Gene/Proteome Database (LMPD)

LMPD ID
LMP001602
Gene ID
23945
Species
Mus musculus (Mouse)
Gene Name
monoglyceride lipase
Gene Symbol
Mgll
Synonyms
AA589436; Magl; Mgl
Chromosome
6
Map Location
6 D1|6
Summary
This gene encodes a monoglyceride lipase, which catalyzes the hydrolysis of monoglycerides into fatty acids and glycerol. This enzyme is also thought to hydrolyze the endocannabinoid 2-arachidonoylglycerol. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]
Orthologs
View orthologs and multiple alignments for Mgll

Proteins

monoglyceride lipase isoform a
Refseq ID NP_001159723
Protein GI 261878516
UniProt ID O35678
mRNA ID NM_001166251
Length 319
RefSeq Status REVIEWED
MQKPRLMETGPKDPCRMPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDELAHMLKGLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDVLQHVDTIQKDYPDVPIFLLGHSMGGAISILVAAERPTYFSGMVLISPLVLANPESASTLKVLAAKLLNFVLPNMTLGRIDSSVLSRNKSEVDLYNSDPLVCRAGLKVCFGIQLLNAVARVERAMPRLTLPFLLLQGSADRLCDSKGAYLLMESSRSQDKTLKMYEGAYHVLHRELPEVTNSVLHEVNSWVSHRIAAAGAGCPP
monoglyceride lipase isoform b
Refseq ID NP_035974
Protein GI 6754690
UniProt ID O35678
mRNA ID NM_011844
Length 303
RefSeq Status REVIEWED
MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDELAHMLKGLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDVLQHVDTIQKDYPDVPIFLLGHSMGGAISILVAAERPTYFSGMVLISPLVLANPESASTLKVLAAKLLNFVLPNMTLGRIDSSVLSRNKSEVDLYNSDPLVCRAGLKVCFGIQLLNAVARVERAMPRLTLPFLLLQGSADRLCDSKGAYLLMESSRSQDKTLKMYEGAYHVLHRELPEVTNSVLHEVNSWVSHRIAAAGAGCPP
monoglyceride lipase isoform c
Refseq ID NP_001159721
Protein GI 261878509
UniProt ID Q3UFN1
mRNA ID NM_001166249
Length 258
RefSeq Status REVIEWED
MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDELAHMLKGLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDVLQHVDTIQKDYPDVPIFLLGHSMGGAISILVAAERPTYFSGMVLISPLVLANPESASTLKVLAAKLLNFVLPNMTLGRIDSSVLSRNKSEGSADRLCDSKGAYLLMESSRSQDKTLKMYEGAYHVLHRELPEVTNSVLHEVNSWVSHRIAAAGAGCPP
monoglyceride lipase isoform d
Refseq ID NP_001159722
Protein GI 261878511
UniProt ID O35678
mRNA ID NM_001166250
Length 132
RefSeq Status REVIEWED
MQKPRLMETGPKDPCRMPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDELAHMLKGLDMLVFAHDHAVMLSAALQSALVIFVRLIWQIIFQGYPRGVCCGGRCHY

Gene Information

Entrez Gene ID
23945
Gene Name
monoglyceride lipase
Gene Symbol
Mgll
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030424 IDA:MGI C axon
GO:0045202 IDA:MGI C synapse
GO:0043196 IDA:MGI C varicosity
GO:0060292 IMP:MGI P long term synaptic depression
GO:0030516 IMP:MGI P regulation of axon extension

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR000073 Alpha/beta hydrolase fold-1
IPR022742 Lysophospholipase_put

UniProt Annotations

Entry Information

Gene Name
monoglyceride lipase
Protein Entry
MGLL_MOUSE
UniProt ID
Q3UFN1
Species
Mouse

Identical and Related Proteins

Unique RefSeq proteins for LMP001602 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
261878516 RefSeq NP_001159723 319 monoglyceride lipase isoform a
6754690 RefSeq NP_035974 303 monoglyceride lipase isoform b
261878509 RefSeq NP_001159721 258 monoglyceride lipase isoform c
261878511 RefSeq NP_001159722 132 monoglyceride lipase isoform d

Identical Sequences to LMP001602 proteins

Reference Database Accession Length Protein Name
GI:6754690 DBBJ BAE20737.1 303 unnamed protein product [Mus musculus]
GI:261878509 DBBJ BAE28529.1 258 unnamed protein product [Mus musculus]
GI:6754690 GenBank ABC13680.1 303 Sequence 83 from patent US 6964849
GI:6754690 GenBank ABE19203.1 303 Sequence 83 from patent US 6991901
GI:6754690 GenBank ABL57300.1 303 Sequence 83 from patent US 7141549
GI:6754690 GenBank EDK99254.1 303 monoglyceride lipase, isoform CRA_b [Mus musculus]
GI:6754690 SwissProt O35678.1 303 RecName: Full=Monoglyceride lipase; Short=MGL; AltName: Full=Monoacylglycerol lipase; Short=MAGL [Mus musculus]

Related Sequences to LMP001602 proteins

Reference Database Accession Length Protein Name
GI:261878511 DBBJ BAB24800.1 116 unnamed protein product [Mus musculus]
GI:261878509 DBBJ BAE20737.1 303 unnamed protein product [Mus musculus]
GI:6754690 DBBJ BAE28433.1 339 unnamed protein product [Mus musculus]
GI:6754690 GenBank AAI07921.1 303 Monoglyceride lipase [Rattus norvegicus]
GI:261878509 GenBank ABC13680.1 303 Sequence 83 from patent US 6964849
GI:261878516 GenBank ABC13680.1 303 Sequence 83 from patent US 6964849
GI:261878516 GenBank ABE19203.1 303 Sequence 83 from patent US 6991901
GI:261878509 GenBank ABE19203.1 303 Sequence 83 from patent US 6991901
GI:261878516 GenBank ABL57300.1 303 Sequence 83 from patent US 7141549
GI:261878509 GenBank ABL57300.1 303 Sequence 83 from patent US 7141549
GI:261878516 GenBank EDK99253.1 337 monoglyceride lipase, isoform CRA_a, partial [Mus musculus]
GI:6754690 GenBank EDK99253.1 337 monoglyceride lipase, isoform CRA_a, partial [Mus musculus]
GI:261878511 GenBank EDK99253.1 337 monoglyceride lipase, isoform CRA_a, partial [Mus musculus]
GI:261878516 GenBank EDK99254.1 303 monoglyceride lipase, isoform CRA_b [Mus musculus]
GI:261878509 GenBank EDK99254.1 303 monoglyceride lipase, isoform CRA_b [Mus musculus]
GI:6754690 GenBank EDL91316.1 303 monoglyceride lipase, isoform CRA_a [Rattus norvegicus]
GI:261878511 GenBank EDL91317.1 319 monoglyceride lipase, isoform CRA_b [Rattus norvegicus]
GI:261878509 RefSeq NP_035974.1 303 monoglyceride lipase isoform b [Mus musculus]
GI:261878516 RefSeq NP_035974.1 303 monoglyceride lipase isoform b [Mus musculus]
GI:6754690 RefSeq NP_612511.1 303 monoglyceride lipase [Rattus norvegicus]
GI:6754690 RefSeq NP_001159723.1 319 monoglyceride lipase isoform a [Mus musculus]
GI:261878511 RefSeq NP_001159723.1 319 monoglyceride lipase isoform a [Mus musculus]
GI:261878511 RefSeq XP_004330295.1 114 PREDICTED: monoglyceride lipase-like, partial [Tursiops truncatus]
GI:261878511 RefSeq XP_008761275.1 319 PREDICTED: monoglyceride lipase isoform X1 [Rattus norvegicus]