Gene/Proteome Database (LMPD)

LMPD ID
LMP001598
Gene ID
18830
Species
Mus musculus (Mouse)
Gene Name
phospholipid transfer protein
Gene Symbol
Pltp
Synonyms
Bpife; OD107
Alternate Names
phospholipid transfer protein; lipid transfer protein II
Chromosome
2
Map Location
2 H3|2 85.27 cM

Proteins

phospholipid transfer protein precursor
Refseq ID NP_035255
Protein GI 6755112
UniProt ID P55065
mRNA ID NM_011125
Length 493
RefSeq Status VALIDATED
MVLLWALFLALLAGAHAELPGCKIRVTSAALDLVKQEGLRFLEQELETITIPDVYGAKGHFYYNISDVRVTQLHLISSELHFQPDQDLLLNISNASLGLHFRRQLLYWFLYDGGYINASAEGVSIRTGLQLSQDSSGRIKVSNVSCEASVSKMNMAFGGTFRRMYNFFSTFITSGMRFLLNQQICPVLYHAGTVLLNSLLDTVPVRSSVDDLVGIDYSLLKDPVVSNGNLDMEFRGAFFPLKEDNWSLPNRAVEPQLEDDERMVYVAFSEFFFDSAMESYFQAGALQLTLVGDKVPSDLDMLLRATYFGSIVLLSPTVINSPLKLKLEATSPPRCTIKPSGTTISITASVTITLAPPMLPEVELSKMIMEGRLSAKLTLRGKALRVKLDLRRFQIYSNQSALESLALIPLQAPLKTLLQIGVMPLLNERTWRGVQIPLPEGINFVREVVTNHAGFVTVGADLHFAKGLREVIDKNRPADVAASHVPPPSAAAA
sig_peptide: 1..17 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1810 peptide sequence: MVLLWALFLALLAGAHA mat_peptide: 18..493 product: Phospholipid transfer protein experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P55065.1) calculated_mol_wt: 52661 peptide sequence: ELPGCKIRVTSAALDLVKQEGLRFLEQELETITIPDVYGAKGHFYYNISDVRVTQLHLISSELHFQPDQDLLLNISNASLGLHFRRQLLYWFLYDGGYINASAEGVSIRTGLQLSQDSSGRIKVSNVSCEASVSKMNMAFGGTFRRMYNFFSTFITSGMRFLLNQQICPVLYHAGTVLLNSLLDTVPVRSSVDDLVGIDYSLLKDPVVSNGNLDMEFRGAFFPLKEDNWSLPNRAVEPQLEDDERMVYVAFSEFFFDSAMESYFQAGALQLTLVGDKVPSDLDMLLRATYFGSIVLLSPTVINSPLKLKLEATSPPRCTIKPSGTTISITASVTITLAPPMLPEVELSKMIMEGRLSAKLTLRGKALRVKLDLRRFQIYSNQSALESLALIPLQAPLKTLLQIGVMPLLNERTWRGVQIPLPEGINFVREVVTNHAGFVTVGADLHFAKGLREVIDKNRPADVAASHVPPPSAAAA

Gene Information

Entrez Gene ID
18830
Gene Name
phospholipid transfer protein
Gene Symbol
Pltp
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005615 IEA:Ensembl C extracellular space
GO:0008289 IEA:InterPro F lipid binding
GO:0006869 IEA:UniProtKB-KW P lipid transport
GO:0030317 IMP:MGI P sperm motility
GO:0010189 IMP:MGI P vitamin E biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu03320 PPAR signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
5893599 HDL-mediated lipid transport

Domain Information

InterPro Annotations

Accession Description
IPR017943 Bactericidal permeability-increasing protein, alpha/beta domain
IPR001124 Lipid-binding serum glycoprotein, C-terminal
IPR017942 Lipid-binding serum glycoprotein, N-terminal
IPR017954 Lipid-binding serum glycoprotein, conserved site

UniProt Annotations

Entry Information

Gene Name
phospholipid transfer protein
Protein Entry
PLTP_MOUSE
UniProt ID
P55065
Species
Mouse

Comments

Comment Type Description
Function Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine. Essential for the transfer of excess surface lipids from triglyceride-rich lipoproteins to HDL, thereby facilitating the formation of smaller lipoprotein remnants, contributing to the formation of LDL, and assisting in the maturation of HDL particles. PLTP also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion. Two distinct forms of PLTP exist in plasma: an active form that can transfer PC from phospholipid vesicles to high-density lipoproteins (HDL), and an inactive form that lacks this capability (By similarity). {ECO:0000250}.
Similarity Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. {ECO:0000305}.
Subcellular Location Secreted.
Tissue Specificity Highest in lung, adipose tissue, brain, and heart.

Identical and Related Proteins

Unique RefSeq proteins for LMP001598 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6755112 RefSeq NP_035255 493 phospholipid transfer protein precursor

Identical Sequences to LMP001598 proteins

Reference Database Accession Length Protein Name
GI:6755112 DBBJ BAE28485.1 493 unnamed protein product [Mus musculus]
GI:6755112 GenBank AAA80542.1 493 plasma phospholipid transfer protein [Mus musculus]
GI:6755112 GenBank ABH98179.1 493 Sequence 15 from patent US 7070929
GI:6755112 GenBank EDL06430.1 493 phospholipid transfer protein [Mus musculus]
GI:6755112 RefSeq XP_006499015.1 493 PREDICTED: phospholipid transfer protein isoform X1 [Mus musculus]
GI:6755112 SwissProt P55065.1 493 RecName: Full=Phospholipid transfer protein; AltName: Full=Lipid transfer protein II; Flags: Precursor [Mus musculus]

Related Sequences to LMP001598 proteins

Reference Database Accession Length Protein Name
GI:6755112 EMBL CAJ18525.1 493 Pltp [Mus musculus]
GI:6755112 GenBank AAA87943.1 491 plasma phospholipid transfer protein [Mus musculus]
GI:6755112 GenBank AAH03782.1 493 Phospholipid transfer protein [Mus musculus]
GI:6755112 RefSeq NP_001162015.1 496 phospholipid transfer protein precursor [Rattus norvegicus]
GI:6755112 RefSeq XP_006235597.1 600 PREDICTED: phospholipid transfer protein isoform X1 [Rattus norvegicus]
GI:6755112 RefSeq XP_008760698.1 598 PREDICTED: phospholipid transfer protein isoform X2 [Rattus norvegicus]