Gene/Proteome Database (LMPD)

LMPD ID
LMP001513
Gene ID
3709
Species
Homo sapiens (Human)
Gene Name
inositol 1,4,5-trisphosphate receptor, type 2
Gene Symbol
ITPR2
Synonyms
CFAP48; IP3R2
Alternate Names
inositol 1,4,5-trisphosphate receptor type 2; IP3R 2; insP3R2; IP3 receptor; type 2 InsP3 receptor; cilia and flagella associated protein 48; inositol 1,4,5-triphosphate receptor, type 2; type 2 inositol 1,4,5-trisphosphate receptor
Chromosome
12
Map Location
12p11

Proteins

inositol 1,4,5-trisphosphate receptor type 2
Refseq ID NP_002214
Protein GI 95147335
UniProt ID Q14571
mRNA ID NM_002223
Length 2701
RefSeq Status VALIDATED
MTEKMSSFLYIGDIVSLYAEGSVNGFISTLGLVDDRCVVHPEAGDLANPPKKFRDCLFKVCPMNRYSAQKQYWKAKQAKQGNHTEAALLKKLQHAAELEQKQNESENKKLLGEIVKYSNVIQLLHIKSNKYLTVNKRLPALLEKNAMRVSLDAAGNEGSWFYIHPFWKLRSEGDNIVVGDKVVLMPVNAGQPLHASNIELLDNPGCKEVNAVNCNTSWKITLFMKYSSYREDVLKGGDVVRLFHAEQEKFLTCDEYEKKQHIFLRTTLRQSATSATSSKALWEIEVVHHDPCRGGAGQWNSLFRFKHLATGNYLAAELNPDYRDAQNEGKNVRDGVPPTSKKKRQAGEKIMYTLVSVPHGNDIASLFELDATTLQRADCLVPRNSYVRLRHLCTNTWVTSTSIPIDTDEERPVMLKIGTCQTKEDKEAFAIVSVPLSEVRDLDFANDANKVLATTVKKLENGTITQNERRFVTKLLEDLIFFVADVPNNGQEVLDVVITKPNRERQKLMREQNILAQVFGILKAPFKEKAGEGSMLRLEDLGDQRYAPYKYMLRLCYRVLRHSQQDYRKNQEYIAKNFCVMQSQIGYDILAEDTITALLHNNRKLLEKHITAKEIETFVSLLRRNREPRFLDYLSDLCVSNTTAIPVTQELICKFMLSPGNADILIQTKVVSMQADNPMESSILSDDIDDEEVWLYWIDSNKEPHGKAIRHLAQEAKEGTKADLEVLTYYRYQLNLFARMCLDRQYLAINQISTQLSVDLILRCVSDESLPFDLRASFCRLMLHMHVDRDPQESVVPVRYARLWTEIPTKITIHEYDSITDSSRNDMKRKFALTMEFVEEYLKEVVNQPFPFGDKEKNKLTFEVVHLARNLIYFGFYSFSELLRLTRTLLAILDIVQAPMSSYFERLSKFQDGGNNVMRTIHGVGEMMTQMVLSRGSIFPMSVPDVPPSIHPSKQGSPTEHEDVTVMDTKLKIIEILQFILSVRLDYRISYMLSIYKKEFGEDNDNAETSASGSPDTLLPSAIVPDIDEIAAQAETMFAGRKEKNPVQLDDEGGRTFLRVLIHLIMHDYPPLLSGALQLLFKHFSQRAEVLQAFKQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWVEKSSNYENGEIGESQVKGGEEPIEESNILSPVQDGTKKPQIDSNKSNNYRIVKEILIRLSKLCVQNKKCRNQHQRLLKNMGAHSVVLDLLQIPYEKNDEKMNEVMNLAHTFLQNFCRGNPQNQVLLHKHLNLFLTPGLLEAETMRHIFMNNYHLCNEISERVVQHFVHCIETHGRHVEYLRFLQTIVKADGKYVKKCQDMVMTELINGGEDVLIFYNDRASFPILLHMMCSERDRGDESGPLAYHITLVELLAACTEGKNVYTEIKCNSLLPLDDIVRVVTHDDCIPEVKIAYVNFVNHCYVDTEVEMKEIYTSNHIWKLFENFLVDMARVCNTTTDRKHADIFLEKCVTESIMNIVSGFFNSPFSDNSTSLQTHQPVFIQLLQSAFRIYNCTWPNPAQKASVESCIRTLAEVAKNRGIAIPVDLDSQVNTLFMKSHSNMVQRAAMGWRLSARSGPRFKEALGGPAWDYRNIIEKLQDVVASLEHQFSPMMQAEFSVLVDVLYSPELLFPEGSDARIRCGAFMSKLINHTKKLMEKEEKLCIKILQTLREMLEKKDSFVEEGNTLRKILLNRYFKGDYSIGVNGHLSGAYSKTAQVGGSFSGQDSDKMGISMSDIQCLLDKEGASELVIDVIVNTKNDRIFSEGIFLGIALLEGGNTQTQYSFYQQLHEQKKSEKFFKVLYDRMKAAQKEIRSTVTVNTIDLGNKKRDDDNELMTSGPRMRVRDSTLHLKEGMKGQLTEASSATSKAYCVYRREMDPEIDIMCTGPEAGNTEEKSAEEVTMSPAIAIMQPILRFLQLLCENHNRELQNFLRNQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEKNVALVNQNLESLTEYCQGPCHENQTCIATHESNGIDIIIALILNDINPLGKYRMDLVLQLKNNASKLLLAIMESRHDSENAERILFNMRPRELVDVMKNAYNQGLECDHGDDEGGDDGVSPKDVGHNIYILAHQLARHNKLLQQMLKPGSDPDEGDEALKYYANHTAQIEIVRHDRTMEQIVFPVPNICEYLTRESKCRVFNTTERDEQGSKVNDFFQQTEDLYNEMKWQKKIRNNPALFWFSRHISLWGSISFNLAVFINLAVALFYPFGDDGDEGTLSPLFSVLLWIAVAICTSMLFFFSKPVGIRPFLVSIMLRSIYTIGLGPTLILLGAANLCNKIVFLVSFVGNRGTFTRGYRAVILDMAFLYHVAYVLVCMLGLFVHEFFYSFLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIIGFLFLKDDFTMEVDRLKNRTPVTGSHQVPTMTLTTMMEACAKENCSPTIPASNTADEEYEDGIERTCDTLLMCIVTVLNQGLRNGGGVGDVLRRPSKDEPLFAARVVYDLLFYFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKSEHNMWHYLYFIVLVKVKDPTEYTGPESYVAQMIVEKNLDWFPRMRAMSLVSNEGDSEQNEIRSLQEKLESTMSLVKQLSGQLAELKEQMTEQRKNKQRLGFLGSNTPHVNHHMPPH

Gene Information

Entrez Gene ID
3709
Gene Name
inositol 1,4,5-trisphosphate receptor, type 2
Gene Symbol
ITPR2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005938 IEA:Ensembl C cell cortex
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016020 IDA:UniProtKB C membrane
GO:0005886 IDA:BHF-UCL C plasma membrane
GO:0031095 TAS:Reactome C platelet dense tubular network membrane
GO:0043235 IDA:MGI C receptor complex
GO:0033017 IMP:BHF-UCL C sarcoplasmic reticulum membrane
GO:0015085 TAS:ProtInc F calcium ion transmembrane transporter activity
GO:0005220 TAS:ProtInc F inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0035091 IEA:Ensembl F phosphatidylinositol binding
GO:0038095 TAS:Reactome P Fc-epsilon receptor signaling pathway
GO:0038096 TAS:Reactome P Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0007202 TAS:Reactome P activation of phospholipase C activity
GO:0007596 TAS:Reactome P blood coagulation
GO:0071320 IEA:Ensembl P cellular response to cAMP
GO:0071361 IEA:Ensembl P cellular response to ethanol
GO:0006112 TAS:Reactome P energy reserve metabolic process
GO:0007173 TAS:Reactome P epidermal growth factor receptor signaling pathway
GO:0008543 TAS:Reactome P fibroblast growth factor receptor signaling pathway
GO:0045087 TAS:Reactome P innate immune response
GO:0048016 TAS:GOC P inositol phosphate-mediated signaling
GO:0048011 TAS:Reactome P neurotrophin TRK receptor signaling pathway
GO:0030168 TAS:Reactome P platelet activation
GO:0050796 TAS:Reactome P regulation of insulin secretion
GO:0001666 IDA:BHF-UCL P response to hypoxia
GO:0007165 TAS:Reactome P signal transduction
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0006810 TAS:ProtInc P transport

KEGG Pathway Links

KEGG Pathway ID Description
hsa04750 Inflammatory mediator regulation of TRP channels
hsa04921 Oxytocin signaling pathway
hsa04611 Platelet activation
hsa04022 cGMP-PKG signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR016024 Armadillo-type fold
IPR000493 Inositol 1,4,5-trisphosphate-binding protein receptor
IPR014821 Inositol 1,4,5-trisphosphate/ryanodine receptor
IPR005821 Ion transport domain
IPR016093 MIR_motif
IPR000699 RIH (RyR and IP3R Homology) domain
IPR013662 RyR/IP3R Homology associated domain
IPR015925 Ryanodine receptor-related

UniProt Annotations

Entry Information

Gene Name
inositol 1,4,5-trisphosphate receptor, type 2
Protein Entry
ITPR2_HUMAN
UniProt ID
Q14571
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=Q14571-1; Sequence=Displayed; Name=Short; Synonyms=TIPR; IsoId=Q14571-2; Sequence=VSP_002699, VSP_002700;
Domain The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand- binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
Function Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity).
Miscellaneous Calcium appears to inhibit ligand binding to the receptor, most probably by interacting with a distinct calcium- binding protein which then inhibits the receptor.
Ptm Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release.
Similarity Belongs to the InsP3 receptor family.
Similarity Contains 5 MIR domains. {ECO
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein.
Subunit Homotetramer (By similarity). Interacts with CABP1.
Tissue Specificity Isoform Short is found in skeletal muscle and heart.

Identical and Related Proteins

Unique RefSeq proteins for LMP001513 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
95147335 RefSeq NP_002214 2701 inositol 1,4,5-trisphosphate receptor type 2

Identical Sequences to LMP001513 proteins

Reference Database Accession Length Protein Name
GI:95147335 GenBank EAW96534.1 2701 inositol 1,4,5-triphosphate receptor, type 2, isoform CRA_a [Homo sapiens]
GI:95147335 GenBank AAI72383.1 2701 Inositol 1,4,5-triphosphate receptor, type 2 [synthetic construct]
GI:95147335 SwissProt Q14571.2 2701 RecName: Full=Inositol 1,4,5-trisphosphate receptor type 2; AltName: Full=IP3 receptor isoform 2; Short=IP3R 2; Short=InsP3R2; AltName: Full=Type 2 inositol 1,4,5-trisphosphate receptor; Short=Type 2 InsP3 receptor [Homo sapiens]

Related Sequences to LMP001513 proteins

Reference Database Accession Length Protein Name
GI:95147335 DBBJ BAA05384.1 2701 type 2 inositol 1,4,5-trisphosphate receptor [Homo sapiens]
GI:95147335 GenBank AED82773.1 2701 Sequence 1510 from patent US 7919467
GI:95147335 GenBank JAA24826.1 2701 inositol 1,4,5-trisphosphate receptor, type 2 [Pan troglodytes]
GI:95147335 GenBank JAA42567.1 2701 inositol 1,4,5-trisphosphate receptor, type 2 [Pan troglodytes]
GI:95147335 GenBank AHD78457.1 2701 Sequence 26455 from patent US 8586006
GI:95147335 RefSeq XP_003313863.2 2701 PREDICTED: inositol 1,4,5-trisphosphate receptor type 2 [Pan troglodytes]