Gene/Proteome Database (LMPD)
LMPD ID
LMP001552
Gene ID
Species
Homo sapiens (Human)
Gene Name
sphingosine-1-phosphate receptor 4
Gene Symbol
Synonyms
EDG6; LPC1; S1P4; SLP4
Alternate Names
sphingosine 1-phosphate receptor 4; S1P receptor 4; S1P receptor Edg-6; sphingosine 1-phosphate receptor Edg-6; endothelial differentiation G-protein coupled receptor 6; endothelial differentiation, G protein coupled receptor 6; endothelial differentiation, G-protein-coupled receptor 6; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 6
Chromosome
19
Map Location
19p13.3
Summary
This gene is a member of the endothelial differentiation, G-protein-coupled (EDG)) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| sphingosine 1-phosphate receptor 4 precursor | |
|---|---|
| Refseq ID | NP_003766 |
| Protein GI | 4503459 |
| UniProt ID | O95977 |
| mRNA ID | NM_003775 |
| Length | 384 |
| RefSeq Status | REVIEWED |
| MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDSFRGSRSLSFRMREPLSSISSVRSI | |
| sig_peptide: 1..22 calculated_mol_wt: 2127 peptide sequence: MNATGTPVAPESCQQLAAGGHS mat_peptide: 23..384 product: sphingosine 1-phosphate receptor 4 calculated_mol_wt: 39514 peptide sequence: RLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDSFRGSRSLSFRMREPLSSISSVRSI | |
Gene Information
Entrez Gene ID
Gene Name
sphingosine-1-phosphate receptor 4
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005887 | TAS:ProtInc | C | integral component of plasma membrane |
| GO:0005886 | TAS:Reactome | C | plasma membrane |
| GO:0004930 | TAS:ProtInc | F | G-protein coupled receptor activity |
| GO:0008289 | TAS:ProtInc | F | lipid binding |
| GO:0038036 | IEA:InterPro | F | sphingosine-1-phosphate receptor activity |
| GO:0007186 | TAS:ProtInc | P | G-protein coupled receptor signaling pathway |
| GO:0007202 | TAS:ProtInc | P | activation of phospholipase C activity |
| GO:0007189 | IEA:Ensembl | P | adenylate cyclase-activating G-protein coupled receptor signaling pathway |
| GO:0006955 | TAS:ProtInc | P | immune response |
| GO:0007204 | TAS:ProtInc | P | positive regulation of cytosolic calcium ion concentration |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa04068 | FoxO signaling pathway |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_19231 | G alpha (i) signalling events |
| REACT_18365 | Lysosphingolipid and LPA receptors |
Domain Information
UniProt Annotations
Entry Information
Gene Name
sphingosine-1-phosphate receptor 4
Protein Entry
S1PR4_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Function | Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes. {ECO |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Specifically expressed in fetal and adult lymphoid and hematopoietic tissue as well as in lung. Considerable level of expression in adult and fetal spleen as well as adult peripheral leukocytes and lung. Lower expression in adult thymus, lymph node, bone marrow, and appendix as well as in fetal liver, thymus, and lung. |
Identical and Related Proteins
Unique RefSeq proteins for LMP001552 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 4503459 | RefSeq | NP_003766 | 384 | sphingosine 1-phosphate receptor 4 precursor |
Identical Sequences to LMP001552 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4503459 | GenBank | EAW69337.1 | 384 | endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 6, isoform CRA_a [Homo sapiens] |
| GI:4503459 | GenBank | ACR85433.1 | 384 | Sequence 10 from patent US 7521192 |
| GI:4503459 | GenBank | ADF24396.1 | 384 | Sequence 37 from patent US 7691563 |
| GI:4503459 | GenBank | AIC50182.1 | 384 | S1PR4, partial [synthetic construct] |
| GI:4503459 | RefSeq | XP_003819303.1 | 384 | PREDICTED: sphingosine 1-phosphate receptor 4 isoform X1 [Pan paniscus] |
| GI:4503459 | RefSeq | XP_004059778.1 | 384 | PREDICTED: sphingosine 1-phosphate receptor 4 [Gorilla gorilla gorilla] |
Related Sequences to LMP001552 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4503459 | EMBL | CAJ28074.1 | 400 | unnamed protein product, partial [Homo sapiens] |
| GI:4503459 | GenBank | AAQ31798.1 | 384 | Sequence 13 from patent US 6566096 |
| GI:4503459 | GenBank | AAY71823.1 | 384 | Sequence 4 from patent US 6887683 |
| GI:4503459 | GenBank | EHH29458.1 | 384 | Sphingosine 1-phosphate receptor 4 [Macaca mulatta] |
| GI:4503459 | RefSeq | XP_002828480.1 | 384 | PREDICTED: sphingosine 1-phosphate receptor 4 [Pongo abelii] |
| GI:4503459 | RefSeq | XP_010365604.1 | 384 | PREDICTED: sphingosine 1-phosphate receptor 4 [Rhinopithecus roxellana] |