Gene/Proteome Database (LMPD)
Proteins
| phospholipid transfer protein precursor | |
|---|---|
| Refseq ID | NP_035255 |
| Protein GI | 6755112 |
| UniProt ID | P55065 |
| mRNA ID | NM_011125 |
| Length | 493 |
| RefSeq Status | VALIDATED |
| MVLLWALFLALLAGAHAELPGCKIRVTSAALDLVKQEGLRFLEQELETITIPDVYGAKGHFYYNISDVRVTQLHLISSELHFQPDQDLLLNISNASLGLHFRRQLLYWFLYDGGYINASAEGVSIRTGLQLSQDSSGRIKVSNVSCEASVSKMNMAFGGTFRRMYNFFSTFITSGMRFLLNQQICPVLYHAGTVLLNSLLDTVPVRSSVDDLVGIDYSLLKDPVVSNGNLDMEFRGAFFPLKEDNWSLPNRAVEPQLEDDERMVYVAFSEFFFDSAMESYFQAGALQLTLVGDKVPSDLDMLLRATYFGSIVLLSPTVINSPLKLKLEATSPPRCTIKPSGTTISITASVTITLAPPMLPEVELSKMIMEGRLSAKLTLRGKALRVKLDLRRFQIYSNQSALESLALIPLQAPLKTLLQIGVMPLLNERTWRGVQIPLPEGINFVREVVTNHAGFVTVGADLHFAKGLREVIDKNRPADVAASHVPPPSAAAA | |
| sig_peptide: 1..17 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1810 peptide sequence: MVLLWALFLALLAGAHA mat_peptide: 18..493 product: Phospholipid transfer protein experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P55065.1) calculated_mol_wt: 52661 peptide sequence: ELPGCKIRVTSAALDLVKQEGLRFLEQELETITIPDVYGAKGHFYYNISDVRVTQLHLISSELHFQPDQDLLLNISNASLGLHFRRQLLYWFLYDGGYINASAEGVSIRTGLQLSQDSSGRIKVSNVSCEASVSKMNMAFGGTFRRMYNFFSTFITSGMRFLLNQQICPVLYHAGTVLLNSLLDTVPVRSSVDDLVGIDYSLLKDPVVSNGNLDMEFRGAFFPLKEDNWSLPNRAVEPQLEDDERMVYVAFSEFFFDSAMESYFQAGALQLTLVGDKVPSDLDMLLRATYFGSIVLLSPTVINSPLKLKLEATSPPRCTIKPSGTTISITASVTITLAPPMLPEVELSKMIMEGRLSAKLTLRGKALRVKLDLRRFQIYSNQSALESLALIPLQAPLKTLLQIGVMPLLNERTWRGVQIPLPEGINFVREVVTNHAGFVTVGADLHFAKGLREVIDKNRPADVAASHVPPPSAAAA | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005615 | IEA:Ensembl | C | extracellular space |
| GO:0008289 | IEA:InterPro | F | lipid binding |
| GO:0006869 | IEA:UniProtKB-KW | P | lipid transport |
| GO:0030317 | IMP:MGI | P | sperm motility |
| GO:0010189 | IMP:MGI | P | vitamin E biosynthetic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| mmu03320 | PPAR signaling pathway |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| 5893599 | HDL-mediated lipid transport |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Function | Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine. Essential for the transfer of excess surface lipids from triglyceride-rich lipoproteins to HDL, thereby facilitating the formation of smaller lipoprotein remnants, contributing to the formation of LDL, and assisting in the maturation of HDL particles. PLTP also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion. Two distinct forms of PLTP exist in plasma: an active form that can transfer PC from phospholipid vesicles to high-density lipoproteins (HDL), and an inactive form that lacks this capability (By similarity). {ECO:0000250}. |
| Similarity | Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. {ECO:0000305}. |
| Subcellular Location | Secreted. |
| Tissue Specificity | Highest in lung, adipose tissue, brain, and heart. |
Identical and Related Proteins
Unique RefSeq proteins for LMP001598 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 6755112 | RefSeq | NP_035255 | 493 | phospholipid transfer protein precursor |
Identical Sequences to LMP001598 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6755112 | DBBJ | BAE28485.1 | 493 | unnamed protein product [Mus musculus] |
| GI:6755112 | GenBank | AAA80542.1 | 493 | plasma phospholipid transfer protein [Mus musculus] |
| GI:6755112 | GenBank | ABH98179.1 | 493 | Sequence 15 from patent US 7070929 |
| GI:6755112 | GenBank | EDL06430.1 | 493 | phospholipid transfer protein [Mus musculus] |
| GI:6755112 | RefSeq | XP_006499015.1 | 493 | PREDICTED: phospholipid transfer protein isoform X1 [Mus musculus] |
| GI:6755112 | SwissProt | P55065.1 | 493 | RecName: Full=Phospholipid transfer protein; AltName: Full=Lipid transfer protein II; Flags: Precursor [Mus musculus] |
Related Sequences to LMP001598 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6755112 | EMBL | CAJ18525.1 | 493 | Pltp [Mus musculus] |
| GI:6755112 | GenBank | AAA87943.1 | 491 | plasma phospholipid transfer protein [Mus musculus] |
| GI:6755112 | GenBank | AAH03782.1 | 493 | Phospholipid transfer protein [Mus musculus] |
| GI:6755112 | RefSeq | NP_001162015.1 | 496 | phospholipid transfer protein precursor [Rattus norvegicus] |
| GI:6755112 | RefSeq | XP_006235597.1 | 600 | PREDICTED: phospholipid transfer protein isoform X1 [Rattus norvegicus] |
| GI:6755112 | RefSeq | XP_008760698.1 | 598 | PREDICTED: phospholipid transfer protein isoform X2 [Rattus norvegicus] |