Gene/Proteome Database (LMPD)

LMPD ID
LMP001632
Gene ID
56341
Species
Homo sapiens (Human)
Gene Name
protein arginine methyltransferase 8
Gene Symbol
PRMT8
Synonyms
HRMT1L3; HRMT1L4
Chromosome
12
Map Location
12p13.3
Summary
Arginine methylation is a widespread posttranslational modification mediated by arginine methyltransferases, such as PRMT8. Arginine methylation is involved in a number of cellular processes, including DNA repair, RNA transcription, signal transduction, protein compartmentalization, and possibly protein translation (Lee et al., 2005 [PubMed 16051612]).[supplied by OMIM, Mar 2008]
Orthologs
View orthologs and multiple alignments for PRMT8

Proteins

protein arginine N-methyltransferase 8 isoform 1
Refseq ID NP_062828
Protein GI 74099699
UniProt ID Q59GT2
mRNA ID NM_019854
Length 394
RefSeq Status VALIDATED
MGMKHSSRCLLLRRKMAENAAESTEVNSPPSQPPQPVVPAKPVQCVHHVSTQPSCPGRGKMSKLLNPEEMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGSGTGILSMFAAKAGAKKVFGIECSSISDYSEKIIKANHLDNIITIFKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWENVYGFDMTCIRDVAMKEPLVDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQIQRNDYVHALVTYFNIEFTKCHKKMGFSTAPDAPYTHWKQTVFYLEDYLTVRRGEEIYGTISMKPNAKNVRDLDFTVDLDFKGQLCETSVSNDYKMR
protein arginine N-methyltransferase 8 isoform 2
Refseq ID NP_001243465
Protein GI 374858040
UniProt ID Q9NR22
mRNA ID NM_001256536
Length 385
RefSeq Status VALIDATED
MESLASDGFKLKEVSSVNSPPSQPPQPVVPAKPVQCVHHVSTQPSCPGRGKMSKLLNPEEMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGSGTGILSMFAAKAGAKKVFGIECSSISDYSEKIIKANHLDNIITIFKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWENVYGFDMTCIRDVAMKEPLVDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQIQRNDYVHALVTYFNIEFTKCHKKMGFSTAPDAPYTHWKQTVFYLEDYLTVRRGEEIYGTISMKPNAKNVRDLDFTVDLDFKGQLCETSVSNDYKMR

Gene Information

Entrez Gene ID
56341
Gene Name
protein arginine methyltransferase 8
Gene Symbol
PRMT8
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0008168 IEA:UniProtKB-KW F methyltransferase activity
GO:0006479 IEA:InterPro P protein methylation

Domain Information

InterPro Annotations

Accession Description
IPR025799 Protein arginine N-methyltransferase
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase

UniProt Annotations

Entry Information

Gene Name
protein arginine methyltransferase 8
Protein Entry
ANM8_HUMAN
UniProt ID
Q9NR22
Species
Human

Identical and Related Proteins

Unique RefSeq proteins for LMP001632 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
74099699 RefSeq NP_062828 394 protein arginine N-methyltransferase 8 isoform 1
374858040 RefSeq NP_001243465 385 protein arginine N-methyltransferase 8 isoform 2

Identical Sequences to LMP001632 proteins

Reference Database Accession Length Protein Name
GI:74099699 DBBJ BAJ20655.1 394 protein arginine methyltransferase 8, partial [synthetic construct]
GI:74099699 GenBank EAW88861.1 394 protein arginine methyltransferase 8, isoform CRA_a [Homo sapiens]
GI:74099699 GenBank ADC20164.1 394 Sequence 385 from patent US 7638288
GI:74099699 GenBank AGD01125.1 394 Sequence 385 from patent US 8338124
GI:74099699 GenBank AHE00795.1 394 Sequence 53752 from patent US 8586006
GI:74099699 SwissProt Q9NR22.2 394 RecName: Full=Protein arginine N-methyltransferase 8; AltName: Full=Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4 [Homo sapiens]

Related Sequences to LMP001632 proteins

Reference Database Accession Length Protein Name
GI:74099699 GenBank AAH22458.2 394 Protein arginine methyltransferase 8 [Homo sapiens]
GI:74099699 GenBank JAB26493.1 394 protein arginine N-methyltransferase 8 isoform 1 [Callithrix jacchus]
GI:374858040 GenBank AHE00795.1 394 Sequence 53752 from patent US 8586006
GI:74099699 RefSeq XP_001156280.1 394 PREDICTED: protein arginine N-methyltransferase 8 isoform X1 [Pan troglodytes]
GI:74099699 RefSeq XP_003820393.1 394 PREDICTED: protein arginine N-methyltransferase 8 isoform X1 [Pan paniscus]
GI:374858040 RefSeq XP_004279059.1 385 PREDICTED: protein arginine N-methyltransferase 8 isoform 2 [Orcinus orca]
GI:374858040 RefSeq XP_005334062.1 385 PREDICTED: protein arginine N-methyltransferase 8 [Ictidomys tridecemlineatus]
GI:374858040 RefSeq XP_005957070.1 385 PREDICTED: protein arginine N-methyltransferase 8 isoform X1 [Pantholops hodgsonii]
GI:74099699 RefSeq XP_007965450.1 394 PREDICTED: protein arginine N-methyltransferase 8 [Chlorocebus sabaeus]
GI:374858040 RefSeq XP_009245605.1 385 PREDICTED: protein arginine N-methyltransferase 8 isoform X2 [Pongo abelii]
GI:74099699 RefSeq XP_010357472.1 394 PREDICTED: protein arginine N-methyltransferase 8 isoform X1 [Rhinopithecus roxellana]
GI:374858040 RefSeq XP_010357473.1 385 PREDICTED: protein arginine N-methyltransferase 8 isoform X2 [Rhinopithecus roxellana]