Gene/Proteome Database (LMPD)
LMPD ID
LMP001478
Gene ID
Species
Mus musculus (Mouse)
Gene Name
choline kinase beta
Gene Symbol
Synonyms
Chetk; Chkl; Ck; Ck/Ek; Ck/Ek-beta; Ckb; Ckekb; Ek
Alternate Names
choline/ethanolamine kinase; ethanolamine kinase; choline/ethanolaminekinase; choline/ethanolamine kinase-b
Chromosome
15
Map Location
15 E3|15
EC Number
2.7.1.32
Proteins
| choline/ethanolamine kinase | |
|---|---|
| Refseq ID | NP_031718 |
| Protein GI | 6671748 |
| UniProt ID | O55229 |
| mRNA ID | NM_007692 |
| Length | 394 |
| RefSeq Status | VALIDATED |
| MAADGTGVVGGGAVGGGLPKDGLQDAKCPEPIPNRRRASSLSRDAQRRAYQWCREYLGGAWRRARPEELSVCPVSGGLSNLLFRCSLPNHVPSVGGEPREVLLRLYGAILQGVDSLVLESVMFAILAERSLGPQLYGVFPEGRLEQYLPSRPLKTQELRDPVLSGAIATRMARFHGMEMPFTKEPRWLFGTMERYLKQIQDLPSTSLPQMNLVEMYSLKDEMNSLRKLLDDTPSPVVFCHNDIQEGNILLLSEPDSDDNLMLVDFEYSSYNYRGFDIGNHFCEWVYDYTYEEWPFYKARPTDYPTREQQLHFIRHYLAEVQKGEILSEEEQKKREEELLLEISRYSLASHFFWGLWSTLQASMSTIEFGYLEYAQSRFQFYFQQKGQLTSSPSS | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
| GO:0004103 | ISS:UniProtKB | F | choline kinase activity |
| GO:0004305 | IEA:UniProtKB-EC | F | ethanolamine kinase activity |
| GO:0006657 | IMP:GOC | P | CDP-choline pathway |
| GO:0007517 | IMP:MGI | P | muscle organ development |
| GO:0006656 | IMP:MGI | P | phosphatidylcholine biosynthetic process |
| GO:0006646 | ISS:UniProtKB | P | phosphatidylethanolamine biosynthetic process |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR011009 | Protein kinase-like domain |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | ATP + choline = ADP + phosphocholine. |
| Catalytic Activity | ATP + ethanolamine = ADP + O- phosphoethanolamine. |
| Disease | Note=Defects in Chkb are a cause of rostrocaudal muscular dystrophy (rmd). The disease is characterized by rapidly progressive muscular dystrophy and neonatal forelimb bone deformity. The dystrophy is only evident in skeletal muscle tissues in an unusual rostral-to-caudal gradient. {ECO:0000269|PubMed:16371353}. |
| Disruption Phenotype | Hindlimb muscular dystrophy. Hindlimb skeletal muscle tissue exhibits impaired phosphatidylcholine biosynthesis and increased phosphatidylcholine catabolism, with concomitant accumulation of choline. Mitochondria are abnormally large and exhibit decreased inner membrane potential. {ECO:0000269|PubMed:19236939}. |
| Function | Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis (By similarity). {ECO:0000250}. |
| Pathway | Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3. |
| Similarity | Belongs to the choline/ethanolamine kinase family. {ECO:0000305}. |
| Subunit | Homodimer, and heterodimer with CHKA. {ECO:0000269|PubMed:16490392}. |
| Tissue Specificity | Expressed ubiquitously with the highest level in testis. |
Identical and Related Proteins
Unique RefSeq proteins for LMP001478 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 6671748 | RefSeq | NP_031718 | 394 | choline/ethanolamine kinase |
Identical Sequences to LMP001478 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6671748 | DBBJ | BAA24896.1 | 394 | choline/ethanolamine kinase [Mus musculus] |
| GI:6671748 | DBBJ | BAA24897.1 | 394 | choline/ethanolamine kinase [Mus musculus] |
| GI:6671748 | DBBJ | BAA88151.1 | 394 | choline/ethanolamine kinase-beta [Mus musculus] |
| GI:6671748 | GenBank | EDL04339.1 | 394 | choline kinase beta, isoform CRA_b [Mus musculus] |
| GI:6671748 | SwissProt | O55229.3 | 394 | RecName: Full=Choline/ethanolamine kinase; AltName: Full=Choline kinase beta; Short=CK; Short=CKB; AltName: Full=Ethanolamine kinase; Short=EK; AltName: Full=choline/ethanolamine kinase beta; Short=CKEKB [Mus musculus] |
Related Sequences to LMP001478 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6671748 | DBBJ | BAA24366.1 | 394 | choline/ethanolamine kinase [Rattus norvegicus] |
| GI:6671748 | GenBank | AAH60515.1 | 394 | Choline kinase beta [Rattus norvegicus] |
| GI:6671748 | GenBank | EDL76571.1 | 394 | choline kinase beta, isoform CRA_a [Rattus norvegicus] |
| GI:6671748 | RefSeq | NP_058873.1 | 394 | choline/ethanolamine kinase [Rattus norvegicus] |
| GI:6671748 | RefSeq | XP_008763899.1 | 407 | PREDICTED: choline/ethanolamine kinase isoform X2 [Rattus norvegicus] |
| GI:6671748 | SwissProt | O54783.3 | 394 | RecName: Full=Choline/ethanolamine kinase; AltName: Full=Choline kinase beta; Short=CK; Short=CKB; AltName: Full=Ethanolamine kinase; Short=EK; AltName: Full=choline/ethanolamine kinase beta; Short=CKEKB [Rattus norvegicus] |