Gene/Proteome Database (LMPD)
LMPD ID
LMP001542
Gene ID
Species
Mus musculus (Mouse)
Gene Name
prostaglandin D2 receptor 2
Gene Symbol
Synonyms
Crth2; Gpr44; Grp45
Alternate Names
prostaglandin D2 receptor 2; PGD2 receptor; G protein-coupled receptor 44; G-protein coupled receptor 44; prostaglandin D2 receptor CRTH2; chemoattractant receptor-homologous molecule expressed on TH2 cells
Chromosome
19
Map Location
19 A|19
Proteins
| prostaglandin D2 receptor 2 | |
|---|---|
| Refseq ID | NP_034092 |
| Protein GI | 6753528 |
| UniProt ID | Q9Z2J6 |
| mRNA ID | NM_009962 |
| Length | 382 |
| RefSeq Status | VALIDATED |
| MANVTLKPLCPLLEEMVQLPNHSNSSLRYIDHVSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCYYNLLLWNPGPDRDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFTCPDMLYKLRRSLRAVLESVLVEDSDQSGGLRNRRRRASSTATPASTLLLADRIPQLRPTRLIGWMRRGSAEVPQRV | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005887 | ISS:MGI | C | integral component of plasma membrane |
| GO:0004930 | IDA:MGI | F | G-protein coupled receptor activity |
| GO:0004956 | IDA:MGI | F | prostaglandin D receptor activity |
| GO:0004958 | IDA:MGI | F | prostaglandin F receptor activity |
| GO:0001785 | IDA:MGI | F | prostaglandin J receptor activity |
| GO:0007186 | ISS:MGI | P | G-protein coupled receptor signaling pathway |
| GO:0007193 | IDA:MGI | P | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway |
| GO:0019722 | IDA:MGI | P | calcium-mediated signaling |
| GO:0006935 | IDA:MGI | P | chemotaxis |
| GO:0045745 | IDA:MGI | P | positive regulation of G-protein coupled receptor protein signaling pathway |
REACTOME Pathway Links
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Disruption Phenotype | Deficient mice are fertile and grew normally. Ear-swelling responses induced by hapten-specific IgE are less pronounced in deficient mice, giving 35-55% of the responses of normal mice. The reduction in cutaneous responses is associated with decreased infiltration of lymphocytes, eosinophils, and basophils and decreased production of macrophage- derived chemokine and RANTES at inflammatory sites. In models of chronic contact hypersensitivity induced by repeated hapten application, CRTH2-deficient mice result in a reduction by approximately half of skin responses and low levels (63% of control) of serum IgE production. {ECO:0000269|PubMed:16888024}. |
| Domain | The 329-DSEL-332 motif is involved in the recycling of PTGDR2 to the cell surface after agonist-induced internalization. This motif seems to be required for ADRBK1/GRK2 and GPRK5/GRK5 to promote agonist-induced internalization (By similarity). Thr-346 is a major site for PKC-induced internalization of the receptor (By similarity). {ECO:0000250}. |
| Function | Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin- sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses (By similarity). {ECO:0000250}. |
| Ptm | Phosphorylated. {ECO:0000250}. |
| Similarity | Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}. |
| Subcellular Location | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Internalized receptors colocalized with RAB11A. {ECO:0000250}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP001542 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 6753528 | RefSeq | NP_034092 | 382 | prostaglandin D2 receptor 2 |
Identical Sequences to LMP001542 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6753528 | DBBJ | BAC81436.1 | 382 | prostaglandin D2 receptor CRTH2 [Mus musculus] |
| GI:6753528 | DBBJ | BAC81437.1 | 382 | prostaglandin D2 receptor CRTH2 [Mus musculus] |
| GI:6753528 | GenBank | AAI11907.1 | 382 | G protein-coupled receptor 44 [Mus musculus] |
| GI:6753528 | GenBank | EDL41395.1 | 382 | G protein-coupled receptor 44 [Mus musculus] |
| GI:6753528 | RefSeq | XP_006526758.1 | 382 | PREDICTED: prostaglandin D2 receptor 2 isoform X1 [Mus musculus] |
| GI:6753528 | RefSeq | XP_006526759.1 | 382 | PREDICTED: prostaglandin D2 receptor 2 isoform X2 [Mus musculus] |
Related Sequences to LMP001542 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6753528 | GenBank | AAP57088.1 | 403 | G protein-coupled receptor 44 [Rattus norvegicus] |
| GI:6753528 | GenBank | EDM12854.1 | 403 | rCG48174 [Rattus norvegicus] |
| GI:6753528 | RefSeq | NP_001012070.1 | 403 | prostaglandin D2 receptor 2 [Rattus norvegicus] |
| GI:6753528 | RefSeq | XP_006231102.1 | 403 | PREDICTED: prostaglandin D2 receptor 2 isoform X1 [Rattus norvegicus] |
| GI:6753528 | RefSeq | XP_008758453.1 | 403 | PREDICTED: prostaglandin D2 receptor 2 isoform X1 [Rattus norvegicus] |
| GI:6753528 | SwissProt | Q6XKD3.1 | 403 | RecName: Full=Prostaglandin D2 receptor 2; AltName: Full=G protein-coupled receptor 44 [Rattus norvegicus] |