Gene/Proteome Database (LMPD)

LMPD ID
LMP001532
Gene ID
5286
Species
Homo sapiens (Human)
Gene Name
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
Gene Symbol
PIK3C2A
Synonyms
CPK; PI3-K-C2(ALPHA); PI3-K-C2A
Chromosome
11
Map Location
11p15.5-p14
Summary
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for PIK3C2A

Proteins

phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
Refseq ID NP_002636
Protein GI 157671929
UniProt ID O00443
mRNA ID NM_002645
Length 1686
RefSeq Status VALIDATED
MAQISSNSGFKECPSSHPEPTRAKDVDKEEALQMEAEALAKLQKDRQVTDNQRGFELSSSTRKKAQVYNKQDYDLMVFPESDSQKRALDIDVEKLTQAELEKLLLDDSFETKKTPVLPVTPILSPSFSAQLYFRPTIQRGQWPPGLPGPSTYALPSIYPSTYSKQAAFQNGFNPRMPTFPSTEPIYLSLPGQSPYFSYPLTPATPFHPQGSLPIYRPVVSTDMAKLFDKIASTSEFLKNGKARTDLEITDSKVSNLQVSPKSEDISKFDWLDLDPLSKPKVDNVEVLDHEEEKNVSSLLAKDPWDAVLLEERSTANCHLERKVNGKSLSVATVTRSQSLNIRTTQLAKAQGHISQKDPNGTSSLPTGSSLLQEVEVQNEEMAAFCRSITKLKTKFPYTNHRTNPGYLLSPVTAQRNICGENASVKVSIDIEGFQLPVTFTCDVSSTVEIIIMQALCWVHDDLNQVDVGSYVLKVCGQEEVLQNNHCLGSHEHIQNCRKWDTEIRLQLLTFSAMCQNLARTAEDDETPVDLNKHLYQIEKPCKEAMTRHPVEELLDSYHNQVELALQIENQHRAVDQVIKAVRKICSALDGVETLAITESVKKLKRAVNLPRSKTADVTSLFGGEDTSRSSTRGSLNPENPVQVSINQLTAAIYDLLRLHANSGRSPTDCAQSSKSVKEAWTTTEQLQFTIFAAHGISSNWVSNYEKYYLICSLSHNGKDLFKPIQSKKVGTYKNFFYLIKWDELIIFPIQISQLPLESVLHLTLFGILNQSSGSSPDSNKQRKGPEALGKVSLPLFDFKRFLTCGTKLLYLWTSSHTNSVPGTVTKKGYVMERIVLQVDFPSPAFDIIYTTPQVDRSIIQQHNLETLENDIKGKLLDILHKDSSLGLSKEDKAFLWEKRYYCFKHPNCLPKILASAPNWKWVNLAKTYSLLHQWPALYPLIALELLDSKFADQEVRSLAVTWIEAISDDELTDLLPQFVQALKYEIYLNSSLVQFLLSRALGNIQIAHNLYWLLKDALHDVQFSTRYEHVLGALLSVGGKRLREELLKQTKLVQLLGGVAEKVRQASGSARQVVLQRSMERVQSFFQKNKCRLPLKPSLVAKELNIKSCSFFSSNAVPLKVTMVNADPMGEEINVMFKVGEDLRQDMLALQMIKIMDKIWLKEGLDLRMVIFKCLSTGRDRGMVELVPASDTLRKIQVEYGVTGSFKDKPLAEWLRKYNPSEEEYEKASENFIYSCAGCCVATYVLGICDRHNDNIMLRSTGHMFHIDFGKFLGHAQMFGSFKRDRAPFVLTSDMAYVINGGEKPTIRFQLFVDLCCQAYNLIRKQTNLFLNLLSLMIPSGLPELTSIQDLKYVRDALQPQTTDAEATIFFTRLIESSLGSIATKFNFFIHNLAQLRFSGLPSNDEPILSFSPKTYSFRQDGRIKEVSVFTYHKKYNPDKHYIYVVRILREGQIEPSFVFRTFDEFQELHNKLSIIFPLWKLPGFPNRMVLGRTHIKDVAAKRKIELNSYLQSLMNASTDVAECDLVCTFFHPLLRDEKAEGIARSADAGSFSPTPGQIGGAVKLSISYRNGTLFIMVMHIKDLVTEDGADPNPYVKTYLLPDNHKTSKRKTKISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFFLGGVTLPLKDFNLSKETVKWYQLTAATYL

Gene Information

Entrez Gene ID
5286
Gene Name
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
Gene Symbol
PIK3C2A
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016303 IEA:Ensembl F 1-phosphatidylinositol-3-kinase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0035091 IEA:InterPro F phosphatidylinositol binding
GO:0048015 IEA:InterPro P phosphatidylinositol-mediated signaling

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_120756 Synthesis of PIPs at the early endosome membrane
REACT_120918 Synthesis of PIPs at the late endosome membrane

Domain Information

InterPro Annotations

Accession Description
IPR016024 Armadillo-type fold
IPR000008 C2 domain
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
IPR002420 Phosphatidylinositol 3-kinase, C2 domain
IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
IPR015433 Phosphatidylinositol Kinase
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
IPR001683 Phox homologous domain
IPR011009 Protein kinase-like domain
IPR029071 Ubiquitin-related domain

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
Protein Entry
P3C2A_HUMAN
UniProt ID
O00443
Species
Human

Comments

Comment Type Description
Similarity Contains 2 C2 domains.
Similarity Contains PI3K/PI4K domain.
Similarity Contains PIK helical domain.

Identical and Related Proteins

Unique RefSeq proteins for LMP001532 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
157671929 RefSeq NP_002636 1686 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

Identical Sequences to LMP001532 proteins

Reference Database Accession Length Protein Name
GI:157671929 DBBJ BAG11017.1 1686 phosphoinositide-3-kinase, class 2, alpha polypeptide, partial [synthetic construct]
GI:157671929 GenBank ADR83442.1 1686 phosphoinositide-3-kinase, class 2, alpha polypeptide, partial [synthetic construct]
GI:157671929 GenBank AGC09601.1 1686 phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha [Homo sapiens]
GI:157671929 RefSeq XP_005253034.1 1686 PREDICTED: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1 [Homo sapiens]
GI:157671929 RefSeq XP_005253035.1 1686 PREDICTED: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X2 [Homo sapiens]
GI:157671929 RefSeq XP_005253036.1 1686 PREDICTED: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X3 [Homo sapiens]

Related Sequences to LMP001532 proteins

Reference Database Accession Length Protein Name
GI:157671929 GenBank JAA10865.1 1686 phosphoinositide-3-kinase, class 2, alpha polypeptide [Pan troglodytes]
GI:157671929 GenBank JAA18033.1 1686 phosphoinositide-3-kinase, class 2, alpha polypeptide [Pan troglodytes]
GI:157671929 GenBank JAA18034.1 1686 phosphoinositide-3-kinase, class 2, alpha polypeptide [Pan troglodytes]
GI:157671929 RefSeq XP_003818252.1 1686 PREDICTED: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1 [Pan paniscus]
GI:157671929 RefSeq XP_008969719.1 1686 PREDICTED: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1 [Pan paniscus]
GI:157671929 RefSeq XP_009458274.1 1686 PREDICTED: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1 [Pan troglodytes]