Gene/Proteome Database (LMPD)

LMPD ID
LMP001477
Gene ID
12355
Species
Mus musculus (Mouse)
Gene Name
nuclear receptor subfamily 1, group I, member 3
Gene Symbol
Nr1i3
Synonyms
AA209988; AI551208; CAR; CAR-beta; Care2; ESTM32; MB67
Alternate Names
nuclear receptor subfamily 1 group I member 3; orphan nuclear receptor MB67; constitutive androstane receptor; constitutively transactivates RAREs
Chromosome
1
Map Location
1 H3|1 79.21 cM

Proteins

nuclear receptor subfamily 1 group I member 3 isoform 1
Refseq ID NP_033933
Protein GI 83921568
UniProt ID O35627
mRNA ID NM_009803
Length 358
RefSeq Status VALIDATED
MTAMLTLETMASEEEYGPRNCVVCGDRATGYHFHALTCEGCKGFFRRTVSKTIGPICPFAGRCEVSKAQRRHCPACRLQKCLNVGMRKDMILSAEALALRRARQAQRRAEKASLQLNQQQKELVQILLGAHTRHVGPMFDQFVQFKPPAYLFMHHRPFQPRGPVLPLLTHFADINTFMVQQIIKFTKDLPLFRSLTMEDQISLLKGAAVEILHISLNTTFCLQTENFFCGPLCYKMEDAVHAGFQYEFLESILHFHKNLKGLHLQEPEYVLMAATALFSPDRPGVTQREEIDQLQEEMALILNNHIMEQQSRLQSRFLYAKLMGLLADLRSINNAYSYELQRLEELSAMTPLLGEICS
nuclear receptor subfamily 1 group I member 3 isoform 2
Refseq ID NP_001229991
Protein GI 340138964
UniProt ID O35627
mRNA ID NM_001243062
Length 286
RefSeq Status VALIDATED
MTAMLTLETMASEEEYGPRNCVVCGDRATGYHFHALTCEGCKGFFRRTVSKTIGPICPFAGRCEVSKAQRRHCPACRLQKCLNVGMRKDMILSAEALALRRARQAQRRAEKASLQLNQQQKELVQILLGAHTRHVGPMFDQFVQFKPPAYLFMHHRPFQPRGPVLPLLTHFADINTFMVQQIIKFTKDLPLFRSLTMEDQISLLKGAAVEILHISLNTTFCLQTENFFCGPLCYKMEDAVHAGFQYEFLESILHFHKNLKGLHLQEPEYVLMAATALFSPGFCMQS
nuclear receptor subfamily 1 group I member 3 isoform 3
Refseq ID NP_001229992
Protein GI 340139037
UniProt ID O35627
mRNA ID NM_001243063
Length 357
RefSeq Status VALIDATED
MTAMLTLETMASEEEYGPRNCVVCGDRATGYHFHALTCEGCKGFFRRTVSKTIGPICPFAGRCEVSKAQRRHCPACRLQKCLNVGMRKDMILSAEALALRRARQAQRRAEKASLQLNQQQKELVQILLGAHTRHVGPMFDQFVQFKPPAYLFMHHRPFQPRGPVLPLLTHFADINTFMVQQIIKFTKDLPLFRSLTMEDQISLLKGAAVEILHISLNTTFCLQTENFFCGPLCYKMEDAVHGFQYEFLESILHFHKNLKGLHLQEPEYVLMAATALFSPDRPGVTQREEIDQLQEEMALILNNHIMEQQSRLQSRFLYAKLMGLLADLRSINNAYSYELQRLEELSAMTPLLGEICS

Gene Information

Entrez Gene ID
12355
Gene Name
nuclear receptor subfamily 1, group I, member 3
Gene Symbol
Nr1i3
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:UniProtKB C cytoplasm
GO:0005856 IEA:UniProtKB-KW C cytoskeleton
GO:0005829 IDA:MGI C cytosol
GO:0005634 IDA:UniProtKB C nucleus
GO:0003677 IDA:MGI F DNA binding
GO:0000977 IEA:Ensembl F RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228 IEA:Ensembl F RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0004887 IEA:InterPro F thyroid hormone receptor activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0045892 IDA:MGI P negative regulation of transcription, DNA-templated
GO:0006355 IDA:MGI P regulation of transcription, DNA-templated

REACTOME Pathway Links

REACTOME Pathway ID Description
5893343 Generic Transcription Pathway
5893658 Nuclear Receptor transcription pathway

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001723 Steroid hormone receptor
IPR001728 Thyroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
nuclear receptor subfamily 1, group I, member 3
Protein Entry
NR1I3_MOUSE
UniProt ID
O35627
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=CAR1; IsoId=O35627-1; Sequence=Displayed; Name=CAR2; IsoId=O35627-2; Sequence=VSP_003671, VSP_003672; Note=Does not seem to act as a transactivator. Lacks the C-terminal portion of the ligand binding/dimerization domain.;
Domain Composed by a short N-terminal domain followed by the DNA binding, hinge, and ligand binding/dimerization domains.
Function Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element (By similarity). {ECO:0000250}.
Ptm Phosphorylated at Thr-48 by PKC, dephosphorylation of Thr-48 is required for nuclear translocation and activation. {ECO:0000250}.
Similarity Belongs to the nuclear hormone receptor family. NR1 subfamily. {ECO:0000305}.
Similarity Contains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}.
Subcellular Location Nucleus. Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Recruited to the cytoplasm by DNAJC7.
Subunit Heterodimer of NR1I3 and RXR. Interacts with PSMC4. Interacts with ECT2. Directly interacts with DNAJC7; this complex may also include HSP90. {ECO:0000269|PubMed:14573755, ECO:0000269|PubMed:15610733, ECO:0000269|PubMed:17904126, ECO:0000269|PubMed:8603043}.
Tissue Specificity Predominantly expressed in liver.

Identical and Related Proteins

Unique RefSeq proteins for LMP001477 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
83921568 RefSeq NP_033933 358 nuclear receptor subfamily 1 group I member 3 isoform 1
340138964 RefSeq NP_001229991 286 nuclear receptor subfamily 1 group I member 3 isoform 2
340139037 RefSeq NP_001229992 357 nuclear receptor subfamily 1 group I member 3 isoform 3

Identical Sequences to LMP001477 proteins

Reference Database Accession Length Protein Name
GI:83921568 DBBJ BAE21697.1 358 unnamed protein product [Mus musculus]
GI:340139037 GenBank AAH89541.1 357 Nuclear receptor subfamily 1, group I, member 3 [Mus musculus]
GI:340138964 GenBank EDL39125.1 286 nuclear receptor subfamily 1, group I, member 3, isoform CRA_a [Mus musculus]
GI:83921568 GenBank EDL39126.1 358 nuclear receptor subfamily 1, group I, member 3, isoform CRA_b [Mus musculus]
GI:83921568 SwissProt O35627.2 358 RecName: Full=Nuclear receptor subfamily 1 group I member 3; AltName: Full=Constitutive androstane receptor; Short=CAR; AltName: Full=Orphan nuclear receptor MB67 [Mus musculus]

Related Sequences to LMP001477 proteins

Reference Database Accession Length Protein Name
GI:340138964 DBBJ BAE21697.1 358 unnamed protein product [Mus musculus]
GI:340139037 DBBJ BAE21697.1 358 unnamed protein product [Mus musculus]
GI:83921568 GenBank AAC53349.1 358 mCAR1 [Mus musculus]
GI:340138964 GenBank AAC53350.1 286 mCAR2 [Mus musculus]
GI:83921568 GenBank ABE18324.1 358 Sequence 12 from patent US 6989242
GI:340139037 GenBank ABE18324.1 358 Sequence 12 from patent US 6989242
GI:83921568 GenBank ABP15312.1 358 Sequence 1 from patent US 7186879
GI:340138964 GenBank ABP15314.1 286 Sequence 27 from patent US 7186879
GI:83921568 GenBank ABP29975.1 358 Sequence 1 from patent US 7193125
GI:340139037 GenBank ABP29975.1 358 Sequence 1 from patent US 7193125
GI:340138964 GenBank ABP29977.1 286 Sequence 27 from patent US 7193125
GI:340138964 GenBank EDL39126.1 358 nuclear receptor subfamily 1, group I, member 3, isoform CRA_b [Mus musculus]
GI:340139037 GenBank EDL39126.1 358 nuclear receptor subfamily 1, group I, member 3, isoform CRA_b [Mus musculus]
GI:83921568 GenBank ACE15471.1 358 Sequence 16 from patent US 7365160
GI:340139037 RefSeq NP_033933.2 358 nuclear receptor subfamily 1 group I member 3 isoform 1 [Mus musculus]
GI:340138964 RefSeq NP_033933.2 358 nuclear receptor subfamily 1 group I member 3 isoform 1 [Mus musculus]
GI:83921568 RefSeq NP_001229992.1 357 nuclear receptor subfamily 1 group I member 3 isoform 3 [Mus musculus]
GI:340139037 SwissProt O35627.2 358 RecName: Full=Nuclear receptor subfamily 1 group I member 3; AltName: Full=Constitutive androstane receptor; Short=CAR; AltName: Full=Orphan nuclear receptor MB67 [Mus musculus]