Gene/Proteome Database (LMPD)
Proteins
| fatty acid synthase | |
|---|---|
| Refseq ID | NP_032014 |
| Protein GI | 93102409 |
| UniProt ID | P19096 |
| mRNA ID | NM_007988 |
| Length | 2504 |
| RefSeq Status | VALIDATED |
| MEEVVIAGMSGKLPESENLQEFWANLIGGVDMVTDDDRRWKAGLYGLPKRSGKLKDLSKFDASFFGVHPKQAHTMDPQLRLLLEVSYEAIVDGGINPASLRGTNTGVWVGVSGSEASEALSRDPETLLGYSMVGCQRAMMANRLSFFFDFKGPSIALDTACSSSLLALQNAYQAIRSGECPAALVGGINLLLKPNTSVQFMKLGMLSPDGTCRSFDDSGSGYCRSEAVVAVLLTKKSLARRVYATILNAGTNTDGSKEQGVTFPSGEVQEQLICSLYQPAGLAPESLEYIEAHGTGTKVGDPQELNGITRSLCAFRQAPLLIGSTKSNMGHPEPASGLAALTKVLLSLEHGVWAPNLHFHNPNPEIPALLDGRLQVVDRPLPVRGGNVGINSFGFGGSNVHVILQPNTRQAPAPTAHAALPHLLHASGRTLEAVQDLLEQGRQHSQDLAFVSMLNDIAATPTAAMPFRGYTVLGVEGRVQEVQQVSTNKRPLWFICSGMGTQWRGMGLSLMRLDSFRESILRSDEAVKPLGVKVSDLLLSTDERTFDDIVHAFVSLTAIQIALIDLLTSVGLKPDGIIGHSLGEVACGYADGCLSQREAVLAAYWRGQCIKDAHLPPGSMAAVGLSWEECKQRCPAGVVPACHNSEDTVTISGPQAAVNEFVEQLKQEGVFAKEVRTGGLAFHSYFMEGIAPTLLQALKKVIREPRPRSARWLSTSIPEAQWQSSLARTSSAEYNVNNLVSPVLFQEALWHIPEHAVVLEIAPHALLQAVLKRGVKSSCTIIPLMKRDHKDNLEFFLTNLGKVHLTGINVNPNALFPPVEFPAPRGTPLISPHIKWDHSQTWDVPVAEDFPNGSSSSSATVYSIDASPESPDHYLVDHCIDGRVIFPGTGYLCLVWKTLARSLGLSLEETPVVFENVSFHQATILPKTGTVALEVRLLEASHAFEVSDTGNLIVSGKVYLWEDPNSKLFDHPEVPTPPESASVSRLTQGEVYKELRLRGYDYGPQFQGICEATLEGEQGKLLWKDNWVTFMDTMLQVSILGSSQQSLQLPTRVTAIYIDPATHRQKVYRLKEDTQVADVTTSRCLGITVSGGIHISRLQTTATSRRQQEQLVPTLEKFVFTPHMEAECLSESTALQKELQLCKGLARALQTKATQQGLKAAMLGQEDPPQHGLPRLLAAACQLQLNGNLQLELGEALAQERLLLPEDPLISGLLNSQALKACVDTALENLSTLKMKVAEVLAGEGHLYSRIPALLNTQPMLQLEYTATDRHPQALKDVQTKLQQHDVAQGQWNPSDPAPSSLGALDLLVCNCALATLGDPALALDNMVAALKEGGFLLVHTVLKGHALGETLACLPSEVQPAPSLLSQEEWESLFSRKALHLVGLKRSFYGTALFLCRRAIPQEKPIFLSVEDTSFQWVDSLKSTLATSSSQPVWLTAMDCPTSGVVGLVNCLRKEPGGHRIRCILLSNLSNTSHAPKLDPGSPELQQVLKHDLVMNVYRDGAWGAFRHFQLEQDKPKEQTAHAFVNVLTRGDLASIRWVSSPLKHTQPSSSGAQLCTVYYASLNFRDIMLATGKLSPDAIPGKWASRDCMLGMEFSGRDRCGRRVMGLVPAEGLATSVLLSSDFLWDVPSSWTLEEAASVPVVYTTAYYSLVVRGRIQRGETVLIHSGSGGVGQAAISIALSLGCRVFTTVGSAEKRAYLQARFPQLDDTSFANSRDTSFEQHVLLHTGGKGVDLVLNSLAEEKLQASVRCLAQHGRFLEIGKFDLSNNHPLGMAIFLKNVTFHGILLDALFEEANDSWREVAALLKAGIRDGVVKPLKCTVFPKAQVEDAFRYMAQGKHIGKVLVQVREEEPEAVLPGAQPTLISAISKTFCPAHKSYIITGGLGGFGLELARWLVLRGAQRLVLTSRSGIRTGYQAKHIREWRRQGIQVLVSTSNVSSLEGARALIAEATKLGPVGGVFNLAMVLRDAMLENQTPELFQDVNKPKYNGTLNLDRATREACPELDYFVAFSSVSCGRGNAGQTNYGFANSTMERICEQRRHDGLPGLAVQWGAIGDVGIVLEAMGTNDTVIGGTLPQRISSCMEVLDLFLNQPHAVLSSFVLAEKKAVAHGDGDTQRDLVKAVAHILGIRDLAGINLDSTLADLGLDSLMGVEVRQILEREHDLVLPMREVRQLTLRKLQEMSSKTDSATDTTAPKSRSDTSLKQNQLNLSTLLVNPEGPTLTQLNSVQSSERPLFLVHPIEGSTTVFHSLAAKLSVPTYGLQCTQAAPLDSIPNLAAYYIDCIKQVQPEGPYRIAGYSFGACVAFEMCSQLQAQQGPAPTHNNLFLFDGSHTYVLAYTQSYRAKMTPGCEAEAEAEALCFFIKQFLDVEHSKVLEALLPLKSLEDRVAASVDLITKSHHSLDRRELSFAAVSFYHKLRAADQYKPKAKYHGNVTLLRAKTGGTYGEDLGADYNLSQVCDGKVSVHIIEGDHRTLLEGSGLESIINIIHSSLAEPRVSVREG | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0070062 | IEA:Ensembl | C | extracellular vesicular exosome |
| GO:0042587 | IDA:MGI | C | glycogen granule |
| GO:0005794 | IEA:Ensembl | C | Golgi apparatus |
| GO:0005739 | IDA:MGI | C | mitochondrion |
| GO:0005886 | IEA:Ensembl | C | plasma membrane |
| GO:0047451 | IEA:UniProtKB-EC | F | 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity |
| GO:0004317 | IEA:InterPro | F | 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity |
| GO:0004316 | IEA:UniProtKB-EC | F | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| GO:0004315 | IEA:UniProtKB-EC | F | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| GO:0004313 | IEA:UniProtKB-EC | F | [acyl-carrier-protein] S-acetyltransferase activity |
| GO:0004314 | IEA:UniProtKB-EC | F | [acyl-carrier-protein] S-malonyltransferase activity |
| GO:0008144 | IEA:Ensembl | F | drug binding |
| GO:0047117 | IEA:UniProtKB-EC | F | enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity |
| GO:0004319 | IEA:InterPro | F | enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity |
| GO:0016295 | IEA:UniProtKB-EC | F | myristoyl-[acyl-carrier-protein] hydrolase activity |
| GO:0070402 | IEA:Ensembl | F | NADPH binding |
| GO:0004320 | IEA:UniProtKB-EC | F | oleoyl-[acyl-carrier-protein] hydrolase activity |
| GO:0016296 | IEA:UniProtKB-EC | F | palmitoyl-[acyl-carrier-protein] hydrolase activity |
| GO:0044822 | IEA:Ensembl | F | poly(A) RNA binding |
| GO:0008270 | IEA:InterPro | F | zinc ion binding |
| GO:0006084 | IEA:Ensembl | P | acetyl-CoA metabolic process |
| GO:0071353 | IDA:MGI | P | cellular response to interleukin-4 |
| GO:0006633 | IEA:UniProtKB-KW | P | fatty acid biosynthetic process |
| GO:0001649 | IEA:Ensembl | P | osteoblast differentiation |
KEGG Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR009081 | Acyl carrier protein-like |
| IPR014043 | Acyl transferase |
| IPR016035 | Acyl transferase/acyl hydrolase/lysophospholipase |
| IPR001227 | Acyl transferase domain |
| IPR013149 | Alcohol dehydrogenase, C-terminal |
| IPR029058 | Alpha/Beta hydrolase fold |
| IPR018201 | Beta-ketoacyl synthase, active site |
| IPR014031 | Beta-ketoacyl synthase, C-terminal |
| IPR014030 | Beta-ketoacyl synthase, N-terminal |
| IPR023102 | Fatty acid synthase, domain 2 |
| IPR011032 | GroES (chaperonin 10)-like |
| IPR016036 | Malonyl-CoA ACP transacylase, ACP-binding |
| IPR013217 | Methyltransferase type 12 |
| IPR016040 | NAD(P)-binding domain |
| IPR006162 | Phosphopantetheine attachment site |
| IPR020843 | Polyketide synthase, enoylreductase domain |
| IPR013968 | Polyketide synthase, ketoreductase domain |
| IPR029063 | S-adenosyl-L-methionine-dependent methyltransferase |
| IPR001031 | Thioesterase |
| IPR016039 | Thiolase-like |
| IPR016038 | Thiolase-like, subgroup |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | (3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl-carrier-protein] + NADPH. |
| Catalytic Activity | A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H(2)O. |
| Catalytic Activity | Acetyl-CoA + [acyl-carrier-protein] = CoA + acetyl-[acyl-carrier-protein]. |
| Catalytic Activity | Acetyl-CoA + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + (n+1) CoA + n CO(2) + 2n NADP(+). |
| Catalytic Activity | Acyl-[acyl-carrier-protein] + malonyl-[acyl- carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein]. |
| Catalytic Activity | An acyl-[acyl-carrier protein] + NADP(+) = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH. |
| Catalytic Activity | Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein]. |
| Catalytic Activity | Oleoyl-[acyl-carrier-protein] + H(2)O = [acyl- carrier-protein] + oleate. |
| Function | Fatty acid synthetase catalyzes the formation of long- chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein. |
| Sequence Caution | Sequence=CAA31525.1; Type=Frameshift; Positions=1842, 1855, 1863, 1964, 1967; Evidence={ECO:0000305}; |
| Similarity | Contains 1 acyl carrier domain. {ECO:0000255|PROSITE- ProRule:PRU00258}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Melanosome {ECO:0000250}. |
| Subunit | Homodimer which is arranged in a head to tail fashion. |
Identical and Related Proteins
Unique RefSeq proteins for LMP001577 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 93102409 | RefSeq | NP_032014 | 2504 | fatty acid synthase |
Identical Sequences to LMP001577 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:93102409 | GenBank | AAG02285.1 | 2504 | fatty acid synthase [Mus musculus] |
| GI:93102409 | GenBank | AAH46513.1 | 2504 | Fatty acid synthase [Mus musculus] |
| GI:93102409 | SwissProt | P19096.2 | 2504 | RecName: Full=Fatty acid synthase; Includes: RecName: Full=[Acyl-carrier-protein] S-acetyltransferase; Includes: RecName: Full=[Acyl-carrier-protein] S-malonyltransferase; Includes: RecName: Full=3-oxoacyl-[acyl-carrier-protein] synthase; Includes: RecName: Full=3-oxoacyl-[acyl-carrier-protein] reductase; Includes: RecName: Full=3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Includes: RecName: Full=Enoyl-[acyl-carrier-protein] reductase; Includes: RecName: Full=Oleoyl-[acyl-carrier-protein] hydrolase [Mus musculus] |
Related Sequences to LMP001577 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:93102409 | DBBJ | BAE27771.1 | 2504 | unnamed protein product [Mus musculus] |
| GI:93102409 | EMBL | CAA44680.1 | 2505 | fatty acid synthase [Rattus norvegicus] |
| GI:93102409 | GenBank | EDL34808.1 | 2518 | fatty acid synthase, isoform CRA_a, partial [Mus musculus] |
| GI:93102409 | GenBank | EDL34809.1 | 2529 | fatty acid synthase, isoform CRA_b [Mus musculus] |
| GI:93102409 | GenBank | EDM06909.1 | 2505 | fatty acid synthase, isoform CRA_b [Rattus norvegicus] |
| GI:93102409 | SwissProt | P12785.3 | 2505 | RecName: Full=Fatty acid synthase; Includes: RecName: Full=[Acyl-carrier-protein] S-acetyltransferase; Includes: RecName: Full=[Acyl-carrier-protein] S-malonyltransferase; Includes: RecName: Full=3-oxoacyl-[acyl-carrier-protein] synthase; Includes: RecName: Full=3-oxoacyl-[acyl-carrier-protein] reductase; Includes: RecName: Full=3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Includes: RecName: Full=Enoyl-[acyl-carrier-protein] reductase; Includes: RecName: Full=Oleoyl-[acyl-carrier-protein] hydrolase [Rattus norvegicus] |