Gene/Proteome Database (LMPD)

LMPD ID
LMP001516
Gene ID
224860
Species
Mus musculus (Mouse)
Gene Name
phospholipase C-like 2
Gene Symbol
Plcl2
Synonyms
PLC-L2; PRIP-2; Plce2; mKIAA1092
Alternate Names
inactive phospholipase C-like protein 2; PLC-L(2); PLC-epsilon-2; phospholipase C-L2; phospholipase C-epsilon-2; phospholipase C, epsilon 2
Chromosome
17
Map Location
17 C|17

Proteins

inactive phospholipase C-like protein 2
Refseq ID NP_038908
Protein GI 226342967
UniProt ID Q8K394
mRNA ID NM_013880
Length 1128
RefSeq Status VALIDATED
MAECGRGAAGGALPTSPSPALGAKGALKAGAGEGGGGGGGGRLGHGRARYDSGGVSNGDCSLGVSGDEARTSPGRGPLGVALARTPSPAAGPVPRDSKPGGLPRRSSIIKDGTKQKRERKKTVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISEQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWISQMFSEIDVDGLGHITLCHAVQCIRNLNPGLKTSKIELKFKELHKSKDKAGTEITKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKILGDKLYTTSPNMEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKENVEQPNHVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNVGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVNQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSPRFLGPDNNPLVVLNLSEPYPTMELQAIVPEVLKKIVTTYDMMMQSLKALIENADAVYEKIVHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNETLENLKQIHFAAVSCGLNKPGTENSEAQKPRRSLEAIPEKASDENGD

Gene Information

Entrez Gene ID
224860
Gene Name
phospholipase C-like 2
Gene Symbol
Plcl2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0050811 ISO:MGI F GABA receptor binding
GO:0005509 IEA:InterPro F calcium ion binding
GO:0004435 IEA:InterPro F phosphatidylinositol phospholipase C activity
GO:0004871 IEA:UniProtKB-KW F signal transducer activity
GO:0002322 IMP:MGI P B cell proliferation involved in immune response
GO:0002337 IMP:MGI P B-1a B cell differentiation
GO:0007214 IGI:MGI P gamma-aminobutyric acid signaling pathway
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0006629 IEA:InterPro P lipid metabolic process
GO:0050859 IMP:MGI P negative regulation of B cell receptor signaling pathway
GO:1900122 IGI:MGI P positive regulation of receptor binding
GO:0033135 IGI:MGI P regulation of peptidyl-serine phosphorylation
GO:0032228 IGI:MGI P regulation of synaptic transmission, GABAergic

Domain Information

InterPro Annotations

Accession Description
IPR000008 C2 domain
IPR011992 EF-hand domain pair
IPR028383 Inactive phospholipase C-like protein 2
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR001192 Phosphoinositide phospholipase C family
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain

UniProt Annotations

Entry Information

Gene Name
phospholipase C-like 2
Protein Entry
PLCL2_MOUSE
UniProt ID
Q8K394
Species
Mouse

Comments

Comment Type Description
Caution In the PI-PLC X-box Thr-487 is present instead of the conserved His which is one of the active site residues. It is therefore expected that this protein lacks catalytic activity. {ECO:0000305}.
Function May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum. {ECO:0000269|PubMed:10581172}.
Similarity Contains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
Similarity Contains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Similarity Contains 1 PI-PLC X-box domain. {ECO:0000255|PROSITE- ProRule:PRU00270}.
Similarity Contains 1 PI-PLC Y-box domain. {ECO:0000255|PROSITE- ProRule:PRU00271}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:10581172}. Note=Predominantly localized to perinuclear areas in both myoblast and myotube C2C12 cells.
Tissue Specificity Ubiquitously expressed, with a strong expression in skeletal muscle. {ECO:0000269|PubMed:10581172}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001516 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
226342967 RefSeq NP_038908 1128 inactive phospholipase C-like protein 2

Identical Sequences to LMP001516 proteins

Reference Database Accession Length Protein Name
GI:226342967 RefSeq XP_006524213.1 1128 PREDICTED: phospholipase C-like 2 isoform X1 [Mus musculus]
GI:226342967 RefSeq XP_006524214.1 1128 PREDICTED: phospholipase C-like 2 isoform X2 [Mus musculus]
GI:226342967 RefSeq XP_006524215.1 1128 PREDICTED: phospholipase C-like 2 isoform X3 [Mus musculus]
GI:226342967 SwissProt Q8K394.2 1128 RecName: Full=Inactive phospholipase C-like protein 2; Short=PLC-L(2); Short=PLC-L2; Short=Phospholipase C-L2; AltName: Full=Phospholipase C-epsilon-2; Short=PLC-epsilon-2 [Mus musculus]

Related Sequences to LMP001516 proteins

Reference Database Accession Length Protein Name
GI:226342967 EMBL CBF74678.1 1128 unnamed protein product [Mus musculus]
GI:226342967 EMBL CBF62940.1 1128 unnamed protein product [Mus musculus]
GI:226342967 EMBL CBU96763.1 1128 unnamed protein product [Mus musculus]
GI:226342967 GenBank AAH27746.1 1128 Plcl2 protein [Mus musculus]
GI:226342967 GenBank AGX54751.1 1128 Sequence 9858 from patent US 8541208
GI:226342967 GenBank AGX64191.1 1128 Sequence 28492 from patent US 8541208