Gene/Proteome Database (LMPD)
LMPD ID
LMP001524
Gene ID
Species
Mus musculus (Mouse)
Gene Name
diacylglycerol kinase, alpha
Gene Symbol
Synonyms
80kDa; AW146112; Dagk1
Alternate Names
diacylglycerol kinase alpha; DGK-alpha; DAG kinase alpha; diglyceride kinase alpha; 80 kDa diacylglycerol kinase; diacylglycerol kinase alpha Flt2-Pr2; truncated diacylglycerol kinase alpha Flt1-Pr1; truncated diacylglycerol kinase alpha Flt1-Pr2
Chromosome
10
Map Location
10 D3|10 77.14 cM
EC Number
2.7.1.107
Proteins
| diacylglycerol kinase alpha | |
|---|---|
| Refseq ID | NP_058091 |
| Protein GI | 31560474 |
| UniProt ID | O88673 |
| mRNA ID | NM_016811 |
| Length | 730 |
| RefSeq Status | PROVISIONAL |
| MAKEKGLISPEDFAQLQKYIEYSTKRVSDVLKVFDDGEMNRFCQGDAIGYLGFEQFMKMYLEMEEVPHHLCWALFWSFHTSQVAAEKTKSKANVICLSDVYCYFTLLEGGRPEDKLEFTFKLYDMDRNGILDSTEVEKIILQMMRVAEYLDWDVSELRPILQEMMREMDQDGSGSVSLDEWVRAGATTVPLLVLLGMDVTMKDDGNHIWRPKRFTRLVYCNLCEQSISLGKQGLSCNFCKYIVHDHCAMKAQPCEVSTYAKSRKDIGVQSHLWVRGGCHSGRCDRCQKKIRTYHSLTGLHCVWCHLEIHDDCLQAVGPECDCGLLRDHILPPCSIYPSVLVSGQECKHKTTDDTSLCTPEAFRIEPVSNTHPLLVFINLKSGGKQGQSVLWKFQYILNPRQVFDLKDGPEPGLRFFKDVPQFRILVCGGDGTVGWVLETIDKANFATVPPVAVLPLGTGNDLARCLRWGRGYEGENLRKILKDIELSKVVYLDRWFLEVIPQQNGEKSDPVPSQIINNYFSIGVDASIAHRFHLMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESVTVEICGKLLDLSDLSLEGIAVLNIPSTHGGSNLWGDTKRPHGDTCEINQALGSAAKIITDPDILKTCVPDMSDKRLEVVGIEGAIEMGQIYTRLKSAGHRLAKCSEITFQTTKTLPMQIDGEPWMQAPCTIKITHKNQMPMLMGPPSNSYNFFGFWS | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005829 | IDA:MGI | C | cytosol |
| GO:0005886 | IDA:MGI | C | plasma membrane |
| GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
| GO:0003951 | IEA:InterPro | F | NAD+ kinase activity |
| GO:0005509 | IEA:InterPro | F | calcium ion binding |
| GO:0004143 | IDA:MGI | F | diacylglycerol kinase activity |
| GO:0005543 | IDA:MGI | F | phospholipid binding |
| GO:0035556 | IEA:InterPro | P | intracellular signal transduction |
| GO:0007205 | IEA:InterPro | P | protein kinase C-activating G-protein coupled receptor signaling pathway |
KEGG Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR016064 | ATP-NAD kinase-like domain |
| IPR029477 | Diacylglycerol kinase type I, N-terminal |
| IPR000756 | Diacylglycerol kinase, accessory domain |
| IPR001206 | Diacylglycerol kinase, catalytic domain |
| IPR018247 | EF-Hand 1, calcium-binding site |
| IPR002048 | EF-hand domain |
| IPR011992 | EF-hand domain pair |
| IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2- diacyl-sn-glycerol 3-phosphate. |
| Enzyme Regulation | Stimulated by calcium and phosphatidylserine. Phosphorylated by protein kinase C (By similarity). {ECO:0000250}. |
| Function | Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity. {ECO:0000250}. |
| Similarity | Belongs to the eukaryotic diacylglycerol kinase family. {ECO:0000305}. |
| Similarity | Contains 1 DAGKc domain. {ECO:0000255|PROSITE- ProRule:PRU00783}. |
| Similarity | Contains 2 EF-hand domains. {ECO:0000255|PROSITE- ProRule:PRU00448}. |
| Similarity | Contains 2 phorbol-ester/DAG-type zinc fingers. {ECO:0000255|PROSITE-ProRule:PRU00226}. |
| Subunit | Monomer. {ECO:0000250}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP001524 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 31560474 | RefSeq | NP_058091 | 730 | diacylglycerol kinase alpha |
Identical Sequences to LMP001524 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:31560474 | EMBL | CAF06477.1 | 730 | unnamed protein product [Mus musculus] |
| GI:31560474 | GenBank | AAH06713.1 | 730 | Diacylglycerol kinase, alpha [Mus musculus] |
| GI:31560474 | GenBank | ABK42184.1 | 730 | DAGk-alpha [synthetic construct] |
| GI:31560474 | GenBank | EDL24607.1 | 730 | diacylglycerol kinase, alpha, isoform CRA_e [Mus musculus] |
| GI:31560474 | GenBank | EDL24608.1 | 730 | diacylglycerol kinase, alpha, isoform CRA_e [Mus musculus] |
| GI:31560474 | SwissProt | O88673.2 | 730 | RecName: Full=Diacylglycerol kinase alpha; Short=DAG kinase alpha; AltName: Full=80 kDa diacylglycerol kinase; AltName: Full=Diglyceride kinase alpha; Short=DGK-alpha [Mus musculus] |
Related Sequences to LMP001524 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:31560474 | GenBank | AAC33483.1 | 730 | alpha diacylglycerol kinase [Mus musculus] |
| GI:31560474 | GenBank | AFJ06821.1 | 730 | diacylglycerol kinase alpha Flt2-Pr2 [Mus musculus] |
| GI:31560474 | RefSeq | XP_006513251.1 | 783 | PREDICTED: diacylglycerol kinase alpha isoform X1 [Mus musculus] |
| GI:31560474 | RefSeq | XP_006513252.1 | 760 | PREDICTED: diacylglycerol kinase alpha isoform X2 [Mus musculus] |
| GI:31560474 | RefSeq | XP_006513253.1 | 760 | PREDICTED: diacylglycerol kinase alpha isoform X3 [Mus musculus] |
| GI:31560474 | RefSeq | XP_006513254.1 | 753 | PREDICTED: diacylglycerol kinase alpha isoform X4 [Mus musculus] |