Gene/Proteome Database (LMPD)

LMPD ID
LMP001603
Gene ID
133522
Species
Homo sapiens (Human)
Gene Name
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
Gene Symbol
PPARGC1B
Synonyms
ERRL1; PERC; PGC-1(beta); PGC1B
Chromosome
5
Map Location
5q32
Summary
The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Orthologs
View orthologs and multiple alignments for PPARGC1B

Proteins

peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform 1
Refseq ID NP_573570
Protein GI 289577088
UniProt ID Q86YN6
mRNA ID NM_133263
Length 1023
RefSeq Status REVIEWED
MAGNDCGALLDEELSSFFLNYLADTQGGGSGEEQLYADFPELDLSQLDASDFDSATCFGELQWCPENSETEPNQYSPDDSELFQIDSENEALLAELTKTLDDIPEDDVGLAAFPALDGGDALSCTSASPAPSSAPPSPAPEKPSAPAPEVDELSLLQKLLLATSYPTSSSDTQKEGTAWRQAGLRSKSQRPCVKADSTQDKKAPMMQSQSRSCTELHKHLTSAQCCLQDRGLQPPCLQSPRLPAKEDKEPGEDCPSPQPAPASPRDSLALGRADPGAPVSQEDMQAMVQLIRYMHTYCLPQRKLPPQTPEPLPKACSNPSQQVRSRPWSRHHSKASWAEFSILRELLAQDVLCDVSKPYRLATPVYASLTPRSRPRPPKDSQASPGRPSSVEEVRIAASPKSTGPRPSLRPLRLEVKREVRRPARLQQQEEEDEEEEEEEEEEEKEEEEEWGRKRPGRGLPWTKLGRKLESSVCPVRRSRRLNPELGPWLTFADEPLVPSEPQGALPSLCLAPKAYDVERELGSPTDEDSGQDQQLLRGPQIPALESPCESGCGDMDEDPSCPQLPPRDSPRCLMLALSQSDPTFGKKSFEQTLTVELCGTAGLTPPTTPPYKPTEEDPFKPDIKHSLGKEIALSLPSPEGLSLKATPGAAHKLPKKHPERSELLSHLRHATAQPASQAGQKRPFSCSFGDHDYCQVLRPEGVLQRKVLRSWEPSGVHLEDWPQQGAPWAEAQAPGREEDRSCDAGAPPKDSTLLRDHEIRASLTKHFGLLETALEEEDLASCKSPEYDTVFEDSSSSSGESSFLPEEEEEEGEEEEEDDEEEDSGVSPTCSDHCPYQSPPSKANRQLCSRSRSSSGSSPCHSWSPATRRNFRCESRGPCSDRTPSIRHARKRREKAIGEGRVVYIQNLSSDMSSRELKRRFEVFGEIEECEVLTRNRRGEKYGFITYRCSEHAALSLTKGAALRKRNEPSFQLSYGGLRHFCWPRYTDYDSNSEEALPASGKSKYEAMDFDSLLKEAQQSLH
peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform 2
Refseq ID NP_001166169
Protein GI 289577090
UniProt ID Q86YN6
mRNA ID NM_001172698
Length 984
RefSeq Status REVIEWED
MAGNDCGALLDEELSSFFLNYLADTQGGGSGEEQLYADFPELDLSQLDASDFDSATCFGELQWCPENSETEPNQYSPDDSELFQIDSENEALLAELTKTLDDIPEDDVGLAAFPALDGGDALSCTSASPAPSSAPPSPAPEKPSAPAPEVDELSLADSTQDKKAPMMQSQSRSCTELHKHLTSAQCCLQDRGLQPPCLQSPRLPAKEDKEPGEDCPSPQPAPASPRDSLALGRADPGAPVSQEDMQAMVQLIRYMHTYCLPQRKLPPQTPEPLPKACSNPSQQVRSRPWSRHHSKASWAEFSILRELLAQDVLCDVSKPYRLATPVYASLTPRSRPRPPKDSQASPGRPSSVEEVRIAASPKSTGPRPSLRPLRLEVKREVRRPARLQQQEEEDEEEEEEEEEEEKEEEEEWGRKRPGRGLPWTKLGRKLESSVCPVRRSRRLNPELGPWLTFADEPLVPSEPQGALPSLCLAPKAYDVERELGSPTDEDSGQDQQLLRGPQIPALESPCESGCGDMDEDPSCPQLPPRDSPRCLMLALSQSDPTFGKKSFEQTLTVELCGTAGLTPPTTPPYKPTEEDPFKPDIKHSLGKEIALSLPSPEGLSLKATPGAAHKLPKKHPERSELLSHLRHATAQPASQAGQKRPFSCSFGDHDYCQVLRPEGVLQRKVLRSWEPSGVHLEDWPQQGAPWAEAQAPGREEDRSCDAGAPPKDSTLLRDHEIRASLTKHFGLLETALEEEDLASCKSPEYDTVFEDSSSSSGESSFLPEEEEEEGEEEEEDDEEEDSGVSPTCSDHCPYQSPPSKANRQLCSRSRSSSGSSPCHSWSPATRRNFRCESRGPCSDRTPSIRHARKRREKAIGEGRVVYIQNLSSDMSSRELKRRFEVFGEIEECEVLTRNRRGEKYGFITYRCSEHAALSLTKGAALRKRNEPSFQLSYGGLRHFCWPRYTDYDSNSEEALPASGKSKYEAMDFDSLLKEAQQSLH
peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform 3
Refseq ID NP_001166170
Protein GI 289577092
UniProt ID Q86YN6
mRNA ID NM_001172699
Length 959
RefSeq Status REVIEWED
MGGGSGEEQLYADFPELDLSQLDASDFDSATCFGELQWCPENSETEPNQYSPDDSELFQIDSENEALLAELTKTLDDIPEDDVGLAAFPALDGGDALSCTSASPAPSSAPPSPAPEKPSAPAPEVDELSLADSTQDKKAPMMQSQSRSCTELHKHLTSAQCCLQDRGLQPPCLQSPRLPAKEDKEPGEDCPSPQPAPASPRDSLALGRADPGAPVSQEDMQAMVQLIRYMHTYCLPQRKLPPQTPEPLPKACSNPSQQVRSRPWSRHHSKASWAEFSILRELLAQDVLCDVSKPYRLATPVYASLTPRSRPRPPKDSQASPGRPSSVEEVRIAASPKSTGPRPSLRPLRLEVKREVRRPARLQQQEEEDEEEEEEEEEEEKEEEEEWGRKRPGRGLPWTKLGRKLESSVCPVRRSRRLNPELGPWLTFADEPLVPSEPQGALPSLCLAPKAYDVERELGSPTDEDSGQDQQLLRGPQIPALESPCESGCGDMDEDPSCPQLPPRDSPRCLMLALSQSDPTFGKKSFEQTLTVELCGTAGLTPPTTPPYKPTEEDPFKPDIKHSLGKEIALSLPSPEGLSLKATPGAAHKLPKKHPERSELLSHLRHATAQPASQAGQKRPFSCSFGDHDYCQVLRPEGVLQRKVLRSWEPSGVHLEDWPQQGAPWAEAQAPGREEDRSCDAGAPPKDSTLLRDHEIRASLTKHFGLLETALEEEDLASCKSPEYDTVFEDSSSSSGESSFLPEEEEEEGEEEEEDDEEEDSGVSPTCSDHCPYQSPPSKANRQLCSRSRSSSGSSPCHSWSPATRRNFRCESRGPCSDRTPSIRHARKRREKAIGEGRVVYIQNLSSDMSSRELKRRFEVFGEIEECEVLTRNRRGEKYGFITYRCSEHAALSLTKGAALRKRNEPSFQLSYGGLRHFCWPRYTDYDSNSEEALPASGKSKYEAMDFDSLLKEAQQSLH

Gene Information

Entrez Gene ID
133522
Gene Name
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
Gene Symbol
PPARGC1B
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016592 IDA:UniProtKB C mediator complex
GO:0005739 IEA:Ensembl C mitochondrion
GO:0005654 TAS:Reactome C nucleoplasm
GO:0005634 IDA:UniProtKB C nucleus
GO:0050682 IPI:UniProtKB F AF-2 domain binding
GO:0003723 NAS:UniProtKB F RNA binding
GO:0001104 IDA:UniProtKB F RNA polymerase II transcription cofactor activity
GO:0030331 IDA:UniProtKB F estrogen receptor binding
GO:0030374 IDA:UniProtKB F ligand-dependent nuclear receptor transcription coactivator activity
GO:0000166 IEA:InterPro F nucleotide binding
GO:0030546 IDA:UniProtKB F receptor activator activity
GO:0007015 IEA:Ensembl P actin filament organization
GO:0060346 IEA:Ensembl P bone trabecula formation
GO:0044255 TAS:Reactome P cellular lipid metabolic process
GO:0034614 IEA:Ensembl P cellular response to reactive oxygen species
GO:0030520 IDA:UniProtKB P intracellular estrogen receptor signaling pathway
GO:0045892 IEA:Ensembl P negative regulation of transcription, DNA-templated
GO:0001503 IEA:Ensembl P ossification
GO:0010694 IEA:Ensembl P positive regulation of alkaline phosphatase activity
GO:0045780 IEA:Ensembl P positive regulation of bone resorption
GO:0045672 IEA:Ensembl P positive regulation of osteoclast differentiation
GO:0042327 IEA:Ensembl P positive regulation of phosphorylation
GO:2000273 IDA:GOC P positive regulation of receptor activity
GO:0045944 IDA:UniProtKB P positive regulation of transcription from RNA polymerase II promoter
GO:0006355 IDA:UniProtKB P regulation of transcription, DNA-templated
GO:0051591 IEA:Ensembl P response to cAMP
GO:0051384 IEA:Ensembl P response to glucocorticoid
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0006366 IDA:GOC P transcription from RNA polymerase II promoter
GO:0006390 IEA:Ensembl P transcription from mitochondrial promoter

Domain Information

InterPro Annotations

Accession Description
IPR012677 Nucleotide-binding alpha-beta plait domain
IPR000504 RNA recognition motif domain

UniProt Annotations

Entry Information

Gene Name
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
Protein Entry
PRGC2_HUMAN
UniProt ID
Q86YN6
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=PGC1beta-1a; IsoId=Q86YN6-1; Sequence=Displayed; Name=2; Synonyms=PGC1beta-2a; IsoId=Q86YN6-2; Sequence=VSP_019299; Name=3; Synonyms=PGC1beta-1b; IsoId=Q86YN6-3; Sequence=VSP_019301; Name=4; Synonyms=PGC1beta-2b; IsoId=Q86YN6-4; Sequence=VSP_019299, VSP_019301; Name=5; Synonyms=PERC-s; IsoId=Q86YN6-5; Sequence=VSP_019300; Note=Lacks LXXLL motif 1 and has a reduced ability to enhance the hormone-dependent activity of estrogen receptor alpha.; Name=6; IsoId=Q86YN6-6; Sequence=VSP_043374, VSP_019300; Note=No experimental confirmation available.;
Domain Contains 2 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which are usually required for the association with nuclear receptors.
Function Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. {ECO
Induction Repressed by saturated fatty acids such as palmitate and stearate in skeletal muscle cells. Induced by insulin and reduced by aging in skeletal muscle biopsies. Down-regulated in type 2 diabetes mellitus subjects as well as in pre-diabetics.
Polymorphism Variation of PPARGC1B may contribute to the pathogenesis of obesity, with a widespread Ala-203 allele being a risk factor for the development of this common disorders.
Similarity Contains 1 RRM (RNA recognition motif) domain.
Subcellular Location Nucleus .
Subunit Interacts with hepatocyte nuclear factor 4-alpha/HNF4A, Sterol regulatory binding transcription factor 1/SREBF1, PPAR- alpha/PPARA, thyroid hormone receptor beta/THRB and host cell factor/HCFC1. Interacts with estrogen-related receptor gamma/ESRRG and alpha/ESRRA. Interacts with PRDM16 (By similarity). Interacts with estrogen receptor alpha/ESR1. {ECO
Tissue Specificity Ubiquitous with higher expression in heart, brain and skeletal muscle. {ECO

Identical and Related Proteins

Unique RefSeq proteins for LMP001603 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
289577088 RefSeq NP_573570 1023 peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform 1
289577090 RefSeq NP_001166169 984 peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform 2
289577092 RefSeq NP_001166170 959 peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform 3

Identical Sequences to LMP001603 proteins

Reference Database Accession Length Protein Name
GI:289577092 DBBJ BAG53922.1 959 unnamed protein product [Homo sapiens]
GI:289577088 GenBank AAL78633.1 1023 PGC-1-related estrogen receptor alpha coactivator [Homo sapiens]
GI:289577090 GenBank AAL78634.1 984 PGC-1-related estrogen receptor alpha coactivator short isoform [Homo sapiens]
GI:289577088 GenBank EAW61759.1 1023 peroxisome proliferative activated receptor, gamma, coactivator 1, beta, isoform CRA_a [Homo sapiens]
GI:289577090 GenBank EAW61761.1 984 peroxisome proliferative activated receptor, gamma, coactivator 1, beta, isoform CRA_c [Homo sapiens]
GI:289577088 GenBank AAI32972.1 1023 Peroxisome proliferator-activated receptor gamma, coactivator 1 beta [Homo sapiens]
GI:289577090 GenBank AED82497.1 984 Sequence 1234 from patent US 7919467
GI:289577088 SwissProt Q86YN6.2 1023 RecName: Full=Peroxisome proliferator-activated receptor gamma coactivator 1-beta; Short=PGC-1-beta; Short=PPAR-gamma coactivator 1-beta; Short=PPARGC-1-beta; AltName: Full=PGC-1-related estrogen receptor alpha coactivator [Homo sapiens]

Related Sequences to LMP001603 proteins

Reference Database Accession Length Protein Name
GI:289577088 DBBJ BAC04541.1 1023 unnamed protein product [Homo sapiens]
GI:289577092 GenBank AAL78634.1 984 PGC-1-related estrogen receptor alpha coactivator short isoform [Homo sapiens]
GI:289577088 GenBank AAO40022.1 1023 peroxisome proliferator-activated receptor gamma coactivator 1beta-1a [Homo sapiens]
GI:289577090 GenBank EAW61759.1 1023 peroxisome proliferative activated receptor, gamma, coactivator 1, beta, isoform CRA_a [Homo sapiens]
GI:289577092 GenBank EAW61761.1 984 peroxisome proliferative activated receptor, gamma, coactivator 1, beta, isoform CRA_c [Homo sapiens]
GI:289577088 GenBank AAI32974.1 1023 Peroxisome proliferator-activated receptor gamma, coactivator 1 beta [Homo sapiens]
GI:289577090 GenBank AAI32972.1 1023 Peroxisome proliferator-activated receptor gamma, coactivator 1 beta [Homo sapiens]
GI:289577088 GenBank ABP28108.1 1023 Sequence 3123 from patent US 7193069
GI:289577088 GenBank ABY15214.1 1023 Sequence 8 from patent US 7306922
GI:289577090 GenBank AAI44252.1 984 PPARGC1B protein [Homo sapiens]
GI:289577092 GenBank AAI44252.1 984 PPARGC1B protein [Homo sapiens]
GI:289577092 GenBank AED82497.1 984 Sequence 1234 from patent US 7919467
GI:289577088 GenBank AHD74356.1 1023 Sequence 13722 from patent US 8586006
GI:289577090 RefSeq NP_573570.3 1023 peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform 1 [Homo sapiens]
GI:289577092 RefSeq NP_001166169.1 984 peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform 2 [Homo sapiens]
GI:289577092 RefSeq XP_003310944.1 984 PREDICTED: peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform X2 [Pan troglodytes]
GI:289577090 RefSeq XP_003310944.1 984 PREDICTED: peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform X2 [Pan troglodytes]
GI:289577090 SwissProt Q86YN6.2 1023 RecName: Full=Peroxisome proliferator-activated receptor gamma coactivator 1-beta; Short=PGC-1-beta; Short=PPAR-gamma coactivator 1-beta; Short=PPARGC-1-beta; AltName: Full=PGC-1-related estrogen receptor alpha coactivator [Homo sapiens]