Gene/Proteome Database (LMPD)

LMPD ID
LMP001546
Gene ID
18010
Species
Mus musculus (Mouse)
Gene Name
neuraminidase 1
Gene Symbol
Neu1
Synonyms
AA407268; AA407316; Aglp; Apl; Bat-7; Bat7; G9; Map-2; Neu; Neu-1
Alternate Names
sialidase-1; sialidase 1; G9 sialidase; lysosomal sialidase; HLA-B-associated transcript 7; N-acetyl-alpha-neuraminidase 1
Chromosome
17
Map Location
17 B1|17 18.48 cM
EC Number
3.2.1.18

Proteins

sialidase-1 precursor
Refseq ID NP_035023
Protein GI 254939721
UniProt ID O35657
mRNA ID NM_010893
Length 409
RefSeq Status VALIDATED
MVGADPTRPRGPLSYWAGRRGQGLAAIFLLLVSAAESEARAEDDFSLVQPLVTMEQLLWVSGKQIGSVDTFRIPLITATPRGTLLAFAEARKKSASDEGAKFIAMRRSTDQGSTWSSTAFIVDDGEASDGLNLGAVVNDVDTGIVFLIYTLCAHKVNCQVASTMLVWSKDDGISWSPPRNLSVDIGTEMFAPGPGSGIQKQREPGKGRLIVCGHGTLERDGVFCLLSDDHGASWHYGTGVSGIPFGQPKHDHDFNPDECQPYELPDGSVIINARNQNNYHCRCRIVLRSYDACDTLRPRDVTFDPELVDPVVAAGALATSSGIVFFSNPAHPEFRVNLTLRWSFSNGTSWQKERVQVWPGPSGYSSLTALENSTDGKKQPPQLFVLYEKGLNRYTESISMVKISVYGTL
sig_peptide: 1..41 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 4313 peptide sequence: MVGADPTRPRGPLSYWAGRRGQGLAAIFLLLVSAAESEARA mat_peptide: 42..409 product: Sialidase-1 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (O35657.1) calculated_mol_wt: 40297 peptide sequence: EDDFSLVQPLVTMEQLLWVSGKQIGSVDTFRIPLITATPRGTLLAFAEARKKSASDEGAKFIAMRRSTDQGSTWSSTAFIVDDGEASDGLNLGAVVNDVDTGIVFLIYTLCAHKVNCQVASTMLVWSKDDGISWSPPRNLSVDIGTEMFAPGPGSGIQKQREPGKGRLIVCGHGTLERDGVFCLLSDDHGASWHYGTGVSGIPFGQPKHDHDFNPDECQPYELPDGSVIINARNQNNYHCRCRIVLRSYDACDTLRPRDVTFDPELVDPVVAAGALATSSGIVFFSNPAHPEFRVNLTLRWSFSNGTSWQKERVQVWPGPSGYSSLTALENSTDGKKQPPQLFVLYEKGLNRYTESISMVKISVYGTL

Gene Information

Entrez Gene ID
18010
Gene Name
neuraminidase 1
Gene Symbol
Neu1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030054 IEA:Ensembl C cell junction
GO:0031410 IEA:UniProtKB-KW C cytoplasmic vesicle
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005764 IDA:MGI C lysosome
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0052794 IEA:UniProtKB-EC F exo-alpha-(2->3)-sialidase activity
GO:0052795 IEA:UniProtKB-EC F exo-alpha-(2->6)-sialidase activity
GO:0052796 IEA:UniProtKB-EC F exo-alpha-(2->8)-sialidase activity
GO:0004308 IDA:MGI F exo-alpha-sialidase activity
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0009313 ISS:UniProtKB P oligosaccharide catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu04142 Lysosome
mmu00600 Sphingolipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5893995 Glycosphingolipid metabolism
5893781 Sialic acid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR026856 Sialidase family
IPR011040 Sialidases

UniProt Annotations

Entry Information

Gene Name
neuraminidase 1
Protein Entry
NEUR1_MOUSE
UniProt ID
O35657
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. {ECO:0000269|PubMed:9363440, ECO:0000269|PubMed:9384611}.
Domain A C-terminal internalization signal (YGTL) appears to allow the targeting of plasma membrane proteins to endosomes.
Function Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage. {ECO:0000269|PubMed:9363440, ECO:0000269|PubMed:9384611}.
Ptm N-glycosylated. {ECO:0000305}.
Ptm Phosphorylation of tyrosine within the internalization signal results in inhibition of sialidase internalization and blockage on the plasma membrane.
Similarity Belongs to the glycosyl hydrolase 33 family. {ECO:0000305}.
Similarity Contains 4 BNR repeats. {ECO:0000305}.
Subcellular Location Lysosome membrane {ECO:0000269|PubMed:9384611}; Peripheral membrane protein {ECO:0000269|PubMed:9384611}; Lumenal side {ECO:0000269|PubMed:9384611}. Lysosome lumen {ECO:0000269|PubMed:9384611}. Cell membrane {ECO:0000269|PubMed:9384611}. Cytoplasmic vesicle {ECO:0000269|PubMed:9384611}. Note=Localized not only on the inner side of the lysosomal membrane and in the lysosomal lumen, but also on the plasma membrane and in intracellular vesicles.
Subunit Interacts with cathepsin A (protective protein), beta- galactosidase and N-acetylgalactosamine-6-sulfate sulfatase in a multienzyme complex.
Tissue Specificity Highly expressed in kidney, epididymis, followed by brain, spinal cord and weakly expressed in adrenal, heart, liver, lung and spleen. {ECO:0000269|PubMed:9384611}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001546 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
254939721 RefSeq NP_035023 409 sialidase-1 precursor

Identical Sequences to LMP001546 proteins

Reference Database Accession Length Protein Name
GI:254939721 DBBJ BAE26586.1 409 unnamed protein product [Mus musculus]
GI:254939721 EMBL CAA72215.1 409 G9 sialidase [Mus musculus]
GI:254939721 GenBank AAC84167.1 409 G9 [Mus musculus]
GI:254939721 GenBank EDL26719.1 409 neuraminidase 1, isoform CRA_a [Mus musculus]
GI:254939721 SwissProt O35657.1 409 RecName: Full=Sialidase-1; AltName: Full=G9 sialidase; AltName: Full=Lysosomal sialidase; AltName: Full=N-acetyl-alpha-neuraminidase 1; Flags: Precursor [Mus musculus]

Related Sequences to LMP001546 proteins

Reference Database Accession Length Protein Name
GI:254939721 EMBL CAE83976.1 409 neuraminidase 1 [Rattus norvegicus]
GI:254939721 GenBank AAC53536.1 409 lysosomal sialidase [Mus musculus]
GI:254939721 GenBank AAH04666.1 409 Neuraminidase 1 [Mus musculus]
GI:254939721 GenBank AAI00640.1 409 Sialidase 1 (lysosomal sialidase) [Rattus norvegicus]
GI:254939721 GenBank EDL83469.1 409 neuraminidase 1, isoform CRA_b [Rattus norvegicus]
GI:254939721 RefSeq NP_113710.2 409 sialidase-1 precursor [Rattus norvegicus]