Gene/Proteome Database (LMPD)

LMPD ID
LMP001616
Gene ID
15487
Species
Mus musculus (Mouse)
Gene Name
hydroxysteroid (17-beta) dehydrogenase 3
Gene Symbol
Hsd17b3
Synonyms
-
Alternate Names
testosterone 17-beta-dehydrogenase 3; 17-beta-HSD 3; 17(beta)HSD type 3; 17-beta-hydroxysteroid dehydrogenase type 3; testicular 17-beta-hydroxysteroid dehydrogenase
Chromosome
13
Map Location
13 B3|13
EC Number
1.1.1.64

Proteins

testosterone 17-beta-dehydrogenase 3
Refseq ID NP_032317
Protein GI 153792573
UniProt ID P70385
mRNA ID NM_008291
Length 305
RefSeq Status VALIDATED
MEKLFIAAGLFVGLVCLVKCMRFSQHLFLRFCKALPSSFLRSMGQWAVITGAGDGIGKAYSFELARHGLNVVLISRTLEKLQTIAEEIERTTGSCVKIVQADFTREDIYDHIKEHLEGLEIGILVNNVGMLPSFFPSHFLSTSGESQNLIHCNITSVVKMTQLVLKHMESRRKGLILNISSGAALRPWPLYSLYSASKAFVYTFSKALSVEYRDKGIIIQVLTPYSISTPMTKYLNNKMTKTADEFVKESLKYVTIGAESCGCLAHEIIAIILNRIPSRIFYSSTAQRFLLTRYSDYLKRNISNR

Gene Information

Entrez Gene ID
15487
Gene Name
hydroxysteroid (17-beta) dehydrogenase 3
Gene Symbol
Hsd17b3
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0047045 IEA:UniProtKB-EC F testosterone 17-beta-dehydrogenase (NADP+) activity
GO:0061370 IEA:UniProtKB-UniPathway P testosterone biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu01100 Metabolic pathways
mmu00140 Steroid hormone biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5893451 Androgen biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR002347 Glucose/ribitol dehydrogenase
IPR016040 NAD(P)-binding domain
IPR002198 Short-chain dehydrogenase/reductase SDR
IPR020904 Short-chain dehydrogenase/reductase, conserved site

UniProt Annotations

Entry Information

Gene Name
hydroxysteroid (17-beta) dehydrogenase 3
Protein Entry
DHB3_MOUSE
UniProt ID
P70385
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Testosterone + NADP(+) = androst-4-ene-3,17- dione + NADPH.
Function Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH (By similarity). {ECO:0000250}.
Pathway Hormone biosynthesis; testosterone biosynthesis.
Similarity Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001616 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
153792573 RefSeq NP_032317 305 testosterone 17-beta-dehydrogenase 3

Identical Sequences to LMP001616 proteins

Reference Database Accession Length Protein Name
GI:153792573 GenBank EDL16224.1 305 hydroxysteroid (17-beta) dehydrogenase 3, isoform CRA_a [Mus musculus]
GI:153792573 GenBank AAI65962.1 305 Hydroxysteroid (17-beta) dehydrogenase 3 [synthetic construct]
GI:153792573 SwissProt P70385.2 305 RecName: Full=Testosterone 17-beta-dehydrogenase 3; AltName: Full=17-beta-hydroxysteroid dehydrogenase type 3; Short=17-beta-HSD 3; AltName: Full=Testicular 17-beta-hydroxysteroid dehydrogenase [Mus musculus]

Related Sequences to LMP001616 proteins

Reference Database Accession Length Protein Name
GI:153792573 GenBank AAB06793.1 305 17-beta-hydroxysteroid dehydrogenase type 3 [Mus musculus]
GI:153792573 GenBank AAB99739.1 306 testicular 17-beta-hydroxysteroid dehydrogenase [Rattus norvegicus]
GI:153792573 RefSeq NP_446459.1 306 testosterone 17-beta-dehydrogenase 3 [Rattus norvegicus]
GI:153792573 RefSeq XP_005371693.1 306 PREDICTED: testosterone 17-beta-dehydrogenase 3 [Microtus ochrogaster]
GI:153792573 RefSeq XP_006981791.1 306 PREDICTED: testosterone 17-beta-dehydrogenase 3 [Peromyscus maniculatus bairdii]
GI:153792573 SwissProt O54939.1 306 RecName: Full=Testosterone 17-beta-dehydrogenase 3; AltName: Full=17-beta-hydroxysteroid dehydrogenase type 3; Short=17-beta-HSD 3; AltName: Full=Testicular 17-beta-hydroxysteroid dehydrogenase [Rattus norvegicus]