Gene/Proteome Database (LMPD)
LMPD ID
LMP001479
Gene ID
Species
Homo sapiens (Human)
Gene Name
solute carrier family 27 (fatty acid transporter), member 2
Gene Symbol
Synonyms
ACSVL1; FACVL1; FATP2; HsT17226; VLACS; VLCS; hFACVL1
Alternate Names
very long-chain acyl-CoA synthetase; FATP-2; THCA-CoA ligase; fatty acid transport protein 2; long-chain-fatty-acid--CoA ligase; solute carrier family 27 member 2; very-long-chain acyl-CoA synthetase; very long-chain-fatty-acid-CoA ligase; very long-chain fatty-acid-coenzyme A ligase 1; fatty-acid-coenzyme A ligase, very long-chain 1
Chromosome
15
Map Location
15q21.2
EC Number
6.2.1.-
Summary
The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme activates long-chain, branched-chain and very-long-chain fatty acids containing 22 or more carbons to their CoA derivatives. It is expressed primarily in liver and kidney, and is present in both endoplasmic reticulum and peroxisomes, but not in mitochondria. Its decreased peroxisomal enzyme activity is in part responsible for the biochemical pathology in X-linked adrenoleukodystrophy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]
Orthologs
Proteins
| very long-chain acyl-CoA synthetase isoform 1 | |
|---|---|
| Refseq ID | NP_003636 |
| Protein GI | 227499619 |
| UniProt ID | O14975 |
| mRNA ID | NM_003645 |
| Length | 620 |
| RefSeq Status | REVIEWED |
| MLSAIYTVLAGLLFLPLLVNLCCPYFFQDIGYFLKVAAVGRRVRSYGKRRPARTILRAFLEKARQTPHKPFLLFRDETLTYAQVDRRSNQVARALHDHLGLRQGDCVALLMGNEPAYVWLWLGLVKLGCAMACLNYNIRAKSLLHCFQCCGAKVLLVSPELQAAVEEILPSLKKDDVSIYYVSRTSNTDGIDSFLDKVDEVSTEPIPESWRSEVTFSTPALYIYTSGTTGLPKAAMITHQRIWYGTGLTFVSGLKADDVIYITLPFYHSAALLIGIHGCIVAGATLALRTKFSASQFWDDCRKYNVTVIQYIGELLRYLCNSPQKPNDRDHKVRLALGNGLRGDVWRQFVKRFGDICIYEFYAATEGNIGFMNYARKVGAVGRVNYLQKKIITYDLIKYDVEKDEPVRDENGYCVRVPKGEVGLLVCKITQLTPFNGYAGAKAQTEKKKLRDVFKKGDLYFNSGDLLMVDHENFIYFHDRVGDTFRWKGENVATTEVADTVGLVDFVQEVNVYGVHVPDHEGRIGMASIKMKENHEFDGKKLFQHIADYLPSYARPRFLRIQDTIEITGTFKHRKMTLVEEGFNPAVIKDALYFLDDTAKMYVPMTEDIYNAISAKTLKL | |
| very long-chain acyl-CoA synthetase isoform 2 | |
|---|---|
| Refseq ID | NP_001153101 |
| Protein GI | 227499621 |
| UniProt ID | O14975 |
| mRNA ID | NM_001159629 |
| Length | 567 |
| RefSeq Status | REVIEWED |
| MLSAIYTVLAGLLFLPLLVNLCCPYFFQDIGYFLKVAAVGRRVRSYGKRRPARTILRAFLEKARQTPHKPFLLFRDETLTYAQVDRRSNQVARALHDHLGLRQGDCVALLMGNEPAYVWLWLGLVKLGCAMACLNYNIRAKSLLHCFQCCGAKVLLVSPELQAAVEEILPSLKKDDVSIYYVSRTSNTDGIDSFLDKVDEVSTEPIPESWRSEVTFSTPALYIYTSGTTGATLALRTKFSASQFWDDCRKYNVTVIQYIGELLRYLCNSPQKPNDRDHKVRLALGNGLRGDVWRQFVKRFGDICIYEFYAATEGNIGFMNYARKVGAVGRVNYLQKKIITYDLIKYDVEKDEPVRDENGYCVRVPKGEVGLLVCKITQLTPFNGYAGAKAQTEKKKLRDVFKKGDLYFNSGDLLMVDHENFIYFHDRVGDTFRWKGENVATTEVADTVGLVDFVQEVNVYGVHVPDHEGRIGMASIKMKENHEFDGKKLFQHIADYLPSYARPRFLRIQDTIEITGTFKHRKMTLVEEGFNPAVIKDALYFLDDTAKMYVPMTEDIYNAISAKTLKL | |
Gene Information
Entrez Gene ID
Gene Name
solute carrier family 27 (fatty acid transporter), member 2
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005788 | IDA:UniProtKB | C | endoplasmic reticulum lumen |
| GO:0005789 | IDA:UniProtKB | C | endoplasmic reticulum membrane |
| GO:0070062 | IDA:UniProt | C | extracellular vesicular exosome |
| GO:0030176 | IDA:UniProtKB | C | integral component of endoplasmic reticulum membrane |
| GO:0005779 | IDA:UniProtKB | C | integral component of peroxisomal membrane |
| GO:0005739 | IEA:Ensembl | C | mitochondrion |
| GO:0005778 | IDA:UniProtKB | C | peroxisomal membrane |
| GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
| GO:0019899 | IPI:UniProtKB | F | enzyme binding |
| GO:0015245 | IEA:Ensembl | F | fatty acid transporter activity |
| GO:0004467 | IDA:UniProtKB | F | long-chain fatty acid-CoA ligase activity |
| GO:0050197 | IDA:UniProtKB | F | phytanate-CoA ligase activity |
| GO:0070251 | IDA:UniProtKB | F | pristanate-CoA ligase activity |
| GO:0005102 | IPI:UniProtKB | F | receptor binding |
| GO:0031957 | IDA:UniProtKB | F | very long-chain fatty acid-CoA ligase activity |
| GO:0006699 | IDA:UniProtKB | P | bile acid biosynthetic process |
| GO:0008206 | TAS:Reactome | P | bile acid metabolic process |
| GO:0044255 | TAS:Reactome | P | cellular lipid metabolic process |
| GO:0001561 | IDA:UniProtKB | P | fatty acid alpha-oxidation |
| GO:0006635 | IDA:UniProtKB | P | fatty acid beta-oxidation |
| GO:0044539 | IDA:UniProtKB | P | long-chain fatty acid import |
| GO:0001676 | IDA:UniProtKB | P | long-chain fatty acid metabolic process |
| GO:0097089 | IDA:UniProtKB | P | methyl-branched fatty acid metabolic process |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
| GO:0042760 | IEA:Ensembl | P | very long-chain fatty acid catabolic process |
KEGG Pathway Links
BIOCYC Pathway Links
Domain Information
UniProt Annotations
Entry Information
Gene Name
solute carrier family 27 (fatty acid transporter), member 2
Protein Entry
S27A2_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O14975-1; Sequence=Displayed; Name=2; IsoId=O14975-2; Sequence=VSP_042726; Note=No experimental confirmation available.; |
| Catalytic Activity | ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA. |
| Catalytic Activity | ATP + a very-long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA. |
| Function | Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes (By similarity). |
| Similarity | Belongs to the ATP-dependent AMP-binding enzyme family. |
| Subcellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Peroxisome membrane; Multi-pass membrane protein. Note=Peripheral membrane associated with the lumenal side of peroxisomes. |
| Tissue Specificity | Expressed in liver, kidney, placenta and pancreas. |
Identical and Related Proteins
Unique RefSeq proteins for LMP001479 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 227499619 | RefSeq | NP_003636 | 620 | very long-chain acyl-CoA synthetase isoform 1 |
| 227499621 | RefSeq | NP_001153101 | 567 | very long-chain acyl-CoA synthetase isoform 2 |
Identical Sequences to LMP001479 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:227499619 | DBBJ | BAD96865.1 | 620 | solute carrier family 27 (fatty acid transporter), member 2 variant, partial [Homo sapiens] |
| GI:227499621 | GenBank | AAH57770.1 | 567 | SLC27A2 protein [Homo sapiens] |
| GI:227499621 | GenBank | AIC50782.1 | 567 | SLC27A2, partial [synthetic construct] |
| GI:227499619 | SwissProt | O14975.2 | 620 | RecName: Full=Very long-chain acyl-CoA synthetase; Short=VLACS; Short=VLCS; AltName: Full=Fatty acid transport protein 2; Short=FATP-2; AltName: Full=Fatty-acid-coenzyme A ligase, very long-chain 1; AltName: Full=Long-chain-fatty-acid--CoA ligase; AltName: Full=Solute carrier family 27 member 2; AltName: Full=THCA-CoA ligase; AltName: Full=Very long-chain-fatty-acid-CoA ligase [Homo sapiens] |
Related Sequences to LMP001479 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:227499619 | DBBJ | BAA23644.1 | 620 | very-long-chain acyl-CoA synthetase [Homo sapiens] |
| GI:227499619 | DBBJ | BAF82951.1 | 620 | unnamed protein product [Homo sapiens] |
| GI:227499619 | GenBank | AAC64973.1 | 620 | very long-chain acyl-CoA synthetase [Homo sapiens] |
| GI:227499619 | GenBank | ABH70742.1 | 620 | Sequence 49 from patent US 7033772 |
| GI:227499621 | GenBank | EAW77384.1 | 567 | solute carrier family 27 (fatty acid transporter), member 2, isoform CRA_a [Homo sapiens] |
| GI:227499619 | GenBank | EAW77386.1 | 620 | solute carrier family 27 (fatty acid transporter), member 2, isoform CRA_c [Homo sapiens] |
| GI:227499621 | GenBank | AHE01382.1 | 620 | Sequence 56298 from patent US 8586006 |
| GI:227499619 | GenBank | AHE01382.1 | 620 | Sequence 56298 from patent US 8586006 |
| GI:227499621 | RefSeq | XP_001168068.1 | 567 | PREDICTED: very long-chain acyl-CoA synthetase isoform X2 [Pan troglodytes] |
| GI:227499621 | RefSeq | XP_002825483.1 | 567 | PREDICTED: very long-chain acyl-CoA synthetase isoform X2 [Pongo abelii] |
| GI:227499621 | RefSeq | XP_003266955.1 | 567 | PREDICTED: very long-chain acyl-CoA synthetase isoform 2 [Nomascus leucogenys] |
| GI:227499621 | RefSeq | XP_003831552.1 | 567 | PREDICTED: very long-chain acyl-CoA synthetase isoform X2 [Pan paniscus] |