Gene/Proteome Database (LMPD)

LMPD ID
LMP001613
Gene ID
15107
Species
Mus musculus (Mouse)
Gene Name
hydroxyacyl-Coenzyme A dehydrogenase
Gene Symbol
Hadh
Synonyms
AA409008; AU019341; AW742602; HCDH; Hadhsc; Schad
Alternate Names
hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; short chain 3-hydroxyacyl-CoA dehydrogenase; short-chain 3-hydroxyacyl-CoA dehydrogenase; hydroxylacyl-Coenzyme A dehydrogenase-dehydrogenase; L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain; medium and short chain L-3-hydroxyacyl-coenzyme A dehydrogenase
Chromosome
3
Map Location
3 G3|3
EC Number
1.1.1.35

Proteins

hydroxyacyl-coenzyme A dehydrogenase, mitochondrial precursor
Refseq ID NP_032238
Protein GI 111038118
UniProt ID Q61425
mRNA ID NM_008212
Length 314
RefSeq Status VALIDATED
MAFVTRQFLRSMSSSSSASAAAKKILIKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGIEESLKRMAKKKFTENPKAGDEFVEKTLSCLSTSTDAASVVHSTDLVVEAIVENLKLKNELFQRLDKFAAEHTIFASNTSSLQITNIANATTRQDRFAGLHFFNPVPMMKLVEVIKTPMTSQKTFESLVDFCKTLGKHPVSCKDTPGFIVNRLLVPYLIEAVRLHERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFILDGWHEMEPENPLFQPSPSMNNLVAQKKLGKKTGEGFYKYK
transit_peptide: 1..12 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q61425.2) calculated_mol_wt: 1487 peptide sequence: MAFVTRQFLRSM mat_peptide: 13..314 product: Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q61425.2) calculated_mol_wt: 32995 peptide sequence: SSSSSASAAAKKILIKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGIEESLKRMAKKKFTENPKAGDEFVEKTLSCLSTSTDAASVVHSTDLVVEAIVENLKLKNELFQRLDKFAAEHTIFASNTSSLQITNIANATTRQDRFAGLHFFNPVPMMKLVEVIKTPMTSQKTFESLVDFCKTLGKHPVSCKDTPGFIVNRLLVPYLIEAVRLHERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFILDGWHEMEPENPLFQPSPSMNNLVAQKKLGKKTGEGFYKYK

Gene Information

Entrez Gene ID
15107
Gene Name
hydroxyacyl-Coenzyme A dehydrogenase
Gene Symbol
Hadh
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005743 IDA:MGI C mitochondrial inner membrane
GO:0005739 IDA:MGI C mitochondrion
GO:0005634 IEA:Ensembl C nucleus
GO:0003857 IDA:MGI F 3-hydroxyacyl-CoA dehydrogenase activity
GO:0070403 IEA:InterPro F NAD+ binding
GO:0006635 IEA:UniProtKB-UniPathway P fatty acid beta-oxidation
GO:0046676 IEA:Ensembl P negative regulation of insulin secretion
GO:0014823 IEA:Ensembl P response to activity
GO:0042493 IEA:Ensembl P response to drug
GO:0032868 IEA:Ensembl P response to insulin

Domain Information

InterPro Annotations

Accession Description
IPR022694 3-hydroxyacyl-CoA dehydrogenase
IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal
IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding
IPR006180 3-hydroxyacyl-CoA dehydrogenase, conserved site
IPR008927 6-phosphogluconate dehydrogenase, C-terminal-like
IPR013328 Dehydrogenase, multihelical
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
hydroxyacyl-Coenzyme A dehydrogenase
Protein Entry
HCDH_MOUSE
UniProt ID
Q61425
Species
Mouse

Comments

Comment Type Description
Catalytic Activity (S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH.
Function Plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA.
Pathway Lipid metabolism; fatty acid beta-oxidation.
Ptm Succinylation at Lys-81, adjacent to a coenzyme A binding site. Desuccinylated by SIRT5. {ECO:0000269|PubMed:23806337}.
Sequence Caution Sequence=BAA06122.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. {ECO:0000305}.
Subcellular Location Mitochondrion matrix.
Subunit Homodimer. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001613 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
111038118 RefSeq NP_032238 314 hydroxyacyl-coenzyme A dehydrogenase, mitochondrial precursor

Identical Sequences to LMP001613 proteins

Reference Database Accession Length Protein Name
GI:111038118 DBBJ BAE28581.1 314 unnamed protein product [Mus musculus]
GI:111038118 DBBJ BAE39197.1 314 unnamed protein product [Mus musculus]
GI:111038118 DBBJ BAE21064.1 314 unnamed protein product [Mus musculus]
GI:111038118 DBBJ BAE40695.1 314 unnamed protein product [Mus musculus]
GI:111038118 GenBank AAH64712.1 314 Hydroxyacyl-Coenzyme A dehydrogenase [Mus musculus]
GI:111038118 GenBank EDL12203.1 314 L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain [Mus musculus]

Related Sequences to LMP001613 proteins

Reference Database Accession Length Protein Name
GI:111038118 DBBJ BAE41023.1 314 unnamed protein product [Mus musculus]
GI:111038118 DBBJ BAE40188.1 314 unnamed protein product [Mus musculus]
GI:111038118 GenBank AAD42162.1 314 L-3-hydroxyacyl-CoA dehydrogenase precursor [Rattus norvegicus]
GI:111038118 GenBank EDL82212.1 314 L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain, isoform CRA_a [Rattus norvegicus]
GI:111038118 RefSeq NP_476534.1 314 hydroxyacyl-coenzyme A dehydrogenase, mitochondrial precursor [Rattus norvegicus]
GI:111038118 SwissProt Q9WVK7.1 314 RecName: Full=Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; Short=HCDH; AltName: Full=Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase; AltName: Full=Short-chain 3-hydroxyacyl-CoA dehydrogenase; Flags: Precursor [Rattus norvegicus]