Gene/Proteome Database (LMPD)

LMPD ID
LMP001672
Gene ID
67260
Species
Mus musculus (Mouse)
Gene Name
ceramide synthase 4
Gene Symbol
Cers4
Synonyms
2900019C14Rik; Lass4; Trh1
Alternate Names
ceramide synthase 4; TRAM homolog 1; longevity assurance homolog 4; LAG1 homolog, ceramide synthase 4; LAG1 longevity assurance homolog 4; translocating chain-associating membrane protein homolog 1
Chromosome
8
Map Location
8|8 A1.2

Proteins

ceramide synthase 4
Refseq ID NP_080334
Protein GI 165972325
UniProt ID Q9D6J1
mRNA ID NM_026058
Length 393
RefSeq Status VALIDATED
MSFSLSEWLWQETYWLPPNVTWAELEDRDGLVFAHPHHVLAAFPVALVLVAVRIVFERFVALPLSRWMGVQDPIRRKIKPNPVLEKYFLRMKQCPEETQMVLLASQCGLTLRQTQRWFRRRRNQDRPSLSKKFCEACWRFVFYLCSFVGGTSILYHESWLWSPSLCWENYPHQTLNLSLYWWYLLELGFYLSLLITLPFDVKRKDFKEQVVHHFVAVGLIGFSYSVNLLRIGAVVLLLHDCSDYLLEGCKILNYAHFRRGCDALFIMFALVFFYTRLIFFPTQVIYTSVYDSIKNSGPFFGYYFFIVLLVMLQILHVYWFCLILRMLYSFLHKGQMTEDIRSDVEEPDSSDDEPVSEGPQLKNGMARGSRVAVTNGPRSRAAACLTNGHTRAT

Gene Information

Entrez Gene ID
67260
Gene Name
ceramide synthase 4
Gene Symbol
Cers4
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:MGI C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0003677 IEA:UniProtKB-KW F DNA binding
GO:0050291 IDA:MGI F sphingosine N-acyltransferase activity
GO:0046513 IDA:MGI P ceramide biosynthetic process
GO:0030148 IDA:MGI P sphingolipid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu00600 Sphingolipid metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY3DJ-12 ceramide biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR001356 Homeobox domain
IPR009057 Homeodomain-like
IPR016439 Longevity assurance, LAG1/LAC1
IPR006634 TRAM/LAG1/CLN8 homology domain

UniProt Annotations

Entry Information

Gene Name
ceramide synthase 4
Protein Entry
CERS4_MOUSE
UniProt ID
Q9D6J1
Species
Mouse

Comments

Comment Type Description
Function May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner. {ECO:0000269|PubMed:12912983}.
Similarity Contains 1 TLC (TRAM/LAG1/CLN8) domain. {ECO:0000255|PROSITE-ProRule:PRU00205}.
Similarity Contains 1 homeobox DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00108}.
Subcellular Location Nucleus membrane {ECO:0000255|PROSITE- ProRule:PRU00108}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:12912983}; Multi-pass membrane protein {ECO:0000269|PubMed:12912983}.
Tissue Specificity Ubiquitously expressed, with highest levels in skin. {ECO:0000269|PubMed:12912983, ECO:0000269|PubMed:15823095}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001672 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
165972325 RefSeq NP_080334 393 ceramide synthase 4

Identical Sequences to LMP001672 proteins

Reference Database Accession Length Protein Name
GI:165972325 DBBJ BAC26876.1 393 unnamed protein product [Mus musculus]
GI:165972325 GenBank EDL22001.1 393 longevity assurance homolog 4 (S. cerevisiae), isoform CRA_a [Mus musculus]
GI:165972325 RefSeq XP_006508924.1 393 PREDICTED: ceramide synthase 4 isoform X1 [Mus musculus]
GI:165972325 RefSeq XP_006508925.1 393 PREDICTED: ceramide synthase 4 isoform X2 [Mus musculus]
GI:165972325 RefSeq XP_006508926.1 393 PREDICTED: ceramide synthase 4 isoform X3 [Mus musculus]
GI:165972325 SwissProt Q9D6J1.1 393 RecName: Full=Ceramide synthase 4; Short=CerS4; AltName: Full=LAG1 longevity assurance homolog 4; AltName: Full=Translocating chain-associating membrane protein homolog 1; Short=TRAM homolog 1 [Mus musculus]

Related Sequences to LMP001672 proteins

Reference Database Accession Length Protein Name
GI:165972325 DBBJ BAC26208.1 393 unnamed protein product [Mus musculus]
GI:165972325 GenBank EDL75005.1 393 longevity assurance homolog 4 (S. cerevisiae) (predicted) [Rattus norvegicus]
GI:165972325 RefSeq NP_001100587.1 393 ceramide synthase 4 [Rattus norvegicus]
GI:165972325 RefSeq XP_005367005.1 393 PREDICTED: ceramide synthase 4 [Microtus ochrogaster]
GI:165972325 RefSeq XP_006248866.1 393 PREDICTED: ceramide synthase 4 isoform X1 [Rattus norvegicus]
GI:165972325 RefSeq XP_006248867.1 393 PREDICTED: ceramide synthase 4 isoform X1 [Rattus norvegicus]