Gene/Proteome Database (LMPD)
LMPD ID
LMP001608
Gene ID
Species
Homo sapiens (Human)
Gene Name
inositol-trisphosphate 3-kinase C
Gene Symbol
Synonyms
IP3-3KC; IP3KC
Alternate Names
inositol-trisphosphate 3-kinase C; IP3K C; IP3 3-kinase C; InsP 3 kinase C; insP 3-kinase C; inositol 1,4,5-trisphosphate 3-kinase C
Chromosome
19
Map Location
19q13.1
EC Number
2.7.1.127
Summary
This gene encodes a member of the inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] 3-kinase family of enzymes that catalyze the phosphorylation of inositol 1,4,5-trisphosphate to 1,3,4,5-tetrakisphosphate. The encoded protein is localized to the nucleus and cytoplasm and has both nuclear import and nuclear export activity. Single nucleotide polymorphisms in this gene are associated with Kawasaki disease.[provided by RefSeq, Sep 2009]
Orthologs
Proteins
| inositol-trisphosphate 3-kinase C | |
|---|---|
| Refseq ID | NP_079470 |
| Protein GI | 18643383 |
| UniProt ID | Q96DU7 |
| mRNA ID | NM_025194 |
| Length | 683 |
| RefSeq Status | REVIEWED |
| MRRCPCRGSLNEAEAGALPAAARMGLEAPRGGRRRQPGQQRPGPGAGAPAGRPEGGGPWARTEGSSLHSEPERAGLGPAPGTESPQAEFWTDGQTEPAAAGLGVETERPKQKTEPDRSSLRTHLEWSWSELETTCLWTETGTDGLWTDPHRSDLQFQPEEASPWTQPGVHGPWTELETHGSQTQPERVKSWADNLWTHQNSSSLQTHPEGACPSKEPSADGSWKELYTDGSRTQQDIEGPWTEPYTDGSQKKQDTEAARKQPGTGGFQIQQDTDGSWTQPSTDGSQTAPGTDCLLGEPEDGPLEEPEPGELLTHLYSHLKCSPLCPVPRLIITPETPEPEAQPVGPPSRVEGGSGGFSSASSFDESEDDVVAGGGGASDPEDRSGSKPWKKLKTVLKYSPFVVSFRKHYPWVQLSGHAGNFQAGEDGRILKRFCQCEQRSLEQLMKDPLRPFVPAYYGMVLQDGQTFNQMEDLLADFEGPSIMDCKMGSRTYLEEELVKARERPRPRKDMYEKMVAVDPGAPTPEEHAQGAVTKPRYMQWRETMSSTSTLGFRIEGIKKADGTCNTNFKKTQALEQVTKVLEDFVDGDHVILQKYVACLEELREALEISPFFKTHEVVGSSLLFVHDHTGLAKVWMIDFGKTVALPDHQTLSHRLPWAEGNREDGYLWGLDNMICLLQGLAQS | |
Gene Information
Entrez Gene ID
Gene Name
inositol-trisphosphate 3-kinase C
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005829 | TAS:Reactome | C | cytosol |
| GO:0005634 | IEA:UniProtKB-KW | C | nucleus |
| GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
| GO:0008440 | IEA:UniProtKB-EC | F | inositol-1,4,5-trisphosphate 3-kinase activity |
| GO:0043647 | TAS:Reactome | P | inositol phosphate metabolic process |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa04020 | Calcium signaling pathway |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY-6362 | 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian) |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_150312 | Synthesis of IP3 and IP4 in the cytosol |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR005522 | Inositol polyphosphate kinase |
UniProt Annotations
Entry Information
Gene Name
inositol-trisphosphate 3-kinase C
Protein Entry
IP3KC_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate. |
| Disease | Kawasaki disease (KWD) [MIM |
| Enzyme Regulation | Activated by calcium/calmodulin. Inhibited by high concentrations of the substrate Ins(1,2,4)P3, and allosterically activated by the product Ins(1,3,4,5)P4. |
| Function | Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate. |
| Similarity | Belongs to the inositol phosphokinase (IPK) family. |
| Subcellular Location | Nucleus . Cytoplasm . Note=Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity. |
| Tissue Specificity | Highly expressed in pancreas, skeletal muscle, liver, placenta and weakly in kidney and brain. |
Identical and Related Proteins
Unique RefSeq proteins for LMP001608 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 18643383 | RefSeq | NP_079470 | 683 | inositol-trisphosphate 3-kinase C |
Identical Sequences to LMP001608 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:18643383 | GenBank | AAH60788.1 | 683 | Inositol 1,4,5-trisphosphate 3-kinase C [Homo sapiens] |
| GI:18643383 | GenBank | EAW56992.1 | 683 | inositol 1,4,5-trisphosphate 3-kinase C, isoform CRA_a [Homo sapiens] |
| GI:18643383 | GenBank | EAW56993.1 | 683 | inositol 1,4,5-trisphosphate 3-kinase C, isoform CRA_a [Homo sapiens] |
| GI:18643383 | GenBank | AHD76245.1 | 683 | Sequence 19518 from patent US 8586006 |
| GI:18643383 | RefSeq | XP_006723467.1 | 683 | PREDICTED: inositol-trisphosphate 3-kinase C isoform X2 [Homo sapiens] |
| GI:18643383 | SwissProt | Q96DU7.1 | 683 | RecName: Full=Inositol-trisphosphate 3-kinase C; AltName: Full=Inositol 1,4,5-trisphosphate 3-kinase C; Short=IP3 3-kinase C; Short=IP3K C; Short=InsP 3-kinase C [Homo sapiens] |
Related Sequences to LMP001608 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:18643383 | GenBank | JAA03619.1 | 683 | inositol-trisphosphate 3-kinase C [Pan troglodytes] |
| GI:18643383 | GenBank | JAA15432.1 | 683 | inositol-trisphosphate 3-kinase C [Pan troglodytes] |
| GI:18643383 | RefSeq | XP_524271.2 | 683 | PREDICTED: inositol-trisphosphate 3-kinase C isoform X1 [Pan troglodytes] |
| GI:18643383 | RefSeq | XP_002829282.1 | 683 | PREDICTED: inositol-trisphosphate 3-kinase C [Pongo abelii] |
| GI:18643383 | RefSeq | XP_003270393.1 | 683 | PREDICTED: inositol-trisphosphate 3-kinase C [Nomascus leucogenys] |
| GI:18643383 | RefSeq | XP_004060808.1 | 683 | PREDICTED: inositol-trisphosphate 3-kinase C [Gorilla gorilla gorilla] |