Gene/Proteome Database (LMPD)

LMPD ID
LMP001587
Gene ID
8877
Species
Homo sapiens (Human)
Gene Name
sphingosine kinase 1
Gene Symbol
SPHK1
Synonyms
SPHK
Chromosome
17
Map Location
17q25.2
Summary
The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Orthologs
View orthologs and multiple alignments for SPHK1

Proteins

sphingosine kinase 1 isoform 1
Refseq ID NP_068807
Protein GI 21361088
UniProt ID Q9NYA1
mRNA ID NM_021972
Length 398
RefSeq Status VALIDATED
MDPVVGCGRGLFGFVFSAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLFLAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFWMVSGCVEPPPSWKPQQMPPPEEPL
sphingosine kinase 1 isoform 2
Refseq ID NP_892010
Protein GI 217272880
UniProt ID Q9NYA1
mRNA ID NM_182965
Length 470
RefSeq Status VALIDATED
MSAQVLGFLRSWTPLPLAAPRGPAAAGNDAGAPAATAPGGEGEPHSRPCDARLGSTDKELKAGAAATGSAPTAPGTPWQREPRVEVMDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLFLAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFWMVSGCVEPPPSWKPQQMPPPEEPL
sphingosine kinase 1 isoform 3
Refseq ID NP_001136073
Protein GI 217272883
UniProt ID Q53ZR5
mRNA ID NM_001142601
Length 384
RefSeq Status VALIDATED
MDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLFLAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFWMVSGCVEPPPSWKPQQMPPPEEPL
sphingosine kinase 1 isoform 3
Refseq ID NP_001136074
Protein GI 217272885
UniProt ID Q53ZR5
mRNA ID NM_001142602
Length 384
RefSeq Status VALIDATED
Protein sequence is identical to GI:217272883 (mRNA isoform)

Gene Information

Entrez Gene ID
8877
Gene Name
sphingosine kinase 1
Gene Symbol
SPHK1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030424 IEA:Ensembl C axon
GO:0005737 IDA:HPA C cytoplasm
GO:0005829 IEA:Ensembl C cytosol
GO:0005886 IDA:HPA C plasma membrane
GO:0008021 IEA:Ensembl C synaptic vesicle
GO:0003951 IEA:InterPro F NAD+ kinase activity
GO:0004143 IEA:InterPro F diacylglycerol kinase activity
GO:0001568 IEA:Ensembl P blood vessel development
GO:0007420 IEA:Ensembl P brain development
GO:0071363 IEA:Ensembl P cellular response to growth factor stimulus
GO:0070301 IEA:Ensembl P cellular response to hydrogen peroxide
GO:0009267 IEA:Ensembl P cellular response to starvation
GO:0019371 IEA:Ensembl P cyclooxygenase pathway
GO:0007565 IEA:Ensembl P female pregnancy
GO:0006954 IEA:Ensembl P inflammatory response
GO:0043066 IEA:Ensembl P negative regulation of apoptotic process
GO:0030335 IEA:Ensembl P positive regulation of cell migration
GO:0008284 IEA:Ensembl P positive regulation of cell proliferation
GO:0010976 IEA:Ensembl P positive regulation of neuron projection development
GO:0001956 IEA:Ensembl P positive regulation of neurotransmitter secretion
GO:0001934 IEA:Ensembl P positive regulation of protein phosphorylation
GO:0007205 IEA:InterPro P protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0032651 IEA:Ensembl P regulation of interleukin-1 beta production
GO:0033198 IEA:Ensembl P response to ATP
GO:0014075 IEA:Ensembl P response to amine
GO:0070555 IEA:Ensembl P response to interleukin-1
GO:0032026 IEA:Ensembl P response to magnesium ion
GO:0032570 IEA:Ensembl P response to progesterone

KEGG Pathway Links

KEGG Pathway ID Description
hsa04666 Fc gamma R-mediated phagocytosis
hsa05152 Tuberculosis

Domain Information

InterPro Annotations

Accession Description
IPR016064 ATP-NAD kinase-like domain
IPR001206 Diacylglycerol kinase, catalytic domain

UniProt Annotations

Entry Information

Gene Name
sphingosine kinase 1
Protein Entry
SPHK1_HUMAN
UniProt ID
Q9NYA1
Species
Human

Identical and Related Proteins

Unique RefSeq proteins for LMP001587 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
21361088 RefSeq NP_068807 398 sphingosine kinase 1 isoform 1
217272880 RefSeq NP_892010 470 sphingosine kinase 1 isoform 2
217272883 RefSeq NP_001136073 384 sphingosine kinase 1 isoform 3

Identical Sequences to LMP001587 proteins

Reference Database Accession Length Protein Name
GI:217272883 DBBJ BAF85303.1 384 unnamed protein product [Homo sapiens]
GI:21361088 GenBank AAH09419.1 398 Sphingosine kinase 1 [Homo sapiens]
GI:217272883 GenBank EAW89390.1 384 sphingosine kinase 1, isoform CRA_a [Homo sapiens]
GI:217272883 GenBank EAW89391.1 384 sphingosine kinase 1, isoform CRA_a [Homo sapiens]
GI:21361088 GenBank EAW89393.1 398 sphingosine kinase 1, isoform CRA_c [Homo sapiens]
GI:217272883 GenBank EAW89394.1 384 sphingosine kinase 1, isoform CRA_a [Homo sapiens]
GI:21361088 GenBank AIC55488.1 398 SPHK1, partial [synthetic construct]
GI:21361088 GenBank AIC62646.1 398 SPHK1, partial [synthetic construct]
GI:217272883 RefSeq NP_001136074.1 384 sphingosine kinase 1 isoform 3 [Homo sapiens]
GI:217272883 RefSeq XP_005257823.1 384 PREDICTED: sphingosine kinase 1 isoform X3 [Homo sapiens]

Related Sequences to LMP001587 proteins

Reference Database Accession Length Protein Name
GI:217272883 DBBJ BAF84983.1 470 unnamed protein product [Homo sapiens]
GI:217272880 DBBJ BAF84983.1 470 unnamed protein product [Homo sapiens]
GI:217272880 GenBank AAH30553.1 470 Sphingosine kinase 1 [Homo sapiens]
GI:217272883 GenBank AAH30553.1 470 Sphingosine kinase 1 [Homo sapiens]
GI:217272883 GenBank AAH14439.1 470 Sphingosine kinase 1 [Homo sapiens]
GI:217272880 GenBank AAH14439.1 470 Sphingosine kinase 1 [Homo sapiens]
GI:21361088 GenBank EAW89392.1 470 sphingosine kinase 1, isoform CRA_b [Homo sapiens]
GI:217272880 GenBank EAW89392.1 470 sphingosine kinase 1, isoform CRA_b [Homo sapiens]
GI:217272883 GenBank EAW89392.1 470 sphingosine kinase 1, isoform CRA_b [Homo sapiens]
GI:217272880 GenBank JAA31730.1 470 sphingosine kinase 1 [Pan troglodytes]
GI:217272883 GenBank AIC55489.1 470 SPHK1, partial [synthetic construct]
GI:217272880 GenBank AIC55489.1 470 SPHK1, partial [synthetic construct]
GI:217272883 RefSeq NP_892010.2 470 sphingosine kinase 1 isoform 2 [Homo sapiens]
GI:21361088 RefSeq XP_003279157.1 457 PREDICTED: sphingosine kinase 1 isoform 4 [Nomascus leucogenys]
GI:21361088 RefSeq XP_004040943.1 398 PREDICTED: sphingosine kinase 1 isoform 4 [Gorilla gorilla gorilla]
GI:21361088 RefSeq XP_005585115.1 398 PREDICTED: sphingosine kinase 1 isoform X2 [Macaca fascicularis]
GI:21361088 RefSeq XP_010385826.1 472 PREDICTED: sphingosine kinase 1 isoform X1 [Rhinopithecus roxellana]
GI:21361088 RefSeq XP_010385827.1 472 PREDICTED: sphingosine kinase 1 isoform X1 [Rhinopithecus roxellana]