Gene/Proteome Database (LMPD)

LMPD ID
LMP001614
Gene ID
55902
Species
Homo sapiens (Human)
Gene Name
acyl-CoA synthetase short-chain family member 2
Gene Symbol
ACSS2
Synonyms
ACAS2; ACECS; ACS; ACSA; dJ1161H23.1
Chromosome
20
Map Location
20q11.22
EC Number
6.2.1.1
Summary
This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
Orthologs
View orthologs and multiple alignments for ACSS2

Proteins

acetyl-coenzyme A synthetase, cytoplasmic isoform 1
Refseq ID NP_061147
Protein GI 8923896
UniProt ID Q6DKJ3
mRNA ID NM_018677
Length 701
RefSeq Status REVIEWED
MGLPEERVRSGSGSRGQEEAGAGGRARSWSPPPEVSRSAHVPSLQRYRELHRRSVEEPREFWGDIAKEFYWKTPCPGPFLRYNFDVTKGKIFIEWMKGATTNICYNVLDRNVHEKKLGDKVAFYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQGIQKGDRVAIYMPMIPELVVAMLACARIGALHSIVFAGFSSESLCERILDSSCSLLITTDAFYRGEKLVNLKELADEALQKCQEKGFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQISWNQGIDLWWHELMQEAGDECEPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHAEDVFWCTADIGWITGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSIVDKYKVTKFYTAPTAIRLLMKFGDEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQTETGGHMLTPLPGATPMKPGSATFPFFGVAPAILNESGEELEGEAEGYLVFKQPWPGIMRTVYGNHERFETTYFKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVVGHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDYIQNAPGLPKTRSGKIMRRVLRKIAQNDHDLGDMSTVADPSVISHLFSHRCLTIQ
acetyl-coenzyme A synthetase, cytoplasmic isoform 2
Refseq ID NP_001070020
Protein GI 253970489
UniProt ID Q96FY7
mRNA ID NM_001076552
Length 714
RefSeq Status REVIEWED
MGLPEERVRSGSGSRGQEEAGAGGRARSWSPPPEVSRSAHVPSLQRYRELHRRSVEEPREFWGDIAKEFYWKTPCPGPFLRYNFDVTKGKIFIEWMKGATTNICYNVLDRNVHEKKLGDKVAFYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQGIQKGDRVAIYMPMIPELVVAMLACARIGALHSIVFAGFSSESLCERILDSSCSLLITTDAFYRGEKLVNLKELADEALQKCQEKGFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQGKLKEKSKRVQPQISWNQGIDLWWHELMQEAGDECEPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHAEDVFWCTADIGWITGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSIVDKYKVTKFYTAPTAIRLLMKFGDEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQTETGGHMLTPLPGATPMKPGSATFPFFGVAPAILNESGEELEGEAEGYLVFKQPWPGIMRTVYGNHERFETTYFKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVVGHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDYIQNAPGLPKTRSGKIMRRVLRKIAQNDHDLGDMSTVADPSVISHLFSHRCLTIQ
acetyl-coenzyme A synthetase, cytoplasmic isoform 3
Refseq ID NP_001229322
Protein GI 334724455
UniProt ID Q4G0E8
mRNA ID NM_001242393
Length 606
RefSeq Status REVIEWED
MKGATTNICYNVLDRNVHEKKLGDKVAFYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQGIQKGDRVAIYMPMIPELVVAMLACARIGALHSIVFAGFSSESLCERILDSSCSLLITTDAFYRGEKLVNLKELADEALQKCQEKGFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQISWNQGIDLWWHELMQEAGDECEPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHAEDVFWCTADIGWITGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSIVDKYKVTKFYTAPTAIRLLMKFGDEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQTETGGHMLTPLPGATPMKPGSATFPFFGVAPAILNESGEELEGEAEGYLVFKQPWPGIMRTVYGNHERFETTYFKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVVGHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDYIQNAPGLPKTRSGKIMRRVLRKIAQNDHDLGDMSTVADPSVISHLFSHRCLTIQ

Gene Information

Entrez Gene ID
55902
Gene Name
acyl-CoA synthetase short-chain family member 2
Gene Symbol
ACSS2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016208 IEA:InterPro F AMP binding
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0003987 IEA:UniProtKB-EC F acetate-CoA ligase activity
GO:0019427 IEA:InterPro P acetyl-CoA biosynthetic process from acetate

KEGG Pathway Links

KEGG Pathway ID Description
hsa01200 Carbon metabolism
hsa00010 Glycolysis / Gluconeogenesis

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY0-1313 acetate conversion to acetyl-CoA

Domain Information

InterPro Annotations

Accession Description
IPR025110 AMP-binding enzyme C-terminal domain
IPR020845 AMP-binding, conserved site
IPR000873 AMP-dependent synthetase/ligase
IPR011904 Acetate-CoA ligase

UniProt Annotations

Entry Information

Gene Name
acyl-CoA synthetase short-chain family member 2
Protein Entry
ACSA_HUMAN
UniProt ID
Q96FY7
Species
Human

Comments

Comment Type Description
Catalytic Activity ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
Similarity Belongs to the ATP-dependent AMP-binding enzyme family.

Identical and Related Proteins

Unique RefSeq proteins for LMP001614 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
8923896 RefSeq NP_061147 701 acetyl-coenzyme A synthetase, cytoplasmic isoform 1
253970489 RefSeq NP_001070020 714 acetyl-coenzyme A synthetase, cytoplasmic isoform 2
334724455 RefSeq NP_001229322 606 acetyl-coenzyme A synthetase, cytoplasmic isoform 3

Identical Sequences to LMP001614 proteins

Reference Database Accession Length Protein Name
GI:334724455 GenBank AAH98422.1 606 ACSS2 protein [Homo sapiens]
GI:253970489 GenBank EAW76248.1 714 acyl-CoA synthetase short-chain family member 2, isoform CRA_f [Homo sapiens]
GI:8923896 GenBank ADT51185.1 701 Sequence 3202 from patent US 7842467
GI:253970489 GenBank ADT51188.1 714 Sequence 3205 from patent US 7842467
GI:8923896 GenBank ADT51191.1 701 Sequence 3208 from patent US 7842467
GI:8923896 GenBank AEW41524.1 701 Sequence 130 from patent US 8076120
GI:8923896 GenBank AFN90989.1 701 Sequence 130 from patent US 8198066
GI:8923896 GenBank AGV79218.1 701 Sequence 130 from patent US 8501455
GI:8923896 GenBank AHD70009.1 701 Sequence 2098 from patent US 8586006
GI:334724455 GenBank AHD70010.1 606 Sequence 2099 from patent US 8586006

Related Sequences to LMP001614 proteins

Reference Database Accession Length Protein Name
GI:253970489 DBBJ BAC03849.1 714 unnamed protein product [Homo sapiens]
GI:253970489 EMBL CBN62119.1 714 unnamed protein product [Homo sapiens]
GI:253970489 EMBL CBN59902.1 714 unnamed protein product [Homo sapiens]
GI:8923896 GenBank AAH12172.1 701 Acyl-CoA synthetase short-chain family member 2 [Homo sapiens]
GI:8923896 GenBank EAW76245.1 703 acyl-CoA synthetase short-chain family member 2, isoform CRA_d [Homo sapiens]
GI:334724455 GenBank EAW76247.1 701 acyl-CoA synthetase short-chain family member 2, isoform CRA_e [Homo sapiens]
GI:334724455 GenBank ACH05719.1 701 Sequence 130 from patent US 7393676
GI:334724455 GenBank ADT42263.1 701 Sequence 1209 from patent US 7833706
GI:8923896 GenBank ADT42266.1 703 Sequence 1212 from patent US 7833706
GI:334724455 GenBank ADT51185.1 701 Sequence 3202 from patent US 7842467
GI:8923896 GenBank ADT51187.1 703 Sequence 3204 from patent US 7842467
GI:334724455 GenBank ADT51191.1 701 Sequence 3208 from patent US 7842467
GI:334724455 GenBank AEW41524.1 701 Sequence 130 from patent US 8076120
GI:8923896 GenBank JAA00757.1 702 acyl-CoA synthetase short-chain family member 2 [Pan troglodytes]
GI:8923896 GenBank JAA12761.1 702 acyl-CoA synthetase short-chain family member 2 [Pan troglodytes]
GI:253970489 RefSeq XP_514806.3 715 PREDICTED: acetyl-coenzyme A synthetase, cytoplasmic isoform X2 [Pan troglodytes]
GI:253970489 RefSeq XP_004062093.1 714 PREDICTED: acetyl-coenzyme A synthetase, cytoplasmic isoform 2 [Gorilla gorilla gorilla]
GI:253970489 RefSeq XP_005260512.1 724 PREDICTED: acetyl-coenzyme A synthetase, cytoplasmic isoform X2 [Homo sapiens]