Gene/Proteome Database (LMPD)
LMPD ID
LMP001560
Gene ID
Species
Homo sapiens (Human)
Gene Name
phosphoinositide-3-kinase, regulatory subunit 2 (beta)
Gene Symbol
Synonyms
MPPH; MPPH1; P85B; p85; p85-BETA
Alternate Names
phosphatidylinositol 3-kinase regulatory subunit beta; PI3-kinase subunit p85-beta; PI3K regulatory subunit beta; ptdIns-3-kinase regulatory subunit p85-beta; phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)
Chromosome
19
Map Location
19q13.2-q13.4
Summary
Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2012]
Orthologs
Proteins
| phosphatidylinositol 3-kinase regulatory subunit beta | |
|---|---|
| Refseq ID | NP_005018 |
| Protein GI | 4826908 |
| UniProt ID | O00459 |
| mRNA ID | NM_005027 |
| Length | 728 |
| RefSeq Status | REVIEWED |
| MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGLNERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSPPDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLALPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVARRAPALGPAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPPALPPKPPKAKPAPTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPPAAR | |
Gene Information
Entrez Gene ID
Gene Name
phosphoinositide-3-kinase, regulatory subunit 2 (beta)
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005829 | TAS:Reactome | C | cytosol |
| GO:0005942 | IEA:InterPro | C | phosphatidylinositol 3-kinase complex |
| GO:0035014 | IEA:InterPro | F | phosphatidylinositol 3-kinase regulator activity |
| GO:0030971 | IPI:UniProtKB | F | receptor tyrosine kinase binding |
| GO:0038095 | TAS:Reactome | P | Fc-epsilon receptor signaling pathway |
| GO:0038096 | TAS:Reactome | P | Fc-gamma receptor signaling pathway involved in phagocytosis |
| GO:0050852 | TAS:Reactome | P | T cell receptor signaling pathway |
| GO:0007596 | TAS:Reactome | P | blood coagulation |
| GO:0007173 | TAS:Reactome | P | epidermal growth factor receptor signaling pathway |
| GO:0008543 | TAS:Reactome | P | fibroblast growth factor receptor signaling pathway |
| GO:0045087 | TAS:Reactome | P | innate immune response |
| GO:0008286 | TAS:Reactome | P | insulin receptor signaling pathway |
| GO:0050900 | TAS:Reactome | P | leukocyte migration |
| GO:0048011 | TAS:Reactome | P | neurotrophin TRK receptor signaling pathway |
| GO:0006661 | TAS:Reactome | P | phosphatidylinositol biosynthetic process |
| GO:0036092 | ISS:GOC | P | phosphatidylinositol-3-phosphate biosynthetic process |
| GO:0048015 | TAS:Reactome | P | phosphatidylinositol-mediated signaling |
| GO:0006644 | TAS:Reactome | P | phospholipid metabolic process |
| GO:0051056 | TAS:Reactome | P | regulation of small GTPase mediated signal transduction |
| GO:0007264 | TAS:Reactome | P | small GTPase mediated signal transduction |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
KEGG Pathway Links
Domain Information
UniProt Annotations
Entry Information
Gene Name
phosphoinositide-3-kinase, regulatory subunit 2 (beta)
Protein Entry
P85B_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Disease | Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1 (MPPH1) [MIM |
| Domain | The SH2 2 domain is required for interaction with FBXL2 and PTPN13. |
| Function | Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5- trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). |
| Interaction | P10275:AR; NbExp=14; IntAct=EBI-346930, EBI-608057; P00533:EGFR; NbExp=3; IntAct=EBI-346930, EBI-297353; P04626:ERBB2; NbExp=6; IntAct=EBI-346930, EBI-641062; P21860:ERBB3; NbExp=16; IntAct=EBI-346930, EBI-720706; Q13480:GAB1; NbExp=23; IntAct=EBI-346930, EBI-517684; P62993:GRB2; NbExp=4; IntAct=EBI-346930, EBI-401755; P42858:HTT; NbExp=6; IntAct=EBI-346930, EBI-466029; P10721:KIT; NbExp=19; IntAct=EBI-346930, EBI-1379503; P08581:MET; NbExp=11; IntAct=EBI-346930, EBI-1039152; P03496:NS (xeno); NbExp=8; IntAct=EBI-346930, EBI-2547442; P42338:PIK3CB; NbExp=3; IntAct=EBI-346930, EBI-2609540; |
| Ptm | Phosphorylated in response to signaling from activated receptor-type protein kinases (PubMed:19690332, PubMed:20068231). Dephosphorylated by PTPRJ (PubMed:18348712). Dephosphorylated at Tyr-655 by PTPN13. Phosphorylation of Tyr-655 impairs while its dephosphorylation promotes interaction with FBXL2 and SCF(FBXL2)- mediated polyubiquitination (PubMed:23604317). {ECO |
| Ptm | Ubiquitinated. Polyubiquitination by the SCF(FBXL2) complex probably promotes proteasomal degradation of PIK3R2. |
| Similarity | Belongs to the PI3K p85 subunit family. |
| Similarity | Contains 1 Rho-GAP domain. {ECO |
| Similarity | Contains 1 SH3 domain. {ECO |
| Similarity | Contains 2 SH2 domains. {ECO |
| Subunit | Heterodimer of a regulatory subunit PIK3R2 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD) (PubMed:23604317). Interacts with AXL (PubMed:9178760). Interacts with FLT1 (tyrosine-phosphorylated) and FLT4 (tyrosine-phosphorylated) (PubMed:9600074, PubMed:15102829). Interacts with NYAP1, NYAP2 and MYO16 (By similarity). Interacts with FBXL2; PIK3R2 is a substrate of the SCF(FBXL2) complex (PubMed:23604317). Interacts with PTPN13; dephosphorylates PIK3R2 (PubMed:23604317). {ECO |
Identical and Related Proteins
Unique RefSeq proteins for LMP001560 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 4826908 | RefSeq | NP_005018 | 728 | phosphatidylinositol 3-kinase regulatory subunit beta |
Identical Sequences to LMP001560 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4826908 | GenBank | JAA29964.1 | 728 | phosphoinositide-3-kinase, regulatory subunit 2 (beta) [Pan troglodytes] |
| GI:4826908 | GenBank | JAA29965.1 | 728 | phosphoinositide-3-kinase, regulatory subunit 2 (beta) [Pan troglodytes] |
| GI:4826908 | GenBank | JAA29966.1 | 728 | phosphoinositide-3-kinase, regulatory subunit 2 (beta) [Pan troglodytes] |
| GI:4826908 | GenBank | JAA41722.1 | 728 | phosphoinositide-3-kinase, regulatory subunit 2 (beta) [Pan troglodytes] |
| GI:4826908 | GenBank | JAA41723.1 | 728 | phosphoinositide-3-kinase, regulatory subunit 2 (beta) [Pan troglodytes] |
| GI:4826908 | GenBank | AHD73277.1 | 728 | Sequence 10345 from patent US 8586006 |
Related Sequences to LMP001560 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4826908 | GenBank | AAD22671.1 | 728 | P85B_HUMAN [Homo sapiens] |
| GI:4826908 | GenBank | EAW84659.1 | 728 | phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta), isoform CRA_a [Homo sapiens] |
| GI:4826908 | GenBank | EAW84660.1 | 728 | phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta), isoform CRA_a [Homo sapiens] |
| GI:4826908 | GenBank | AFH32818.1 | 727 | phosphatidylinositol 3-kinase regulatory subunit beta [Macaca mulatta] |
| GI:4826908 | RefSeq | XP_003275871.1 | 727 | PREDICTED: phosphatidylinositol 3-kinase regulatory subunit beta isoform 1 [Nomascus leucogenys] |
| GI:4826908 | SwissProt | O00459.2 | 728 | RecName: Full=Phosphatidylinositol 3-kinase regulatory subunit beta; Short=PI3-kinase regulatory subunit beta; Short=PI3K regulatory subunit beta; Short=PtdIns-3-kinase regulatory subunit beta; AltName: Full=Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta; Short=PI3-kinase subunit p85-beta; Short=PtdIns-3-kinase regulatory subunit p85-beta [Homo sapiens] |