Gene/Proteome Database (LMPD)
LMPD ID
LMP001592
Gene ID
Species
Homo sapiens (Human)
Gene Name
mevalonate (diphospho) decarboxylase
Gene Symbol
Synonyms
FP17780; MPD
Alternate Names
diphosphomevalonate decarboxylase; MDDase; mevalonate pyrophosphate decarboxylase; mevalonate pyrophosphate decarboxylase
Chromosome
16
Map Location
16q24.3
EC Number
4.1.1.33
Summary
The enzyme mevalonate pyrophosphate decarboxylase catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in cholesterol biosynthesis. It decarboxylates and dehydrates its substrate while hydrolyzing ATP. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| diphosphomevalonate decarboxylase | |
|---|---|
| Refseq ID | NP_002452 |
| Protein GI | 4505289 |
| UniProt ID | P53602 |
| mRNA ID | NM_002461 |
| Length | 400 |
| RefSeq Status | REVIEWED |
| MASEKPLAAVTCTAPVNIAVIKYWGKRDEELVLPINSSLSVTLHQDQLKTTTTAVISKDFTEDRIWLNGREEDVGQPRLQACLREIRCLARKRRNSRDGDPLPSSLSCKVHVASVNNFPTAAGLASSAAGYACLAYTLARVYGVESDLSEVARRGSGSACRSLYGGFVEWQMGEQADGKDSIARQVAPESHWPELRVLILVVSAEKKLTGSTVGMRASVETSPLLRFRAESVVPARMAEMARCIRERDFPSFAQLTMKDSNQFHATCLDTFPPISYLNAISWRIIHLVHRFNAHHGDTKVAYTFDAGPNAVIFTLDDTVAEFVAAVWHGFPPGSNGDTFLKGLQVRPAPLSAELQAALAMEPTPGGVKYIIVTQVGPGPQILDDPCAHLLGPDGLPKPAA | |
Gene Information
Entrez Gene ID
Gene Name
mevalonate (diphospho) decarboxylase
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005829 | IDA:UniProtKB | C | cytosol |
| GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
| GO:0030544 | IPI:UniProtKB | F | Hsp70 protein binding |
| GO:0004163 | IDA:UniProtKB | F | diphosphomevalonate decarboxylase activity |
| GO:0042803 | IDA:UniProtKB | F | protein homodimerization activity |
| GO:0044267 | TAS:Reactome | P | cellular protein metabolic process |
| GO:0006695 | NAS:UniProtKB | P | cholesterol biosynthetic process |
| GO:0006488 | TAS:Reactome | P | dolichol-linked oligosaccharide biosynthetic process |
| GO:0006489 | TAS:Reactome | P | dolichyl diphosphate biosynthetic process |
| GO:0019287 | IEA:InterPro | P | isopentenyl diphosphate biosynthetic process, mevalonate pathway |
| GO:0008299 | IDA:UniProtKB | P | isoprenoid biosynthetic process |
| GO:0008284 | IMP:UniProtKB | P | positive regulation of cell proliferation |
| GO:0043687 | TAS:Reactome | P | post-translational protein modification |
| GO:0018279 | TAS:Reactome | P | protein N-linked glycosylation via asparagine |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa00900 | Terpenoid backbone biosynthesis |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_147904 | Activation of gene expression by SREBF (SREBP) |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR029765 | Diphosphomevalonate decarboxylase |
| IPR005935 | Diphosphomevalonate/phosphomevalonate decarboxylase |
| IPR006204 | GHMP kinase N-terminal domain |
| IPR013750 | GHMP kinase, C-terminal domain |
| IPR020568 | Ribosomal protein S5 domain 2-type fold |
| IPR014721 | Ribosomal protein S5 domain 2-type fold, subgroup |
UniProt Annotations
Entry Information
Gene Name
mevalonate (diphospho) decarboxylase
Protein Entry
MVD1_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Biophysicochemical Properties | Kinetic parameters: KM=7.4 uM for (R)-5-diphosphomevalonate ; KM=0.32 mM for ATP ; |
| Catalytic Activity | ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO(2). |
| Function | Performs the first committed step in the biosynthesis of isoprenes. |
| Pathway | Steroid biosynthesis; cholesterol biosynthesis. |
| Similarity | Belongs to the diphosphomevalonate decarboxylase family. |
| Subunit | Homodimer. |
| Tissue Specificity | Expressed in heart, skeletal muscle, lung, liver, brain, pancreas, kidney and placenta. |
Identical and Related Proteins
Unique RefSeq proteins for LMP001592 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 4505289 | RefSeq | NP_002452 | 400 | diphosphomevalonate decarboxylase |
Identical Sequences to LMP001592 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4505289 | DBBJ | BAI45751.1 | 400 | mevalonate (diphospho) decarboxylase, partial [synthetic construct] |
| GI:4505289 | GenBank | EAW66792.1 | 400 | mevalonate (diphospho) decarboxylase, isoform CRA_c [Homo sapiens] |
| GI:4505289 | GenBank | ABM84650.1 | 400 | mevalonate (diphospho) decarboxylase, partial [synthetic construct] |
| GI:4505289 | GenBank | ABM92179.1 | 400 | mevalonate (diphospho) decarboxylase [synthetic construct] |
| GI:4505289 | PDB | 3D4J | 400 | Chain A, Crystal Structure Of Human Mevalonate Diphosphate Decarboxylase |
| GI:4505289 | PDB | 3D4J | 400 | Chain B, Crystal Structure Of Human Mevalonate Diphosphate Decarboxylase |
Related Sequences to LMP001592 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4505289 | GenBank | AAP36301.1 | 401 | Homo sapiens mevalonate (diphospho) decarboxylase, partial [synthetic construct] |
| GI:4505289 | GenBank | AAX43880.1 | 401 | mevalonate (diphospho) decarboxylase, partial [synthetic construct] |
| GI:4505289 | GenBank | JAA13716.1 | 400 | mevalonate (diphospho) decarboxylase [Pan troglodytes] |
| GI:4505289 | GenBank | JAA34833.1 | 400 | mevalonate (diphospho) decarboxylase [Pan troglodytes] |
| GI:4505289 | RefSeq | XP_523460.3 | 400 | PREDICTED: diphosphomevalonate decarboxylase [Pan troglodytes] |
| GI:4505289 | RefSeq | XP_003805806.1 | 400 | PREDICTED: diphosphomevalonate decarboxylase [Pan paniscus] |