Gene/Proteome Database (LMPD)
LMPD ID
LMP001473
Gene ID
Species
Homo sapiens (Human)
Gene Name
phospholipase A2, group VI (cytosolic, calcium-independent)
Gene Symbol
Synonyms
CaI-PLA2; GVI; INAD1; IPLA2-VIA; NBIA2; NBIA2A; NBIA2B; PARK14; PLA2; PNPLA9; iPLA2; iPLA2beta
Chromosome
22
Map Location
22q13.1
EC Number
3.1.1.4
Summary
The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date. [provided by RefSeq, Dec 2010]
Orthologs
Proteins
| 85/88 kDa calcium-independent phospholipase A2 isoform a | |
|---|---|
| Refseq ID | NP_003551 |
| Protein GI | 52486194 |
| UniProt ID | O60733 |
| mRNA ID | NM_003560 |
| Length | 806 |
| RefSeq Status | REVIEWED |
| MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAEYCFPPIHGVPAEQGSAAPHHPFSLERAQPPPISLNNLELQDLMHISRARKPAFILGSMRDEKRTHDHLLCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGMYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVMLTGTLSDRQPAELHLFRNYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEYNQDLIRKGQANKVKKLSIVVSLGTGRSPQVPVTCVDVFRPSNPWELAKTVFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVSDTVLVNALWETEVYIYEHREEFQKLIQLLLSP | |
| 85/88 kDa calcium-independent phospholipase A2 isoform b | |
|---|---|
| Refseq ID | NP_001186491 |
| Protein GI | 313760592 |
| UniProt ID | O60733 |
| mRNA ID | NM_001199562 |
| Length | 752 |
| RefSeq Status | REVIEWED |
| MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRQLQDLMHISRARKPAFILGSMRDEKRTHDHLLCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGMYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVMLTGTLSDRQPAELHLFRNYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEYNQDLIRKGQANKVKKLSIVVSLGTGRSPQVPVTCVDVFRPSNPWELAKTVFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVSDTVLVNALWETEVYIYEHREEFQKLIQLLLSP | |
| 85/88 kDa calcium-independent phospholipase A2 isoform b | |
|---|---|
| Refseq ID | NP_001004426 |
| Protein GI | 52486251 |
| UniProt ID | O60733 |
| mRNA ID | NM_001004426 |
| Length | 752 |
| RefSeq Status | REVIEWED |
| Protein sequence is identical to GI:313760592 (mRNA isoform) | |
Gene Information
Entrez Gene ID
Gene Name
phospholipase A2, group VI (cytosolic, calcium-independent)
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005829 | TAS:Reactome | C | cytosol |
| GO:0016020 | IEA:UniProtKB-KW | C | membrane |
| GO:0005739 | IEA:Ensembl | C | mitochondrion |
| GO:0047499 | IEA:Ensembl | F | calcium-independent phospholipase A2 activity |
| GO:0004623 | TAS:ProtInc | F | phospholipase A2 activity |
| GO:0038096 | TAS:Reactome | P | Fc-gamma receptor signaling pathway involved in phagocytosis |
| GO:0035965 | TAS:Reactome | P | cardiolipin acyl-chain remodeling |
| GO:0032049 | IMP:UniProtKB | P | cardiolipin biosynthetic process |
| GO:0008219 | IEA:UniProtKB-KW | P | cell death |
| GO:0006935 | IEA:UniProtKB-KW | P | chemotaxis |
| GO:0046474 | TAS:Reactome | P | glycerophospholipid biosynthetic process |
| GO:0045087 | TAS:Reactome | P | innate immune response |
| GO:0016042 | IEA:UniProtKB-KW | P | lipid catabolic process |
| GO:0060135 | IEA:Ensembl | P | maternal process involved in female pregnancy |
| GO:0007613 | IEA:Ensembl | P | memory |
| GO:0051967 | IEA:Ensembl | P | negative regulation of synaptic transmission, glutamatergic |
| GO:0036151 | TAS:Reactome | P | phosphatidylcholine acyl-chain remodeling |
| GO:0036152 | TAS:Reactome | P | phosphatidylethanolamine acyl-chain remodeling |
| GO:0006644 | TAS:Reactome | P | phospholipid metabolic process |
| GO:0090238 | IEA:Ensembl | P | positive regulation of arachidonic acid secretion |
| GO:2000304 | IEA:Ensembl | P | positive regulation of ceramide biosynthetic process |
| GO:0007204 | IEA:Ensembl | P | positive regulation of cytosolic calcium ion concentration |
| GO:0045921 | IEA:Ensembl | P | positive regulation of exocytosis |
| GO:0035774 | IEA:Ensembl | P | positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| GO:0090037 | IEA:Ensembl | P | positive regulation of protein kinase C signaling |
| GO:0001934 | IEA:Ensembl | P | positive regulation of protein phosphorylation |
| GO:0090200 | IEA:Ensembl | P | positive regulation of release of cytochrome c from mitochondria |
| GO:0045909 | IEA:Ensembl | P | positive regulation of vasodilation |
| GO:1901339 | IEA:Ensembl | P | regulation of store-operated calcium channel activity |
| GO:0034976 | IEA:Ensembl | P | response to endoplasmic reticulum stress |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
| GO:0014832 | IEA:Ensembl | P | urinary bladder smooth muscle contraction |
KEGG Pathway Links
Domain Information
UniProt Annotations
Entry Information
Gene Name
phospholipase A2, group VI (cytosolic, calcium-independent)
Protein Entry
PLPL9_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=4; Name=LH-iPLA2; IsoId=O60733-1; Sequence=Displayed; Name=SH-iPLA2; IsoId=O60733-2; Sequence=VSP_000278; Name=Ankyrin-iPLA2-1; IsoId=O60733-3; Sequence=VSP_000281, VSP_000282; Name=Ankyrin-iPLA2-2; IsoId=O60733-4; Sequence=VSP_000277, VSP_000279, VSP_000280; |
| Catalytic Activity | Phosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate. |
| Disease | Neurodegeneration with brain iron accumulation 2A (NBIA2A) [MIM |
| Disease | Neurodegeneration with brain iron accumulation 2B (NBIA2B) [MIM |
| Disease | Parkinson disease 14 (PARK14) [MIM |
| Enzyme Regulation | Inhibited by calcium-activated calmodulin. |
| Function | Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F- actin polymerization at the pseudopods. |
| Function | Isoform ankyrin-iPLA2-1 and isoform ankyrin-iPLA2-2, which lack the catalytic domain, are probably involved in the negative regulation of iPLA2 activity. |
| Pharmaceutical | Potential target for therapeutic intervention of Barth syndrome. |
| Similarity | Contains 1 patatin domain. |
| Similarity | Contains 7 ANK repeats. {ECO |
| Subcellular Location | Isoform LH-iPLA2: Membrane; Peripheral membrane protein. Note=Recruited to the membrane-enriched pseudopod upon MCP1/CCL2 stimulation in monocytes. |
| Subcellular Location | Isoform SH-iPLA2: Cytoplasm. |
| Subunit | Forms large oligomeric 270-350 kDa structures. |
| Tissue Specificity | Four different transcripts were found to be expressed in a distinct tissue distribution. |
| Web Resource | Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/pla2g6/"; |
Identical and Related Proteins
Unique RefSeq proteins for LMP001473 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 52486194 | RefSeq | NP_003551 | 806 | 85/88 kDa calcium-independent phospholipase A2 isoform a |
| 313760592 | RefSeq | NP_001186491 | 752 | 85/88 kDa calcium-independent phospholipase A2 isoform b |
Identical Sequences to LMP001473 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:313760592 | GenBank | EAW60219.1 | 752 | phospholipase A2, group VI (cytosolic, calcium-independent), isoform CRA_a [Homo sapiens] |
| GI:313760592 | GenBank | AEU43312.1 | 752 | Sequence 61 from patent US 8052970 |
| GI:313760592 | GenBank | AEU43396.1 | 752 | Sequence 145 from patent US 8052970 |
| GI:313760592 | GenBank | AEU43429.1 | 752 | Sequence 178 from patent US 8052970 |
| GI:313760592 | GenBank | AEU43440.1 | 752 | Sequence 189 from patent US 8052970 |
| GI:52486194 | GenBank | AEU43461.1 | 806 | Sequence 210 from patent US 8052970 |
| GI:52486194 | GenBank | AEU43526.1 | 806 | Sequence 275 from patent US 8052970 |
| GI:313760592 | RefSeq | NP_001004426.1 | 752 | 85/88 kDa calcium-independent phospholipase A2 isoform b [Homo sapiens] |
| GI:52486194 | RefSeq | XP_005261821.1 | 806 | PREDICTED: 85/88 kDa calcium-independent phospholipase A2 isoform X1 [Homo sapiens] |
| GI:52486194 | RefSeq | XP_005261822.1 | 806 | PREDICTED: 85/88 kDa calcium-independent phospholipase A2 isoform X2 [Homo sapiens] |
| GI:52486194 | RefSeq | XP_005261823.1 | 806 | PREDICTED: 85/88 kDa calcium-independent phospholipase A2 isoform X3 [Homo sapiens] |
| GI:52486194 | RefSeq | XP_006724395.1 | 806 | PREDICTED: 85/88 kDa calcium-independent phospholipase A2 isoform X13 [Homo sapiens] |
Related Sequences to LMP001473 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:313760592 | DBBJ | BAF83514.1 | 752 | unnamed protein product [Homo sapiens] |
| GI:52486194 | GenBank | AAC97486.1 | 806 | calcium-independent phospholipase A2 [Homo sapiens] |
| GI:313760592 | GenBank | AAD41722.1 | 752 | Ca2+-independent phospholipase A2 short isoform [Homo sapiens] |
| GI:52486194 | GenBank | AAD41723.1 | 806 | Ca2+-independent phospholipase A2 long isoform [Homo sapiens] |
| GI:52486194 | GenBank | ACM85450.1 | 819 | Sequence 10948 from patent US 6812339 |
| GI:52486194 | GenBank | ADT55019.1 | 806 | Sequence 146 from patent US 7842852 |
| GI:52486194 | GenBank | AEU43370.1 | 806 | Sequence 119 from patent US 8052970 |
| GI:313760592 | GenBank | AEU43393.1 | 752 | Sequence 142 from patent US 8052970 |
| GI:313760592 | GenBank | AEU43527.1 | 752 | Sequence 276 from patent US 8052970 |
| GI:313760592 | GenBank | AFG95859.1 | 752 | Sequence 1 from patent US 8148097 |
| GI:52486194 | PIR | - | 851 | hypothetical protein DKFZp434A102.1 - human (fragment) [Homo sapiens] |
| GI:313760592 | RefSeq | XP_003317277.1 | 752 | PREDICTED: 85/88 kDa calcium-independent phospholipase A2 isoform X4 [Pan troglodytes] |