Gene/Proteome Database (LMPD)

LMPD ID
LMP001574
Gene ID
5360
Species
Homo sapiens (Human)
Gene Name
phospholipid transfer protein
Gene Symbol
PLTP
Synonyms
BPIFE; HDLCQ9
Alternate Names
phospholipid transfer protein; lipid transfer protein II; BPI fold containing family E
Chromosome
20
Map Location
20q13.12
Summary
The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for PLTP

Proteins

phospholipid transfer protein isoform a precursor
Refseq ID NP_006218
Protein GI 5453914
UniProt ID P55058
mRNA ID NM_006227
Length 493
RefSeq Status REVIEWED
MALFGALFLALLAGAHAEFPGCKIRVTSKALELVKQEGLRFLEQELETITIPDLRGKEGHFYYNISEVKVTELQLTSSELDFQPQQELMLQITNASLGLRFRRQLLYWFFYDGGYINASAEGVSIRTGLELSRDPAGRMKVSNVSCQASVSRMHAAFGGTFKKVYDFLSTFITSGMRFLLNQQICPVLYHAGTVLLNSLLDTVPVRSSVDELVGIDYSLMKDPVASTSNLDMDFRGAFFPLTERNWSLPNRAVEPQLQEEERMVYVAFSEFFFDSAMESYFRAGALQLLLVGDKVPHDLDMLLRATYFGSIVLLSPAVIDSPLKLELRVLAPPRCTIKPSGTTISVTASVTIALVPPDQPEVQLSSMTMDARLSAKMALRGKALRTQLDLRRFRIYSNHSALESLALIPLQAPLKTMLQIGVMPMLNERTWRGVQIPLPEGINFVHEVVTNHAGFLTIGADLHFAKGLREVIEKNRPADVRASTAPTPSTAAV
phospholipid transfer protein isoform b precursor
Refseq ID NP_872617
Protein GI 33356541
UniProt ID P55058
mRNA ID NM_182676
Length 441
RefSeq Status REVIEWED
MALFGALFLALLAGAHAEFPGCKIRVTSKALELVKQEGLRFLEQELETITIPDLRGKEGHFYYNISEVKVTELQLTSSELDFQPQQELMLQITNASLGLRFRRQLLYWFLKVYDFLSTFITSGMRFLLNQQICPVLYHAGTVLLNSLLDTVPVRSSVDELVGIDYSLMKDPVASTSNLDMDFRGAFFPLTERNWSLPNRAVEPQLQEEERMVYVAFSEFFFDSAMESYFRAGALQLLLVGDKVPHDLDMLLRATYFGSIVLLSPAVIDSPLKLELRVLAPPRCTIKPSGTTISVTASVTIALVPPDQPEVQLSSMTMDARLSAKMALRGKALRTQLDLRRFRIYSNHSALESLALIPLQAPLKTMLQIGVMPMLNERTWRGVQIPLPEGINFVHEVVTNHAGFLTIGADLHFAKGLREVIEKNRPADVRASTAPTPSTAAV
sig_peptide: 1..17 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1687 peptide sequence: MALFGALFLALLAGAHA mat_peptide: 18..398 product: phospholipid transfer protein isoform c calculated_mol_wt: 42467 peptide sequence: EFPGCKIRVTSKALELVKQEGLRFLEQELETITIPDLRGKEGHFYYNISEKVYDFLSTFITSGMRFLLNQQICPVLYHAGTVLLNSLLDTVPVRSSVDELVGIDYSLMKDPVASTSNLDMDFRGAFFPLTERNWSLPNRAVEPQLQEEERMVYVAFSEFFFDSAMESYFRAGALQLLLVGDKVPHDLDMLLRATYFGSIVLLSPAVIDSPLKLELRVLAPPRCTIKPSGTTISVTASVTIALVPPDQPEVQLSSMTMDARLSAKMALRGKALRTQLDLRRFRIYSNHSALESLALIPLQAPLKTMLQIGVMPMLNERTWRGVQIPLPEGINFVHEVVTNHAGFLTIGADLHFAKGLREVIEKNRPADVRASTAPTPSTAAV sig_peptide: 1..17 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1687 peptide sequence: MALFGALFLALLAGAHA mat_peptide: 18..493 product: phospholipid transfer protein isoform a calculated_mol_wt: 53071 peptide sequence: EFPGCKIRVTSKALELVKQEGLRFLEQELETITIPDLRGKEGHFYYNISEVKVTELQLTSSELDFQPQQELMLQITNASLGLRFRRQLLYWFFYDGGYINASAEGVSIRTGLELSRDPAGRMKVSNVSCQASVSRMHAAFGGTFKKVYDFLSTFITSGMRFLLNQQICPVLYHAGTVLLNSLLDTVPVRSSVDELVGIDYSLMKDPVASTSNLDMDFRGAFFPLTERNWSLPNRAVEPQLQEEERMVYVAFSEFFFDSAMESYFRAGALQLLLVGDKVPHDLDMLLRATYFGSIVLLSPAVIDSPLKLELRVLAPPRCTIKPSGTTISVTASVTIALVPPDQPEVQLSSMTMDARLSAKMALRGKALRTQLDLRRFRIYSNHSALESLALIPLQAPLKTMLQIGVMPMLNERTWRGVQIPLPEGINFVHEVVTNHAGFLTIGADLHFAKGLREVIEKNRPADVRASTAPTPSTAAV sig_peptide: 1..17 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1687 peptide sequence: MALFGALFLALLAGAHA mat_peptide: 18..441 product: phospholipid transfer protein isoform b calculated_mol_wt: 47604 peptide sequence: EFPGCKIRVTSKALELVKQEGLRFLEQELETITIPDLRGKEGHFYYNISEVKVTELQLTSSELDFQPQQELMLQITNASLGLRFRRQLLYWFLKVYDFLSTFITSGMRFLLNQQICPVLYHAGTVLLNSLLDTVPVRSSVDELVGIDYSLMKDPVASTSNLDMDFRGAFFPLTERNWSLPNRAVEPQLQEEERMVYVAFSEFFFDSAMESYFRAGALQLLLVGDKVPHDLDMLLRATYFGSIVLLSPAVIDSPLKLELRVLAPPRCTIKPSGTTISVTASVTIALVPPDQPEVQLSSMTMDARLSAKMALRGKALRTQLDLRRFRIYSNHSALESLALIPLQAPLKTMLQIGVMPMLNERTWRGVQIPLPEGINFVHEVVTNHAGFLTIGADLHFAKGLREVIEKNRPADVRASTAPTPSTAAV
phospholipid transfer protein isoform c precursor
Refseq ID NP_001229849
Protein GI 339275807
UniProt ID P55058
mRNA ID NM_001242920
Length 398
RefSeq Status REVIEWED
MALFGALFLALLAGAHAEFPGCKIRVTSKALELVKQEGLRFLEQELETITIPDLRGKEGHFYYNISEKVYDFLSTFITSGMRFLLNQQICPVLYHAGTVLLNSLLDTVPVRSSVDELVGIDYSLMKDPVASTSNLDMDFRGAFFPLTERNWSLPNRAVEPQLQEEERMVYVAFSEFFFDSAMESYFRAGALQLLLVGDKVPHDLDMLLRATYFGSIVLLSPAVIDSPLKLELRVLAPPRCTIKPSGTTISVTASVTIALVPPDQPEVQLSSMTMDARLSAKMALRGKALRTQLDLRRFRIYSNHSALESLALIPLQAPLKTMLQIGVMPMLNERTWRGVQIPLPEGINFVHEVVTNHAGFLTIGADLHFAKGLREVIEKNRPADVRASTAPTPSTAAV
phospholipid transfer protein isoform d
Refseq ID NP_001229850
Protein GI 339275807
UniProt ID P55058
mRNA ID NM_001242921
Length 398
RefSeq Status REVIEWED
MALFGALFLALLAGAHAEFPGCKIRVTSKALELVKQEGLRFLEQELETITIPDLRGKEGHFYYNISEKVYDFLSTFITSGMRFLLNQQICPVLYHAGTVLLNSLLDTVPVRSSVDELVGIDYSLMKDPVASTSNLDMDFRGAFFPLTERNWSLPNRAVEPQLQEEERMVYVAFSEFFFDSAMESYFRAGALQLLLVGDKVPHDLDMLLRATYFGSIVLLSPAVIDSPLKLELRVLAPPRCTIKPSGTTISVTASVTIALVPPDQPEVQLSSMTMDARLSAKMALRGKALRTQLDLRRFRIYSNHSALESLALIPLQAPLKTMLQIGVMPMLNERTWRGVQIPLPEGINFVHEVVTNHAGFLTIGADLHFAKGLREVIEKNRPADVRASTAPTPSTAAV

Gene Information

Entrez Gene ID
5360
Gene Name
phospholipid transfer protein
Gene Symbol
PLTP
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005576 TAS:ProtInc C extracellular region
GO:0005615 IDA:UniProt C extracellular space
GO:0008289 IEA:InterPro F lipid binding
GO:0006629 TAS:ProtInc P lipid metabolic process
GO:0006869 IEA:UniProtKB-KW P lipid transport
GO:0030317 IEA:Ensembl P sperm motility
GO:0010189 IEA:Ensembl P vitamin E biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa03320 PPAR signaling pathway
ko03320 PPAR signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_13621 HDL-mediated lipid transport

Domain Information

InterPro Annotations

Accession Description
IPR017943 Bactericidal permeability-increasing protein, alpha/beta domain
IPR001124 Lipid-binding serum glycoprotein, C-terminal
IPR017942 Lipid-binding serum glycoprotein, N-terminal
IPR017954 Lipid-binding serum glycoprotein, conserved site

UniProt Annotations

Entry Information

Gene Name
phospholipid transfer protein
Protein Entry
PLTP_HUMAN
UniProt ID
P55058
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=P55058-1; Sequence=Displayed; Name=2; IsoId=P55058-2; Sequence=VSP_003050; Name=3; IsoId=P55058-3; Sequence=VSP_045877; Note=No experimental confirmation available.; Name=4; IsoId=P55058-4; Sequence=VSP_054028; Note=No experimental confirmation available.;
Function Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine. Essential for the transfer of excess surface lipids from triglyceride-rich lipoproteins to HDL, thereby facilitating the formation of smaller lipoprotein remnants, contributing to the formation of LDL, and assisting in the maturation of HDL particles. PLTP also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion. Two distinct forms of PLTP exist in plasma: an active form that can transfer PC from phospholipid vesicles to high-density lipoproteins (HDL), and an inactive form that lacks this capability.
Similarity Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
Subcellular Location Secreted.
Tissue Specificity Wide tissue distribution. Placenta > pancreas > lung > kidney > heart > liver > skeletal muscle > brain.
Web Resource Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/pltp/";

Identical and Related Proteins

Unique RefSeq proteins for LMP001574 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
5453914 RefSeq NP_006218 493 phospholipid transfer protein isoform a precursor
33356541 RefSeq NP_872617 441 phospholipid transfer protein isoform b precursor
339275807 RefSeq NP_001229849 398 phospholipid transfer protein isoform c precursor
339275807 RefSeq NP_001229850 398 phospholipid transfer protein isoform d

Identical Sequences to LMP001574 proteins

Reference Database Accession Length Protein Name
GI:33356541 DBBJ BAF82060.1 441 unnamed protein product [Homo sapiens]
GI:339275807 GenBank ACW17287.1 398 Sequence 735 from patent US 7553948
GI:339275807 GenBank ACW17287.1 398 Sequence 735 from patent US 7553948
GI:339275807 GenBank ACW32778.1 398 Sequence 1327 from patent US 7569662
GI:339275807 GenBank ACW32778.1 398 Sequence 1327 from patent US 7569662
GI:339275807 GenBank ADF17277.1 398 Sequence 1327 from patent US 7667001
GI:339275807 GenBank ADF17277.1 398 Sequence 1327 from patent US 7667001
GI:33356541 GenBank ADT47298.1 441 Sequence 959 from patent US 7842466
GI:339275807 GenBank AED65101.1 398 Sequence 735 from patent US 7906635
GI:339275807 GenBank AED65101.1 398 Sequence 735 from patent US 7906635
GI:33356541 GenBank AFL26172.1 441 Sequence 521 from patent US 8168586
GI:5453914 GenBank AGV81945.1 493 Sequence 267 from patent US 8524238
GI:5453914 GenBank AGV81946.1 493 Sequence 268 from patent US 8524238
GI:5453914 GenBank AGV81947.1 493 Sequence 269 from patent US 8524238
GI:5453914 GenBank AGV81948.1 493 Sequence 270 from patent US 8524238
GI:5453914 GenBank AGV81950.1 493 Sequence 272 from patent US 8524238
GI:33356541 GenBank AGV82199.1 441 Sequence 521 from patent US 8524238
GI:5453914 GenBank AHD78235.1 493 Sequence 25572 from patent US 8586006
GI:33356541 GenBank AHD78236.1 441 Sequence 25573 from patent US 8586006
GI:33356541 GenBank AIC49417.1 441 PLTP, partial [synthetic construct]

Related Sequences to LMP001574 proteins

Reference Database Accession Length Protein Name
GI:5453914 DBBJ BAG53407.1 513 unnamed protein product [Homo sapiens]
GI:33356541 GenBank ABA67436.1 439 Sequence 3078 from patent US 6943241
GI:5453914 GenBank EAW75784.1 513 phospholipid transfer protein, isoform CRA_c [Homo sapiens]
GI:33356541 GenBank ADT47292.1 493 Sequence 953 from patent US 7842466
GI:33356541 GenBank ADT47293.1 493 Sequence 954 from patent US 7842466
GI:33356541 GenBank ADT47294.1 493 Sequence 955 from patent US 7842466
GI:5453914 GenBank ADT47299.1 513 Sequence 960 from patent US 7842466
GI:5453914 GenBank AFL25924.1 513 Sequence 273 from patent US 8168586
GI:5453914 GenBank AGV81951.1 513 Sequence 273 from patent US 8524238
GI:5453914 RefSeq XP_005260496.1 513 PREDICTED: phospholipid transfer protein isoform X1 [Homo sapiens]
GI:339275807 RefSeq XP_005569253.1 461 PREDICTED: phospholipid transfer protein isoform X3 [Macaca fascicularis]
GI:33356541 RefSeq XP_005569253.1 461 PREDICTED: phospholipid transfer protein isoform X3 [Macaca fascicularis]
GI:339275807 RefSeq XP_005569253.1 461 PREDICTED: phospholipid transfer protein isoform X3 [Macaca fascicularis]
GI:33356541 RefSeq XP_005569254.1 441 PREDICTED: phospholipid transfer protein isoform X4 [Macaca fascicularis]
GI:339275807 RefSeq XP_005569254.1 441 PREDICTED: phospholipid transfer protein isoform X4 [Macaca fascicularis]
GI:339275807 RefSeq XP_005569254.1 441 PREDICTED: phospholipid transfer protein isoform X4 [Macaca fascicularis]
GI:339275807 RefSeq XP_005569255.1 418 PREDICTED: phospholipid transfer protein isoform X5 [Macaca fascicularis]
GI:339275807 RefSeq XP_005569255.1 418 PREDICTED: phospholipid transfer protein isoform X5 [Macaca fascicularis]
GI:339275807 RefSeq XP_005569257.1 398 PREDICTED: phospholipid transfer protein isoform X7 [Macaca fascicularis]
GI:339275807 RefSeq XP_005569257.1 398 PREDICTED: phospholipid transfer protein isoform X7 [Macaca fascicularis]
GI:339275807 RefSeq XP_008949626.1 398 PREDICTED: phospholipid transfer protein isoform X2 [Pan paniscus]
GI:339275807 RefSeq XP_008949626.1 398 PREDICTED: phospholipid transfer protein isoform X2 [Pan paniscus]
GI:339275807 RefSeq XP_009435597.1 398 PREDICTED: phospholipid transfer protein isoform X4 [Pan troglodytes]
GI:339275807 RefSeq XP_009435597.1 398 PREDICTED: phospholipid transfer protein isoform X4 [Pan troglodytes]