Gene/Proteome Database (LMPD)
LMPD ID
LMP001600
Gene ID
Species
Homo sapiens (Human)
Gene Name
protein geranylgeranyltransferase type I, beta subunit
Gene Symbol
Synonyms
BGGI; GGTI
Alternate Names
geranylgeranyl transferase type-1 subunit beta; GGTase-I-beta; geranylgeranyltransferase type I beta subunit; geranylgeranyl transferase type I subunit beta; type I protein geranyl-geranyltransferase subunit beta
Chromosome
5
Map Location
5q22.3
EC Number
2.5.1.59
Summary
Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). The enzyme is composed of a 48-kD alpha subunit (FNTA; MIM 134635) and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase.[supplied by OMIM, Mar 2010]
Orthologs
Proteins
| geranylgeranyl transferase type-1 subunit beta | |
|---|---|
| Refseq ID | NP_005014 |
| Protein GI | 167860116 |
| UniProt ID | P53609 |
| mRNA ID | NM_005023 |
| Length | 377 |
| RefSeq Status | VALIDATED |
| MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST | |
Gene Information
Entrez Gene ID
Gene Name
protein geranylgeranyltransferase type I, beta subunit
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005953 | IDA:UniProtKB | C | CAAX-protein geranylgeranyltransferase complex |
| GO:0004662 | ISS:UniProtKB | F | CAAX-protein geranylgeranyltransferase activity |
| GO:0004661 | IDA:UniProtKB | F | protein geranylgeranyltransferase activity |
| GO:0008270 | ISS:UniProtKB | F | zinc ion binding |
| GO:0051771 | IEA:Ensembl | P | negative regulation of nitric-oxide synthase biosynthetic process |
| GO:0045787 | IEA:Ensembl | P | positive regulation of cell cycle |
| GO:0008284 | IEA:Ensembl | P | positive regulation of cell proliferation |
| GO:0018344 | IDA:UniProtKB | P | protein geranylgeranylation |
| GO:0034097 | IEA:Ensembl | P | response to cytokine |
Domain Information
UniProt Annotations
Entry Information
Gene Name
protein geranylgeranyltransferase type I, beta subunit
Protein Entry
PGTB1_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P53609-1; Sequence=Displayed; Name=2; IsoId=P53609-2; Sequence=VSP_021827; Note=No experimental confirmation available.; |
| Catalytic Activity | Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. |
| Cofactor | Name=Zn(2+); Xref=ChEBI |
| Function | Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B. |
| Similarity | Belongs to the protein prenyltransferase subunit beta family. |
| Similarity | Contains 4 PFTB repeats. |
| Subunit | Heterodimer of FNTA and PGGT1B. PGGT1B mediates interaction with substrate peptides. |
Identical and Related Proteins
Unique RefSeq proteins for LMP001600 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 167860116 | RefSeq | NP_005014 | 377 | geranylgeranyl transferase type-1 subunit beta |
Identical Sequences to LMP001600 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:167860116 | GenBank | EHH54447.1 | 377 | hypothetical protein EGM_15293 [Macaca fascicularis] |
| GI:167860116 | GenBank | AFE64256.1 | 377 | geranylgeranyl transferase type-1 subunit beta [Macaca mulatta] |
| GI:167860116 | RefSeq | NP_001248139.1 | 377 | geranylgeranyl transferase type-1 subunit beta [Macaca mulatta] |
| GI:167860116 | RefSeq | XP_003826773.1 | 377 | PREDICTED: geranylgeranyl transferase type-1 subunit beta isoform X3 [Pan paniscus] |
| GI:167860116 | RefSeq | XP_004042418.1 | 377 | PREDICTED: geranylgeranyl transferase type-1 subunit beta isoform 1 [Gorilla gorilla gorilla] |
| GI:167860116 | RefSeq | XP_005557597.1 | 377 | PREDICTED: geranylgeranyl transferase type-1 subunit beta isoform X2 [Macaca fascicularis] |
Related Sequences to LMP001600 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:167860116 | GenBank | ACM84700.1 | 454 | Sequence 10198 from patent US 6812339 |
| GI:167860116 | GenBank | JAA03934.1 | 377 | protein geranylgeranyltransferase type I, beta subunit [Pan troglodytes] |
| GI:167860116 | GenBank | JAA20834.1 | 377 | protein geranylgeranyltransferase type I, beta subunit [Pan troglodytes] |
| GI:167860116 | GenBank | JAA23089.1 | 377 | protein geranylgeranyltransferase type I, beta subunit [Pan troglodytes] |
| GI:167860116 | GenBank | JAA40326.1 | 377 | protein geranylgeranyltransferase type I, beta subunit [Pan troglodytes] |
| GI:167860116 | RefSeq | XP_003900055.1 | 377 | PREDICTED: geranylgeranyl transferase type-1 subunit beta [Papio anubis] |