Gene/Proteome Database (LMPD)

LMPD ID
LMP001639
Gene ID
9468
Species
Homo sapiens (Human)
Gene Name
phosphate cytidylyltransferase 1, choline, beta
Gene Symbol
PCYT1B
Synonyms
CCTB; CTB
Alternate Names
choline-phosphate cytidylyltransferase B; CT B; CCT B; CCT-beta; phosphorylcholine transferase B; CTP:phosphocholine cytidylyltransferase b
Chromosome
X
Map Location
Xp22.11
EC Number
2.7.7.15
Summary
The protein encoded by this gene belongs to the cytidylyltransferase family. It is involved in the regulation of phosphatidylcholine biosynthesis. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Orthologs
View orthologs and multiple alignments for PCYT1B

Proteins

choline-phosphate cytidylyltransferase B isoform 1
Refseq ID NP_004836
Protein GI 21361202
UniProt ID Q9Y5K3
mRNA ID NM_004845
Length 369
RefSeq Status REVIEWED
MPVVTTDAESETGIPKSLSNEPPSETMEEIEHTCPQPRLTLTAPAPFADETNCQCQAPHEKLTIAQARLGTPADRPVRVYADGIFDLFHSGHARALMQAKTLFPNSYLLVGVCSDDLTHKFKGFTVMNEAERYEALRHCRYVDEVIRDAPWTLTPEFLEKHKIDFVAHDDIPYSSAGSDDVYKHIKEAGMFVPTQRTEGISTSDIITRIVRDYDVYARRNLQRGYTAKELNVSFINEKRYRFQNQVDKMKEKVKNVEERSKEFVNRVEEKSHDLIQKWEEKSREFIGNFLELFGPDGAWKQMFQERSSRMLQALSPKQSPVSSPTRSRSPSRSPSPTFSWLPLKTSPPSSPKAASASISSMSEGDEDEK
choline-phosphate cytidylyltransferase B isoform 2
Refseq ID NP_001156736
Protein GI 253795514
UniProt ID Q9Y5K3
mRNA ID NM_001163264
Length 351
RefSeq Status REVIEWED
MVGHQECIMEEDNRAPQLWRKTLTAPAPFADETNCQCQAPHEKLTIAQARLGTPADRPVRVYADGIFDLFHSGHARALMQAKTLFPNSYLLVGVCSDDLTHKFKGFTVMNEAERYEALRHCRYVDEVIRDAPWTLTPEFLEKHKIDFVAHDDIPYSSAGSDDVYKHIKEAGMFVPTQRTEGISTSDIITRIVRDYDVYARRNLQRGYTAKELNVSFINEKRYRFQNQVDKMKEKVKNVEERSKEFVNRVEEKSHDLIQKWEEKSREFIGNFLELFGPDGAWKQMFQERSSRMLQALSPKQSPVSSPTRSRSPSRSPSPTFSWLPLKTSPPSSPKAASASISSMSEGDEDEK
choline-phosphate cytidylyltransferase B isoform 3
Refseq ID NP_001156737
Protein GI 253795516
UniProt ID Q9Y5K3
mRNA ID NM_001163265
Length 330
RefSeq Status REVIEWED
MPVVTTDAESETGIPKSLSNEPPSETMEEIEHTCPQPRLTLTAPAPFADETNCQCQAPHEKLTIAQARLGTPADRPVRVYADGIFDLFHSGHARALMQAKTLFPNSYLLVGVCSDDLTHKFKGFTVMNEAERYEALRHCRYVDEVIRDAPWTLTPEFLEKHKIDFVAHDDIPYSSAGSDDVYKHIKEAGMFVPTQRTEGISTSDIITRIVRDYDVYARRNLQRGYTAKELNVSFINEKRYRFQNQVDKMKEKVKNVEERSKEFVNRVEEKSHDLIQKWEEKSREFIGNFLELFGPDGAWKQMFQERSSRMLQALSPKQSPLKSWARCRDF

Gene Information

Entrez Gene ID
9468
Gene Name
phosphate cytidylyltransferase 1, choline, beta
Gene Symbol
PCYT1B
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 TAS:ProtInc C cytoplasm
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0004105 TAS:ProtInc F choline-phosphate cytidylyltransferase activity
GO:0006657 TAS:GOC P CDP-choline pathway
GO:0046474 TAS:Reactome P glycerophospholipid biosynthetic process
GO:0001541 IEA:Ensembl P ovarian follicle development
GO:0006656 TAS:Reactome P phosphatidylcholine biosynthetic process
GO:0006644 TAS:Reactome P phospholipid metabolic process
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0007283 IEA:Ensembl P spermatogenesis

KEGG Pathway Links

KEGG Pathway ID Description
hsa00564 Glycerophospholipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_121401 Glycerophospholipid biosynthesis
REACT_121238 Synthesis of PC

Domain Information

InterPro Annotations

Accession Description
IPR004821 Cytidyltransferase-like domain
IPR014729 Rossmann-like alpha/beta/alpha sandwich fold

UniProt Annotations

Entry Information

Gene Name
phosphate cytidylyltransferase 1, choline, beta
Protein Entry
PCY1B_HUMAN
UniProt ID
Q9Y5K3
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=4; Name=2; IsoId=Q9Y5K3-1; Sequence=Displayed; Name=1; IsoId=Q9Y5K3-2; Sequence=VSP_001226; Name=3; IsoId=Q9Y5K3-3; Sequence=VSP_020045, VSP_020046; Note=No experimental confirmation available.; Name=4; IsoId=Q9Y5K3-4; Sequence=VSP_044659; Note=No experimental confirmation available.;
Catalytic Activity CTP + phosphocholine = diphosphate + CDP- choline.
Function Controls phosphatidylcholine synthesis.
Pathway Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2.
Ptm Extensively phosphorylated. The beta-1 isoform seems to be much less phosphorylated.
Similarity Belongs to the cytidylyltransferase family.
Subcellular Location Endoplasmic reticulum.
Tissue Specificity Highly expressed in testis, placenta, brain, ovary and fetus.
Web Resource Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/pcyt1b/";

Identical and Related Proteins

Unique RefSeq proteins for LMP001639 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
21361202 RefSeq NP_004836 369 choline-phosphate cytidylyltransferase B isoform 1
253795514 RefSeq NP_001156736 351 choline-phosphate cytidylyltransferase B isoform 2
253795516 RefSeq NP_001156737 330 choline-phosphate cytidylyltransferase B isoform 3

Identical Sequences to LMP001639 proteins

Reference Database Accession Length Protein Name
GI:253795516 GenBank AAC39754.1 330 CTP:phosphocholine cytidylyltransferase b [Homo sapiens]
GI:253795516 GenBank EAW99023.1 330 phosphate cytidylyltransferase 1, choline, beta, isoform CRA_c [Homo sapiens]
GI:21361202 GenBank JAA01254.1 369 phosphate cytidylyltransferase 1, choline, beta [Pan troglodytes]
GI:21361202 GenBank AGX57896.1 369 Sequence 16093 from patent US 8541208
GI:21361202 GenBank AHD79536.1 369 Sequence 29180 from patent US 8586006
GI:21361202 RefSeq XP_003261210.1 369 PREDICTED: choline-phosphate cytidylyltransferase B isoform 1 [Nomascus leucogenys]
GI:253795514 RefSeq XP_520980.3 351 PREDICTED: choline-phosphate cytidylyltransferase B isoform X1 [Pan troglodytes]
GI:21361202 RefSeq XP_003819632.1 369 PREDICTED: choline-phosphate cytidylyltransferase B isoform X1 [Pan paniscus]
GI:21361202 RefSeq XP_004063972.1 369 PREDICTED: choline-phosphate cytidylyltransferase B isoform 1 [Gorilla gorilla gorilla]

Related Sequences to LMP001639 proteins

Reference Database Accession Length Protein Name
GI:253795514 DBBJ BAG59022.1 351 unnamed protein product [Homo sapiens]
GI:253795516 GenBank ACM81720.1 336 Sequence 7218 from patent US 6812339
GI:21361202 GenBank EHH30598.1 369 Choline-phosphate cytidylyltransferase B [Macaca mulatta]
GI:21361202 GenBank EHH60770.1 369 Choline-phosphate cytidylyltransferase B [Macaca fascicularis]
GI:253795514 GenBank AFE64572.1 351 choline-phosphate cytidylyltransferase B isoform 2 [Macaca mulatta]
GI:253795514 GenBank AFI38830.1 351 choline-phosphate cytidylyltransferase B isoform 2 [Macaca mulatta]
GI:253795514 RefSeq XP_003917564.1 351 PREDICTED: choline-phosphate cytidylyltransferase B isoform X2 [Papio anubis]
GI:21361202 RefSeq XP_005593249.1 369 PREDICTED: choline-phosphate cytidylyltransferase B isoform X1 [Macaca fascicularis]
GI:21361202 RefSeq XP_005593250.1 369 PREDICTED: choline-phosphate cytidylyltransferase B isoform X2 [Macaca fascicularis]
GI:253795514 RefSeq XP_005593251.1 351 PREDICTED: choline-phosphate cytidylyltransferase B isoform X3 [Macaca fascicularis]
GI:253795516 RefSeq XP_005593252.1 338 PREDICTED: choline-phosphate cytidylyltransferase B isoform X4 [Macaca fascicularis]
GI:21361202 RefSeq XP_007989508.1 369 PREDICTED: choline-phosphate cytidylyltransferase B isoform X1 [Chlorocebus sabaeus]
GI:253795516 RefSeq XP_007989512.1 338 PREDICTED: choline-phosphate cytidylyltransferase B isoform X4 [Chlorocebus sabaeus]
GI:253795516 RefSeq XP_008971237.1 338 PREDICTED: choline-phosphate cytidylyltransferase B isoform X2 [Pan paniscus]
GI:253795516 RefSeq XP_009195615.1 338 PREDICTED: choline-phosphate cytidylyltransferase B isoform X3 [Papio anubis]
GI:21361202 RefSeq XP_010351526.1 369 PREDICTED: choline-phosphate cytidylyltransferase B isoform X1 [Rhinopithecus roxellana]
GI:253795514 RefSeq XP_010351527.1 351 PREDICTED: choline-phosphate cytidylyltransferase B isoform X2 [Rhinopithecus roxellana]
GI:253795516 RefSeq XP_010351528.1 338 PREDICTED: choline-phosphate cytidylyltransferase B isoform X3 [Rhinopithecus roxellana]