Gene/Proteome Database (LMPD)

LMPD ID
LMP001599
Gene ID
19378
Species
Mus musculus (Mouse)
Gene Name
aldehyde dehydrogenase family 1, subfamily A2
Gene Symbol
Aldh1a2
Synonyms
AV116159; Aldh1a7; Raldh1; Raldh2
Alternate Names
retinal dehydrogenase 2; RALDH 2; RALDH(II); retinaldehyde dehydrogenase 2; aldehyde dehydrogenase family 1 member A2; retinaldehyde-specific dehydrogenase type 2; alcohol dehydrogenase family 1, subfamily A2; alcohol dehydrogenase family 1, subfamily A7
Chromosome
9
Map Location
9 D|9 39.85 cM
EC Number
1.2.1.36

Proteins

retinal dehydrogenase 2
Refseq ID NP_033048
Protein GI 225735569
UniProt ID Q62148
mRNA ID NM_009022
Length 518
RefSeq Status VALIDATED
MTSSEIAMPGEVKADPAALMASLQLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVCNPATGEQVCEVQEADKVDIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRATLATMESLNGGKPFLQAFYIDLQGVIKTLRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFTWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVVNILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVKRSVERAKRRIVGSPFDPTTEQGPQIDKKQYNKVLELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALMVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS

Gene Information

Entrez Gene ID
19378
Gene Name
aldehyde dehydrogenase family 1, subfamily A2
Gene Symbol
Aldh1a2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IEA:Ensembl C cytosol
GO:0048471 IEA:Ensembl C perinuclear region of cytoplasm
GO:0004028 IDA:MGI F 3-chloroallyl aldehyde dehydrogenase activity
GO:0016918 IEA:Ensembl F retinal binding
GO:0001758 IDA:MGI F retinal dehydrogenase activity
GO:0042904 IDA:MGI P 9-cis-retinoic acid biosynthetic process
GO:0009952 IMP:MGI P anterior/posterior pattern specification
GO:0001568 IMP:MGI P blood vessel development
GO:0043010 IMP:MGI P camera-type eye development
GO:0048738 IMP:MGI P cardiac muscle tissue development
GO:0071300 IEP:UniProtKB P cellular response to retinoic acid
GO:0009855 IMP:MGI P determination of bilateral symmetry
GO:0031076 IGI:MGI P embryonic camera-type eye development
GO:0048566 IMP:MGI P embryonic digestive tract development
GO:0035115 IMP:MGI P embryonic forelimb morphogenesis
GO:0030326 IMP:MGI P embryonic limb morphogenesis
GO:0060324 IMP:MGI P face development
GO:0030900 IMP:MGI P forebrain development
GO:0007507 TAS:DFLAT P heart development
GO:0001947 TAS:DFLAT P heart looping
GO:0003007 IMP:MGI P heart morphogenesis
GO:0030902 IMP:MGI P hindbrain development
GO:0001822 IEA:Ensembl P kidney development
GO:0001889 IEA:Ensembl P liver development
GO:0030324 IMP:MGI P lung development
GO:0007494 IEA:Ensembl P midgut development
GO:0016331 IMP:MGI P morphogenesis of embryonic epithelium
GO:0008285 IEA:Ensembl P negative regulation of cell proliferation
GO:0014032 IMP:MGI P neural crest cell development
GO:0021915 IEA:Ensembl P neural tube development
GO:0030182 IMP:MGI P neuron differentiation
GO:0031016 IMP:MGI P pancreas development
GO:0021983 IEA:Ensembl P pituitary gland development
GO:0043065 IMP:MGI P positive regulation of apoptotic process
GO:0008284 IMP:MGI P positive regulation of cell proliferation
GO:0010628 IMP:MGI P positive regulation of gene expression
GO:0009954 IMP:MGI P proximal/distal pattern formation
GO:0001936 IMP:MGI P regulation of endothelial cell proliferation
GO:0034097 IEA:Ensembl P response to cytokine
GO:0032355 IEA:Ensembl P response to estradiol
GO:0033189 IEA:Ensembl P response to vitamin A
GO:0042574 IDA:MGI P retinal metabolic process
GO:0042573 IDA:MGI P retinoic acid metabolic process
GO:0048384 IMP:MGI P retinoic acid receptor signaling pathway
GO:0001523 TAS:DFLAT P retinoid metabolic process
GO:0042572 IEA:UniProtKB-UniPathway P retinol metabolic process
GO:0035799 IMP:MGI P ureter maturation

KEGG Pathway Links

KEGG Pathway ID Description
mmu01100 Metabolic pathways
mmu00830 Retinol metabolism

Domain Information

InterPro Annotations

Accession Description
IPR016162 Aldehyde dehydrogenase N-terminal domain
IPR015590 Aldehyde dehydrogenase domain
IPR016163 Aldehyde dehydrogenase, C-terminal
IPR016160 Aldehyde dehydrogenase, cysteine active site
IPR029510 Aldehyde dehydrogenase, glutamic acid active site
IPR016161 Aldehyde/histidinol dehydrogenase

UniProt Annotations

Entry Information

Gene Name
aldehyde dehydrogenase family 1, subfamily A2
Protein Entry
AL1A2_MOUSE
UniProt ID
Q62148
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Retinal + NAD(+) + H(2)O = retinoate + NADH.
Function Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently (By similarity). {ECO:0000250}.
Pathway Cofactor metabolism; retinol metabolism.
Sequence Caution Sequence=BAC37332.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA67666.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Belongs to the aldehyde dehydrogenase family. {ECO:0000305}.
Subcellular Location Cytoplasm.
Subunit Homotetramer. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001599 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
225735569 RefSeq NP_033048 518 retinal dehydrogenase 2

Identical Sequences to LMP001599 proteins

Reference Database Accession Length Protein Name
GI:225735569 GenBank AAH75704.1 518 Aldh1a2 protein [Mus musculus]
GI:225735569 GenBank EDL26223.1 518 aldehyde dehydrogenase family 1, subfamily A2 [Mus musculus]
GI:225735569 SwissProt Q62148.2 518 RecName: Full=Retinal dehydrogenase 2; Short=RALDH 2; Short=RalDH2; AltName: Full=Aldehyde dehydrogenase family 1 member A2; AltName: Full=Retinaldehyde-specific dehydrogenase type 2; Short=RALDH(II) [Mus musculus]

Related Sequences to LMP001599 proteins

Reference Database Accession Length Protein Name
GI:225735569 GenBank AAH98910.1 518 Aldh1a2 protein [Rattus norvegicus]
GI:225735569 GenBank EDL84165.1 518 aldehyde dehydrogenase family 1, subfamily A2 [Rattus norvegicus]
GI:225735569 RefSeq NP_446348.2 518 retinal dehydrogenase 2 [Rattus norvegicus]
GI:225735569 RefSeq XP_005075520.1 518 PREDICTED: retinal dehydrogenase 2 isoform X1 [Mesocricetus auratus]
GI:225735569 RefSeq XP_007621935.1 518 PREDICTED: retinal dehydrogenase 2 isoform X2 [Cricetulus griseus]
GI:225735569 SwissProt Q63639.2 518 RecName: Full=Retinal dehydrogenase 2; Short=RALDH 2; Short=RalDH2; AltName: Full=Aldehyde dehydrogenase family 1 member A2; AltName: Full=Retinaldehyde-specific dehydrogenase type 2; Short=RALDH(II) [Rattus norvegicus]