeq Status VALIDATED
MTTILTSTFRNLSTTSKWALRSSIRPLSCSSQLHSAPAVQTKSKKTLAKPNMKNIVVVEGVRIPFLLSGTSYKDLMPHDLARAALSGLLHRTNIPKDVVDYIIFGTVIQEVKTSNVAREAALGAGFSDKTPAHTVTMACISSNQAMTTAVGLIASGQCDVVVAGGVELMSDVPIRHSRNMRKMMLDLNKAKTLGQRLSLLSKFRLNFLSPELPAVAEFSTNETMGHSADRLAAAFAVSRMEQDEYALRSHSLAKKAQDEGHLSDIVPFKVPGKDTVTKDNGIRPSSLEQMAKLKPAFIKPYGTVTAANSSFLTDGASAMLIMSEDRALAMGYKPKAYLRDFIYVSQDPKDQLLLGPTYATPKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAQNYMGRKTKVGSPPLEKFNIWGGSLSLGHPFGATGCRLVMAAANRLRKDGGQYALVAACAAGGQGHAMIVEAYPK
transit_peptide: 1..34 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q99JY0.1) calculated_mol_wt: 3825 peptide sequence: MTTILTSTFRNLSTTSKWALRSSIRPLSCSSQLH mat_peptide: 35..475 product: Trifunctional enzyme subunit beta, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q99JY0.1) calculated_mol_wt: 47579 peptide sequence: SAPAVQTKSKKTLAKPNMKNIVVVEGVRIPFLLSGTSYKDLMPHDLARAALSGLLHRTNIPKDVVDYIIFGTVIQEVKTSNVAREAALGAGFSDKTPAHTVTMACISSNQAMTTAVGLIASGQCDVVVAGGVELMSDVPIRHSRNMRKMMLDLNKAKTLGQRLSLLSKFRLNFLSPELPAVAEFSTNETMGHSADRLAAAFAVSRMEQDEYALRSHSLAKKAQDEGHLSDIVPFKVPGKDTVTKDNGIRPSSLEQMAKLKPAFIKPYGTVTAANSSFLTDGASAMLIMSEDRALAMGYKPKAYLRDFIYVSQDPKDQLLLGPTYATPKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAQNYMGRKTKVGSPPLEKFNIWGGSLSLGHPFGATGCRLVMAAANRLRKDGGQYALVAACAAGGQGHAMIVEAYPK transit_peptide: 1..34 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q99JY0.1) calculated_mol_wt: 3825 peptide sequence: MTTILTSTFRNLSTTSKWALRSSIRPLSCSSQLH mat_peptide: 35..475 product: Trifunctional enzyme subunit beta, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q99JY0.1) calculated_mol_wt: 47579 peptide sequence: SAPAVQTKSKKTLAKPNMKNIVVVEGVRIPFLLSGTSYKDLMPHDLARAALSGLLHRTNIPKDVVDYIIFGTVIQEVKTSNVAREAALGAGFSDKTPAHTVTMACISSNQAMTTAVGLIASGQCDVVVAGGVELMSDVPIRHSRNMRKMMLDLNKAKTLGQRLSLLSKFRLNFLSPELPAVAEFSTNETMGHSADRLAAAFAVSRMEQDEYALRSHSLAKKAQDEGHLSDIVPFKVPGKDTVTKDNGIRPSSLEQMAKLKPAFIKPYGTVTAANSSFLTDGASAMLIMSEDRALAMGYKPKAYLRDFIYVSQDPKDQLLLGPTYATPKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAQNYMGRKTKVGSPPLEKFNIWGGSLSLGHPFGATGCRLVMAAANRLRKDGGQYALVAACAAGGQGHAMIVEAYPK transit_peptide: 1..34 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q99JY0.1) calculated_mol_wt: 3825 peptide sequence: MTTILTSTFRNLSTTSKWALRSSIRPLSCSSQLH mat_peptide: 35..475 product: Trifunctional enzyme subunit beta, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q99JY0.1) calculated_mol_wt: 47579 peptide sequence: SAPAVQTKSKKTLAKPNMKNIVVVEGVRIPFLLSGTSYKDLMPHDLARAALSGLLHRTNIPKDVVDYIIFGTVIQEVKTSNVAREAALGAGFSDKTPAHTVTMACISSNQAMTTAVGLIASGQCDVVVAGGVELMSDVPIRHSRNMRKMMLDLNKAKTLGQRLSLLSKFRLNFLSPELPAVAEFSTNETMGHSADRLAAAFAVSRMEQDEYALRSHSLAKKAQDEGHLSDIVPFKVPGKDTVTKDNGIRPSSLEQMAKLKPAFIKPYGTVTAANSSFLTDGASAMLIMSEDRALAMGYKPKAYLRDFIYVSQDPKDQLLLGPTYATPKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAQNYMGRKTKVGSPPLEKFNIWGGSLSLGHPFGATGCRLVMAAANRLRKDGGQYALVAACAAGGQGHAMIVEAYPK
trifunctional enzyme subunit beta, mitochondrial precursor
Refseq ID NP_001276728
Protein GI 577019532
UniProt ID Q99JY0
mRNA ID NM_001289799
Length 475
RefSeq Status VALIDATED
Protein sequence is identical to GI:21704100 (mRNA isoform)
trifunctional enzyme subunit beta, mitochondrial precursor
Refseq ID NP_001276727
Protein GI 577019542
UniProt ID Q99JY0
mRNA ID NM_001289798
Length 475
RefSeq Status VALIDATED
Protein sequence is identical to GI:21704100 (mRNA isoform)

Gene Information

Entrez Gene ID
231086
Gene Name
hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit
Gene Symbol
Hadhb
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 ISS:UniProtKB C endoplasmic reticulum
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0016507 IC:MGI C mitochondrial fatty acid beta-oxidation multienzyme complex
GO:0005743 IDA:MGI C mitochondrial inner membrane
GO:0042645 IEA:Ensembl C mitochondrial nucleoid
GO:0005741 ISS:UniProtKB C mitochondrial outer membrane
GO:0005739 IDA:MGI C mitochondrion
GO:0003988 IDA:MGI F acetyl-CoA C-acyltransferase activity
GO:0004300 IEA:Ensembl F enoyl-CoA hydratase activity
GO:0000062 IEA:Ensembl F fatty-acyl-CoA binding
GO:0016509 IMP:MGI F long-chain-3-hydroxyacyl-CoA dehydrogenase activity
GO:0016508 IEA:Ensembl F long-chain-enoyl-CoA hydratase activity
GO:0051287 IEA:Ensembl F NAD binding
GO:0044822 IEA:Ensembl F poly(A) RNA binding
GO:0006635 TAS:MGI P fatty acid beta-oxidation

KEGG Pathway Links

KEGG Pathway ID Description
mmu00071 Fatty acid degradation

Domain Information

InterPro Annotations

Accession Description
IPR002155 Thiolase
IPR020610 Thiolase, active site
IPR020615 Thiolase, acyl-enzyme intermediate active site
IPR020613 Thiolase, conserved site
IPR020617 Thiolase, C-terminal
IPR016039 Thiolase-like
IPR016038 Thiolase-like, subgroup
IPR020616 Thiolase, N-terminal

UniProt Annotations

Entry Information

Gene Name
hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit
Protein Entry
ECHB_MOUSE
UniProt ID
Q99JY0
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.
Pathway Lipid metabolism; fatty acid beta-oxidation.
Ptm Acetylation of Lys-202 is observed in liver mitochondria from fasted mice but not from fed mice. {ECO:0000269|PubMed:23576753}.
Similarity Belongs to the thiolase family. {ECO:0000305}.
Subcellular Location Mitochondrion {ECO:0000250}. Mitochondrion inner membrane {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
Subunit Octamer of 4 alpha (HADHA) and 4 beta (HADHB) subunits. Interacts with RSAD2/viperin. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001450 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
21704100 RefSeq NP_663533 475 trifunctional enzyme subunit beta, mitochondrial precursor

Identical Sequences to LMP001450 proteins

Reference Database Accession Length Protein Name
GI:21704100 DBBJ BAE41269.1 475 unnamed protein product [Mus musculus]
GI:21704100 DBBJ BAE29936.1 475 unnamed protein product [Mus musculus]
GI:21704100 GenBank EDL37264.1 475 mCG11629, isoform CRA_a [Mus musculus]
GI:21704100 GenBank EDL37266.1 475 mCG11629, isoform CRA_a [Mus musculus]
GI:21704100 RefSeq NP_001276728.1 475 trifunctional enzyme subunit beta, mitochondrial precursor [Mus musculus]
GI:21704100 RefSeq NP_001276727.1 475 trifunctional enzyme subunit beta, mitochondrial precursor [Mus musculus]

Related Sequences to LMP001450 proteins

Reference Database Accession Length Protein Name
GI:21704100 DBBJ BAC36493.1 475 unnamed protein product [Mus musculus]
GI:21704100 DBBJ BAC38790.1 475 unnamed protein product [Mus musculus]
GI:21704100 DBBJ BAC39015.1 475 unnamed protein product [Mus musculus]
GI:21704100 GenBank EDL37268.1 509 mCG11629, isoform CRA_d, partial [Mus musculus]
GI:21704100 RefSeq XP_006535768.1 531 PREDICTED: trifunctional enzyme subunit beta, mitochondrial isoform X1 [Mus musculus]
GI:21704100 RefSeq XP_006535769.1 530 PREDICTED: trifunctional enzyme subunit beta, mitochondrial isoform X2 [Mus musculus]