Gene/Proteome Database (LMPD)

LMPD ID
LMP001666
Gene ID
7357
Species
Homo sapiens (Human)
Gene Name
UDP-glucose ceramide glucosyltransferase
Gene Symbol
UGCG
Synonyms
GCS; GLCT1
Alternate Names
ceramide glucosyltransferase; GLCT-1; glucosylceramide synthase; UDP-glucose:N-acylsphingosine D-glucosyltransferase
Chromosome
9
Map Location
9q31
EC Number
2.4.1.80
Summary
Glycosphingolipids (GSLs) are a group of membrane components that contain lipid and sugar moieties. They are present in essentially all animal cells and are believed to have important roles in various cellular processes. UDP-glucose ceramide glucosyltransferase catalyzes the first glycosylation step in glycosphingolipid biosynthesis. The product, glucosylceramide, is the core structure of more than 300 GSLs. UGCG is widely expressed and transcription is upregulated during keratinocyte differentiation. [provided by RefSeq, Oct 2009]
Orthologs
View orthologs and multiple alignments for UGCG

Proteins

ceramide glucosyltransferase
Refseq ID NP_003349
Protein GI 4507811
UniProt ID Q16739
mRNA ID NM_003358
Length 394
RefSeq Status REVIEWED
MALLDLALEGMAVFGFVLFLVLWLMHFMAIIYTRLHLNKKATDKQPYSKLPGVSLLKPLKGVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVGINPKINNLMPGYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGFAATLEQVYFGTSHPRYYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMAKAIADRGWRFAMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVASLIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMTIYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV

Gene Information

Entrez Gene ID
7357
Gene Name
UDP-glucose ceramide glucosyltransferase
Gene Symbol
UGCG
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0000139 TAS:Reactome C Golgi membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016020 TAS:ProtInc C membrane
GO:0008120 TAS:ProtInc F ceramide glucosyltransferase activity
GO:0008544 TAS:ProtInc P epidermis development
GO:0006679 TAS:ProtInc P glucosylceramide biosynthetic process
GO:0006688 TAS:ProtInc P glycosphingolipid biosynthetic process
GO:0006687 TAS:Reactome P glycosphingolipid metabolic process
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0006665 TAS:Reactome P sphingolipid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00600 Sphingolipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_116105 Glycosphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR025993 Ceramide glucosyltransferase
IPR029044 Nucleotide-diphospho-sugar transferases

UniProt Annotations

Entry Information

Gene Name
UDP-glucose ceramide glucosyltransferase
Protein Entry
CEGT_HUMAN
UniProt ID
Q16739
Species
Human

Comments

Comment Type Description
Catalytic Activity UDP-glucose + N-acylsphingosine = UDP + D- glucosyl-N-acylsphingosine.
Function Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. May also serve as a "flippase".
Pathway Lipid metabolism; sphingolipid metabolism.
Similarity Belongs to the glycosyltransferase 2 family.
Subcellular Location Golgi apparatus membrane ; Multi-pass membrane protein .
Tissue Specificity Found in all tissues examined.
Web Resource Name=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=UGCG";

Identical and Related Proteins

Unique RefSeq proteins for LMP001666 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
4507811 RefSeq NP_003349 394 ceramide glucosyltransferase

Identical Sequences to LMP001666 proteins

Reference Database Accession Length Protein Name
GI:4507811 GenBank AHD78271.1 394 Sequence 25608 from patent US 8586006
GI:4507811 GenBank AHE15992.1 394 Sequence 25 from patent US 8613929
GI:4507811 GenBank AIC55288.1 394 UGCG, partial [synthetic construct]
GI:4507811 RefSeq XP_005581124.1 394 PREDICTED: ceramide glucosyltransferase [Macaca fascicularis]
GI:4507811 RefSeq XP_007966607.1 394 PREDICTED: ceramide glucosyltransferase [Chlorocebus sabaeus]
GI:4507811 RefSeq XP_009455362.1 394 PREDICTED: ceramide glucosyltransferase [Pan troglodytes]

Related Sequences to LMP001666 proteins

Reference Database Accession Length Protein Name
GI:4507811 GenBank AAX29899.1 395 UDP-glucose ceramide glucosyltransferase, partial [synthetic construct]
GI:4507811 GenBank ACM83968.1 490 Sequence 9466 from patent US 6812339
GI:4507811 GenBank JAB10774.1 394 ceramide glucosyltransferase [Callithrix jacchus]
GI:4507811 GenBank JAB13065.1 394 ceramide glucosyltransferase [Callithrix jacchus]
GI:4507811 GenBank JAB23570.1 394 ceramide glucosyltransferase [Callithrix jacchus]
GI:4507811 RefSeq XP_003264049.1 394 PREDICTED: ceramide glucosyltransferase [Nomascus leucogenys]