Gene/Proteome Database (LMPD)

LMPD ID
LMP001566
Gene ID
11835
Species
Mus musculus (Mouse)
Gene Name
androgen receptor
Gene Symbol
Ar
Synonyms
AW320017; Tfm
Alternate Names
androgen receptor; testicular feminization; dihydrotestosterone receptor; nuclear receptor subfamily 3 group C member 4
Chromosome
X
Map Location
X C3|X 42.82 cM

Proteins

androgen receptor
Refseq ID NP_038504
Protein GI 7304901
UniProt ID P19091
mRNA ID NM_013476
Length 899
RefSeq Status PROVISIONAL
MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREAIQNPGPRHPEAANIAPPGACLQQRQETSPRRRRRQQHTEDGSPQAHIRGPTGYLALEEEQQPSQQQAASEGHPESSCLPEPGAATAPGKGLPQQPPAPPDQDDSAAPSTLSLLGPTFPGLSSCSADIKDILNEAGTMQLLQQQQQQQQHQQQHQQHQQQQEVISEGSSARAREATGAPSSSKDSYLGGNSTISDSAKELCKAVSVSMGLGVEALEHLSPGEQLRGDCMYASLLGGPPAVRPTPCAPLPECKGLPLDEGPGKSTEETAEYSSFKGGYAKGLEGESLGCSGSSEAGSSGTLEIPSSLSLYKSGALDEAAAYQNRDYYNFPLALSGPPHPPPPTHPHARIKLENPLDYGSAWAAAAAQCRYGDLGSLHGGSVAGPSTGSPPATTSSSWHTLFTAEEGQLYGPGGGGGSSSPSDAGPVAPYGYTRPPQGLTSQESDYSASEVWYPGGVVNRVPYPSPNCVKSEMGPWMENYSGPYGDMRLDSTRDHVLPIDYYFPPQKTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGENSNAGSPTEDPSQKMTVSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ

Gene Information

Entrez Gene ID
11835
Gene Name
androgen receptor
Gene Symbol
Ar
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030424 IEA:Ensembl C axon
GO:0005737 ISS:UniProtKB C cytoplasm
GO:0030425 IEA:Ensembl C dendrite
GO:0000790 ISS:UniProtKB C nuclear chromatin
GO:0005634 ISS:UniProtKB C nucleus
GO:0005886 IDA:MGI C plasma membrane
GO:0043234 ISO:MGI C protein complex
GO:0070974 IDA:UniProtKB F POU domain binding
GO:0005497 IEA:Ensembl F androgen binding
GO:0004882 ISS:UniProtKB F androgen receptor activity
GO:0008013 ISS:UniProtKB F beta-catenin binding
GO:0019899 IPI:BHF-UCL F enzyme binding
GO:0004879 ISS:BHF-UCL F ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0043565 IDA:MGI F sequence-specific DNA binding
GO:0003700 ISS:UniProtKB F sequence-specific DNA binding transcription factor activity
GO:0044212 ISS:UniProtKB F transcription regulatory region DNA binding
GO:0008270 IEA:InterPro F zinc ion binding
GO:0033327 IMP:MGI P Leydig cell differentiation
GO:0060520 IMP:MGI P activation of prostate induction by androgen receptor signaling pathway
GO:0030521 IDA:MGI P androgen receptor signaling pathway
GO:0009987 IDA:MGI P cellular process
GO:0060742 IMP:MGI P epithelial cell differentiation involved in prostate gland development
GO:0003382 IGI:MGI P epithelial cell morphogenesis
GO:0009566 IMP:MGI P fertilization
GO:0001701 IMP:MGI P in utero embryonic development
GO:0030522 ISS:BHF-UCL P intracellular receptor signaling pathway
GO:0060599 IMP:MGI P lateral sprouting involved in mammary gland duct morphogenesis
GO:0048808 IMP:MGI P male genitalia morphogenesis
GO:0008584 IMP:MGI P male gonad development
GO:0019102 IMP:MGI P male somatic sex determination
GO:0060749 IMP:MGI P mammary gland alveolus development
GO:0060571 IMP:MGI P morphogenesis of an epithelial fold
GO:0035264 IGI:MGI P multicellular organism growth
GO:0050680 IMP:MGI P negative regulation of epithelial cell proliferation
GO:2001237 ISS:BHF-UCL P negative regulation of extrinsic apoptotic signaling pathway
GO:0045720 ISS:UniProtKB P negative regulation of integrin biosynthetic process
GO:0048645 IMP:MGI P organ formation
GO:0043410 IMP:MGI P positive regulation of MAPK cascade
GO:0051092 ISS:UniProtKB P positive regulation of NF-kappaB transcription factor activity
GO:0008284 ISS:UniProtKB P positive regulation of cell proliferation
GO:0043568 IMP:MGI P positive regulation of insulin-like growth factor receptor signaling pathway
GO:0033148 IMP:MGI P positive regulation of intracellular estrogen receptor signaling pathway
GO:0042327 ISS:UniProtKB P positive regulation of phosphorylation
GO:0045944 ISS:UniProtKB P positive regulation of transcription from RNA polymerase II promoter
GO:0045893 ISS:UniProtKB P positive regulation of transcription, DNA-templated
GO:0060740 IMP:MGI P prostate gland epithelium morphogenesis
GO:0060736 IMP:MGI P prostate gland growth
GO:0051259 ISO:MGI P protein oligomerization
GO:0050790 IMP:MGI P regulation of catalytic activity
GO:0048638 IMP:MGI P regulation of developmental growth
GO:0090003 ISS:UniProtKB P regulation of establishment of protein localization to plasma membrane
GO:0010468 IMP:MGI P regulation of gene expression
GO:0060685 IGI:MGI P regulation of prostatic bud formation
GO:0003073 IGI:MGI P regulation of systemic arterial blood pressure
GO:0006357 IMP:MGI P regulation of transcription from RNA polymerase II promoter
GO:0006355 IDA:MGI P regulation of transcription, DNA-templated
GO:0048608 IMP:MGI P reproductive structure development
GO:0061458 IGI:MGI P reproductive system development
GO:0032868 IEA:Ensembl P response to insulin
GO:0072520 IMP:MGI P seminiferous tubule development
GO:0007338 IGI:MGI P single fertilization
GO:0007283 IMP:MGI P spermatogenesis
GO:0060748 IMP:MGI P tertiary branching involved in mammary gland duct morphogenesis
GO:0006351 ISS:UniProtKB P transcription, DNA-templated

KEGG Pathway Links

KEGG Pathway ID Description
mmu04114 Oocyte meiosis

Domain Information

InterPro Annotations

Accession Description
IPR001103 Androgen receptor
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
androgen receptor
Protein Entry
ANDR_MOUSE
UniProt ID
P19091
Species
Mouse

Comments

Comment Type Description
Domain Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. In the presence of bound steroid the ligand-binding domain interacts with the N-terminal modulating domain, and thereby activates AR transcription factor activity. Agonist binding is required for dimerization and binding to target DNA. The transcription factor activity of the complex formed by ligand-activated AR and DNA is modulated by interactions with coactivator and corepressor proteins. Interaction with RANBP9 is mediated by both the N- terminal domain and the DNA-binding domain. Interaction with EFCAB6/DJBP is mediated by the DNA-binding domain (By similarity). {ECO:0000250}.
Function Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 (By similarity). {ECO:0000250}.
Interaction O89110:Casp8; NbExp=2; IntAct=EBI-1776062, EBI-851690;
Miscellaneous In the absence of ligand, steroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity. The hormone- receptor complex appears to recognize discrete DNA sequences upstream of transcriptional start sites.
Miscellaneous Transcriptional activity is enhanced by binding to RANBP9.
Ptm Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation (By similarity). {ECO:0000250}.
Ptm Phosphorylated in prostate cancer cells in response to several growth factors including EGF. Phosphorylation is induced by c-Src kinase (CSK). Tyr-514 is one of the major phosphorylation sites and an increase in phosphorylation and Src kinase activity is associated with prostate cancer progression (By similarity). Phosphorylation by TNK2 enhances the DNA-binding and transcriptional activity. Phosphorylation at Ser-61 by CDK9 regulates AR promoter selectivity and cell growth. Phosphorylation by PAK6 leads to AR-mediated transcription inhibition (By similarity). {ECO:0000250}.
Ptm Sumoylated on Lys-381 (major) and Lys-500 (By similarity). Ubiquitinated. Deubiquitinated by USP26 (By similarity). 'Lys-6' and 'Lys-27'-linked polyubiquitination by RNF6 modulates AR transcriptional activity and specificity (By similarity). {ECO:0000250}.
Similarity Belongs to the nuclear hormone receptor family. NR3 subfamily. {ECO:0000305}.
Similarity Contains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}.
Subcellular Location Nucleus. Cytoplasm {ECO:0000250}. Note=Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of GNB2L1 (By similarity). {ECO:0000250}.
Subunit Binds DNA as a homodimer. Part of a ternary complex containing AR, EFCAB6/DJBP and PARK7. Interacts with HIPK3 and NR0B2 in the presence of androgen. The ligand binding domain interacts with KAT7/HBO1 in the presence of dihydrotestosterone. Interacts with EFCAB6/DJBP, PELP1, PQBP1, RANBP9, SPDEF, SRA1, TGFB1I1, ZNF318 and RREB1. The AR N-terminal poly-Gln region binds Ran resulting in enhancement of AR-mediated transactivation. Ran- binding decreases as the poly-Gln length increases. Interacts with ZMIZ1/ZIMP10 and ZMIZ2/ZMIP7 which both enhance its transactivation activity. Interacts with RBAK. Interacts via the ligand-binding domain with LXXLL and FXXLF motifs from NCOA1, NCOA2, NCOA3, NCOA4 and MAGEA11. Interacts with HIP1 (via coiled coil domain). Interacts with SLC30A9 and RAD54L2/ARIP4. Interacts with MACROD1. Interacts (via ligand-binding domain) with TRIM68. Interacts with TNK2. Interacts with USP26. Interacts with RNF6. Interacts (regulated by RNF6 probably through polyubiquitination) with RNF14; regulates AR transcriptional activity. Interacts with PRMT2 and TRIM24. Interacts with GNB2L1/RACK1. Interacts with RANBP10; this interaction enhances hormone-induced AR transcriptional activity. Interacts with PRPF6 in a hormone- independent way; this interaction enhances hormone-induced AR transcriptional activity. Interacts with STK4/MST1. Interacts with ZIPK/DAPK3. Interacts with LPXN. Interacts with MAK. Part of a complex containing AR, MAK and NCOA3. Interacts with CRY1. {ECO:0000269|PubMed:12058073, ECO:0000269|PubMed:15199138, ECO:0000269|PubMed:15882980, ECO:0000269|PubMed:15988012, ECO:0000269|PubMed:17911242, ECO:0000269|PubMed:22170608}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001566 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
7304901 RefSeq NP_038504 899 androgen receptor

Identical Sequences to LMP001566 proteins

Reference Database Accession Length Protein Name
GI:7304901 GenBank ADR86071.1 899 Sequence 84 from patent US 7737125
GI:7304901 GenBank AED74997.1 899 Sequence 4 from patent US 7910565
GI:7304901 GenBank AEL83935.1 899 Sequence 84 from patent US 7989429
GI:7304901 GenBank AGN43278.1 899 Sequence 84 from patent US 8450290
GI:7304901 GenBank AGV91522.1 899 Sequence 78 from patent US 8530168
GI:7304901 GenBank AGV97422.1 899 Sequence 4 from patent US 8513210

Related Sequences to LMP001566 proteins

Reference Database Accession Length Protein Name
GI:7304901 GenBank AAA40734.1 901 androgen receptor [Rattus norvegicus]
GI:7304901 GenBank AAA40759.1 902 androgen receptor [Rattus norvegicus]
GI:7304901 GenBank EDL14205.1 885 androgen receptor [Mus musculus]
GI:7304901 GenBank EDL95957.1 902 androgen receptor, isoform CRA_b [Rattus norvegicus]
GI:7304901 pat WO 902 Sequence 3 from Patent WO 8909223
GI:7304901 SwissProt P15207.1 902 RecName: Full=Androgen receptor; AltName: Full=Dihydrotestosterone receptor; AltName: Full=Nuclear receptor subfamily 3 group C member 4 [Rattus norvegicus]