Gene/Proteome Database (LMPD)
LMPD ID
LMP001565
Gene ID
Species
Mus musculus (Mouse)
Gene Name
sphingomyelin phosphodiesterase 2, neutral
Gene Symbol
Synonyms
AW108287; nSMase; nSMase1
Alternate Names
sphingomyelin phosphodiesterase 2; N-SMase; lyso-PAF-PLC; neutral sphingomyelinase 1; lyso-platelet-activating factor-phospholipase C
Chromosome
10
Map Location
10 B2|10
EC Number
3.1.4.12
Summary
This gene encodes a protein with similarity to the human nSMase1 protein. In humans, the nSMase1 protein was initially identified as a sphingomyelinase based on sequence similarity between bacterial sphingomyelinases and a yeast protein. Subsequent studies showed that its biological function is less likely to be as a sphingomyelinase and instead as a lysophospholipase. [provided by RefSeq, Oct 2009]
Orthologs
Proteins
| sphingomyelin phosphodiesterase 2 | |
|---|---|
| Refseq ID | NP_033239 |
| Protein GI | 6678031 |
| UniProt ID | O70572 |
| mRNA ID | NM_009213 |
| Length | 419 |
| RefSeq Status | VALIDATED |
| MKLNFSLRLRVFNLNCWDIPYLSKHRADRMKRLGDFLNLENFDLALLEEVWSEQDFQYLRQRLSLTYPDAHYFRSGMIGSGLCVFSKHPIQEIFQHVYSLNGYPYMFHHGDWFCGKSVGLLVLRLSGLVLNAYVTHLHAEYSRQKDIYFAHRVAQAWELAQFIHHTSKNADVVLLCGDLNMHPKDLGCCLLKEWTGLHDAFVETEDFKGSDDGCTMVPKNCYVSQQDLGPFPSGIRIDYVLYKAVSEFHVCCETLKTTTGCDPHSDKPFSDHEALMATLYVKHSPPQEDPCTACGPLERSDLISVLREARTELGLGIAKARWWAAFSGYVIVWGLSLLVLLCVLAAGEEAREVAIILCIPSVGLVLVAGAVYLFHKQEAKGLCRAQAEMLHVLTRETETQDRGSEPHLAYCLQQEGDRA | |
Gene Information
Entrez Gene ID
Gene Name
sphingomyelin phosphodiesterase 2, neutral
Gene Symbol
Species
Mus musculus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005901 | IEA:Ensembl | C | caveola |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0046872 | IEA:UniProtKB-KW | F | metal ion binding |
| GO:0004767 | IMP:MGI | F | sphingomyelin phosphodiesterase activity |
| GO:0046513 | IEA:Ensembl | P | ceramide biosynthetic process |
| GO:0009612 | IEA:Ensembl | P | response to mechanical stimulus |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| mmu00600 | Sphingolipid metabolism |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY3DJ-11281 | sphingomyelin metabolism |
REACTOME Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR005135 | Endonuclease/exonuclease/phosphatase |
UniProt Annotations
Entry Information
Gene Name
sphingomyelin phosphodiesterase 2, neutral
Protein Entry
NSMA_MOUSE
UniProt ID
Species
Mouse
Comments
| Comment Type | Description |
|---|---|
| Biophysicochemical Properties | pH dependence: Optimum pH is 6.5-7.5.; |
| Catalytic Activity | Sphingomyelin + H(2)O = N-acylsphingosine + phosphocholine. |
| Cofactor | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| Disruption Phenotype | Mice lacking Smpd2 and Smpd3 are completely devoid of neutral SMase activity but do not developed sphingomyelin storage abnormalities. {ECO:0000269|PubMed:15764706}. |
| Function | Converts sphingomyelin to ceramide. Hydrolyze 1-acyl-2- lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso- sn-glycero-3-phosphocholine (lyso-platelet-activating factor). The physiological substrate seems to be Lyso-PAF (By similarity). {ECO:0000250}. |
| Pathway | Lipid metabolism; sphingolipid metabolism. |
| Similarity | Belongs to the neutral sphingomyelinase family. {ECO:0000305}. |
| Subcellular Location | Membrane; Multi-pass membrane protein. |
| Tissue Specificity | Although widely expressed in all tissues examined, except the spleen, high enzymatic activity occurs only in the brain. {ECO:0000269|PubMed:9520418}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP001565 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 6678031 | RefSeq | NP_033239 | 419 | sphingomyelin phosphodiesterase 2 |
Identical Sequences to LMP001565 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6678031 | EMBL | CAA10994.1 | 419 | neutral Sphingomyelinase [Mus musculus] |
| GI:6678031 | GenBank | AAH10978.1 | 419 | Sphingomyelin phosphodiesterase 2, neutral [Mus musculus] |
| GI:6678031 | GenBank | AAV98795.1 | 419 | Sequence 2 from patent US 6740512 |
| GI:6678031 | GenBank | EDL04975.1 | 419 | sphingomyelin phosphodiesterase 2, neutral, isoform CRA_b [Mus musculus] |
| GI:6678031 | SwissProt | O70572.1 | 419 | RecName: Full=Sphingomyelin phosphodiesterase 2; AltName: Full=Lyso-platelet-activating factor-phospholipase C; Short=Lyso-PAF-PLC; AltName: Full=Neutral sphingomyelinase; Short=N-SMase; Short=nSMase [Mus musculus] |
Related Sequences to LMP001565 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6678031 | DBBJ | BAB08219.1 | 422 | neutral sphingomyelinase [Rattus norvegicus] |
| GI:6678031 | DBBJ | BAC35861.1 | 419 | unnamed protein product [Mus musculus] |
| GI:6678031 | GenBank | EDL99735.1 | 422 | sphingomyelin phosphodiesterase 2, neutral, isoform CRA_b [Rattus norvegicus] |
| GI:6678031 | RefSeq | NP_112650.1 | 422 | sphingomyelin phosphodiesterase 2 [Rattus norvegicus] |
| GI:6678031 | RefSeq | XP_008771229.1 | 422 | PREDICTED: sphingomyelin phosphodiesterase 2 isoform X1 [Rattus norvegicus] |
| GI:6678031 | SwissProt | Q9ET64.1 | 422 | RecName: Full=Sphingomyelin phosphodiesterase 2; AltName: Full=Lyso-platelet-activating factor-phospholipase C; Short=Lyso-PAF-PLC; AltName: Full=Neutral sphingomyelinase; Short=N-SMase; Short=nSMase [Rattus norvegicus] |